cold fjord writes "The Washington Examiner reports, 'Oregon ... signed up just 44 people for insurance through November, despite spending more than $300 million on its state-based exchange. The state's exchange had the fewest sign-ups in the nation, according to a new report today by the Department of Health and Human Services. The weak number of sign-ups undercuts two major defenses of Obamacare from its supporters. One defense was that state-based exchanges were performing a lot better than the federal healthcare.gov website servicing 36 states. But Oregon's website problems have forced the state to rely on paper applications to sign up participants. Another defense of the Obama administration has attributed the troubled rollout of Obamacare to the obstruction of Republican governors who wanted to see the law fail as well as a lack of funding. But Oregon is a Democratic state that embraced Obamacare early and enthusiastically.'"
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Freshly Exhumed writes "What a father eats before his child is conceived may influence the chance a baby will be born with a birth defect, a new study suggests. Much of the focus on how diet relates to birth has been done on moms. A father's diet before conception plays a crucial role in the health of his offspring, researchers in Canada suggest. Sarah Kimmins, a researcher at McGill University in Montreal, said the study focused on vitamin B9, also known as folate, which is found in green leafy vegetables, cereal, fruit and meat. The researchers found that the mouse offspring of folate-deficient fathers had a 30 percent increased risk of birth defects, compared to those offspring who had received a sufficient amount of folate."
Nerval's Lobster writes "Amazon is apparently not alone in its desire to use miniature drones to deliver packages. On the morning of Monday, Dec. 9, employees at the Bonn, Germany headquarters of package-delivery giant DHL challenged Amazon's plan for dominance of the skies by having medicine delivered from a local pharmacy via a mustard-yellow package-carrying helicopter the Germans dubbed 'Paketkopter.' The quad-rotored mini-drone flew a box of medicines from a launching point near the pharmacy, above traffic and across the Rhine River to DHL's headquarters just over a kilometer away. It made the flight in about two minutes, was unloaded quickly and returned to the launch team near the pharmacy. Amazon has owned total mindshare of the still-imaginary drone-based package delivery market since CEO Jeff Bezos gushed about his plans for Amazon PrimeAir during a TV interview last week. The plan generated immediate controversy due to the negative image of drones following heavy use for surveillance and targeted anti-personnel strikes by the U.S. military in Afghanistan and Iraq. Within the United States, the FAA, FTC and a host of consumer-protection groups objected to the possibility that thousands of autonomous drones would be hovering over U.S. cities, potentially invading the privacy and endangering the lives of those who might run afoul of either cameras or rotors."
An anonymous reader writes "One of this year's winners of the Nobel Peace prize has declared a boycott on leading academic journals after he accused them of contributing to the 'disfigurement' of science. Randy Schekman, who won the Nobel Prize in physiology or medicine, said he would no longer contribute papers or research to the prestigious journals, Nature, Cell and Science, and called for other scientists to fight the 'tyranny' of the publications." And if you'd rather not listen to the sound of auto-playing ads, you'll find Schekman's manifesto at The Guardian.
An anonymous reader writes "There's an interesting story on CNN about the University of Pennsylvania's human trial results on curing intractable cancer by retraining the patient's own immune system. Quoting: 'Nick Wilkins was diagnosed with leukemia when he was 4 years old, and when the cancer kept bouncing back, impervious to all the different treatments the doctors tried, his father sat him down for a talk. John Wilkins explained to Nick, who was by then 14, that doctors had tried chemotherapy, radiation, even a bone marrow transplant from his sister. ... A few months later, Nick traveled from his home in Virginia to Philadelphia to become a part of the experiment. This new therapy was decidedly different from the treatments he'd received before: Instead of attacking his cancer with poisons like chemotherapy and radiation, the Philadelphia doctors taught Nick's own immune cells to become more adept at killing the cancer. Two months later, he emerged cancer-free. It's been six months since Nick, now 15, received the personalized cell therapy, and doctors still can find no trace of leukemia in his system. ... Twenty-one other young people received the same treatment at The Children's Hospital of Philadelphia, and 18 of them, like Nick, went into complete remission -- one of them has been disease-free for 20 months.'"
