The Trump administration will decline to pay tens of millions of dollars owed to the World Health Organization (WHO) in annual dues as part of the U.S.'s withdrawal from the global body, which is scheduled for next year. The Hill reports: The Associated Press reported that the U.S. will not pay just over $60 million owed in 2020 dues to the organization, and Reuters reported that the decision also will affect about $19 million still owed in 2019 dues. A decision to forgo the payments comes as the Trump administration has hammered the WHO for months over supposedly bowing to China's wishes and essentially acting as a PR shop for China's government during the early stages of the pandemic while Chinese officials allegedly stymied international health experts from learning about the virus.

In a statement, a WHO spokesperson said the agency would review its options and encourage the U.S. to reverse course. "We refer you to our previous statements of regret regarding the U.S. decision to withdraw. We await further details, which we will consider carefully," the spokesperson told Reuters.

schwit1 shares a report from the New York Post: As governments around the world scramble to approve a vaccine against the deadly coronavirus, an increasing number of scientists have started administering DIY vaccines to themselves and even their friends and family members. The methods, results, and claims have varied widely among the dozens of scientists around the world who have taken this unconventional route.

One such effort is by scientist Johnny Stine, who runs North Coast Biologics, a biotech company in Seattle. In June, Washington attorney general slapped Stine with a lawsuit for administering his DIY vaccine to San Juan Island Mayor Farhad Ghatan and around 30 people, charging them $400, the New York Times reported. Another vaccine effort going outside FDA approval is the Rapid Deployment Vaccine Collaborative, or RaDVaC, which has among its 23 collaborators Harvard geneticist George Church. Proponents have welcomed the idea of going outside the normal regulatory process, given the extraordinary circumstances of the pandemic. But critics say these DIY vaccines are not being put to the test of placebo-controlled studies and could have unforeseen negative consequences.

Thelasko shares a report from Medium: Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process -- which involved analyzing 2.5 billion genetic combinations -- still took more than a week. When Summit was done, researchers analyzed the results. It was, in the words of Dr. Daniel Jacobson, lead researcher and chief scientist for computational systems biology at Oak Ridge, a 'eureka moment.' The computer had revealed a new theory about how Covid-19 impacts the body: the bradykinin hypothesis. The hypothesis provides a model that explains many aspects of Covid-19, including some of its most bizarre symptoms. It also suggests 10-plus potential treatments, many of which are already FDA approved. Jacobson's group published their results in a paper in the journal eLife in early July.

According to the team's findings, a Covid-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose, (The receptors, which the virus is known to target, are abundant there.) The virus then proceeds through the body, entering cells in other places where ACE2 is also present: the intestines, kidneys, and heart. This likely accounts for at least some of the disease's cardiac and GI symptoms. But once Covid-19 has established itself in the body, things start to get really interesting. According to Jacobson's group, the data Summit analyzed shows that Covid-19 isn't content to simply infect cells that already express lots of ACE2 receptors. Instead, it actively hijacks the body's own systems, tricking it into upregulating ACE2 receptors in places where they're usually expressed at low or medium levels, including the lungs.

The renin-angiotensin system (RAS) controls many aspects of the circulatory system, including the body's levels of a chemical called bradykinin, which normally helps to regulate blood pressure. According to the team's analysis, when the virus tweaks the RAS, it causes the body's mechanisms for regulating bradykinin to go haywire. Bradykinin receptors are resensitized, and the body also stops effectively breaking down bradykinin. (ACE normally degrades bradykinin, but when the virus downregulates it, it can't do this as effectively.) The end result, the researchers say, is to release a bradykinin storm -- a massive, runaway buildup of bradykinin in the body. According to the bradykinin hypothesis, it's this storm that is ultimately responsible for many of Covid-19's deadly effects. Several drugs target aspects of the RAS and are already FDA approved, including danazol, stanozolol, and ecallantide, which reduce bradykinin production and could potentially stop a deadly bradykinin storm.

