Having trouble falling asleep, a writer for Vulture pondered a study from February in the Journal of Sleep Research that "runs refreshingly counter to common sleep-and-screens wisdom." For years, science and conventional wisdom have stated unequivocally that looking at a device — like a smartphone, tablet, laptop, or television — before bed is akin to lighting years of your natural life on fire, then letting the flames consume your children, your community, and the very concept of human progress....

Specifically interested in the use of "entertainment media" (streaming services, video games, podcasts) before bed, [the new February study's] researchers asked a group of 58 adults to keep a sleep diary and found that, if participants consumed entertainment media in the hour before bed, the habit was associated with an earlier bedtime as well as more sleep overall (though the benefits diminished if participants binged for longer than an hour or multitasked on their phones). Essentially, these researchers explored screen use before bed as a form of relaxation rather than a form of self-harm, which is exactly how I and probably 5 billion other people use it — as a way of distracting our minds from the onslaught of material reality just before we drift off to temporary oblivion.
Vulture's writer interviews Dr. Morgan Ellithorpe, one of the authors of the Journal of Sleep Research study and an assistant professor in the Department of Communication at the University of Delaware who specializes in media psychology. Dr. Ellithorpe is a proponent of intentional media use as a way to relieve stress, but she tells me that, in her research, she's found that the worst types of media to absorb before bed are those that have no "stopping point" — Instagram, TikTok, shows designed to be binge-watched. If you intend to binge a show, that might be fine: "Making a plan and sticking to it seems to matter," she says. We agree that humans are famously bad at that, and that's where the problems begin. The solution, Dr. Ellithorpe says, is figuring out why we're on our screens and if that reason is "meaningful." Are we turning to a screen in order to recover from an eventful day? Because we want something to talk about with our friends? Because we're seeking, as she puts it, a moment of "hedonic enjoyment"? The key is that you must be able to recognize when that need is fulfilled. Then "you're likely to have a good experience, and you won't need to force yourself to stop. But it takes practice."

Dr. Ellithorpe cites several studies for me to review — on gratification, mood-management theory, selective exposure, and self-determination theory — all of which, to various extents, grapple with the notion that human beings can make decisions to use media for purposeful things. "There's this push now to realize that people aren't a monolith, and media uses that seem bad for some people can actually be really good for other people." Although many researchers like Dr. Ellithorpe and her cohort are onboard with this push, she admits that "the movement has not filtered out to the public yet. So the public is still on this kick of 'Oh, media's bad.'"

And that's a huge part of the issue. "We sabotage ourselves when it comes to benefiting from media because we've been taught in our society to feel guilty for spending leisure time with media," Dr. Ellithorpe says. "The research in this area suggests that people who want to use media to recover from stress, if they then feel bad about doing so, they don't actually get the benefit from the media use."

But even Dr. Ellithorpe is prone to unintentional sleep moralizing, saying she is often "bad" and "on her phone two seconds before I turn off the light." She recommends watching a "low-challenge show" before bed and, like Dr. Kennedy, cites Stranger Things specifically as a dangerous pre-bed content choice because "you have to keep track of all the characters, remember what happened three seasons ago, and it's emotionally charged. It might be difficult afterward to come down from that and go to bed." In the end, she suggests watching whatever you want as long as it doesn't delay your bedtime.

The Guardian notes that "While leap seconds pass by unnoticed for most people, they can cause problems for a range of systems that require an exact, uninterrupted flow of time, such as satellite navigation, software, telecommunication, trade and even space travel."

So now Nature magazine reports that "The practice of adding 'leap seconds' to official clocks to keep them in sync with Earth's rotation will be put on hold from 2035, the world's foremost metrology body has decided." The decision was made by representatives from governments worldwide at the General Conference on Weights and Measures (CGPM) outside Paris on 18 November. It means that from 2035, or possibly earlier, astronomical time (known as UT1) will be allowed to diverge by more than one second from coordinated universal time (UTC), which is based on the steady tick of atomic clocks. Since 1972, whenever the two time systems have drifted apart by more than 0.9 seconds, a leap second has been added....

