Thelasko shares a report from the BBC: At least one person in the UK has died with the Omicron coronavirus variant, the prime minister has said. Boris Johnson said the new variant was also resulting in hospital admissions, and the "best thing" people could do was get their booster jab. Health Secretary Sajid Javid told MPs Omicron now represented 20% of cases in England. The PM has set a new target for all adults in England to be offered a booster by the end of the month. Mr Johnson said on Monday that people needed to recognize "the sheer pace at which [Omicron] accelerates through the population" and that they should set aside the idea that Omicron was a milder variant.

The UK recorded 54,661 new coronavirus cases on Monday, as well as 38 deaths within 28 days of a positive test. There are 4,713 confirmed cases of the Omicron variant but Mr Javid said the UK Health Security Agency (UKHSA) estimated the current number of daily infections was around 200,000. Omicron has risen to more than 44% of cases in London and is expected to become the dominant variant in the city in the next 48 hours, he said.

An anonymous reader shares an excerpt from a report by Gizmodo, written by Isaac Schultz: The Dark Matter Radio project is attempting to detect hidden photons in a specific frequency range by methodically turning the dial, in what amounts to a patient, sweeping search of the wavelengths where such a particle could sound off. Later generations of the radio will hunt axions. [...] The current Dark Matter Radio experiment is the prototype, or Pathfinder, for larger projects down the line. It consists of a liter-volume cylinder made of superconducting niobium metal, around which is tightly wound niobium wire. It looks a bit like someone wound guitar string on a spool's vertical axis instead of its horizontal axis. That's the Pathfinder's inductor. If a hidden photon resonating at the frequency the Pathfinder was tuned to passed through it, the change in magnetic field would induce a voltage around the contraption's inductor. "The null hypothesis is that there shouldn't be any radio waves inside of that box unless, in this case, hidden photons, which are our particular flavor of dark matter," said Stephen Kuenstner, a physicist at Stanford University and a member of the DM Radio team. Hidden photons "can pass through the box and they have some probability of interacting with the circuit in the same way that a radio wave would," Kuenstner said.

To amplify any signal the Pathfinder picks up, there's a hexagonal shield of niobium plates sheathing the aforesaid components that acts as a capacitor. That amplified signal is then transported to a quantum sensor called a SQUID (a Superconducting QUantum Interference Device), a technology invented by the Ford Motor Company in the 1960s. The SQUID lives on the bottom of the radio and measures and records any signals picked up. The smaller the expected mass for the axion becomes, the more elusive the particle is, as its interactions with ordinary matter are proportional to its mass. So it's important that the next generation of DM Radio becomes more sensitive. The way the experiment is set up, "the frequency on the dial is the mass of the axion," [said Kent Irwin, a physicist at Stanford University and SLAC and the principal investigator of Dark Matter Radio]. Convenient! The mass of these particles doesn't even compare to the smallest things you might think of, like atoms or quarks. These particles would be somewhere between a trillionth and a millionth of an electronvolt, and an electronvolt is about a billionth of a proton's mass.

The helium Pathfinder uses is gaseous, and remains a relatively warm 4 kelvin (in other words, four degrees above absolute zero), but the next experiment -- Dark Matter Radio 50L -- will use liquified helium, cooled to less than one degree above absolute zero. All the better for hearing dark matter with. DM Radio 50L sits in the corner of a large room in the Hansen Experimental Physics Lab at Stanford. The room looks a little bit like the TV room in Willy Wonka's factory; it has high ceilings, lots of inscrutable equipment, and is glaringly white. Two 6-foot-tall dilution refrigerators on one side, abutting a deep closet, are the radio. The two machines are fed gaseous helium sitting in tanks in the next room, which they then cool down into liquid helium of a frigid 2 kelvin. Magnets inside gold-plated copper and aluminum sheathes will do the job of converting any detected axions into radio waves for physicists to interpret. "The particle physics community is -- the analogy is often said -- just like a battleship. It takes a while to turn and it has a lot of momentum," Irwin said. "So even though I think that there's a lot of reasons to believe that these radio-like dark matter signals are more attractive -- the axionic signals -- than [Weakly Interactinv Massive Particles (WIMPs)], there's still a lot of giant experiments searching for little things, which is good." The team behind the Dark Matter Radio is "currently working with the Department of Energy on a next-next-generation experiment that will look for axions in a cubic meter, hence its name of DM Radio-m3," adds Gizmodo. "In the more distant future, Irwin and his team have aspirations for a project called DM Radio-GUT, which would be closer to the scale of some of the largest physics experiments on the planet."

