For example, researchers can use the model to predict what will happen to a protein when there’s a mistake in part of the regulatory code. Mutations in splicing instructions have already been linked to diseases such as spinal muscular atrophy, a leading cause of infant death, and some forms of colorectal cancer. In the new study, researchers used the trained model to analyze genetic data from people afflicted with some of those diseases. The scientists identified some known mutations linked to these maladies, verifying that the model works. They picked out some new candidate mutations as well, most notably for autism.
One of the benefits of the model, Frey said, is that it wasn’t trained using disease data, so it should work on any disease or trait of interest. The researchers plan to make the system publicly available, which means that scientists will be able to apply it to many more diseases.
In a process known as DNA methylation, clusters of atoms, called methyl groups, attach to the outside of a gene like microscopic mollusks and make the gene more or less able to receive and respond to biochemical signals from the body. In the exercised portions of the bodies, many of the methylation changes were on portions of the genome known as enhancers that can amplify the expression of proteins by genes. And gene expression was noticeably increased or changed in thousands of the muscle-cell genes that the researchers studied. Most of the genes in question are known to play a role in energy metabolism, insulin response and inflammation within muscles. In other words, they affect how healthy and fit our muscles — and bodies — become. Many mysteries still remain but the message of the study is unambiguous. "Through endurance training — a lifestyle change that is easily available for most people and doesn't cost much money," says Sara Lindholm, "we can induce changes that affect how we use our genes and, through that, get healthier and more functional muscles that ultimately improve our quality of life."
The defining feature of these missions is the vehicle that will be doing the atmospheric exploring: a helium-filled, solar-powered airship. The robotic version would be 31 meters long (about half the size of the Goodyear blimp), while the crewed version would be nearly 130 meters long, or twice the size of a Boeing 747. The top of the airship would be covered with more than 1,000 square meters of solar panels, with a gondola slung underneath for instruments and, in the crewed version, a small habitat and the ascent vehicle that the astronauts would use to return to Venus's orbit, and home."
The first burn—the boostback burn—adjusts the impact point of the vehicle and is followed by the supersonic retro propulsion burn that, along with the drag of the atmosphere, slows the vehicle's speed from 1300 m/s to about 250 m/s. The final burn is the landing burn, during which the legs deploy and the vehicle's speed is further reduced to around 2 m/s. ... To complicate matters further, the landing site is limited in size and not entirely stationary. The autonomous spaceport drone ship is 300 by 100 feet, with wings that extend its width to 170 feet. While that may sound huge at first, to a Falcon 9 first stage coming from space, it seems very small. The legspan of the Falcon 9 first stage is about 70 feet and while the ship is equipped with powerful thrusters to help it stay in place, it is not actually anchored, so finding the bullseye becomes particularly tricky."