Interestingly, the researchers suggest vitamin D as a potentially useful Covid-19 drug. "The vitamin is involved in the RAS system and could prove helpful by reducing levels of another compound, known as REN," the report says. "Again, this could stop potentially deadly bradykinin storms from forming." Other compounds could treat symptoms associated with bradykinin storms, such as Hymecromone and timbetasin.

The Trump administration said it will not join a global effort to develop, manufacture and equitably distribute a coronavirus vaccine, in part because the World Health Organization is involved, a decision that could shape the course of the pandemic and the country's role in health diplomacy. The Washington Post reports: More than 170 countries are in talks to participate in the Covid-19 Vaccines Global Access (Covax) Facility, which aims to speed vaccine development and secure doses for all countries and distribute them to the most high-risk segment of each population. The plan, which is co-led by the WHO, the Coalition for Epidemic Preparedness Innovations and Gavi, the vaccine alliance, was of interest to some members of the Trump administration and is backed by traditional U.S. allies, including Japan, Germany and the European Commission, the executive arm of the European Union.

But the United States will not participate, in part because the White House does not want to work with the WHO, which President Trump has criticized over what he characterized as its "China-centric" response to the pandemic. "The United States will continue to engage our international partners to ensure we defeat this virus, but we will not be constrained by multilateral organizations influenced by the corrupt World Health Organization and China," said Judd Deere, a spokesman for the White House. The Covax decision, which has not been previously reported, is effectively a doubling down by the administration on its bet that the United States will win the vaccine race. It eliminates the chance to secure doses from a pool of promising vaccine candidates -- a potentially risky strategy.

An anonymous reader quotes a report from the BBC: Apple has begun letting its iPhones carry out contact-tracing without the need for users to download an official Covid-19 app. As an alternative, owners are being invited to opt in to a scheme called Exposure Notifications Express (ENE). This keeps a 14-day log of other phones detected via Bluetooth and serves an alert if one or more of their users is later diagnosed to have the virus. The local public health authority will determine what the notification says. It might tell the user to download a more fully functional app for further guidance. However, it also gives officials the option of not developing an app of their own, in which case the user could be directed to go to a testing centre or to call a hotline for more information.

IPhone owners who become ill without having received a warning message can still cause a cascade of alerts to be sent to others. But since they will not have an app to start the process, this will be done by tapping on a text message sent by the public health authority to their smartphone after a positive diagnosis. The facility is being rolled out as part of the latest update to Apple's mobile operating system, iOS 13.7, which has just been released. Android is expected to have a similar scheme that will launch later this month. "It will go by the same name, but rather than go down the app-less route, Google has opted to automatically create a basic coronavirus tracing app for public health authorities based on the criteria they provide," reports the BBC.

The Guardian ran an article by the author of Pale Rider: The Spanish Flu of 1918 and How It Changed the World looking at problems with our own race for a vaccine in 2020: On 2 August, Steven Salzberg, a computational biologist at Johns Hopkins University in Baltimore, Maryland, suggested in Forbes magazine that a promising vaccine be rolled out to a wider pool of volunteers before clinical trials had been completed, triggering an outcry (and some sympathy) that prompted him to recant the next day. Meanwhile, a research group with links to Harvard University continues to defend its publication in July of a recipe for a do-it-yourself Covid-19 vaccine — one that only the group's 20-odd members had previously tested...

The accumulation of such incidents has left many scientists feeling deeply uneasy. "I'm more and more concerned that things are getting done in a rush," says Beate Kampmann, who directs the Vaccine Centre at the London School of Hygiene and Tropical Medicine (and whose work email account was subject to a failed hack in July). On 13 August, the editor-in-chief of the journal Science issued a call to order. "Short cuts in testing for vaccine safety and efficacy endanger millions of lives in the short term and will damage public confidence in vaccines and in science for a long time to come," wrote H Holden Thorp.

He went on to point out that the stakes are higher than with unproven therapies such as hydroxychloroquine, because a vaccine is given to healthy people. "Approval of a vaccine that is harmful or isn't effective could be leveraged by political forces that already propagate vaccine fears," he warned... Kampmann, meanwhile, feels it's important not to let the recent shenanigans in the vaccine community overshadow its huge achievements. If current forecasts are correct, a Covid-19 vaccine will be available in 2021 — smashing all records for vaccine development — and there will be many more reasons to trust it than not to. Still, those with their eye on that glittering prize should remember what is at stake. "We have to be careful," she says, "because what we do with Covid-19 could have repercussions for trust in all vaccine programs."