"All told, Irwin said, the favored area for axion mass could be searched in the next couple of decades using larger experiments -- though the team could simply find an axion before then, potentially ending the hunt for dark matter in its entirety. With enough listening, we might have an entirely new particle for the textbooks. Or maybe there'll be radio silence."

South Korea will soon roll out a pilot project to use artificial intelligence, facial recognition and thousands of CCTV cameras to track the movement of people infected with the coronavirus, despite concerns about the invasion of privacy. Reuters reports: The nationally funded project in Bucheon, one of the country's most densely populated cities on the outskirts of Seoul, is due to become operational in January, a city official told Reuters. The system uses an AI algorithms and facial recognition technology to analyze footage gathered by more than 10,820 CCTV cameras and track an infected person's movements, anyone they had close contact with, and whether they were wearing a mask, according to a 110-page business plan from the city submitted to the Ministry of Science and ICT (Information and Communications Technology), and provided to Reuters by a parliamentary lawmaker critical of the project.

The Bucheon official said the system should reduce the strain on overworked tracing teams in a city with a population of more than 800,000 people, and help use the teams more efficiently and accurately. [...] The Ministry of Science and ICT said it has no current plans to expand the project to the national level. It said the purpose of the system was to digitize some of the manual labour that contact tracers currently have to carry out. The Bucheon system can simultaneously track up to ten people in five to ten minutes, cutting the time spent on manual work that takes around half an hour to one hour to trace one person, the plan said.

An anonymous reader quotes a report from Futurism: In a revelation that will surprise almost no one, the 2022 World Inequality Report found that one space flight emits more carbon dioxide than most of the world's population will create in their entire lifetime. While other parts of the report focus on labor, income and economic inequality, the researchers also included a statistic -- spotted by folks on social media and highlighted by Gizmodo -- that perfectly sums up the relationship between those who create greenhouse gases versus those who suffer most from them.

"Perhaps the most conspicuous illustration of extreme pollution associated with wealth inequality in recent years is the development of space travel," the report states. "An 11-minute flight emits no fewer than 75 tonnes of carbon per passenger About one billion individuals emit less than one tonne per person per year. Over their lifetime, this group of one billion individuals does not emit more than 75 tonnes of carbon per person." If you're wondering which space flight the World Inequality Report is addressing, well, the team didn't call anyone out by name. But Jeff Bezos' much-publicized space flight back in July was about that length of time, as Gizmodo pointed out. Bezos, the Amazon founder currently wrapped up in Blue Origin's space tourism junket, effectively puts out more carbon than most humans could create in their lifetime each time he sends up a rocket.

The World Inequality Report argues that to hold the biggest greenhouse gas emitters responsible, we need to better track global emission numbers. "Large inequalities in emissions suggest that climate policies should target wealthy polluters more," the authors write. "So far, climate policies such as carbon taxes have often disproportionately impacted low and middle income groups." It's the equivalent of being told to recycle your cardboard and pay for municipal recycling pickup, in other words -- it's a nice gesture, but no matter how hard you try, you'll never offset a single Bezos space journey. "The report also noted that the top 1% wealthiest individuals emit about 110 tons of carbon emissions per year, an extreme number dwarf by the top .1% (467 tons) and the top .01% (2,530 tons)," notes Gizmodo.

