ISS

Astronaut Watches Russian Space Station Module Fall From Space In Fiery Demise (space.com) 25

On Monday, astronauts said goodbye to a cornerstone of the International Space Station and captured stunning images of the compartment burning up in Earth's atmosphere. Space.com reports: A Russian Progress cargo vehicle towed the module, called Pirs, away from the space station and down through Earth's atmosphere to ensure the module burned up completely and reduce the odds of any large chunks making it to Earth's surface. Russia had launched its Pirs module in 2001; since then, the module, which served as a port to the space station, hosted more than 70 different capsules and supported Russian cosmonauts conducting extravehicular activities, or spacewalks. To make room for Russia's new science module, dubbed Nauka, which launched on July 21 and will arrive at the station on Thursday (July 29), Pirs had to go. Yesterday's fiery retirement ceremony marks the first time a major component of the International Space Station has been discarded. The attached Progress vehicle, which had arrived at the space station in February, controlled Pirs' re-entry to ensure that the module was destroyed as thoroughly as possible. European Space Agency astronaut Thomas Pesquet shared the photographs on Flickr.
Medicine

CDC: Vaccinated People in COVID Hotspots Should Resume Wearing Masks (axios.com) 600

The Centers for Disease Control and Prevention issued updated guidance on Tuesday recommending that vaccinated people wear masks in indoor, public settings if they are in parts of the U.S. with substantial to high transmission, among other circumstances. From a report: The guidance, a reversal from recommendations made two months ago, comes as the Delta variant continues to drive up case rates across the country. Millions of people in the U.S. -- either by choice or who are ineligible -- remain unvaccinated and at risk of serious infection. Community leaders in areas with high transmission rates should encourage vaccination and masking, the agency says. In another reversal, the CDC also recommends universal indoor masking for all teachers, staff, students and visitors to K-12 schools this incoming school year, regardless of vaccination status. Los Angeles County, New Orleans, Savannah and Chicago are among the major metropolitan areas that reinstated mask mandates amid a rise in cases.
Moon

50 Years Ago, NASA Put a Car on the Moon (nytimes.com) 32

The lunar rovers of Apollo 15, 16 and 17 parked American automotive culture on the lunar surface, and expanded the scientific range of the missions' astronaut explorers. From a report: Dave Scott was not about to pass by an interesting rock without stopping. It was July 31, 1971, and he and Jim Irwin, his fellow Apollo 15 astronaut, were the first people to drive on the moon. After a 6-hour inaugural jaunt in the new lunar rover, the two were heading back to their lander, the Falcon, when Mr. Scott made an unscheduled pit stop. West of a crater called Rhysling, Mr. Scott scrambled out of the rover and quickly picked up a black lava rock, full of holes formed by escaping gas. Mr. Scott and Mr. Irwin had been trained in geology and knew the specimen, a vesicular rock, would be valuable to scientists on Earth. They also knew that if they asked for permission to stop and get it, clock-watching mission managers would say no. So Mr. Scott made up a story that they stopped the rover because he was fidgeting with his seatbelt. The sample was discovered when the astronauts returned to Earth, Mr. Scott described what he'd done, and "Seatbelt Rock" became one of the most prized geologic finds from Apollo 15.

Like many lunar samples returned to Earth by the final Apollo missions, Seatbelt Rock never would have been collected if the astronauts had not brought a car with them. Apollo 11 and Apollo 13 are the NASA lunar missions that tend to be remembered most vividly. But at the 50th anniversary of Apollo 15, which launched on July 26, 1971, some space enthusiasts, historians and authors are giving the lunar rover its due as one of the most enduring symbols of the American moon exploration program. Foldable, durable, battery-powered and built by Boeing and General Motors, the vehicle is seen by some as making the last three missions into the crowning achievement of the Apollo era. "Every mission in the crewed space program, dating back to Alan Shepard's first flight, had been laying the groundwork for the last three Apollo missions," said Earl Swift, author of a new book about the lunar rover, "Across the Airless Wilds: The Lunar Rover and the Triumph of the Final Moon Landings. You see NASA take all of that collected wisdom, gleaned over the previous decade in space, and apply it," Mr. Swift said. "It's a much more swashbuckling kind of science."

