An anonymous reader quotes a report from the New York Times: For the first time, scientists are tracking the migration of monarch butterflies across much of North America, actively monitoring individual insects on journeys from as far away as Ontario all the way to their overwintering colonies in central Mexico. This long-sought achievement could provide crucial insights into the poorly understood life cycles of hundreds of species of butterflies, bees and other flying insects at a time when many are in steep decline.

The breakthrough is the result of a tiny solar-powered radio tag that weighs just 60 milligrams and sells for $200. Researchers have tagged more than 400 monarchs this year and are now following their journeys on a cellphone app created by the New Jersey-based company that makes the tags, Cellular Tracking Technologies. Most monarchs weigh 500 to 600 milligrams, so each tag-bearing migrator making the transcontinental journey is, by weight, equivalent to a half-raisin carrying three uncooked grains of rice.

Researchers are tracking more than 400 tagged monarch butterflies as they fly toward winter colonies in central Mexico. The maps [in the article] follow six butterflies. [...] Tracking the world's most famous insect migration may also have a big social impact, with monarch lovers able to follow the progress of individual butterflies on the free app, called Project Monarch Science. Many of the butterflies are flying over cities and suburbs where pollinator gardens are increasingly popular. Some tracks could even lead to the discovery of new winter hideaways. "There's nothing that's not amazing about this," said Cheryl Schultz, a butterfly scientist at Washington State University and the senior author of a recent study documenting a 22 percent drop in butterfly abundance in North America over a recent 20-year period. "Now we will have answers that could help us turn the tide for these bugs."

alternative_right shares a report from ScienceAlert: A new study from researchers in Australia reveals that the people who never forget faces look "smarter, not harder." In other words, they naturally focus on a person's most distinguishing facial features. "Their skill isn't something you can learn like a trick," explains lead author James Dunn, a psychology researcher at the University of New South Wales (UNSW) Sydney. "It's an automatic, dynamic way of picking up what makes each face unique."

To see what super-recognizers see, Dunn and his colleagues used eye-tracking technology to reconstruct how people surveyed new faces. They did this with 37 super-recognizers and 68 people with ordinary facial recognition skills, noting where and for how long participants looked at pictures of faces displayed on a computer screen. The researchers then fed the data into machine learning algorithms trained to recognize faces. The algorithms, a type known as deep neural networks, were tasked with deciding if two faces belonged to the same person. "These findings suggest that the perceptual foundations of individual differences in face recognition ability may originate at the earliest stages of visual processing -- at the level of retinal encoding," Dunn and colleagues write in their paper.

The findings have been published in the journal Proceedings of the Royal Society B: Biological Sciences.

"To be clear, the current economics of space-based data centers don't make sense," writes the Wall Street Journal.

"But they could in the future, perhaps as soon as a decade or so from now, according to an analysis by Phil Metzger, a research professor at the University of Central Florida and formerly of the National Aeronautics and Space Administration." "Space enthusiasts (comme moi) have long sought a business case to enable human migration beyond our home world," he posted on X amid the new hype. "I think AI servers in space is the first real business case that will lead to many more...."

The argument essentially boils down to the belief that AI's needs are eventually going to grow so great that we need to move to outer space. There the sun's power can be more efficiently harvested. In space, the sun's rays can be direct and constant for solar panels to collect — no clouds, no rainstorms, no nighttime. Demands for cooling could also be cut because of the vacuum of space. Plus, there aren't those pesky regulations that executives like to complain about, slowing construction of new power plants to meet the data-center needs. In space, no one can hear the Nimbys scream. "We will be able to beat the cost of terrestrial data centers in space in the next couple of decades," Bezos said at a tech conference last month. "Space will end up being one of the places that keeps making Earth better."

It's still early days. At Alphabet, Google's plans sound almost conservative. The search-engine company in recent days announced Project Suncatcher, which it describes as a moonshot project to scale machine learning in space. It plans to launch two prototype satellites by early 2027 to test its hardware in orbit. "Like any moonshot, it's going to require us to solve a lot of complex engineering challenges," Pichai posted on social media. Nvidia, too, has announced a partnership with startup Starcloud to work on space-based data centers. Not to be outdone, Elon Musk has been painting his own updated vision for the heavens... in recent weeks he has been talking more about how he can use his spaceships to deploy new versions of his solar-powered Starlink satellites equipped with high-speed lasers to build out in-space data centers.