What's absent from the report, however, are the everyday benefits of space exploration, such as scientific discoveries and the creation of scientific and technical jobs, among other things. The tradeoff between the negative carbon emissions and positive benefits of space travel remains to be seen.

"The Federal Aviation Administration said on Friday that it was ending a program that awarded small gold pins called 'Commercial Space Astronaut Wings' to certain people who flew to space on private spacecraft," reports the New York Times. (Alternate URL here.) But before the program officially retires in January, all who applied for the gold wings after flying to space this year will still receive them, the agency said.

That means Mr. Bezos, the billionaire founder of Amazon who rode a rocket with his space company, Blue Origin, to the edge of space in July, will be considered a commercial astronaut. So will Richard Branson, the founder of the space tourism firm Virgin Galactic who flew his own company's rocket plane to space in the same month. William Shatner, the Star Trek star who flew with Blue Origin to the edge of space in October, will also receive astronaut wings to go with his Starfleet paraphernalia. Twelve other people were also added to the federal agency's list of wing recipients on Friday [bringing the list up to 30 people].

The changes will help the F.A.A. avoid the potentially awkward position of proclaiming that some space tourists are only passengers, not astronauts.

The Commercial Space Astronaut Wings Program was created by Patti Grace Smith, the first chief of the F.A.A.'s commercial space office, to promote the private development of human spaceflight — a mandate from a 1984 law that aimed to accelerate innovation of space vehicles. The program began handing out pins to qualified individuals in 2004, when Mike Melvill, a test pilot who flew the Scaled Composites SpaceShipOne plane, became its first recipient. To qualify for the commercial astronaut wings under the original guidelines, a person had to reach an altitude of at least 50 miles, the marker of space recognized by NASA and the U.S. Air Force, and be a member of the spacecraft's "flight crew..."

Although no one will receive the little gold pins after 2021, those who fly above 50 miles on an F.A.A.-licensed rocket will be honored in the agency's online database.

But future space tourists should not despair a lack of post-flight flair. Virgin Galactic, Blue Origin and SpaceX have each presented paying and guest passengers with custom-designed wings.
Or, as the Associated Press put it, "The FAA said Friday it's clipping its astronaut wings because too many people are now launching into space and it's getting out of the astronaut designation business entirely...." "The U.S. commercial human spaceflight industry has come a long way from conducting test flights to launching paying customers into space," the FAA's associate administrator Wayne Monteith said in a statement. "Now it's time to offer recognition to a larger group of adventurers daring to go to space."
Thanks to long-time Slashdot reader schwit1 for submitting the story.

Long-time Slashdot reader fahrbot-bot quotes SciTechDaily: A discovery by researchers at the Texas A&M College of Medicine could lead to new therapies to prevent the virus from proliferating in the human body... The underlying mechanism of how SARS-CoV-2 escapes from the immune system has been poorly understood. However, researchers from the Texas A&M University College of Medicine and Hokkaido University have recently discovered a major mechanism that explains how SARS-CoV-2 can escape from the immune system and replicate in the human body. Their findings were recently published in the journal Nature Communications.

"We found that the SARS-CoV-2 virus carries a suppressive gene that acts to inhibit a human gene in the immune system that is essential for destroying infected cells," said Dr. Koichi Kobayashi, adjunct professor at the College of Medicine and lead author of the paper.

Naturally, the cells in a human's immune system are able to control virus infection by destroying infected cells so that the virus cannot be replicated. The gene that is essential in executing this process, called NLRC5, regulates major histocompatibility complex (MHC) class I genes, which are genes that create a pathway that is vital in providing antiviral immunity. Kobayashi and his colleagues discovered this in 2012.

"During infection, the amount and activity of NLRC5 gene become augmented in order to boost our ability of eradication of viruses," Kobayashi said. "We discovered that the reason why SARS-CoV-2 can replicate so easily is because the virus carries a suppressive gene, called ORF6, that acts to inhibit the function of NLRC5, thus inhibiting the MHC class I pathway as well."