Science

Scientists Create One-Atom-Thin Magnet That Works At Room Temperature (scitechdaily.com) 45

Mogster shares a report from SciTechDaily: A one-atom-thin 2D magnet developed by Berkeley Lab and UC Berkeley could advance new applications in computing and electronics. The researchers synthesized the new 2D magnet -- called a cobalt-doped van der Waals zinc-oxide magnet -- from a solution of graphene oxide, zinc, and cobalt. The new material -- which can be bent into almost any shape without breaking, and is a million times thinner than a sheet of paper -- could help advance the application of spin electronics or spintronics, a new technology that uses the orientation of an electron's spin rather than its charge to encode data. And unlike previous 2D magnets, which lose their magnetism at room temperature or above, the researchers found that the new 2D magnet not only works at room temperature but also at 100 degrees Celsius (212 degrees Fahrenheit).
NASA

Bezos Offers To Cover $2 Billion In NASA Costs In Exchange For Astronaut Lunar Lander Contract (cnbc.com) 195

Blue Origin founder Jeff Bezos on Monday offered to cover billions of dollars of NASA costs in exchange for a contract to build a lunar lander to land astronauts on the moon. CNBC reports: Bezos said Blue Origin would waive all payments up to $2 billion from the National Aeronautics and Space Administration in the current and next two government fiscal years. Blue Origin would also fund its own pathfinder mission to low-Earth orbit, according to Bezos. In return, the company requested a fixed-priced contract from the government agency. "This offer is not a deferral, but is an outright and permanent waiver of those payments. This offer provides time for government appropriation actions to catch up," Bezos said in an open letter to NASA Administrator Bill Nelson.

NASA in April awarded Elon Musk's SpaceX with a sole $2.89 billion contract to build the next crewed lunar lander under its Human Landing Systems program. Before selecting the winner of the contest, NASA gave 10-month study contracts to SpaceX, Blue Origin and Dynetics to begin work on lunar landers. "Instead of this single source approach, NASA should embrace its original strategy of competition," Bezos said. "Without competition, a short time into the contract, NASA will find itself with limited options as it attempts to negotiate missed deadlines, design changes, and cost overruns."

Earth

'Record-Shattering' Heat Becoming Much More Likely, Says Climate Study (theguardian.com) 279

An anonymous reader quotes a report from The Guardian: Record-shattering" heatwaves, even worse than the one that recently hit north-west America, are set to become much more likely in future, according to research. The study is a stark new warning on the rapidly escalating risks the climate emergency poses to lives. The research found that highly populated regions in North America, Europe and China were where the record-shattering extremes are most likely to occur. One illustrative heatwave produced by the computer models used in the study showed some locations in mid-northern America having temperatures 18C higher than average. The new computing modeling study [...] looked for the first time at the highest margins by which week-long heatwave records could be broken in future.

It found that heatwaves that smash previous records by roughly 5C would become two to seven times more likely in the next three decades and three to 21 times more likely from 2051-2080, unless carbon emissions are immediately slashed. Such extreme heatwaves are all but impossible without global heating. The vulnerability of North America, Europe and China was striking, said Erich Fischer, at ETH Zurich in Switzerland, who led the research. "Here we see the largest jumps in record-shattering events. This is really quite worrying," he added. "Many places have by far not seen anything close to what's possible, even in present-day conditions, because only looking at the past record is really dangerous."

The study also showed that record-shattering events could come in sharp bursts, rather than gradually becoming more frequent. "That is really concerning," Fischer said: "Planning for heatwaves that get 0.1C more intense every two or three years would still be very worrying, but it would be much easier to prepare for." The new research, published in the journal Nature Climate Change, concluded: "Record-shattering extremes are [currently] very rare but their expected probability increases rapidly in the coming three decades." It found the rate of global heating was critical in increasing the risk, rather than simply the global temperature reached. This indicates that sharp cuts in emissions are needed as soon as possible, rather than emissions continuing and being sucked back out of the atmosphere at a later date. The scientists used a scenario in which carbon emissions are not reduced, which some experts have argued is unrealistic, given that some climate action is being taken. However, global emissions are not yet falling, bar the blip caused by the coronavirus pandemic, and the researchers argue the scenario remains relevant until CO2 emissions are consistently falling.