Hugh Pickens DOT Com writes "Suzanne Koven, a primary-care doctor at Massachusetts General Hospital in Boston, writes in the New Yorker that the FDA has currently approved four drugs that will help patients lose weight but few primary-care physicians will prescribe them. Qsymia and Belviq work by suppressing appetite and by increasing metabolism, and by other mechanisms that are not yet fully understood. 'But I've never prescribed diet drugs, and few doctors in my primary-care practice have, either,' writes Koven and the problem is that, while specialists who study obesity view it as a chronic but treatable disease, primary-care physicians are not fully convinced that they should be treating obesity at all. The inauspicious history of diet drugs no doubt contributes to doctors' reluctance to prescribe them. In the nineteen-forties, when doctors began prescribing amphetamines for weight loss, rates of addiction soared. But in addition, George Bray thinks that socioeconomic factors play into physicians' lack of enthusiasm for treating obesity because obesity is, disproportionately, a disease of poverty. Because of this association, many erroneously see obesity as more of a social condition than a medical one, a condition that simply requires people to try harder. Louis Aronne likens the current attitude toward obesity to the prevailing attitude toward mental illness years ago and remembers, during his medical training, seeing psychotic patients warehoused and sedated, treated as less than human. 'What the hell was I thinking when I didn't do anything to help them? How wrong could I have been?' Specialists are now developing programs to aid primary-care physicians in treating obesity more aggressively and effectively but first primary-care physicians will have to want to treat it. 'Whether you call it a disease or not is not so germane,' says Lee M. Kaplan. 'The root problem is that whatever you call it, nobody's taking it seriously enough.'"
sciencehabit writes "The company 23andMe will no longer provide health information to people who purchase its DNA testing kit, it announced last night.The change was 'to comply with the U.S. Food and Drug Administration's directive to discontinue new consumer access during our regulatory review process,' the statement said. While current customers will still have access to a 23andMe online database noting the health issues associated with their particular DNA, the company will not update that information, and customers who purchased its Personal Genome Service (PGS) on or after 22 November will receive only information about their ancestry and their raw genetic data without interpretation." It would be great to see a secondary market in this kind of analysis emerge.
An anonymous reader writes "A medical radioactive material truck has been stolen just outside Mexico City. From the article: 'BBC world affairs correspondent Rajesh Mirchandani says Cobalt-60 could theoretically be used in a so-called "dirty bomb" - an explosive device that could spread radioactive material over a wide area - although there is no official suggestion this was the purpose of the theft. Mexican police are currently conducting a search for the truck and its contents and have issued a press release to alert the public to its potential dangers.'"
KentuckyFC writes "Epidemiologists have long known how to model the way disease spreads through a population using a computer simulation. This generally involves three populations of individuals: those who are susceptible to disease, those who are infected and those who recover, return to the population and are no longer susceptible. Researchers then feed data about the number of infections and so on into the model which can then work out the disease characteristics such as infection rates. And with this information, they can predict the future evolution of the disease. Now researchers have used a similar model to simulate the spread of infection during a zombie epidemic. They've gathered infection data from real zombie movies, put this into the model and used it to predict the disease characteristics. The results show two clear types of zombie infection which differ in what happens to people after they die. In the first, epitomized by Night of the Living Dead, everybody who dies becomes a zombie. In the second, as in Shaun of the Dead, not everyone who dies becomes a zombie--contact with a zombie beforehand is required. This allows the interesting dynamic of escaping zombification by committing suicide. It also shows how close these zombies have come to winning. The research isn't entirely frivolous. The researchers say exactly the same process of model-building, data gathering and simulation works equally well on real diseases such as influenza. So their approach is a useful teaching tool for budding epidemiologists of the future."