"To date, nearly 28,000 near-Earth asteroids have been found by survey telescopes that continually scan the night sky, adding new discoveries at a rate of about 3,000 per year..." according to an article from NASA:

"The first version of Sentry was a very capable system that was in operation for almost 20 years," said Javier Roa Vicens, who led the development of Sentry-II while working at JPL as a navigation engineer and recently moved to SpaceX. "It was based on some very smart mathematics: In under an hour, you could reliably get the impact probability for a newly discovered asteroid over the next 100 years — an incredible feat."
But RockDoctor (Slashdot reader #15,477), summarizes some new changes: For nearly 20 years, newly discovered asteroids had orbital predictions processed by a system called "Sentry", resulting in quick estimates on the impact risk they represent with Earth. Generally this has worked well, but several things in the future required updates, and a new system adds a number of useful features too.

The coming wave of big survey telescopes which will check the whole sky every few days is going to greatly increase the number of discoveries. That requires streamlining of the overall system to improve processing speed. The new system can also automatically incorporate factors which previously required manual intervention to calculate, particularly the effect of asteroid rotation creating non-gravitational forces on a new discovery's future orbit. Objects like asteroid Bennu (recently subject of a sampling mission) had significant uncertainty on their future path because of these effects. That doesn't mean that Bennu can possibly hit us in the next few centuries, but it became harder to say over the next few millennia. As NASA puts it:

Popular culture often depicts asteroids as chaotic objects that zoom haphazardly around our solar system, changing course unpredictably and threatening our planet without a moment's notice. This is not the reality. Asteroids are extremely predictable celestial bodies that obey the laws of physics and follow knowable orbital paths around the Sun.

But sometimes, those paths can come very close to Earth's future position and, because of small uncertainties in the asteroids' positions, a future Earth impact cannot be completely ruled out. So, astronomers use sophisticated impact monitoring software to automatically calculate the impact risk....

[T]he researchers have made the impact monitoring system more robust, enabling NASA to confidently assess all potential impacts with odds as low as a few chances in 10 million.


The article includes videos explaining the future uncertainties on the orbits of potentially hazardous asteroids Bennu and Apophis.

Slashdot reader DevNull127 writes: It's a newspaper puzzle that's like Sudoku, except it's impossible. [Sort of...] They call it "The Challenger" puzzle — but when the newspaper leaves out a crucial instruction, you can end up searching forever for a unique solution which doesn't exist!

"If you're thinking 'This could be a 9 or an 8....' — you're right!" complains Lou Cabron. "Everyone's a winner today! Just start scribbling in numbers! And you'd be a fool to try to keep narrowing them down by, say, using your math and logic skills. A fool like me..." (Albeit a fool who once solved a Sudoku puzzle entirely in his head.) But two hours of frustration later — and one night of bad dreams — he's stumbled onto the web page of Dr. Robert J. Lopez, an emeritus math professor in Indiana, who's calculated that in fact Challenger puzzles can have up to 190 solutions... and there's more than one solution for more than 97% of them!

At the end of the day, it becomes an appreciation for the local newspaper, and the puzzles they run next to the funnies. But with a friendly reminder "that they ought to honor and respect that love — by always providing the complete instructions."

"A study in 2019 found that the spatial memory used for navigating through the world tends to be worse for people who've made extensive use of map apps and GPS devices..." reports NBC News.

But that's just the beginning, according to Adrian Ward, who studies psychology at the University of Texas at Austin. NBC says Ward's research suggests "People who lean on a search engine such as Google may get the right answers but they can also end up with a wrong idea of how strong their own memory is." In Ward's research, published in October in the journal Proceedings of the National Academy of Sciences of the United States, he used a series of eight experiments to test how people used and thought about their own knowledge as they completed short quizzes of general knowledge. Some participants had access to Google while answering the questions — "What is the most widely spoken language in the world?" was one — while others did not. They also completed surveys. He found that people who used Google were more confident in their own ability to think and remember, and erroneously predicted that they would know significantly more in future quizzes without the help of the internet. Ward attributed that to Google's design: simple and easy, less like a library and more like a "neural prosthetic" that simulates a search in a human brain.