On Friday, Musk further reiterated how those AI satellites would be able to generate 100 gigawatts of annual solar power — or, what he said, would be roughly a quarter of what the U.S. consumes on average in a year. "We have a plan mapped out to do it," he told investor Ron Baron during an event. "It gets crazy." Previously, he has suggested he was four to five years away from that ability. He's also touted even wilder ideas, saying on X that 100 terawatts a year "is possible from a lunar base producing solar-powered AI satellites locally and accelerating them to escape velocity with a mass driver." Simply put, he's suggesting a moon base will crank out satellites and throw them into orbit with a catapult. And those satellites' solar panels would generate 100,000 gigawatts a year. "I think we'll see intelligence continue to scale all the way up to where...most of the power of the sun is harnessed for compute," Musk told a tech conference in September.

"Three Chinese astronauts returned from their nation's space station Friday," reports the Associated Press, "after more than a week's delay because the return capsule they had planned to use was damaged, likely from being hit by space debris." The team left their Shenzhou-20 spacecraft in orbit and came back using the recently arrived Shenzhou-21, which had ferried a three-person replacement crew to the station, China's Manned Space Agency said. The original return plan was scrapped because a window in the Shenzhou-20 capsule had tiny cracks, most likely caused by impact from space debris, the space agency said Friday... Their return was delayed for nine days, and their 204-day stay in space was the longest for any astronaut at China's space station...

China developed the Tiangong space station after the country was excluded from the International Space Station over U.S. national security concerns. China's space program is controlled by its military.

An anonymous reader shared this report from the Guardian: The number of deaths linked to superbugs that do not respond to frontline antibiotics increased by 17% in England last year, according to official figures that raise concerns about the ongoing increase in antimicrobial resistance.

The figures, released by the UK Health Security Agency, also revealed a large rise in private prescriptions for antibiotics, with 22% dispensed through the private sector in 2024. The increase in private prescribing is partly explained by the Pharmacy First scheme, a flagship policy of Rishi Sunak's government that allows patients to be prescribed antibiotics for common illnesses without seeing a GP, raising questions about whether the shift in prescribing patterns risks contributing to the rise in resistance.

"Antibiotic resistance is one of the greatest health threats we face," said the UKHSA's chief executive, Prof Susan Hopkins. "More people than ever are acquiring infections that cannot be effectively treated by antibiotics. This puts them at greater risk of serious illness and even death, with our poorest communities hit the hardest... It's positive that we've seen antibiotic use fall in England within the NHS but we need to go further, faster," said Hopkins.

"Please remember to only take antibiotics if you have been told to do so by a healthcare professional. Do not save some for later or share them with friends and family. If you have leftover antibiotics, please bring them to a pharmacy for appropriate disposal."

The dream of quantum computers has been hampered by the challenge of error correction, writes the Harvard Gazette, since qubits "are inherently susceptible to slipping out of their quantum states and losing their encoded information."

But in a newly-published paper, a research team "combined various methods to create complex circuits with dozens of error correction layers" that "suppresses errors below a critical threshold — the point where adding qubits further reduces errors rather than increasing them." "For the first time, we combined all essential elements for a scalable, error-corrected quantum computation in an integrated architecture," said Mikhail Lukin, co-director of the Quantum Science and Engineering Initiative, Joshua and Beth Friedman University Professor, and senior author of the new paper. "These experiments — by several measures the most advanced that have been done on any quantum platform to date — create the scientific foundation for practical large-scale quantum computation..."

"There are still a lot of technical challenges remaining to get to very large-scale computer with millions of qubits, but this is the first time we have an architecture that is conceptually scalable," said lead author Dolev Bluvstein, Ph.D. '25, who did the research during his graduate studies at Harvard and is now an assistant professor at Caltech. "It's going to take a lot of effort and technical development, but it's becoming clear that we can build fault-tolerant quantum computers...."