Medicine

Fauci Wants To Make Vaccines for the Next Pandemic Before It Hits (nytimes.com) 267

If funded, a government program costing several billion dollars could develop "prototype" vaccines to protect against 20 families of viruses. From a report: In one sense, the world got lucky with the new coronavirus. By sheer chance, scientists just happened to have spent years studying coronaviruses, developing exactly the tools needed to make Covid vaccines as soon as the virus's genetic sequence was published. But what will happen if the next pandemic comes from a virus that causes Lassa fever, or from the Sudan strain of Ebola, or from a Nipah virus? Dr. Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, is promoting an ambitious and expensive plan to prepare for such nightmare scenarios. It would cost "a few billion dollars" a year, take five years for the first crop of results and engage a huge cadre of scientists, he said. The idea is to make "prototype" vaccines to protect against viruses from about 20 families that might spark a new pandemic. Using research tools that proved successful for Covid-19, researchers would uncover the molecular structure of each virus, learn where antibodies must strike it, and how to prod the body into making exactly those antibodies.

âoeIf we get the funding, which I believe we will, it likely will start in 2022,â Dr. Fauci said, adding that he has been promoting the idea âoein discussions with the White House and others.â Dr. Francis Collins, director of the National Institutes of Health, also thought it likely that the necessary funds would be allocated, calling the project "compelling." "As we begin to contemplate a successful end to the Covid-19 pandemic, we must not shift back into complacency," Dr. Collins said. Much of the financial support would come from Dr. Fauci's institute, but a project of this scope would require additional funds that would have to be allocated by Congress. This year's budget for the infectious diseases institute is a little over $6 billion. Dr. Fauci did not specify how much additional money would be needed. If surveillance networks detected a new virus spilling over from animals into people, the logic goes, scientists could stop it by immunizing people in the outbreak by quickly manufacturing the prototype vaccine. And if the virus spread before the world realized what was happening, the prototype vaccines could be deployed more widely.

Japan

Japan Pitches 'Society 5.0' To Keep Its Edge In Tech and Science (nikkei.com) 21

The Cabinet Office of Japan is co-hosting an event dedicated to "Society 5.0," a future society the government believes Japan should aspire to. Defined by the Cabinet Office as "a human-centered society [helped] by a system that highly integrates cyberspace and physical space," Society 5.0 is a concept intended to broaden the discussion of innovation from science and technology to all of socioeconomic activity. Nikkei Asia Review reports: The government has also established multiple large-scale programs to encourage companies, involved in everything from health care and mobility to energy, to invest in research and development, not only at the level of pure technology but also to bring it to a pilot level. The exhibition includes some achievements from these programs, including Cyberdyne's HAL, standing for "hybrid assistive limb," which the company claims to be the world's first "wearable cyborg." A HAL exoskeleton autonomously walks on a treadmill at the venue. When worn on a leg, HAL can read faint signals sent to muscles from the brain thanks to electrodes attached to the wearer's skin, determining the wearer's desired movements. "Even if your nerves are not connected at first, they gradually recover through the wearing of HAL, and you can eventually move your own body parts without wearing it," said a person from Cyberdyne.

SkyDrive's "flying car" also attracts the attention of visitors, who can observe a full-scale model of the SD-03, which performed the first successful public manned flights of a flying car in Japan in August 2020. Co-founded by former Toyota Motor engineer Tomohiro Fukuzawa, the startup plans to offer commercial mobility service during Expo 2025, to be held in Osaka. "It is as if we are traveling to the future," said Shinji Inoue, a minister of state who heads science and technology policy, when he visited the exhibition last week. Asked by reporters how to make these cutting-edge tools an everyday reality, Inoue spoke of a need to deregulate the market when it comes to obtaining operating permits for such items. Indeed, the government acknowledges challenges in keeping up with the country's capabilities in implementing scientific progress. Digitalization initiatives, the premise for achieving Society 5.0, "could not sufficiently create new business models through data collaboration, like what we see in other countries," said a report from the Cabinet Office analyzing the previous five-year plan through fiscal 2020. Instead, the initiatives aimed at improving the efficiency of existing operations, failing to drive innovation.

