A team of scientists at a university in western Japan has developed masks that glow when exposed to ultraviolet light if they contain traces of the coronavirus, using antibodies extracted from ostrich eggs. From a report: The team at Kyoto Prefectural University, headed by its president, Yasuhiro Tsukamoto, 52, hopes the masks will offer users an easy way to test whether they have contracted the virus. With testing continuing to put them into practical use, the team aims to gain government approval to sell the masks possibly next year. Ostriches are capable of producing several different kinds of antibody, or proteins that neutralize foreign entities in the body. In February last year, the team injected an inactive and non-threatening form of the coronavirus into female ostriches, successfully extracting a large quantity of antibodies from the eggs that they laid.

A brand-new space telescope will soon reveal a hidden vision of the cosmos, potentially transforming our understanding of black holes, supernovas and even the nature of the universe itself. No, not that one. From a report: Much attention is being devoted this month to the James Webb Space Telescope, from NASA and the European Space Agency, which is set to launch on Dec. 22. But a more exclusive cadre of astronomers watched excitedly on Thursday during the trip to space of a smaller, but also transformative, observatory. NASA launched the Imaging X-ray Polarimetry Explorer, or IXPE mission, on a SpaceX Falcon 9 rocket from Kennedy Space Center in Florida at 1 a.m. Eastern. The spacecraft cost a mere $188 million, compared with the James Webb's mammoth budget of $9.7 billion, and is expected to demonstrate a new form of astronomy. It will, for the first time, perform imaging X-ray polarimetry in orbit, a technique that could offer astronomers insights that no other telescope can match.

"It's giving us information about some of the most bizarre and exciting objects in space," said Thomas Zurbuchen, the associate administrator of NASA's science mission directorate. IXPE (pronounced by the mission team as "ix-pee") was placed into an orbit 340 miles above Earth after its launch. The telescope will spend several weeks there deploying its scientific instruments and testing its equipment, then begin its two-year mission. X-rays are a useful way to observe the universe. Emitted from extremely energetic objects, they allow astronomers to probe events -- superheated jets near black holes or explosions of stars, for example -- in a way other wavelengths, such as visible light, cannot. But X-rays can be studied only from space because they are mostly absorbed by Earth's atmosphere. A variety of dedicated X-ray space telescopes and instruments have launched to orbit, most notably NASA's Chandra X-ray and ESA's XMM-Newton observatories, which both launched in 1999. With spacecraft like these, scientists have unveiled the birthplaces of stars inside gaseous nebulas and mapped the spread of dark matter in clusters of galaxies, among other pioneering work.

The Food and Drug Administration authorized the first injectable monoclonal antibody cocktail for long-term prevention of Covid-19 among people with weakened immune systems before they have been exposed to the coronavirus. NBC News reports: The FDA issued an emergency use authorization Wednesday for AstraZeneca's antibody cocktail, Evusheld, for what is known as pre-exposure prophylaxis, or PrEP, against Covid-19. To date, such laboratory-produced antibodies have been authorized only as early treatment of Covid-19 or as preventive therapy for high-risk people immediately after close contact with someone who has tested positive.

Evusheld can be used as PrEP by people ages 12 and older who are moderately to severely immunocompromised and may not get adequate immune responses from a Covid vaccine. The therapy is also an option for the rare people who have histories of severe adverse reactions to a Covid vaccine or its components. The AstraZeneca therapy involves getting preventive injections as often as every six months. According to a large placebo-controlled clinical trial, the cocktail is about 83 percent effective at preventing symptomatic disease during such an interval. It's unclear how the highly mutated omicron variant of the coronavirus -- which is spreading in 57 countries, including the U.S. -- might affect the efficacy of the monoclonal antibody therapy.

Microplastics cause damage to human cells in the laboratory at the levels known to be eaten by people via their food, a study has found. From a report: The harm included cell death and allergic reactions and the research is the first to show this happens at levels relevant to human exposure. However, the health impact to the human body is uncertain because it is not known how long microplastics remain in the body before being excreted. Microplastics pollution has contaminated the entire planet, from the summit of Mount Everest to the deepest oceans. People were already known to consume the tiny particles via food and water as well as breathing them in. The research analysed 17 previous studies which looked at the toxicological impacts of microplastics on human cell lines. The scientists compared the level of microplastics at which damage was caused to the cells with the levels consumed by people through contaminated drinking water, seafood and table salt. They found specific types of harm -- cell death, allergic response, and damage to cell walls -- were caused by the levels of microplastics that people ingest.