Hartmut Neven, vice president of engineering at the Google Quantum AI team, said the new paper came amid an "incredibly exciting" race between qubit platforms. "This work represents a significant advance toward our shared goal of building a large-scale, useful quantum computer," he said... With recent advances, Lukin believes the core elements for building quantum computers are falling into place. "This big dream that many of us had for several decades, for the first time, is really in direct sight," he said.
"In theory, a system of 300 quantum bits can store more information than the number of particles in the known universe..." the article points out.

"The new paper represents an important advance in a three-decade pursuit of quantum error correction."

Thanks to long-time Slashdot reader schwit1 for sharing the article.

alternative_right shares a report from ScienceAlert: A thorough investigation published in May 2023 found that the inner core of the Moon is, in fact, a solid ball with a density similar to that of iron. To figure it out once and for all, [astronomer Arthur Briaud of the French National Centre for Scientific Research in France] and his colleagues collected data from space missions and lunar laser-ranging experiments to compile a profile of various lunar characteristics. These include the degree of its deformation by its gravitational interaction with Earth, the variation in its distance from Earth, and its density.

... they found that the lunar core is very similar to that of Earth â" with an outer fluid layer and a solid inner core. According to their modeling, the outer core has a radius of about 362 kilometers (225 miles), and the inner core has a radius of about 258 kilometers (160 miles). That's about 15 percent of the entire radius of the Moon. The inner core, the team found, also has a density of about 7,822 kilograms per cubic meter. That's very close to the density of iron. [...] The research has been published in Nature.

One of the most common viruses in the world could be the cause of lupus, an autoimmune disease with wide-ranging symptoms, according to a new study. From a report: Until now, lupus was somewhat mysterious: No single root cause of the disease had been found, and while there is no cure, there are medications that can treat it.

The research, published in the journal Science Translational Medicine, suggests that Epstein-Barr virus -- which 95% of people acquire at some point in life -- could cause lupus by driving the body to attack its own healthy cells.

It adds to mounting evidence that Epstein-Barr is associated with multiple long-term health issues, including other autoimmune conditions. As this evidence stacks up, scientists have accelerated calls for a vaccine that targets the virus.

"If we now better understand how this fastidious virus is responsible for autoimmune diseases, I think it's time to figure out how to prevent it," said Dr. Anca Askanase, clinical director of the Lupus Center at Columbia University, who wasn't involved in the new research.

An anonymous reader quotes a report from TechCrunch: Jeff Bezos' Blue Origin has landed the booster of its New Glenn mega-rocket on a drone ship in the Atlantic Ocean on just its second attempt -- making it the second company to perform such a feat, following Elon Musk's SpaceX. It's an accomplishment that will help the new rocket system become an option to send larger payloads to space, the Moon, and beyond. Thursday's launch wasn't just about the landing attempt, though. Roughly 34 minutes after takeoff, the upper stage of New Glenn successfully deployed the rocket's first commercial payload: twin spacecraft for NASA that will travel to Mars to study the red planet's atmosphere. The pair of achievements are remarkable for the second-ever launch of such a massive rocket system. And it could put Blue Origin in position to compete with SpaceX, which dominates the world's launch market with its Falcon 9, Falcon Heavy, and Starship rockets. You can watch a recording of the launch here.

For the first time, astronomers captured the shockwave of a supernova bursting through the surface of a dying red supergiant star, revealing a surprisingly symmetrical, grape-shaped explosion. Space.com reports: Seeing this moment in detail has previously been elusive because it's rare for a supernova to be spotted early enough and for telescopes to be trained on it -- and when they have been, the exploding star has been too far away. So, when supernova 2024ggi went boom on April 10, 2024 in the relatively nearby spiral galaxy NGC 3621, which is 22 million light-years away in the constellation of Hydra, the Water Snake, astronomer Yi Yang of Tsinghua University in Beijing knew he had to act.

Although the supernova itself couldn't be resolved as anything put a point of light, the polarization of that light held the clues as to the geometry of the breakout. "The geometry of a supernova explosion provides fundamental information on stellar evolution and the physical processes leading to these cosmic fireworks," said Yang. "Spectropolarimetry delivers information about the geometry of the explosion that other types of observation cannot provide because the angular scales are too tiny," said another team-member, Lifan Wang of Texas A&M University.