Facebook's parent company, Meta, and Google are among the tech companies that have called for leap seconds to be scrapped. The CGPM — which also oversees the international system of units (SI) — has proposed that no leap second should be added for at least a century, allowing UT1 and UTC to slide out of sync by about 1 minute. But it plans to consult with other international organizations and decide by 2026 on what upper limit, if any, to put on how much they be allowed to diverge....

Although in the long term Earth's rotation slows due to the pull of the Moon, a speed-up since 2020 has also made the issue more pressing, because for the first time, a leap second might need to be removed, rather than added. UTC has only ever had to slow a beat to wait for Earth, not skip ahead to catch up with it. "It's kind of being described as a Y2K issue, because it's just something that we've never had to deal with," said Elizabeth Donley, who leads the Time and Frequency division at the National Institute of Standards and Technology, in Boulder, Colorado.

For the first time, America's Food and Drug Administration has "approved a treatment that can delay the onset of Type 1 diabetes," reports ABC News: Teplizumab, a monoclonal antibody that will be marketed under the brand name Tzield from pharmaceutical companies ProventionBio and Sanofi, is administered through intravenous infusion. The injection was shown in clinical trials to delay onset of insulin-dependent Type 1 diabetes for patients with autoantibody markers of early risk by over two years, with hopes for some that it can delay onset even longer.... Tzield was approved to delay the onset of stage 3 Type 1 diabetes in adults and children ages 8 and up who currently have stage 2 Type 1 diabetes.

The medication is thought to slow down the body's attack on its own insulin-producing cells and thus give people more time before they become dependent on pharmaceutical insulin. Tzield is not suitable for people with insulin-dependent Type 1 diabetes, people who are pre-Type 2 diabetics or those with type 2 diabetes. "This approval is a watershed moment for the treatment and prevention of type 1 diabetes," said Dr. Mark S. Anderson, director of the University of California San Francisco Diabetes Center. "Until now, the only real therapy for patients has been a lifetime of insulin replacement. This new therapy targets and helps to halt the autoimmune process that leads to the loss of insulin...."

Studies have shown that 75% of people with these diagnostic markers usually become insulin-dependent within five years and nearly 100% at some point in their lifetime.
ABC News also shares this quote from Dr. John Sharretts, director of the Division of Diabetes, Lipid Disorders, and Obesity in the FDA's Center for Drug Evaluation and Research. "The drug's potential to delay clinical diagnosis of type 1 diabetes may provide patients with months to years without the burdens of disease."

sciencehabit shares a report from Science Magazine: Triple threat. Tripledemic. A viral perfect storm. These frightening phrases have dominated recent headlines as some health officials, clinicians, and scientists forecast that SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) could surge at the same time in Northern Hemisphere locales that have relaxed masking, social distancing, and other COVID-19 precautions. But a growing body of epidemiological and laboratory evidence offers some reassurance: SARS-CoV-2 and other respiratory viruses often "interfere" with each other. Although waves of each virus may stress emergency rooms and intensive care units, the small clique of researchers who study these viral collisions say there is little chance the trio will peak together and collectively crash hospital systems the way COVID-19 did at the pandemic's start.

"Flu and other respiratory viruses and SARS-CoV-2 just don't get along very well together," says virologist Richard Webby, an influenza researcher at St. Jude Children's Research Hospital. "It's unlikely that they will circulate widely at the same time." "One virus tends to bully the others," adds epidemiologist Ben Cowling at the University of Hong Kong School of Public Health. During the surge of the highly transmissible Omicron variant of SARS-CoV-2 in Hong Kong in March, Cowling found that other respiratory viruses "disappeared ... and they came back again in April." When a respiratory virus sweeps through a community, interferons can broadly raise the body's defenses and temporarily erect a populationwide immune barrier against subsequent viruses that target the respiratory system. "Basically, every virus triggers the interferon response to some extent, and every virus is susceptible to it," says immunologist Ellen Foxman at Yale University, who has been exploring interference between SARS-CoV-2 and other viruses in a laboratory model of the human airway. Rhinoviruses, which cause common colds, can trip up influenza A (the most prevalent flu virus). RSV can bump rhinoviruses and human metapneumoviruses. Influenza A can thwart its distant cousin influenza B. "There are a lot of major health implications from viral interference," says Guy Boivin, a virologist at Laval University who co-authored a review (PDF) on viral interference earlier this year.