CNET reports: Twice a year most of the U.S. stumbles around in confusion while missing appointments, resetting their clocks and grumbling about daylight saving time. The American Academy of Sleep Medicine thinks we should knock that nonsense off and just stick with standard time year-round. The AASM released a position statement this week as an accepted paper in the Journal of Clinical Sleep Medicine calling for an end to daylight saving time...

The professional organization represents sleep medicine professionals and accredits sleep medicine facilities. "Permanent, year-round standard time is the best choice to most closely match our circadian sleep-wake cycle," said lead author M. Adeel Rishi, a sleep specialist with the Mayo Clinic and vice chair of the AASM Public Safety Committee. "Daylight saving time results in more darkness in the morning and more light in the evening, disrupting the body's natural rhythm."

Studies have pointed to health risks connected to daylight saving time and the sleep disruptions it causes. The AASM called out stroke risks, stress reactions and an increase in motor vehicles crashes, particularly in relation to the springtime clock change. "Because the adoption of permanent standard time would be beneficial for public health and safety, the AASM will be advocating at the federal level for this legislative change," said AASM president Kannan Ramar in a release on Thursday.

gollum123 shared this article from MarketWatch: Do masks really work? Ask the dozens of Starbucks customers who tested positive for COVID-19 in Seoul this month after a woman with coronavirus sat under one of the cafe's air-conditioners. According to a local news report, at least 56 coronavirus cases have been linked to that one customer. The kicker: The four masked workers avoided infection...

"This speaks volumes about the role masks can play," Ma Sang Hyuk, a pediatric infectious diseases physician in South Korea, explained to Bloomberg News. "Masks may not provide 100% protection, but there's nothing out there that's as effective."

Local authorities made it mandatory this week for everybody to wear masks both indoors and outdoors, as the greater Seoul area has seen a surge in coronavirus cases.

A Nevada resident is thought to be the first person in the United States to be infected twice by the coronavirus, according to findings released this week. The New York Post reports: The 25-year-old man, of Reno, experienced a sore throat, cough, headache, nausea and diarrhea -- and first tested positive for the COVID-19 on April 18, according to a study published to the website SSRN Thursday, which has yet to be peer-reviewed. His symptoms had resolved by April 27, and he tested negative for the virus twice in May, the study says. Then on May 31, he sought treatment again for the same symptoms, in addition to a fever and dizziness, according to the study. The patient was hospitalized five days later as his symptoms worsened to include muscle aches, a cough and shortness of breath. He then tested positive for the coronavirus a second time. Another test revealed he had antibodies against the infection. A Hong Kong man was the first patient ever confirmed to be reinfected with the coronavirus. Two European cases of COVID-19 reinfection were reported one day later.

Earlier today, Elon Musk demonstrated his startup Neuralink's brain link device working in a pig named Gertrude. While the science and the device itself were front-and-center at the presentation, the surgical robot the company debuted is equally as important because it's designed to handle the full surgical installation process. "That includes opening up the scalp, removing a portion of the skull, inserting the hundreds of 'thread' electrodes 6mm deep along with the accompanying chip, then closing the incision," reports CNET. TechCrunch takes a closer look at the robot: The rounded polycarbonate sci-fi design of the brain surgeon bot looks like something out of the Portal franchise, but it's actually the creation of Vancouver-based industrial design firm Woke Studio. To be clear, Musk's engineers and scientists have created the underlying technology, but Woke built the robot's look and user experience, as well as the behind-the-ear communication end piece that Neuralink has shown in prior presentations. Neuralink's bot features clean white (required for ensuring sterility, per Woke), arcing lines and smooth surfaces for a look that at once flags its advanced technical capabilities, but also contains some soothing and more approachable elements, which is wise considering what the machine is intended to do.