The measurement showed that the shape of the breakout explosion was flattened, like an olive or grape. Crucially, though, the explosion propagated symmetrically, and continued to do so even when it collided with a ring of circumstellar material. "These findings suggest a common physical mechanism that drives the explosion of many massive stars, which manifests a well-defined axial symmetry and acts on large scales," said Yang. The findings will allow astronomers to rule out some models and strengthen others that describe what drives the shockwave in a supernova explosion. The findings have been described in a paper on the ESO website.

Animal testing in science would be phased out faster under a new plan to increase the use of artificial intelligence and 3D bioprinted human tissues, a UK minister has said. The Guardian: The roadmap unveiled by the science minister, Patrick Vallance, backs replacing certain animal tests that are still used where necessary to determine the safety of products such as life-saving vaccines and the impact pesticides have on living beings and the environment. The strategy says phasing out the use of animals in science can only happen when reliable and effective alternative methods with the same level of safety for human exposure can replace them.

The government said new funding for researchers and streamlined regulation would help develop methods such as organ-on-a-chip systems -- tiny devices that mimic how human organs work using real human cells. Greater use of AI to analyse vast amounts of data about molecules and predict whether new medicines will be safe and work well on humans would be deployed, while 3D bioprinted tissues could create realistic human tissue samples, from skin to liver, for testing.

Other plans under the strategy include an end to regulatory testing on animals to assess the potential for skin and eye irritation and skin sensitisation by the end of 2026. By 2027, researchers are expected under the strategy to end tests of the strength of botox on mice, while by 2030 pharmacokinetic studies -- which track how a drug moves through the body over time -- on dogs and non-human primates will be reduced.

The UK and China today signed a new bilateral agreement on scientific collaboration [non-paywalled source], narrowing the scope of their partnership to exclude sensitive technologies. Lord Patrick Vallance, Britain's science and technology minister, met his Chinese counterpart Chen Jiachang in Beijing and agreed to focus cooperation on health, climate, planetary sciences, and agriculture.

The previous agreement from 2017 had included satellites, remote sensing technology and robotics. Those fields are absent from the new accord. The countries announced no new funding for joint research. Vallance said the UK had "deliberately gone for areas which we think are not carrying such a security risk."

After more than a decade of planning, the launch of the African Medicines Agency (AMA) is being celebrated in Mombasa, Kenya, this week at the Seventh Biennial Scientific Conference on Medical Products Regulation in Africa. From a report: The agency's establishment marks a pivotal moment in Africa's public health, at a time when the need for biomedical research conducted in Africa, focused on African health problems, has never been greater. Africa holds higher levels of human genetic diversity than anywhere else on Earth, but this diversity has not been adequately studied. And many globally approved treatments and vaccines for diseases such as HIV/AIDS, malaria and tuberculosis are less effective, and can even be harmful in some people of African ancestry.

This year, cuts of billions of US dollars in international funding for biomedical research and health services in Africa have left millions of people without access to life-saving treatments or, in the case of researchers and health-care workers, unemployed. This demonstrates the immense vulnerability that comes with relying on funding from external donors.

What's more, Africa's phenomenal population growth and pace of urbanization is bringing fresh challenges -- as well as opportunities -- around health and disease. In Africa's cities today, the inhabitants of increasingly affluent neighbourhoods are demanding high-quality medicines and health care. But in low-income areas, high population density, inadequate housing and poor sanitation are facilitating the spread of respiratory and diarrhoeal infections. And everywhere, inadequate diets, air pollution, smoking and physical inactivity are driving increased rates of cardiovascular disease, diabetes and cancer. By 2100, Africa is expected to host 13 of the world's 20 largest cities, and such inequalities are likely to worsen.

Should we leave space exploration to robots — or prioritize human spaceflight, making us a multiplanetary species?