Over 40 million people in the United States had their personal health information exposed in data breaches this year, a significant jump from 2020 and a continuation of a trend toward more and more health data hacks and leaks. The Verge reports: Health organizations are required to report any health data breaches that impact 500 or more people to the Office for Civil Rights at the Department of Health and Human Services, which makes the breaches public. So far this year, the office has received reports of 578 breaches, according to its database. That's fewer than the 599 breaches reported in 2020 (PDF), but last year's breaches only affected about 26 million people. Since 2015, hacks or other IT incidents have been the leading reason people have their health records exposed, according to a report (PDF) from security company Bitglass. Before then, lost or stolen devices led to the most data breaches.

fahrbot-bot shares a report from Gizmodo: Scientists have spotted an unusually large exoplanet in orbit around b Centauri, a massive two-star system that is visible to the unaided eye. With a combined weight of roughly 10 Suns, it's now the heaviest star system known to host a planet. The details of this discovery were published today in Nature. The newly discovered planet, called "b Cen (AB)b," is likely a gas giant and is heavier than 10 Jupiters combined, making it one of the most massive planets ever discovered. It orbits the b Centauri binary system, which is located 325 light-years from Earth and has a combined mass of nearly 10 Suns. At 52 billion miles from its host stars, this planet has one of the widest orbits ever detected. By comparison, Pluto orbits the Sun at around 3.3 billion miles, so yeah, that's an unbelievable separation. Until now, planets had not been found in orbit around star systems weighing more than three solar masses. Astronomers didn't think planets could form around systems like this, so it's forcing a major rethink of what's possible in terms of planetary architectures and the conditions under which planets can form.

That a planet exists in this star system is indeed surprising. Young stars have protoplanetary disks around them, from which planets eventually emerge. A hot star system like b Centauri, however, is not supposed to be conducive to planetary formation, owing to tremendous amounts of ultraviolet and X-ray radiation. This high-energy radiation "tends to destroy the disks in a very short time," and it was "thought that this wouldn't give planets enough time to form in the disk before it disappeared," [said Markus Janson, an astronomer at Stockholm University and the first author of the study]. Yet there it is -- a full fledged planet around the b Centauri system. [...] A neat observation is how the ratio between the masses of the star system and its planet closely matches that of our Sun and Jupiter. But that's where the comparison ends, as the scale of b Centauri is far vaster, as the planet is 10 times the mass of Jupiter and with an orbit that's 100 times wider. [...]

From an astrobiological perspective, Janson added that b Centauri is "possibly one of the worst places in the galaxy to host life." Together, the binary pair spew enormous amounts of UV and X-ray radiation, "which would sterilize any surface that is exposed to it," so "life on any surface in the system is certainly not very likely." Still, Janson did not rule out the possibility that life could exist in subterranean oceans, matching ongoing speculation about basic life existing on Jupiter's moon Europa or Saturn's moon Enceladus.

fahrbot-bot shares a report from The New York Times: What if something in the blood of an athlete could boost the brainpower of someone who doesn't or can't exercise? Could a protein that gets amplified when people exercise help stave off symptoms of Alzheimer's and other memory disorders? That's the tantalizing prospect raised by a new study in which researchers injected sedentary mice with blood from mice that ran for miles on exercise wheels, and found that the sedentary mice then did better on tests of learning and memory. The study, published Wednesday in the journal Nature, also found that the type of brain inflammation involved in Alzheimer's and other neurological disorders was reduced in sedentary mice after they received their athletic counterparts' blood. Scientific results with mice don't necessarily translate to humans. Still, experts said the study supports a growing body of research.

The study involved mice that were about three months old -- roughly the equivalent of 25-to-30-year olds for humans. Some of the mice, nocturnal animals that love to run, could freely use exercise wheels in their cages and logged about four to six miles on the wheels each night. The wheels were locked for other mice that could scoot around their cages but could not get an extended cardio workout. [...] After 28 days, the researchers took a third group of mice that also did not exercise and injected them with blood plasma, the liquid that surrounds blood cells, from either the runner mice or the non-runner mice. Mice receiving runner blood did better on two tests of learning and memory than those receiving blood from the non-runner mice. In one test, which measures how long a mouse will freeze in fear when it is returned to a cage where it previously received an electric foot shock, mice with runner blood froze 25 percent longer, indicating they had better memory of the stressful event [...]. In the other test, mice with runner blood were twice as fast at finding a platform submerged in opaque water, he said. The team also found that the brains of mice with runner blood produced more of several types of brain cells, including those that generate new neurons in the hippocampus, a region involved in memory and spatial learning. A genetic analysis showed that about 1,950 genes had changed in response to the infusion of runner blood, becoming either more or less activated. Most of the 250 genes with the greatest activation changes were involved in inflammation and their changes suggested that brain inflammation was reduced.