"The speed makes it so you never understand what you don't know," Ward said.

The findings echo and build on earlier research, including a widely cited 2011 paper on the "Google effect": a phenomenon in which people are less likely to remember information if they know they can find it later on the internet.... In a review of recent studies in the field, published in September, researchers at Duke University found that the "externalization" of memories into digital spheres "changes what people attend to and remember about their own experiences." Digital media is new and different, they wrote, because of factors such as how easily images are edited or the huge number of memories at people's fingertips.

Each photographic cue means another chance for a memory to be "updated," maybe with a false impression, and each manipulation of a piece of social media content is a chance for distortion, wrote the researchers, doctoral student Emmaline Drew Eliseev and Elizabeth Marsh, a professor of psychology and neuroscience and director of a lab dedicated to studying memory.

New FDA-approved eye drops could replace reading glasses for millions: "It's definitely a life changer" "A newly approved eye drop hitting the market on Thursday could change the lives of millions of Americans with age-related blurred near vision, a condition affecting mostly people 40 and older," reports CBS News.

"Vuity, which was approved by the Food and Drug Administration in October, would potentially replace reading glasses for some of the 128 million Americans who have trouble seeing close-up." The new medicine takes effect in about 15 minutes, with one drop on each eye providing sharper vision for six to 10 hours, according to the company.... Vuity is the first FDA-approved eye drop to treat age-related blurry near vision, also known as presbyopia. The prescription drug utilizes the eye's natural ability to reduce its pupil size, said Dr. George Waring, the principal investigator for the trial.

"Reducing the pupil size expands the depth of field or the depth of focus, and that allows you to focus at different ranges naturally," he said.

A 30-day supply of the drug will cost about $80 and works best in people 40 to 55 years old, a Vuity spokesperson said. Side effects detected in the three-month trial included headaches and red eyes, the company said.

An Israeli study tracked more than 843,000 people who received two doses of the Pfizer vaccine — and then explored whether the results improved for the 758,000 who then also got a booster shot.

The results? HealthDay reports: Boosted folks are 90% less likely to die from a Delta infection than people relying solely on the initial two-dose vaccination, Israeli data show.

That protection will be critically important during the next couple of months as the Delta variant continues to dominate throughout the United States, said Dr. William Schaffner, medical director of the National Foundation for Infectious Diseases. "While we are preoccupied with Omicron, you need to remember that Delta is essentially in every town and city in the United States today — being transmitted, infecting new people, sending people to the hospital, in some parts of the country stressing the health care system once again," Schaffner said. "Although we have Omicron in the United States and it's starting to take hold, nonetheless well over 95% of all new infections today are caused by Delta...."

A second study out of Israel focused on infection and severity of illness, and it also produced good tidings for boosters in the face of the Delta variant. This study involved nearly 4.7 million Israelis who'd been fully vaccinated with Pfizer and were eligible for boosters. Confirmed infections were tenfold lower in the group of people who got the Pfizer booster, researchers reported. Further, results showed that the longer a booster was in a person's system, the more resistant they became to infection from the Delta strain.

Blue Origin successfully completed a 10-minute suborbital spaceflight this morning.

But with SpaceX, Virgin Galactic, and the space agencies of Russia and China, Blue Origin also helped humanity achieve another milestone Saturday. The Washington Post explains how it will push us far past a record set in 1985 when America's space shuttle made nine flights into space: Saturday's launch will be the 13th human spaceflight of the year, two more than in 1985, when NASA carried out those nine shuttle flights, and the Russian Soyuz vehicle carried astronauts on two launches.