First time accepted submitter Josiah Zayner writes "Katie Drummond at The Verge reports that 'the Infectious Diseases Society of America warned that the pipeline of new antibiotics was "on life support," with only seven drugs in advanced stages of development to treat multidrug-resistant gram-negative superbugs. That's in part because, unlike drugs prescribed to treat chronic conditions, antibiotics are only taken for a few days or weeks at a time — meaning they're less profitable for pharmaceutical companies.' Dr. Josiah Zayner, a synthetic biology fellow at NASA, and Dr. Mark Opal, a neurobiologist and drug development specialist have started an Indiegogo campaign: The ILIAD Project. ILIAD stands for the International Laboratory for Identification of Antibacterial Drugs. Contributors to the project will receive Science kits with all the materials needed for testing environmental samples, such as plants, insects, and bacteria, for antibiotic properties. The information will then be documented in Open manner on Wiki-style website to create the first Massively Multi-Scientist Open Experiment."
kkleiner writes "Among the possible uses for Google Glass that early adopters are dreaming up, you can now add 'surgical assistance' to the list. With approval from the institutional review board, a UCSF cardiothoracic surgeon recently utilized Glass during procedures by utilizing its voice activation features to refer to patient x-ray scans. Aimed at providing surgeons with the most up-to-date patient data, a startup named VitaMedicals is building apps to stream in patient records and live scans to the device. Even though it's early days for Glass, its potential in the medical space is huge and could revolutionize how doctor's access and apply information from patient records."
An anonymous reader writes "Following a BBC report showing abnormal variation in the number of people taken into police custody with mental health problems, concerns have been raised about the legal definition of "mental illness". Prof. Steve Fuller argues that a much sharper legal distinction is required to ensure criminals with mental disorders are not released without appropriate treatment. Fuller distinguishes between two cases: a 'client', who pays a therapist and enjoys a liberal, level-playing field in face-to-face interactions, and a 'patient' who is being treated by a doctor for a particular disorder. If the former relationship cannot be established due to person's mental state, then the latter one should be enforced. Thus, Fuller calls for 'a return to institutions analogous to the asylums of the early 19th century.'"
The much-discussed health care finance sign-up website HealthCare.gov has benefited from the flurry of improvements that have been thrown at it in the last several weeks. Centers for Medicare and Medicaid spokesman Aaron Albright told Fox News Saturday that "[w]ith the scheduled upgrades last night and tonight, we're on track to meet our stated goal for the site to work for the vast majority of users." CMM spokeswoman Julie Bataille. "said the installation of new servers Friday night helped improved the response times and error rates, even with heavier-than-usual weekend traffic." If you've used the site this weekend, what has your experience been like?
ananyo writes "By analysing the chemical structure of a drug, researchers can see if it is likely to bind to, or 'dock' with, a biological target such as a protein. Researchers have now unveiled a computational effort that used Google's supercomputers to assesses billions of potential dockings on the basis of drug and protein information held in public databases. The effort will help researchers to find potentially toxic side effects and to predict how and where a compound might work in the body. 'It's the largest computational docking ever done by mankind,' says Timothy Cardozo, a pharmacologist at New York University's Langone Medical Center, who presented the project at the US National Institutes of Health's High Risk–High Reward Symposium in Bethesda, Maryland. The result, a website called Drugable, is still in testing, but it will eventually be available for free, allowing researchers to predict how and where a compound might work in the body, purely on the basis of chemical structure."
Jah-Wren Ryel writes "In 2012, Canadian Ellen Richardson was hospitalized for clinical depression. This past Monday she tried to board a plane to New York for a $6,000 Caribbean cruise. DHS denied her entry, citing supposedly private medical records listing her hospitalization. From the story: '“I was turned away, I was told, because I had a hospitalization in the summer of 2012 for clinical depression,’’ said Richardson, who is a paraplegic and set up her cruise in collaboration with a March of Dimes group of about 12 others.'"
Rambo Tribble writes "The BBC is reporting that an investigation into a UK-based Amazon facility has uncovered conditions that experts believe foster mental illness. At the root of the problem seems to be unreasonable performance expectations combined with a fundamentally dehumanizing environment. From the article: 'Amazon said that official safety inspections had not raised any concerns and that an independent expert appointed by the company advised that the picking job is "similar to jobs in many other industries and does not increase the risk of mental and physical illness."'"