Switzerland is giving the green light to so-called "suicide capsules" -- 3-D printed pods that allow people to choose the place where they want to die an assisted death. Global News reports: The country's medical review board announced the legalization of the Sarco Suicide Pods this week. They can be operated by the user from the inside. Dr. Philip Nitschke, the developer of the pods and founder of Exit International, a pro-euthanasia group, told SwissInfo.ch the machines can be "towed anywhere for the death" and one of the most positive features of the capsules is that they can be transported to an "idyllic outdoor setting."

Currently, assisted suicide in Switzerland means swallowing a capsule filled with a cocktail of controlled substances that puts the person into a deep coma before they die. But Sarco pods -- short for sarcophagus -- allow a person to control their death inside the pod by quickly reducing internal oxygen levels. The person intending to end their life is required to answer a set of pre-recorded questions, then press a button that floods the interior with nitrogen. The oxygen level inside is quickly reduced from 21 per cent to one per cent. After death, the pod can be used as a coffin. [...]

Nitschke said his method of death is painless, and the person will feel a little bit disoriented and/or euphoric before they lose consciousness. He said there are only two capsule prototypes in existence, but a third machine is being printed now, and he expects this method to become available to the Swiss public next year.

sciencehabit writes: When Thomas Edison hit a wall with his inventions, he would nap in an armchair while holding a steel ball. As he started to fall asleep and his muscles relaxed, the ball would strike the floor, waking him with insights into his problems. Or so the story goes. Now, more than 100 years later, scientists have repeated the trick in a lab, revealing that the famous inventor was on to something. People following his recipe tripled their chances of solving a math problem. The trick was to wake up in the transition between sleep and wakefulness, just before deep sleep.

The study team also identified a brain activity pattern linked to the creativity-boosting phase: moderate levels of brain waves at a slow frequency known as alpha, associated with relaxation, and low levels of delta waves, a hallmark of deep sleep. Experts say researchers can now focus on this brain signature when investigating the neural mechanisms of creative problem-solving. One team has already planned an experiment to help people reach a creative zone by monitoring their brain waves in real time. "Edison's intuition was somewhat right," says the lead scientist, "and now we have a lot more to explore."

Older people who have cataract surgery to improve their eyesight are less likely to develop dementia afterwards. From a report: The effect could be because people who lose their eyesight typically spend more time at home, and so get less mental stimulation -- or it could be down to a strange effect that cataracts have on the colours that reach the retina at the back of the eye. Cataracts, which involve the lens of the eye becoming more cloudy with age, are one of the most common causes of vision loss in older people. They can be fixed by surgically removing the lens to replace it with a plastic one. Sight loss was already known to be a risk factor for developing Alzheimer's disease and other forms of dementia. Cecilia Lee at the University of Washington in Seattle wondered whether cataract surgery would have a noticeable correlation with dementia incidence.

Pfizer and BioNTech said initial lab studies show a third dose of their Covid-19 vaccine neutralizes the omicron variant, results that will accelerate booster shot drives around the world. From a report: A booster with the current version of the vaccine increased antibodies 25-fold, providing a similar level as observed after two doses against the original virus and other variants, the companies said Wednesday. Blood plasma from people immunized with two doses of the vaccine has neutralizing antibody levels more than 25-fold less versus omicron than against the original strain of the virus, the companies said. "It's clear from these preliminary data that protection is improved with a third dose," Pfizer Chief Executive Officer Albert Bourla said in a statement. The initial data show a third dose could offer still offer enough protection from disease, BioNTech CEO Ugur Sahin said.

Hmmmmmm shares a report from the Associated Press: Eight years ago, a team of researchers launched a project to carefully repeat early but influential lab experiments in cancer research. They recreated 50 experiments, the type of preliminary research with mice and test tubes that sets the stage for new cancer drugs. The results reported Tuesday: About half the scientific claims didn't hold up. [...] For the project, the researchers tried to repeat experiments from cancer biology papers published from 2010 to 2012 in major journals such as Cell, Science and Nature. Overall, 54% of the original findings failed to measure up to statistical criteria set ahead of time by the Reproducibility Project, according to the team's [two studies] published online Tuesday by eLife. The nonprofit eLife receives funding from the Howard Hughes Medical Institute, which also supports The Associated Press Health and Science Department.