Harvard professor Robin Wordsworth, who's researched the evolution and habitability of terrestrial-type planets, shares his thoughts: In space, as on Earth, industrial structures degrade with time, and a truly sustainable life support system must have the capability to rebuild and recycle them. We've only partially solved this problem on Earth, which is why industrial civilization is currently causing serious environmental damage. There are no inherent physical limitations to life in the solar system beyond Earth — both elemental building blocks and energy from the sun are abundant — but technological society, which developed as an outgrowth of the biosphere, cannot yet exist independently of it. The challenge of building and maintaining robust life-support systems for humans beyond Earth is a key reason why a machine-dominated approach to space exploration is so appealing...

However, it's notable that machines in space have not yet accomplished a basic task that biology performs continuously on Earth: acquiring raw materials and utilizing them for self-repair and growth. To many, this critical distinction is what separates living from non-living systems... The most advanced designs for self-assembling robots today begin with small subcomponents that must be manufactured separately beforehand. Overall, industrial technology remains Earth-centric in many important ways. Supply chains for electronic components are long and complex, and many raw materials are hard to source off-world... If we view the future expansion of life into space in a similar way as the emergence of complex life on land in the Paleozoic era, we can predict that new forms will emerge, shaped by their changed environment, while many historical characteristics will be preserved. For machine technology in the near term, evolution in a more life-like direction seems likely, with greater focus on regenerative parts and recycling, as well as increasingly sophisticated self-assembly capabilities. The inherent cost of transporting material out of Earth's gravity well will provide a particularly strong incentive for this to happen.

If building space habitats is hard and machine technology is gradually developing more life-like capabilities, does this mean we humans might as well remain Earth-bound forever? This feels hard to accept because exploration is an intrinsic part of the human spirit... To me, the eventual extension of the entire biosphere beyond Earth, rather than either just robots or humans surrounded by mechanical life-support systems, seems like the most interesting and inspiring future possibility. Initially, this could take the form of enclosed habitats capable of supporting closed-loop ecosystems, on the moon, Mars or water-rich asteroids, in the mold of Biosphere 2. Habitats would be manufactured industrially or grown organically from locally available materials. Over time, technological advances and adaptation, whether natural or guided, would allow the spread of life to an increasingly wide range of locations in the solar system.
The article ponders the benefits (and the history) of both approaches — with some fasincating insights along the way.

"If genuine alien life is out there somewhere, we'll have a much better chance of comprehending it once we have direct experience of sustaining life beyond our home planet."

"For months, a small company in San Francisco has been pursuing a secretive project: the birth of a genetically engineered baby," reports the Wall Street Journal: Backed by OpenAI chief executive Sam Altman and his husband, along with Coinbase co-founder and CEO Brian Armstrong, the startup — called Preventive — has been quietly preparing what would amount to a biological first. They are working toward creating a child born from an embryo edited to prevent a hereditary disease.... Editing genes in embryos with the intention of creating babies from them is banned in the U.S. and many countries. Preventive has been searching for places to experiment where embryo editing is allowed, including the United Arab Emirates, according to correspondence reviewed by The Wall Street Journal...

Preventive is in the vanguard of a growing number of startups, funded by some of the most powerful people in Silicon Valley, that are pushing the boundaries of fertility and working to commercialize reproductive genetic technologies. Some are working on embryo editing, while others are already selling genetic screening tools that seek to account for the influence of dozens or hundreds of genes on a trait. They say their ultimate goal is to produce babies who are free of genetic disease and resilient against illnesses. Some say they can also give parents the ability to choose embryos that will have higher IQs and preferred traits such as height and eye color. Armstrong, the cryptocurrency billionaire, is leading the charge to make embryo editing a reality. He has told people that gene-editing technology could produce children who are less prone to heart disease, with lower cholesterol and stronger bones to prevent osteoporosis. According to documents and people briefed on his plans, he is already an investor or in talks with embryo editing ventures...

After the Journal approached people close to the company last month to ask about its work, Preventive announced on its website that it had raised $30 million in investment to explore embryo editing. The statement pledged not to advance to human trials "if safety cannot be established through extensive research..." Other embryo editing startups are Manhattan Genomics, co-founded by Thiel Fellow Cathy Tie, and Bootstrap Bio, which plans to conduct tests in Honduras. Both companies are in early stages.
The article notes the only known instance of children born from edited embryos was in 2018, when Chinese scientist He Jiankui "shocked the world with news that he had produced three children genetically altered as embryos to be immune to HIV. He was sentenced to prison in China for three years for the illegal practice of medicine.