All of those flights reached orbit, while several of the flights this year barely scratched the edge of space in relatively short suborbital jaunts. Still, this year is "the busiest year in human spaceflight," Jennifer Levasseur, a curator at the National Air and Space Museum in Washington, said in an interview. "We're entering a new phase of activity that we've never, frankly, seen before. And it creates a lot of excitement."

Saturday's Blue Origin flight will also carry Dylan Taylor, chairman and CEO of space exploration firm Voyager Space; Evan Dick, an investor; Lane and Cameron Bess, the first parent-child pair to fly to space; and Laura Shepard Churchley, a daughter of Alan Shepard, the first American to go to space...

China, which is building a space station in low Earth orbit, flew two crewed missions this year, and Russia has flown three, including the flight this week. The flurry of activity is reminiscent of 1985, Levasseur said, a time when NASA was optimistic that it would fly dozens of times a year, carrying all sorts of people to space.
The Post ultimately calls 2021 "one of the most remarkable years for human spaceflight."

Jackie Wattles writes via CNN Business: Jeff Bezos' rocket company, Blue Origin, became the subject of a federal review this fall after a group of 21 current and former employees co-signed an essay that raised serious questions about the safety of the company's rockets -- including the rocket making headlines for flying Bezos and other celebrities to space. But that review was hamstrung by a lack of legal protections for whistleblowers in the commercial spaceflight industry, according to emails from Federal Aviation Administration investigators that were obtained by CNN Business. The FAA also confirmed in a statement Friday that its Blue Origin review is now closed, saying the "FAA investigated the safety allegations made against Blue Origin's human spaceflight program" and "found no specific safety issues."

The emails obtained by CNN Business, however, reveal that investigators were not able to speak with any of the engineers who signed the letter anonymously. Investigators also were not able to go to Blue Origin and ask for documents or interviews with current employees or management, according to the FAA. The situation highlights how commercial spaceflight companies like Blue Origin are operating in a regulatory bubble, insulated from much of the scrutiny other industries are put under. There are no federal whistleblower statues that would protect employees in the commercial space industry if they aid FAA investigators, according to the agency.

The commercial space industry is in a legally designated "learning period" until at least October 2023 -- a "learning period" that has been extended several times, most recently by a 2015 law called the Commercial Space Launch Competitiveness Act. The idea is to allow the industry to mature and give companies a chance to self-regulate without overbearing government interference. But that designation effectively bars federal regulators from implementing certain new rules or wielding the same oversight powers for commercial space companies as it does for aviation. That meant that investigators had to rely on current and former Blue Origin employees voluntarily coming forward to offer information.

A team of scientists at a university in western Japan has developed masks that glow when exposed to ultraviolet light if they contain traces of the coronavirus, using antibodies extracted from ostrich eggs. From a report: The team at Kyoto Prefectural University, headed by its president, Yasuhiro Tsukamoto, 52, hopes the masks will offer users an easy way to test whether they have contracted the virus. With testing continuing to put them into practical use, the team aims to gain government approval to sell the masks possibly next year. Ostriches are capable of producing several different kinds of antibody, or proteins that neutralize foreign entities in the body. In February last year, the team injected an inactive and non-threatening form of the coronavirus into female ostriches, successfully extracting a large quantity of antibodies from the eggs that they laid.

A brand-new space telescope will soon reveal a hidden vision of the cosmos, potentially transforming our understanding of black holes, supernovas and even the nature of the universe itself. No, not that one. From a report: Much attention is being devoted this month to the James Webb Space Telescope, from NASA and the European Space Agency, which is set to launch on Dec. 22. But a more exclusive cadre of astronomers watched excitedly on Thursday during the trip to space of a smaller, but also transformative, observatory. NASA launched the Imaging X-ray Polarimetry Explorer, or IXPE mission, on a SpaceX Falcon 9 rocket from Kennedy Space Center in Florida at 1 a.m. Eastern. The spacecraft cost a mere $188 million, compared with the James Webb's mammoth budget of $9.7 billion, and is expected to demonstrate a new form of astronomy. It will, for the first time, perform imaging X-ray polarimetry in orbit, a technique that could offer astronomers insights that no other telescope can match.