Woke says the Neuralink surgical robot can be separated into three main parts: The head, the body and base. The head of the robot is that helmet-like piece, which actually holds the head of the patient. It also includes a guide for the surgical needle, as well as embedded cameras and sensors to map the patent's brain. The intent of the design of this piece, which includes a mint-colored interior, is to give the robot "an anthroprmorphic characteristic" that helps distract from the invasive nature of the procedure. There are also single-use disposable bags that line the interior of the helmet for sterile operation. The Neuralink robot also has a "body," that humped rear assembly, which includes all the parts responsible for the motion of the robot as it sets up from the procedure. The third element is the base, which basically keeps the whole thing from tipping over, and apparently also contains the computing brains of the brain-bot itself.

An anonymous reader shares a report: For every 1,000 people infected with the coronavirus who are under the age of 50, almost none will die. For people in their fifties and early sixties, about five will die -- more men than women. The risk then climbs steeply as the years accrue. For every 1,000 people in their mid-seventies or older who are infected, around 116 will die. These are the stark statistics obtained by some of the first detailed studies into the mortality risk for COVID-19. Trends in coronavirus deaths by age have been clear since early in the pandemic. Research teams looking at the presence of antibodies against SARS-CoV-2 in people in the general population -- in Spain, England, Italy and Geneva in Switzerland -- have now quantified that risk, says Marm Kilpatrick, an infectious-disease researcher at the University of California, Santa Cruz. "It gives us a much sharper tool when asking what the impact might be on a certain population that has a certain demographic," says Kilpatrick. The studies reveal that age is by far the strongest predictor of an infected person's risk of dying -- a metric known as the infection fatality ratio (IFR), which is the proportion of people infected with the virus, including those who didn't get tested or show symptoms, who will die as a result.

schwit1 writes: The Food and Drug Administration on Wednesday authorized the first rapid coronavirus test that doesn't need any special computer equipment to get results. The 15-minute test from Abbott Laboratories will sell for $5, giving it a competitive edge over similar tests that need to be popped into a small machine. The self-contained test is the size of a credit card and is based on the same technology used to test for the flu, strep throat and other infections. It's the latest cheaper, simpler test to hit the U.S. market, providing new options to expand testing as schools and businesses struggle to reopen and flu season approaches. The FDA also recently greenlighted a saliva test from Yale University that bypasses some of the supplies that have led to testing bottlenecks. Both tests have limitations and neither can be done at home. Several companies are developing rapid, at-home tests, but none have yet won approval. Abbott's new test still requires a nasal swab by a health worker, like most older coronavirus tests. The Yale saliva test eliminates the need for a swab, but can only be run at high-grade laboratories. And in general, rapid tests like Abbott's are less accurate than lab-developed tests.

schwit1 shares a report from The Boston Globe: A new study estimates the Biogen conference held at Boston's Marriott Long Wharf hotel in February played a far greater role in spreading the coronavirus than previously thought. The research team analyzed the genetic sequences of the virus that caused COVID-19 in the 772 patients, almost all from Essex, Middlesex, Norfolk, and Suffolk counties. By examining mutations in the genetic code that naturally occur as the virus makes copies of itself -- subtle changes that act like a passport stamp showing where the pathogen has been -- the sleuths identified more than 80 distinct SARS-CoV-2 genomes of viruses that infected the Boston area in the first five months of the year. Most of the viruses came from elsewhere in the United States and Western Europe, the scientists said. But one virus with a unique genetic signature had an outsize impact. Some 289 of the 772 patients, or more than a third, were infected with a virus traceable to the meeting held on Feb. 26-27 by Cambridge biotech Biogen.

In a remarkable sign of how the virus can spread unpredictably and take a disproportionate toll on society's most vulnerable members, the 289 conference-related cases included 122 people living in Boston-area homeless shelters and employees who work there, the study says. It's unclear what path the virus took to get there. By multiplying the proportion of conference-related viral genomes in each of the four counties by the total number of coronavirus infections in Essex, Middlesex, Norfolk, and Suffolk, the scientists estimate that 20,000 infections could be linked to the Marriott event. The study never mentions Biogen by name. It simply refers to an "international business conference held in Boston from February 26-27." "We never would have knowingly put anyone at risk," it said in a statement. "When we learned a number of our colleagues were ill, we did not know the cause was COVID-19, but we immediately notified public health authorities and took steps to limit the spread."