"He hasn't publicly shared the children's identities but says they are healthy.

UPDATE (1:16 PST) Today's launch has been scrubbed due to weather, and Blue Origin is now reviewing opportunities for new launch windows.

Sunday Morning Blue Origin livestreamed the planned launch of its New Glenn rocket, which will carry a very unique mission for NASA. "Twin spacecraft are set to take off on an unprecedented, winding journey to Mars," reports CNN, "where they will investigate why the barren red planet began to lose its atmosphere billions of years ago." By observing two Mars locations simultaneously, this mission can measure how Mars responds to space weather in real time — and how the Martian magnetosphere changes... Called EscaPADE, the mission will aim for an orbital trajectory that has never been attempted before, according to aerospace company Advanced Space, which is supporting the project. If successful, it could be a crucial case study that can allow extraordinary flexibility for planetary science missions down the road. The robotic mission plans to spend a year idling in an orbital backroad before heading to its target destination... [R]ather than turning toward Mars, the two orbiters will instead aim for Lagrange Point 2, or L2 — a cosmic balance point about 1.5 million kilometers (930,000 miles) from Earth. Lagrange points are special because they act as gravitational wells in which the pull of the sun and Earth are in perfect balance. The conditions can allow spacecraft to linger without being dragged away... The spacecraft will then loop endlessly in a kidney bean-shaped orbit around L2 until next year's Mars transfer window opens.
This "launch and loiter" project is part of NASA's SIMPLEx [Small, Innovative Missions for Planetary Exploration] program, which seeks high-value missions for less money, notes CNN. "EscaPADE's cost was less than $100 million, compared with the roughly $300 million to $600 million price tags of other NASA satellites orbiting Mars."

"Blue Origin is also attempting to land and recover New Glenn's first-stage booster," notes another CNN article.

A CRISPR-based drug given to study participants by infusion is raising hopes for a much easier way to lower cholesterol, reports CNN: With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine.

The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off. Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the "bad" cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide. The study, which will be presented Saturday at the American Heart Association Scientific Sessions in New Orleans, also found an average 55% reduction in triglycerides, a different type of fat in the blood that is also linked to an increased risk of cardiovascular disease.

"We hope this is a permanent solution, where younger people with severe disease can undergo a 'one and done' gene therapy and have reduced LDL and triglycerides for the rest of their lives," said senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio.... Today, cardiologists want people with existing heart disease or those born with a predisposition for hard-to-control cholesterol to lower their LDL well below 100, which is the average in the US, said Dr. Pradeep Natarajan, director of preventive cardiology at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School in Boston...

People with a nonfunctioning ANGPTL3 gene — which Natarajan says applies to about 1 in 250 people in the US — have lifelong levels of low LDL cholesterol and triglycerides without any apparent negative consequences. They also have exceedingly low or no risk for cardiovascular disease. "It's a naturally occurring mutation that's protective against cardiovascular disease," said Nissen, who holds the Lewis and Patricia Dickey Chair in Cardiovascular Medicine at Cleveland Clinic. "And now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection."
"Phase 2 clinical trials will begin soon, quickly followed by Phase 3 trials, which are designed to show the effect of the drug on a larger population, Nissen said."

And CNN quotes Nissen as saying "We hope to do all this by the end of next year. We're moving very fast because this is a huge unmet medical need — millions of people have these disorders and many of them are not on treatment or have stopped treatment for whatever reason."

The Associated Press reports that "For the past decade, Dr. Priscilla Chan and her husband Mark Zuckerberg have focused part of their philanthropy on a lofty goal — 'to cure, prevent or manage all disease' — if not in their lifetime, then in their children's."