Now, viral interference researchers are closely watching the newest respiratory virus to circle the globe. "What interactions could SARS-CoV-2 have with other viruses?" Murcia asks. "To this day, there are no robust epidemiological data." For one thing, the widespread social distancing and mask wearing in many countries meant there was little chance to see interference in action. "There was almost no circulation of other respiratory viruses during the first 3 years of the pandemic," Boivin says. Also, SARS-CoV-2 has many defenses against interferons, including preventing their production, which might affect its interactions with other viruses. Still, Foxman has published evidence that, in her organoid model, rhinovirus can interfere with SARS-CoV-2. And Boivin's team has reported (PDF) that influenza A and SARS-CoV-2 each can block the other in cell studies.

A new map of the universe displays for the first time the span of the entire known cosmos with pinpoint accuracy and sweeping beauty. Phys.Org reports: Created by Johns Hopkins University astronomers with data mined over two decades by the Sloan Digital Sky Survey, the map allows the public to experience data previously only accessible to scientists. The interactive map, which depicts the actual position and real colors of 200,000 galaxies, is available online, where it can also be downloaded for free.

The Sloan Digital Sky Survey is a pioneering effort to capture the night sky through a telescope based in New Mexico. Night after night for years, the telescope aimed at slightly different locations to capture this unusually broad perspective. The map, which [map creator Brice Manard] assembled with the help of former Johns Hopkins computer science student Nikita Shtarkman, visualizes a slice of the universe, or about 200,000 galaxies -- each dot on the map is a galaxy and each galaxy contains billions of stars and planets. The Milky Way is simply one of these dots, the one at the very bottom of the map.

The expansion of the universe contributes to make this map even more colorful. The farther an object, the redder it appears. The top of the map reveals the first flash of radiation emitted soon after the Big Bang, 13.7 billion years ago. "In this map, we are just a speck at the very bottom, just one pixel. And when I say we, I mean our galaxy, the Milky Way which has billions of stars and planets," Manard says. "We are used to seeing astronomical pictures showing one galaxy here, one galaxy there or perhaps a group of galaxies. But what this map shows is a very, very different scale." For those interested, Johns Hopkins University published a video about the map on YouTube.

An anonymous reader quotes a report from Phys.Org: Say hello to ronnagrams and quettameters: International scientists gathered in France voted on Friday for new metric prefixes to express the world's largest and smallest measurements, prompted by an ever-growing amount of data. It marks the first time in more than three decades that new prefixes have been added to the International System of Units (SI), the agreed global standard for the metric system. Joining the ranks of well-known prefixes like kilo and milli are ronna and quetta for the largest numbers -- and ronto and quecto for the smallest.

The change was voted on by scientists and government representatives from across the world attending the 27th General Conference on Weights and Measures, which governs the SI and meets roughly every four years at Versailles Palace, west of Paris. The prefixes make it easier to express large amounts -- for example, always referring to a kilometer as 1,000 meters or a millimeter as one thousandth of a meter would quickly become cumbersome. Since the SI was established in 1960, scientific need has led to a growing number of prefixes. The last time was in 1991, when chemists wanting to express vast molecular quantities spurred the addition of zetta and yotta.

The new prefixes can simplify how we talk about some pretty big objects. "If we think about mass, instead of distance, the Earth weighs approximately six ronnagrams," which is a six followed by 27 zeroes, [sad Richard Brown, the head of metrology at the UK's National Physical Laboratory]. "Jupiter, that's about two quettagrams," he added -- a two followed by 30 zeros. Brown said he had the idea for the update when he saw media reports using unsanctioned prefixes for data storage such as brontobytes and hellabytes. Google in particular has been using hella for bytes since 2010. "Those were terms that were unofficially in circulation, so it was clear that the SI had to do something," he said.