Among the studies that did not hold up was one that found a certain gut bacteria was tied to colon cancer in humans. Another was for a type of drug that shrunk breast tumors in mice. A third was a mouse study of a potential prostate cancer drug. The researchers tried to minimize differences in how the cancer experiments were conducted. Often, they couldn't get help from the scientists who did the original work when they had questions about which strain of mice to use or where to find specially engineered tumor cells. "I wasn't surprised, but it is concerning that about a third of scientists were not helpful, and, in some cases, were beyond not helpful," said Michael Lauer, deputy director of extramural research at the National Institutes of Health. NIH will try to improve data sharing among scientists by requiring it of grant-funded institutions in 2023, Lauer said.

An anonymous reader quotes a report from NPR: It's Dr. Francis Collins' last few weeks as director of the National Institutes of Health after 12 years, serving under three presidents. Collins made his name doing the kind of biomedical research NIH is famous for, especially running The Human Genome Project, which fully sequenced the human genetic code. The focus on biomedicine and cures has helped him grow the agency's budget to over $40 billion a year and win allies in both political parties.

Still, in a broad sense, Americans' health hasn't improved much in those 12 years, especially compared with people in peer countries, and some have argued the agency hasn't done enough to try to turn these trends around. One recently retired NIH division director has quipped that one way to increase funding for this line of research would be if "out of every $100, $1 would be put into the 'Hey, how come nobody's healthy?' fund."

In a wide-ranging conversation, Collins answers NPR's questions as to why -- for all the taxpayer dollars going to NIH research -- there haven't been more gains when it comes to Americans' overall health. He also talks about how tribalism in American culture has fueled vaccine hesitancy, and he advises his successor on how to persevere on research of politically charged topics -- like guns and obesity and maternal health -- even if powerful lobbies might want that research not to get done. In regard to Americans not getting healthier over the last 12 years, NPR asked Collins why there haven't been more gains and what role NIH should play in understanding these trends and trying to turn them around. Here's what he said: Well, sure, it does bother me. In many ways, the 28 years I have been at NIH have just been an amazing ride of discoveries upon discoveries. But you're right, we haven't seen that translate necessarily into advances. Let's be clear, there are some things that have happened that are pretty exciting. Cancer deaths are dropping every year by 1 or 2%. When you add that up over 20 years, cancer deaths are down by almost 25% from where they were at the turn of the century. And that's a consequence of all the hard work that's gone into developing therapeutics based on genomics, as well as immunotherapy that's made a big dent in an otherwise terrible disease.

But we've lost ground in other areas, and a lot of them are a function of the fact that we don't have a very healthy lifestyle in our nation. Particularly with obesity and diabetes, those risk factors have been getting worse instead of better. We haven't, apparently, come up with strategies to turn that around. On top of that, the other main reason for seeing a drop in life expectancy -- other than obesity and COVID -- is the opioid crisis. We at NIH are working as fast and as hard as we can to address that by trying to both identify better ways to prevent and treat drug addiction, but also to come up with treatments for chronic pain that are not addictive, because those 25 million people who suffer from chronic pain every day deserve something better than a drug that is going to be harmful.

In all of these instances, as a research enterprise -- because that's our mandate -- it feels like we're making great progress. But the implementation of those findings runs up against a whole lot of obstacles, in terms of the way in which our society operates, in terms of the fact that our health care system is clearly full of disparities, full of racial inequities. We're not -- at NIH -- able to reach out and fix that, but we can sure shine a bright light on it and we can try to come up with pilot interventions to see what would help.

fahrbot-bot shares a report from ScienceAlert: Usage of the medication sildenafil -- better known to most as the brand-name drug Viagra -- is associated with dramatically reduced incidence of Alzheimer's disease, new research suggests. According to a study led by researchers at the Cleveland Clinic, taking sildenafil is tied to a nearly 70 percent lower risk of developing Alzheimer's compared to non-users. That's based on an analysis of health insurance claim data from over 7.2 million people, in which records showed that claimants who took the medication were much less likely to develop Alzheimer's over the next six years of follow up, compared to matched control patients who didn't use sildenafil.