During that decade they also funded other initiatives (including underprivileged schools and immigration reform), according to the article. But there's a change coming: Now, the billionaire couple is shifting the bulk of their philanthropic resources to Biohub, the pair's science organization, and focusing on using artificial intelligence to accelerate scientific discovery. The idea is to develop virtual, AI-based cell models to understand how they work in the human body, study inflammation and use AI to "harness the immune system" for disease detection, prevention and treatment. "I feel like the science work that we've done, the Biohub model in particular, has been the most impactful thing that we have done. So we want to really double down on that. Biohub is going to be the main focus of our philanthropy going forward," Zuckerberg said Wednesday evening at an event at the Biohub Imaging Institute in Redwood City, California.... Chan and Zuckerberg have pledged 99% of their lifetime wealth — from shares of Meta Platforms, where Zuckerberg is CEO — toward these efforts...

On Thursday, Chan and Zuckerberg also announced that Biohub has hired the team at EvolutionaryScale, an AI research lab that has created large-scale AI systems for the life sciences... Biohub's ambition for the next years and decades is to create virtual cell systems that would not have been possible without recent advances in AI. Similar to how large language models learn from vast databases of digital books, online writings and other media, its researchers and scientists are working toward building virtual systems that serve as digital representations of human physiology on all levels, such as molecular, cellular or genome. As it is open source — free and publicly available — scientists can then conduct virtual experiments on a scale not possible in physical laboratories.
"We will continue the model we've pioneered of bringing together scientists and engineers in our own state-of-the-art labs to build tools that advance the field," according to Thursday's blog post. "We'll then use those tools to generate new data sets for training new biological AI models to create virtual cells and immune systems and engineer our cells to detect and treat disease....

"We have also established the first large-scale GPU cluster for biological research, as well as the largest datasets around human cell types. This collection of resources does not exist anywhere else."

Unesco has adopted the first global ethical standards for neurotechnology, defining "neural data" and outlining more than 100 recommendations aimed at safeguarding mental privacy. "There is no control," said Unesco's chief of bioethics, Dafna Feinholz. "We have to inform the people about the risks, the potential benefits, the alternatives, so that people have the possibility to say 'I accept, or I don't accept.'" The Guardian reports: She said the new standards were driven by two recent developments in neurotechnology: artificial intelligence (AI), which offers vast possibilities in decoding brain data, and the proliferation of consumer-grade neurotech devices such as earbuds that claim to read brain activity and glasses that track eye movements.

The standards define a new category of data, "neural data," and suggest guidelines governing its protection. A list of more than 100 recommendations ranges from rights-based concerns to addressing scenarios that are -- at least for now -- science fiction, such as companies using neurotechnology to subliminally market to people during their dreams. "Neurotechnology has the potential to define the next frontier of human progress, but it is not without risks," said Unesco's director general, Audrey Azoulay. The new standards would "enshrine the inviolability of the human mind," she said.

An anonymous reader quotes a report from MIT Technology Review: Vanguard feels and smells like a new RV. It has long, gray banquettes that convert into bunks, a microwave cleverly hidden under a counter, a functional steel sink with a French press and crockery above. A weird little toilet hides behind a curtain. But some clues hint that you can't just fire up Vanguard's engine and roll off the lot. The least subtle is its door, a massive disc of steel complete with a wheel that spins to lock. Once it is sealed and moved to its permanent home beneath the waves of the Florida Keys National Marine Sanctuary early next year, Vanguard will be the world's first new subsea habitat in nearly four decades. Teams of four scientists will live and work on the seabed for a week at a time, entering and leaving the habitat as scuba divers. Their missions could include reef restoration, species surveys, underwater archaeology, or even astronaut training.

One of Vanguard's modules, unappetizingly named the "wet porch," has a permanent opening in the floor (a.k.a. a "moon pool") that doesn't flood because Vanguard's air pressure is matched to the water around it.It is this pressurization that makes the habitat so useful. Scuba divers working at its maximum operational depth of 50 meters would typically need to make a lengthy stop on their way back to the surface to avoid decompression sickness. This painful and potentially fatal condition, better known as the bends, develops if divers surface too quickly. A traditional 50-meter dive gives scuba divers only a handful of minutes on the seafloor, and they can make only a couple of such dives a day. With Vanguard's atmosphere at the same pressure as the water, its aquanauts need to decompress only once, at the end of their stay. They can potentially dive for many hours every day. That could unlock all kinds of new science and exploration.