Two patients were reinfected with the coronavirus in Europe, according to local broadcasters who confirmed the incidents with virologists. The Hill reports: The patients, one from Belgium and the other from the Netherlands, were confirmed to have been reinfected with COVID-19, Reuters reported. Marian Koopmans, a Dutch virologist, confirmed to broadcaster NOS that the patient from the Netherlands was elderly with a compromised immune system, but did not provide more details about the infection. Koopmans told NOS that in order for reinfection, a virus must change its genetic code. She added during the interview with the broadcaster that, given the veracity of the virus, recurrence of infection was to be expected.

The second patient in Belgium was a woman who had contracted COVID-19 first in March and then a second time in June, Reuters reported. The woman, who was reported to be in her 50s, had a low level of coronavirus antibodies in her system, Belgian virologist Marc Van Ranst told broadcaster VRT. Like Koopmans, Van Ranst cited a genetic mutation of the virus that may have been the cause for reinfection. And whether or not the recurrence of infection will be more rampant in the community is still uncertain. Yesterday, researchers in Hong Kong reported the area's first confirmed reinfection of the virus, 4 1/2 months after the patient's initial infection.

Africa has been declared free from wild polio by the independent body, the Africa Regional Certification Commission. From a report: Polio usually affects children under five, sometimes leading to irreversible paralysis. Death can occur when breathing muscles are affected. Twenty-five years ago thousands of children in Africa were paralysed by the virus. The disease is now only found in Afghanistan and Pakistan. There is no cure but the polio vaccine protects children for life. Nigeria is the last African country to be declared free from wild polio, having accounted for more than half of all global cases less than a decade ago.

An anonymous reader quotes a report from The Guardian: Growing up in a greener urban environment boosts children's intelligence and lowers levels of difficult behavior, a study has found. The analysis of more than 600 children aged 10-15 showed a 3% increase in the greenness of their neighborhood raised their IQ score by an average of 2.6 points. The effect was seen in both richer and poorer areas. There is already significant evidence that green spaces improve various aspects of children's cognitive development but this is the first research to examine IQ. The cause is uncertain but may be linked to lower stress levels, more play and social contact or a quieter environment. The increase in IQ points was particularly significant for those children at the lower end of the spectrum, where small increases could make a big difference, the researchers said.

The study, published in the journal Plos Medicine, used satellite images to measure the level of greenness in neighborhoods, including parks, gardens, street trees and all other vegetation. The average IQ score was 105 but the scientists found 4% of children in areas with low levels of greenery scored below 80, while no children scored below 80 in areas with more greenery. The benefits of more greenery that were recorded in urban areas were not replicated in suburban or rural areas. [T]his may be because those places had enough greenness for all children living there to benefit. Behavioral difficulties such as poor attention and aggressiveness were also measured in the children using a standard rating scale, and the average score was 46. In this case, a 3% rise in greenery resulted in a two-point reduction in behavioral problems, in line with previous studies.

phalse phace writes: Researchers in Hong Kong on Monday reported what appears to be the first confirmed case of Covid-19 reinfection, a 33-year-old man who was first infected by SARS-CoV-2 in late March and then, four and a half months later, seemingly contracted the virus again while traveling in Europe. The case raises questions about the durability of immune protection from the coronavirus.

There have been scattered reports of cases of Covid-19 reinfection. Those reports, though, have been based on anecdotal evidence and largely attributed to flaws in testing. But in this case, researchers at the University of Hong Kong sequenced the virus from the patient's two infections and found that they did not match, indicating the second infection was not tied to the first. There was a difference of 24 nucleotides -- the 'letters' that make up the virus' RNA -- between the two infections. Experts cautioned that this patient's case could be an outlier among the tens of millions of cases around the world and that immune protection may generally last longer than just a few months.