"It's giving us information about some of the most bizarre and exciting objects in space," said Thomas Zurbuchen, the associate administrator of NASA's science mission directorate. IXPE (pronounced by the mission team as "ix-pee") was placed into an orbit 340 miles above Earth after its launch. The telescope will spend several weeks there deploying its scientific instruments and testing its equipment, then begin its two-year mission. X-rays are a useful way to observe the universe. Emitted from extremely energetic objects, they allow astronomers to probe events -- superheated jets near black holes or explosions of stars, for example -- in a way other wavelengths, such as visible light, cannot. But X-rays can be studied only from space because they are mostly absorbed by Earth's atmosphere. A variety of dedicated X-ray space telescopes and instruments have launched to orbit, most notably NASA's Chandra X-ray and ESA's XMM-Newton observatories, which both launched in 1999. With spacecraft like these, scientists have unveiled the birthplaces of stars inside gaseous nebulas and mapped the spread of dark matter in clusters of galaxies, among other pioneering work.

The Food and Drug Administration authorized the first injectable monoclonal antibody cocktail for long-term prevention of Covid-19 among people with weakened immune systems before they have been exposed to the coronavirus. NBC News reports: The FDA issued an emergency use authorization Wednesday for AstraZeneca's antibody cocktail, Evusheld, for what is known as pre-exposure prophylaxis, or PrEP, against Covid-19. To date, such laboratory-produced antibodies have been authorized only as early treatment of Covid-19 or as preventive therapy for high-risk people immediately after close contact with someone who has tested positive.

Evusheld can be used as PrEP by people ages 12 and older who are moderately to severely immunocompromised and may not get adequate immune responses from a Covid vaccine. The therapy is also an option for the rare people who have histories of severe adverse reactions to a Covid vaccine or its components. The AstraZeneca therapy involves getting preventive injections as often as every six months. According to a large placebo-controlled clinical trial, the cocktail is about 83 percent effective at preventing symptomatic disease during such an interval. It's unclear how the highly mutated omicron variant of the coronavirus -- which is spreading in 57 countries, including the U.S. -- might affect the efficacy of the monoclonal antibody therapy.

Microplastics cause damage to human cells in the laboratory at the levels known to be eaten by people via their food, a study has found. From a report: The harm included cell death and allergic reactions and the research is the first to show this happens at levels relevant to human exposure. However, the health impact to the human body is uncertain because it is not known how long microplastics remain in the body before being excreted. Microplastics pollution has contaminated the entire planet, from the summit of Mount Everest to the deepest oceans. People were already known to consume the tiny particles via food and water as well as breathing them in. The research analysed 17 previous studies which looked at the toxicological impacts of microplastics on human cell lines. The scientists compared the level of microplastics at which damage was caused to the cells with the levels consumed by people through contaminated drinking water, seafood and table salt. They found specific types of harm -- cell death, allergic response, and damage to cell walls -- were caused by the levels of microplastics that people ingest.

Over 40 million people in the United States had their personal health information exposed in data breaches this year, a significant jump from 2020 and a continuation of a trend toward more and more health data hacks and leaks. The Verge reports: Health organizations are required to report any health data breaches that impact 500 or more people to the Office for Civil Rights at the Department of Health and Human Services, which makes the breaches public. So far this year, the office has received reports of 578 breaches, according to its database. That's fewer than the 599 breaches reported in 2020 (PDF), but last year's breaches only affected about 26 million people. Since 2015, hacks or other IT incidents have been the leading reason people have their health records exposed, according to a report (PDF) from security company Bitglass. Before then, lost or stolen devices led to the most data breaches.