Theranos founder Elizabeth Holmes was sentenced Friday in a federal court to 135 months, more than 11 years in prison following her conviction on four counts of criminal fraud. The court found she deceived investors, including News Corp.'s Rupert Murdoch and a host of other luminaries, about the efficacy of Theranos' blood-testing technology. CNBC reports: Holmes cried while speaking to the court ahead of her sentencing. "I loved Theranos. It was my life's work," Holmes said. "My team meant the world to me. I am devastated by my failings. I'm so so sorry. I gave everything I had to build my company." Her defense team argued she should face a maximum sentence of 18 months, according to court filings.

The Wall Street Journal first broke the story of how Theranos' blood-testing technology was struggling to meet expectations in 2015. Whistleblowers and other witnesses came forth to provide detailed accounts of how Holmes and former operating chief Ramesh "Sunny" Balwani deceived patients, partners, investors and employees about the company's progress and the capabilities of its technology. "Thank you for having me. Thank you for the courtesy and respect you have shown me," she said Friday. "I have felt deep pain for what people went through because I failed them. To investors, patients, I am sorry." Prosecutors sought a 15 year sentence for the pregnant 38-year-old former billionaire and Silicon Valley celebrity. Developing...

What happens when old atomic bombs are retired? Last month, the Biden administration announced its intention to withdraw the nation's most powerful weapon from the U.S. nuclear arsenal. From a report: The bomb is called the B83. It is a hydrogen bomb that debuted in 1983 -- a time when President Reagan was denouncing Russia as "an evil empire." The government made 660 of the deadly weapons, which were to be delivered by fast bombers. The B83 was 12 feet long, had fins and packed an explosive force roughly 80 times greater than that of the Hiroshima bomb. Its job was to obliterate hardened military sites and command bunkers, including Moscow's.

What now for the B83? How many still exist is a federal secret, but not the weapon's likely fate, which may surprise anyone who assumes that getting rid of a nuclear weapon means that it vanishes from the face of the earth. Typically, nuclear arms retired from the U.S. arsenal are not melted down, pulverized, crushed, buried or otherwise destroyed. Instead, they are painstakingly disassembled, and their parts, including their deadly plutonium cores, are kept in a maze of bunkers and warehouses across the United States. Any individual facility within this gargantuan complex can act as a kind of used-parts superstore from which new weapons can -- and do -- emerge.

India launched its first rocket developed by a startup into space on Friday, with the aim of testing the company's technology that will be used to design three orbital vehicles. From a report: The Vikram-S rocket, developed by Hyderabad-based Skyroot Aerospace, took off at 11:30 a.m. local time from Sriharikota, an island near Chennai in southeastern India. The rocket reached an altitude of 89.5 kilometers (56 miles) and all systems worked as planned, Pawan Goenka, head of an industry space body said.

"It's a major step forward to India developing its own space ecosystem and emerging as a front-line nation in space," Space Minister Jitendra Singh said. Built in just two years, the sub-orbital validated the pressure, temperature and vibration in Skyroot's orbital vehicles, with the first of the series, Vikram I, scheduled to launch next year. It carried a payload from two Indian aerospace startups and a non-profit space research laboratory in Armenia.

The world's first vaccine to treat deadly cancerous brain tumors can potentially give patients years of extra life, a global clinical trial has concluded. The Guardian reports: A senior NHS doctor who was one of the trial's chief investigators said the evidence showed DCVax had resulted in "astonishing" enhanced survival for patients. One patient in the 331-person multicenter global study lived for more than eight years after receiving DCVax. In Britain, 53-year-old Nigel French is still alive seven years after having it. If approved by medical regulators, DCVax would be the first new treatment in 17 years for newly diagnosed glioblastoma patients and the first in 27 years for people in whom it had returned. "The total results are astonishing," said Prof Keyoumars Ashkan, a neurosurgeon at King's College hospital in London who was the European chief investigator of the trial. "The final results of this phase three trial... offer fresh hope to patients battling with glioblastoma."