It's important to note that observed associations like this -- even on a huge scale -- are not the same as proof of a causative effect. For example, it's possible that the people in the cohort who took sildenafil might have something else to thank for their improved chances of not developing Alzheimer's. Nonetheless, the researchers say the correlation shown here -- in addition to other indicators in the study -- is enough to identify sildenafil as a promising candidate drug for Alzheimer's disease, the viability of which can be explored in future randomized clinical trials designed to test whether causality does indeed exist.

Reeses writes: The Debrief just reported that DARPA just "accidentally" created the world's first warp bubble. From the article:

Warp drive pioneer and former NASA warp drive specialist Dr. Harold G "Sonny" White has reported the successful manifestation of an actual, real-world "Warp Bubble." And, according to White, this first of its kind breakthrough by his Limitless Space Institute (LSI) team sets a new starting point for those trying to manufacture a full-sized, warp-capable spacecraft.

There's also a video of the announcement, The Very First Warp-Bubble Created by DARPA Funded Team.

European space company ArianeGroup will develop a reusable mini-launcher to compete with the likes of Elon Musk's SpaceX, French Finance Minister Bruno Le Maire said on Monday. Reuters reports: The launcher "must be able to be operational in 2026," Le Maire said during a trip to the ArianeGroup site at Vernon in Normandy, where the engines of Ariane rockets are tested. "For the first time Europe...will have access to a reusable launcher. In other words, we will have our SpaceX, we will have our Falcon 9. We will make up for a bad strategic choice made 10 years ago," Le Maire said.

Astronomers say they've located six galaxies that appear to have either very little or absolutely no dark matter. The team will present its findings in Monthly Notices of the Royal Astronomical Society. CNET reports: Mentioning that they'd previously been told "measure again, you'll see there will be dark matter around your galaxy," the researchers zeroed in on one seemingly dark-matter-free region dubbed AGC 114905 to strengthen their evidence. Lurking 250 million light-years away from Earth, it's about the size of the Milky Way, with a thousand times fewer stars. So it's rather dim. The researchers used a standard technique to detect the presence of dark matter in AGC 114905 that involves graphing the position and rotation speed of the galaxy's gas. After 40 hours of scrutiny with the high-powered Very Large Array Radio Telescope in New Mexico, they found the movements of the gas were perfectly explainable by normal matter alone.

"The problem remains that the theory predicts that there must be dark matter in AGC 114905," Pavel Mancera Piñabut of the Kapteyn Astronomical Institute at the University of Groningenour and an author of the study, said in a statement, referring to classic dark matter hypotheses. "Observations say there isn't -- in fact, the difference between theory and observation is only getting bigger." One caveat, the team says, is that perhaps the angle at which they viewed AGC 114905 affected their observational results. "But that angle has to deviate very much from our estimate before there is room for dark matter again," Tom Oosterloo of Astron at the Netherlands Institute for Radio Astronomy and co-author of the study, said in a statement.

And if they're correct? The team offers up a few reasons for why AGC 114905 may not have any dark matter. For instance, what if super large galaxies nearby somehow stripped it of the force? As a rebuttal, though, Mancera Pinabut says there don't seem to be any such galaxies in the vicinity. Further, he says, "in the most reputed galaxy formation framework, the so-called cold dark matter model, we would have to introduce extreme parameter values that are far beyond the usual range. Also with modified Newtonian dynamics, an alternative theory to cold dark matter, we cannot reproduce the motions of the gas within the galaxy."

Chinese weather authorities successfully controlled the weather ahead of a major political celebration earlier this year, according to a Beijing university study. The Guardian reports: On 1 July the Chinese Communist party marked its centenary with major celebrations including tens of thousands of people at a ceremony in Tiananmen Square, and a research paper from Tsinghua University has said an extensive cloud-seeding operation in the hours prior ensured clear skies and low air pollution. [...] On Monday the South China Morning Post reported a recent research paper which found definitive signs that a cloud-seeding operation on the eve of the centenary had produced a marked drop in air pollution.

The centenary celebration faced what the paper reportedly termed unprecedented challenges, including an unexpected increase in air pollutants and an overcast sky during one of the wettest summers on record. Factories and other polluting activities had been halted in the days ahead of the event but low airflow meant the pollution hadn't dissipated, it said. The paper, published in the peer-reviewed Environmental Science journal and led by environmental science professor, Wang Can, said a two-hour cloud-seeding operation was launched on the eve of the ceremony, and residents in nearby mountain regions reported seeing rockets shot into the sky on 30 June. The paper said the rockets were carrying silver iodine into the sky to stimulate rainfall.