A new cluster of Covid-19 cases in New Zealand prompted a widespread investigation to identify where they're coming from. The New Zealand Herald reports: Nearly 90 new cases of Covid-19 have now been linked back to the new cluster, which itself stemmed from an "index case" — a 50-year-old man working at Mt Wellington's Americold coolstore, with no history or link to overseas travel. Contact tracers have been trying to work backwards from that index case, who tested positive on August 11, in hopes of finding the "primary case" — or the person who brought the virus into the country in the first place.

Friday — more than a week and 175,000 tests since the start of the outbreak — Prime Minister Jacinda Ardern shared some details on how exhaustive that process had been. Virtually all of the country's border and managed isolation staff have been tested in the past 10 days, and so far there had been no additional cases, outside the mystery infection of a maintenance worker at Auckland's Rydges hotel...

University of Auckland microbiologist Associate Professor Siouxsie Wiles says it's quite possible we'll never get any further. "Is that a big deal? From the testing we've done so far, it looks like this is a pretty tight cluster — so I would say, no," she said. "What we have lost is the opportunity to know how it happened, or what gaps need plugging. But at the same time, we have to remember that nothing is 100 per cent guaranteed to work all of the time."

A plan to release over 750 million genetically modified mosquitoes into the Florida Keys in 2021 and 2022 received final approval from local authorities, against the objection of many local residents and a coalition of environmental advocacy groups. The proposal had already won state and federal approval. CNN reports: Approved by the Environment Protection Agency in May, the pilot project is designed to test if a genetically modified mosquito is a viable alternative to spraying insecticides to control the Aedes aegypti. It's a species of mosquito that carries several deadly diseases, such as Zika, dengue, chikungunya and yellow fever. The mosquito, named OX5034, has been altered to produce female offspring that die in the larval stage, well before hatching and growing large enough to bite and spread disease. Only the female mosquito bites for blood, which she needs to mature her eggs. Males feed only on nectar, and are thus not a carrier for disease.

The mosquito also won federal approval to be released into Harris County, Texas, beginning in 2021, according to Oxitec, the US-owned, British-based company that developed the genetically modified organism (GMO). The Environmental Protection Agency granted Oxitec's request after years of investigating the impact of the genetically altered mosquito on human and environmental health. "This is an exciting development because it represents the ground-breaking work of hundreds of passionate people over more than a decade in multiple countries, all of whom want to protect communities from dengue, Zika, yellow fever, and other vector-borne diseases," Oxitec CEO Grey Frandsen said in a statement at the time. However, state and local approval for the Texas release has not been granted, said Sam Bissett, a communication specialist with Harris County Public Health.

The EPA permit requires Oxitec to notify state officials 72 hours before releasing the mosquitoes and conduct ongoing tests for at least 10 weeks to ensure none of the female mosquitoes reach adulthood. However, environmental groups worry that the spread of the genetically modified male genes into the wild population could potentially harm threatened and endangered species of birds, insects and mammals that feed on the mosquitoes.

AleRunner writes: In the first half of 2020, Sweden has recorded its highest death total in 150 years. "In total, 51,405 Swedes died in the six-month period, a higher number than in any year since 1869, when 55,431 people died, partly as a result of a famine," reports The Guardian. In what may be a reaction to this failure, which makes Sweden the worst coronavirus country in Scandinavia, Sweden has announced a change to their new contact-tracing policy. The Local explains: "If you test positive for the coronavirus you may now be given instructions to call people with whom you have been in contact and may have infected, instead of healthcare staff doing the job for you, or it not being done at all."

In early June, Sweden switched from its failed "herd immunity" strategy to a contact-tracing strategy and has since seen a strong fall in new infections, though with a recent slight increase. The new contact-tracing strategy will be critical for the return of the Swedish economy with Sweden currently facing travel restrictions from Scandinavian neighbors such as Finland, whilst other Scandinavian and Baltic countries are already open for trade and tourism. Swedes will be hoping that the adjustment of their new coronavirus strategy will be a signpost for other countries rather than the warning of their old strategy.

Not so long ago, in June, we discussed how Sweden's old strategy had made Sweden a Pariah state and in May we had discussed how Sweden's old strategy caused many deaths whilst failing to deliver immunity.