Trial researchers found that newly diagnosed patients who had the vaccine survived for 19.3 months on average, compared with 16.5 months for those who received a placebo. Participants with recurrent glioblastoma who had had DCVax lived on average for 13.2 months after receiving it, compared with just 7.8 months for those who did not. Overall 13% of people who received it lived for at least five years after diagnosis, while just 5.7% of those in the control group did so, according to the results of the trial, which were published on Thursday in the Journal of the American Medical Association Oncology.

The vaccine is a form of immunotherapy, in which the body's immune system is programmed to track down and attack the tumor. It is the first developed to tackle brain tumors. "The vaccine works by stimulating the patient's own immune system to fight against the patient's tumor. It provides a personalized solution, working with a patient's immune system, which is the most intelligent system known to man," said Ashkan. "The vaccine is produced by combining proteins from a patient's own tumor with their white blood cells. This educates the white cells to recognize the tumor. "When the vaccine is administered, these educated white blood cells then help the rest of the patient's immune system recognize the tumor as something it needs to fight against and destroy. Almost like training a sniffer dog."

The US Food and Drug Administration has given a safety clearance to lab-grown meat for the first time. From a report: Upside Foods, a California-based company that makes meat from cultured chicken cells, will be able to begin selling its products once its facilities have been inspected by the US Department of Agriculture. The agency said it had evaluated the information submitted by Upside Foods and it had "no further questions at this time about the firm's safety conclusion."

"Advancements in cell culture technology are enabling food developers to use animal cells obtained from livestock, poultry, and seafood in the production of food, with these products expected to be ready for the U.S. market in the near future," Dr. Robert M. Califf, the FDA's commissioner of food and drugs and Susan T. Mayne, director of the FDA's Center for Food Safety and Applied Nutrition (CFSAN), said in a statement.

A super-pressurized, 290-mile-long river is running under the ice sheet. That could be bad news for sea-level rise. From a report: For all its treacherousness and general inclination to kill you, Antarctica's icy surface is fairly tranquil: vast stretches of miles-thick whiteness, with not a plant or animal to speak of. But way below the surface, where that ice meets land, things get wild. What scientists used to think was a ho-hum subglacial environment is in fact humming with hydrological activity, recent research is revealing, with major implications for global sea-level rise. Researchers just found that, at the base of Antarctica's ice, an area the size of Germany and France combined is feeding meltwater into a super-pressurized, 290-mile-long river running to the sea. "Thirty years ago, we thought the whole of the ice pretty much was frozen to the bed," says Imperial College London glaciologist Martin Siegert, coauthor of a new paper in Nature Geoscience describing the finding. "Now we're in a position that we've just never been in before, to understand the whole of the Antarctic ice sheet."

Antarctica's ice is divided into two main components: the ice sheet that sits on land, and the ice shelf that extends off the coast, floating on seawater. Where the two meet -- where the ice lifts off the bed and starts touching the ocean -- is known as the grounding line. But the underside of all that ice is obscured. To find out what's going on below, some scientists have hiked across glaciers while dragging ground-penetrating radar units on sleds -- the pings travel through thousands of feet of ice and bounce off the underlying seawater, so the researchers can build detailed maps of what used to be hidden. Others are setting off explosions, then analyzing the seismic waves that come back to the surface to indicate whether there's land or water below. Still others are lowering torpedo-shaped robots through boreholes to get unprecedented imagery of the underside of the floating ice shelf. Up in the sky, satellites can measure minute changes in surface elevation, which indicates the features below -- a swell, for instance, might betray a subglacial lake.

The James Webb space telescope has revealed its latest image of celestial majesty, an ethereal hourglass of orange and blue dust being shot out from a newly forming star at its center. The Guardian reports: The colourful clouds are only visible in infrared light, so had never been seen before being captured by Webb's Near-Infrared Camera (Nircam), Nasa and the European Space Agency said in a statement on Wednesday. The very young star, known as protostar L1527, is hidden in darkness by the edge of a rotating disk of gas at the neck of the hourglass. However, light spills out from the top and bottom of the disk, lighting up the hourglass-shaped clouds.