The researchers said the resulting artificial rain reduced the level of PM2.5 air pollutants by more than two-thirds, and shifted the air quality index reading, based on World Health Organization standards, from "moderate" to "good." The team said the artificial rain "was the only disruptive event in this period," so it was unlikely the drop in pollution had a natural cause.

The artificial intelligence (AI) program DeepMind has gotten closer to proving a math conjecture that's bedeviled mathematicians for decades and revealed another new conjecture that may unravel how mathematicians understand knots. Live Science reports: The two pure math conjectures are the first-ever important advances in pure mathematics (or math not directly linked to any non-math application) generated by artificial intelligence, the researchers reported Dec. 1 in the journal Nature. [...] The first challenge was setting DeepMind onto a useful path. [...] They focused on two fields: knot theory, which is the mathematical study of knots; and representation theory, which is a field that focuses on abstract algebraic structures, such as rings and lattices, and relates those abstract structures to linear algebraic equations, or the familiar equations with Xs, Ys, pluses and minuses that might be found in a high-school math class.

In understanding knots, mathematicians rely on something called invariants, which are algebraic, geometric or numerical quantities that are the same. In this case, they looked at invariants that were the same in equivalent knots; equivalence can be defined in several ways, but knots can be considered equivalent if you can distort one into another without breaking the knot. Geometric invariants are essentially measurements of a knot's overall shape, whereas algebraic invariants describe how the knots twist in and around each other. "Up until now, there was no proven connection between those two things," [said Alex Davies, a machine-learning specialist at DeepMind and one of the authors of the new paper], referring to geometric and algebraic invariants. But mathematicians thought there might be some kind of relationship between the two, so the researchers decided to use DeepMind to find it. With the help of the AI program, they were able to identify a new geometric measurement, which they dubbed the "natural slope" of a knot. This measurement was mathematically related to a known algebraic invariant called the signature, which describes certain surfaces on knots.

In the second case, DeepMind took a conjecture generated by mathematicians in the late 1970s and helped reveal why that conjecture works. For 40 years, mathematicians have conjectured that it's possible to look at a specific kind of very complex, multidimensional graph and figure out a particular kind of equation to represent it. But they haven't quite worked out how to do it. Now, DeepMind has come closer by linking specific features of the graphs to predictions about these equations, which are called Kazhdan-Lusztig (KL) polynomials, named after the mathematicians who first proposed them. "What we were able to do is train some machine-learning models that were able to predict what the polynomial was, very accurately, from the graph," Davies said. The team also analyzed what features of the graph DeepMind was using to make those predictions, which got them closer to a general rule about how the two map to each other. This means DeepMind has made significant progress on solving this conjecture, known as the combinatorial invariance conjecture.

In an open letter to Mark Zuckerberg published Monday, a group of academics called for Meta to be more transparent about its research into how Facebook, Instagram, and WhatsApp affect the mental health of children and adolescents. The Verge reports: The letter calls for the company to allow independent reviews of its internal work, contribute data to external research projects, and set up an independent scientific oversight group. "You and your organizations have an ethical and moral obligation to align your internal research on children and adolescents with established standards for evidence in mental health science," the letter, signed by researchers from universities around the world, reads.

The open letter comes after leaks from Facebook revealed some data from the company's internal research, which found that Instagram was linked with anxiety and body image issues for some teenage girls. The research released, though, is limited and relied on subjective information collected through interviews. While this strategy can produce useful insights, it can't prove that social media caused any of the mental health outcomes. The information available so far appears to show that the studies Facebook researchers conducted don't meet the standards academic researchers use to conduct trials, the new open letter said. The information available also isn't complete, the authors noted -- Meta hasn't made its research methods or data public, so it can't be scrutinized by independent experts. The authors called for the company to allow independent review of past and future research, which would include releasing research materials and data.

The letter also asked Meta to contribute its data to ongoing independent research efforts on the mental health of adolescents. It's a longstanding frustration that big tech companies don't release data, which makes it challenging for external researchers to scrutinize and understand their products. "It will be impossible to identify and promote mental health in the 21st century if we cannot study how young people are interacting online," the authors said. [...] The open letter also called on Meta to establish an independent scientific trust to evaluate any risks to mental health from the use of platforms like Facebook and Instagram and to help implement "truly evidence-based solutions for online risks on a world-wide scale." The trust could be similar to the existing Facebook Oversight Board, which helps the company with content moderation decisions.