fahrbot-bot shares a report from Gizmodo: Scientists have spotted an unusually large exoplanet in orbit around b Centauri, a massive two-star system that is visible to the unaided eye. With a combined weight of roughly 10 Suns, it's now the heaviest star system known to host a planet. The details of this discovery were published today in Nature. The newly discovered planet, called "b Cen (AB)b," is likely a gas giant and is heavier than 10 Jupiters combined, making it one of the most massive planets ever discovered. It orbits the b Centauri binary system, which is located 325 light-years from Earth and has a combined mass of nearly 10 Suns. At 52 billion miles from its host stars, this planet has one of the widest orbits ever detected. By comparison, Pluto orbits the Sun at around 3.3 billion miles, so yeah, that's an unbelievable separation. Until now, planets had not been found in orbit around star systems weighing more than three solar masses. Astronomers didn't think planets could form around systems like this, so it's forcing a major rethink of what's possible in terms of planetary architectures and the conditions under which planets can form.

That a planet exists in this star system is indeed surprising. Young stars have protoplanetary disks around them, from which planets eventually emerge. A hot star system like b Centauri, however, is not supposed to be conducive to planetary formation, owing to tremendous amounts of ultraviolet and X-ray radiation. This high-energy radiation "tends to destroy the disks in a very short time," and it was "thought that this wouldn't give planets enough time to form in the disk before it disappeared," [said Markus Janson, an astronomer at Stockholm University and the first author of the study]. Yet there it is -- a full fledged planet around the b Centauri system. [...] A neat observation is how the ratio between the masses of the star system and its planet closely matches that of our Sun and Jupiter. But that's where the comparison ends, as the scale of b Centauri is far vaster, as the planet is 10 times the mass of Jupiter and with an orbit that's 100 times wider. [...]

From an astrobiological perspective, Janson added that b Centauri is "possibly one of the worst places in the galaxy to host life." Together, the binary pair spew enormous amounts of UV and X-ray radiation, "which would sterilize any surface that is exposed to it," so "life on any surface in the system is certainly not very likely." Still, Janson did not rule out the possibility that life could exist in subterranean oceans, matching ongoing speculation about basic life existing on Jupiter's moon Europa or Saturn's moon Enceladus.

fahrbot-bot shares a report from The New York Times: What if something in the blood of an athlete could boost the brainpower of someone who doesn't or can't exercise? Could a protein that gets amplified when people exercise help stave off symptoms of Alzheimer's and other memory disorders? That's the tantalizing prospect raised by a new study in which researchers injected sedentary mice with blood from mice that ran for miles on exercise wheels, and found that the sedentary mice then did better on tests of learning and memory. The study, published Wednesday in the journal Nature, also found that the type of brain inflammation involved in Alzheimer's and other neurological disorders was reduced in sedentary mice after they received their athletic counterparts' blood. Scientific results with mice don't necessarily translate to humans. Still, experts said the study supports a growing body of research.

The study involved mice that were about three months old -- roughly the equivalent of 25-to-30-year olds for humans. Some of the mice, nocturnal animals that love to run, could freely use exercise wheels in their cages and logged about four to six miles on the wheels each night. The wheels were locked for other mice that could scoot around their cages but could not get an extended cardio workout. [...] After 28 days, the researchers took a third group of mice that also did not exercise and injected them with blood plasma, the liquid that surrounds blood cells, from either the runner mice or the non-runner mice. Mice receiving runner blood did better on two tests of learning and memory than those receiving blood from the non-runner mice. In one test, which measures how long a mouse will freeze in fear when it is returned to a cage where it previously received an electric foot shock, mice with runner blood froze 25 percent longer, indicating they had better memory of the stressful event [...]. In the other test, mice with runner blood were twice as fast at finding a platform submerged in opaque water, he said. The team also found that the brains of mice with runner blood produced more of several types of brain cells, including those that generate new neurons in the hippocampus, a region involved in memory and spatial learning. A genetic analysis showed that about 1,950 genes had changed in response to the infusion of runner blood, becoming either more or less activated. Most of the 250 genes with the greatest activation changes were involved in inflammation and their changes suggested that brain inflammation was reduced.