The clouds are created by material ejected from the star colliding with surrounding matter, the statement said. The dust is thinnest in the blue sections and thickest in the orange parts, it added. The protostar, which is just 100,000 years old and at the earliest stage of star formation, is not yet able to generate its own energy. The surrounding black disk, which is about the size of our solar system, will feed material to the protostar until it eventually reaches "the threshold for nuclear fusion to begin," the statement said. "Ultimately, this view of L1527 provides a window into what our sun and solar system looked like in their infancy," it added. The protostar is located in the Taurus molecular cloud, a stellar nursery home to hundreds of nearly formed stars around 430 light years from Earth.

Dairy cows fed industrial hemp produced milk with detectable levels of the buzz-inducing molecular compound THC, according to a new study from Germany that could influence the potential uses of hemp as an ingredient in animal feed. The dairy cows also showed behavioral changes -- yawning and salivating a lot, moving a little unsteadily on their hoofs, standing in one place for a protracted period, and having a "somnolent appearance." The Washington Post reports: The peer-reviewed study, conducted on Holstein cows in Berlin and published Monday in the journal Nature Food, is one of the first major investigations of the use of industrial hemp as a potential supplement in animal feed. For now, such use is illegal under U.S. law, which does not allow THC in the food chain. But the new research comes as hemp, which has many industrial uses, continues to emerge from an agricultural exile that dates to the "reefer madness" hysteria of the 1930s. [...]

The researchers at the German Federal Institute for Risk Assessment found no behavioral change in cows given the entire hemp plant, which contained very low levels of THC. Only when fed solely the portions of the hemp plant with higher THC concentrations -- including the flowers and leaves -- did the behavioral effects appear, according to the study. Those effects included slower heart rate and respiration, "pronounced tongue play, increased yawning, salivation, nasal secretion formation," and reddening of a portion of the eyes, the report states. Some animals "displayed careful, occasionally unsteady gait, unusually long standing and abnormal posture." The animals also ate less and produced less milk, according to Robert Pieper, head of the department of food chain safety for the institute and co-author of the new paper. "That is a strong effect on animal health. Not a positive effect," he said. But he did not predict how it would play out in the policy world.

Researchers have developed a fentanyl vaccine that could eliminate the drug's "high" by blocking its ability to enter the brain -- which could be a major step forward in the ongoing opioid crisis. Yahoo News reports: The study, conducted by a research team led by the University of Houston and funded by the Department of Defense through the Alcohol and Substance Abuse Disorder Research Program, was published in the journal Pharmaceutics at the end of October. Colin Haile, a research associate professor of psychology and lead author of the study, said in a news release that the vaccine "is able to generate anti-fentanyl antibodies that bind to the consumed fentanyl and prevent it from entering the brain, allowing it to be eliminated out of the body via the kidneys. "Thus, the individual will not feel the euphoric effects and can "get back on the wagon' to sobriety."

Haile added that the anti-fentanyl antibodies didn't cross-react with other opioids, meaning a vaccinated person could still be treated for pain relief with other opioids. The vaccine did not cause any adverse side effects in rats involved in lab studies, and clinical trials in humans are planned "soon," with manufacturing of clinical-grade vaccine to begin in the coming months.

A partnership with Driscoll's exemplifies a shift toward more pedestrian projects with actual commercial applications. From a report: When Deb Menicos walks a strawberry field, she doesn't just look at the berries. Menicos, who holds a Ph.D. in plant breeding from Ohio State University and works as a senior scientist at Driscoll's, will often find herself counting leaves and examining the small stalks protruding from the base of the plant. These parts, known as trusses, are important because they're where the flowers and berries grow. "We want a small plant, with compact leaves and trusses poking out -- not too long, because we don't want them to touch the dirt," she says. Developing a new berry variety at Driscoll's takes at least five years. It begins with a crop of 25,000 genetically distinct plants that grow in the company's breeding field near its headquarters in Watsonville, California. Menicos and her colleagues winnow that down first to 250 plants, then clone them and replant them, narrowing the field until they have a winner.