An anonymous reader writes in with this excerpt from Shirky.com. "The idea that 'failure is not an option' is a fantasy version of how non-engineers should motivate engineers. That sentiment was invented by a screenwriter, riffing on an after-the-fact observation about Apollo 13; no one said it at the time. (If you ever say it, wash your mouth out with soap. If anyone ever says it to you, run.) Even NASA's vaunted moonshot, so often referred to as the best of government innovation, tested with dozens of unmanned missions first, several of which failed outright. Failure is always an option. Engineers work as hard as they do because they understand the risk of failure. And for anything it might have meant in its screenplay version, here that sentiment means the opposite; the unnamed executives were saying 'Addressing the possibility of failure is not an option.' ... Healthcare.gov was unable to complete even a thousand enrollments a day at launch, and for weeks afterwards. As we now know, programmers, stakeholders, and testers all expressed reservations about Healthcare.gov's ability to do what it was supposed to do. Yet no one who understood the problems was able to tell the President. Worse, every senior political figure—every one—who could have bridged the gap between knowledgeable employees and the President decided not to. And so it was that, even on launch day, the President was allowed to make things worse for himself and his signature program by bragging about the already-failing site and inviting people to log in and use something that mostly wouldn't work. Whatever happens to government procurement or hiring (and we should all hope those things get better) a culture that prefers deluding the boss over delivering bad news isn't well equipped to try new things.'"
Hugh Pickens DOT Com writes "Joseph Stromberg writes at the Smithsonian that one afternoon in October 2005, neuroscientist James Fallon was sifting through thousands of PET scans to find anatomical patterns in the brain that correlated with psychopathic tendencies in the real world. 'Out of serendipity, I was also doing a study on Alzheimer's and as part of that, had brain scans from me and everyone in my family right on my desk,' writes Fallon. 'I got to the bottom of the stack, and saw this scan that was obviously pathological.' When he looked up the code, he was greeted by an unsettling revelation: the psychopathic brain pictured in the scan was his own. When he underwent a series of genetic tests, he got more bad news. 'I had all these high-risk alleles for aggression, violence and low empathy,' he says, such as a variant of the MAO-A gene that has been linked with aggressive behavior. It wasn't entirely a shock to Fallon, as he'd always been aware that he was someone especially motivated by power and manipulating others. Additionally, his family line included seven alleged murderers, including Lizzie Borden, infamously accused of killing her father and stepmother in 1892. Many of us would hide this discovery and never tell a soul, out of fear or embarrassment of being labeled a psychopath. Perhaps because boldness and disinhibition are noted psychopathic tendencies, Fallon has gone in the opposite direction, telling the world about his finding in a TED Talk, an NPR interview and now a new book published last month, The Psychopath Inside. 'Since finding all this out and looking into it, I've made an effort to try to change my behavior,' says Fallon. 'I've more consciously been doing things that are considered "the right thing to do," and thinking more about other people's feelings.'"
MTorrice writes "To understand the brain and its chemical complexities, researchers would like to peer inside the skull and measure neurotransmitters levels as the brain at work. Unfortunately, research methods to measure levels of chemicals in the brain require drilling holes in the skull, and noninvasive imaging techniques, such as MRI, can't detect specific molecules. Now, as a first step toward a new imaging tool, chemists report they can detect molecules hidden behind 3- to 8-mm-thick bone."
cartechboy writes "The electric car challenge is what insiders call "getting butts in seats" — and a lot of butts today still belong to humans who are not yet buying electric cars. The big question is: Why? Surveys show drivers are interested in electric cars--and that they love them once they drive them. EVs also cost less to maintain (though more to buy in the first place) and many experts say they're simply nicer to drive. So what's the problem? Disinterested dealers, uneven distribution, limited supplies, and media bias are some potential challenges. Or maybe it's just lousy marketing--casting electric cars as a moral imperative or a duty, like medicine you have to take."