The goal is to make the most and tastiest berries while minimizing the cost of fertilizers, pesticides and labor. Today, determining which genetic attributes translate into the easiest plants to harvest comes down to "observations and feelings," Menicos says. "We want to have better data, more quantitative data. And that's where Mineral comes in." Mineral is another way of saying Google. The closely guarded project grew out of an effort by the company's famous innovation lab, X, to use cameras and machine learning to help farmers make better decisions. Working with Driscoll's, Mineral created large unmanned rovers -- the vehicles are a little bigger than a Smart car and are packed with sensors and cameras -- that drive up and down crop rows collecting data that tell farmers which plants are thriving and which aren't.

This is known as "phenotyping," and it's a huge challenge for farmers, says Elliott Grant, Mineral's general manager. "The price of genetic modeling went down to pretty much nothing, but you still don't know what the plant does when you engineer it," he says. "Breeders and crop researchers are still going into the fields with tape measures and notepads." [...] Besides at Driscoll's, Google is testing versions of its agricultural technology with more than a dozen other companies including Syngenta, the Chinese state-owned agricultural giant that develops seeds, insecticides and herbicides for staples such as soybeans, corn and wheat.

NASA's Artemis 1 rocket blasted off the Kennedy Space Center in the early hours of Wednesday, "lighting up the night sky and accelerating on a journey that will take an astronaut-less capsule around the moon and back," reports the New York Times. From the report: At around 1:47 a.m. Eastern time, the four engines on the rocket's core stage ignited, along with two skinnier side boosters. As the countdown hit zero, clamps holding the rocket down let go, and the vehicle slipped Earth's bonds. A few minutes later, the side boosters and then the giant core stage dropped away. The rocket's upper engine then ignited to carry the Orion spacecraft, where astronauts will sit during later missions, toward orbit. Less than the two hours after launch, the upper stage will fire one last time to send Orion on a path toward the moon. On Monday, Orion will pass within 60 miles of the moon's surface. After going around the moon for a couple of weeks, Orion will head back to Earth, splashing down on Dec. 11 in the Pacific Ocean, about 60 miles off the coast of California.

This flight, evoking the bygone Apollo era, is a crucial test for NASA's Artemis program that aims to put astronauts, after five decades of loitering in low-Earth orbit, back on the moon. For NASA, the mission ushers in a new era of lunar exploration, one that seeks to unravel scientific mysteries in the shadows of craters in the polar regions, test technologies for dreamed-of journeys to Mars and spur private enterprise to chase new entrepreneurial frontiers farther out in the solar system. [...] The launch occurred years behind schedule, and billions of dollars over budget. The delays and cost overruns of S.L.S. and Orion highlight the shortcomings of how NASA has managed its programs. The next Artemis mission, which is to take four astronauts on a journey around the moon but not to the surface, will launch no earlier than 2024. Artemis III, in which two astronauts will land near the moon's south pole, is currently scheduled for 2025, though that date is very likely to slip further into the future. NASA posted a video of the liftoff on their Twitter. Additional updates are available @NASA_SLS.

UPDATE 7:22 UTC: NASA's Artemis 1 rocket blasted off the Kennedy Space Center in the early hours of Wednesday, "lighting up the night sky and accelerating on a journey that will take an astronaut-less capsule around the moon and back," reports the New York Times. From the report: At around 1:47 a.m. Eastern time, the four engines on the rocket's core stage ignited, along with two skinnier side boosters. As the countdown hit zero, clamps holding the rocket down let go, and the vehicle slipped Earth's bonds. A few minutes later, the side boosters and then the giant core stage dropped away. The rocket's upper engine then ignited to carry the Orion spacecraft, where astronauts will sit during later missions, toward orbit. Less than the two hours after launch, the upper stage will fire one last time to send Orion on a path toward the moon. On Monday, Orion will pass within 60 miles of the moon's surface. After going around the moon for a couple of weeks, Orion will head back to Earth, splashing down on Dec. 11 in the Pacific Ocean, about 60 miles off the coast of California.

This flight, evoking the bygone Apollo era, is a crucial test for NASA's Artemis program that aims to put astronauts, after five decades of loitering in low-Earth orbit, back on the moon. For NASA, the mission ushers in a new era of lunar exploration, one that seeks to unravel scientific mysteries in the shadows of craters in the polar regions, test technologies for dreamed-of journeys to Mars and spur private enterprise to chase new entrepreneurial frontiers farther out in the solar system. [...] The launch occurred years behind schedule, and billions of dollars over budget. The delays and cost overruns of S.L.S. and Orion highlight the shortcomings of how NASA has managed its programs. The next Artemis mission, which is to take four astronauts on a journey around the moon but not to the surface, will launch no earlier than 2024. Artemis III, in which two astronauts will land near the moon's south pole, is currently scheduled for 2025, though that date is very likely to slip further into the future. The original story from Space.com: NASA's Artemis 1 moon mission will once again attempt to launch after all. Mission managers met on Monday (Nov. 14) to discuss the flight readiness of the Artemis 1's Space Launch System (SLS) rocket and Orion spacecraft following slight damage caused by Hurricane Nicole, which was swiftly downgraded to a tropical storm after making landfall, on Thursday (Nov. 10). Despite the fact that a band of insulating caulking on Orion was damaged by high winds during the storm's landfall, Mike Sarafin, Artemis mission manager at NASA headquarters in Washington, said "there's no change in our plan to attempt to launch on the 16th" during a media teleconference today (Nov. 14).

"The unanimous recommendation for the team was that we were in a good position to go ahead and proceed with the launch countdown," added Jeremy Parsons, deputy manager of NASA's Exploration Ground Systems program at Kennedy Space Center (KSC) in Florida. If all goes according to plan during additional preflight checks and the cryogenic fueling process on Tuesday (Nov. 15), the Artemis 1 mission will launch from Launch Pad 39B at 1:04 a.m. EST (0604 GMT) on Nov. 16. You can watch the countdown, fueling and launch of Artemis 1 live online here on Space.com courtesy of NASA.

Amazon is starting a health referral service that seeks to link patients to virtual visits with providers who treat conditions like acne, hair loss and allergies. From a report: The initiative, called Amazon Clinic, is the Seattle company's latest effort to break into health care. It already operates an online pharmacy, and is in the process of buying 1Life Healthcare, which manages clinics under the One Medical brand, for $3.49 billion.

In a blog post announcing the service on Tuesday, Amazon called the new clinic a "virtual health storefront," connecting patients to "award-winning telehealth providers." The post didn't name those partners. The offering will be initially available in 32 US states and doesn't yet accept insurance, Amazon said. Patients select their condition, choose a provider from a list, and complete an intake questionnaire. From there, they connect directly to the provider through a "message-based portal."

Two new U.S. studies show that automatic emergency braking can cut the number of rear-end automobile crashes in half, and reduce pickup truck crashes by more than 40%. From a report: The studies released Tuesday, one by a government-auto industry partnership and the other by the insurance industry, each used crash data to make the calculations. Automatic emergency braking can stop vehicles if a crash is imminent, or slow them to reduce the severity. Some automakers are moving toward a voluntary commitment by 20 companies to make the braking technology standard equipment on 95% of their light-duty models during the current model year that ends next August.

A study by The Partnership for Analytics Research in Traffic Safety compared data on auto equipment with 12 million police-reported crashes from 13 states that was collected by the National Highway Traffic Safety Administration, the partnership said in a statement Tuesday. The group studied forward collision warning as well as emergency braking. The group found front-to-rear crashes were cut 49% when the striking vehicle had forward collision alert plus automatic braking, when compared with vehicles that didn't have either system. Rear crashes with injuries were cut by 53%, the study found. Vehicles with forward collision warning systems only reduced rear-end crashes by 16%, and cut rear crashes with injuries by 19%.