NASA

NASA Taps SpaceX Falcon Heavy Rocket To Launch Jupiter Moon Mission (cnet.com) 44

Jupiter's unusual icy moon Europa may be one of the best spots in the solar system to check for signs of alien life. But first we have to get there. NASA's Europa Clipper spacecraft will get a boost in the right direction from a SpaceX Falcon Heavy, one of the most powerful rockets ever built. From a report: NASA announced Friday that it has selected SpaceX to provide the launch services for the Jupiter moon mission. The launch is scheduled for October 2024 from the Kennedy Space Center in Florida. The contract is worth about $178 million. Europa Clipper will try to determine if the moon could possibly host life. "Key mission objectives are to produce high-resolution images of Europa's surface, determine its composition, look for signs of recent or ongoing geological activity, measure the thickness of the moon's icy shell, search for subsurface lakes, and determine the depth and salinity of Europa's ocean," said NASA. SpaceX has been working with NASA on many fronts, including carrying astronauts to and from the International Space Station, delivering cargo to the ISS and developing a human landing system to return astronauts to the moon through the Artemis program.
Mars

Quake-Measuring Device on Mars Gets Detailed Look at Red Planet's Interior (apnews.com) 10

"A quake-measuring device on Mars is providing the first detailed look at the red planet's interior, revealing a surprisingly thin crust and a hot molten core beneath the frigid surface," reports the Associated Press: In a series of articles published this week, scientists reported that the Martian crust is within the thickness range of Earth's. The Martian mantle between the crust and core is roughly half as thick as Earth's. And the Martian core is on the high side of what scientists anticipated, although smaller than the core of our own nearly twice-as-big planet.

These new studies confirm that the Martian core is molten. But more research is needed to know whether Mars has a solid inner core like Earth's, surrounded by a molten outer core, according to the international research teams. Stronger marsquakes could help identify any multiple core layers, scientists said Friday. The findings are based on about 35 marsquakes registered by a French seismometer on NASA's InSight stationary lander, which arrived at Mars in 2018...

InSight has been hit with a power crunch in recent months. Dust covered its solar panels, just as Mars was approaching the farthest point in its orbit around the sun. Flight controllers have boosted power by using the lander's robot arm to release sand into the blowing wind to knock off some of the dust on the panels. The seismometer has continued working, but all other science instruments remain on hiatus because of the power situation — except for a German heat probe was declared dead in January after it failed to burrow more than a couple feet (half a meter) into the planet.

The three studies and a companion article appeared in Thursday's edition of the journal Science.

ISS

Russia Encounters More Problems Sending Long-Delayed Module and Robotic Arm to Space Station (gizmodo.com) 41

First Slashdot reader Thelasko quotes the BBC's report Wednesday: A Russian rocket has departed the Baikonur Cosmodrome, Kazakhstan, to deliver a new science module to the International space station (ISS). The 13m-long, 20-tonne [44,000-pound] Nauka laboratory will go on the rear of the orbiting platform, connected to the other major Russian segments, Zvezda and Zarya. The new module carries with it a large robotic arm supplied by the European Space Agency (Esa).

Nauka is much delayed. It was originally supposed to launch in 2007. But it suffered repeated slips in schedule, in part because of budget difficulties but also because engineers encountered a raft of technical problems during development.

The module will result in a significant boost in habitable volume for the ISS, raising it by 70 cubic metres.

It's expected to dock this Thursday (July29), according to CBS News, after which "It will take up to 11 Russian spacewalks over about seven months to electrically connect and outfit the new lab module, providing a new airlock, research space, living quarters, a European Space Agency robot arm and other systems."

But Friday Gizmodo reported the attempt to deliver the module to the Space Station "is still having problems." The first glitch in Nauka's journey happened yesterday, when the spacecraft didn't complete its first orbit-raising burn. This meant that the uncrewed Nauka wasn't on track to actually intercept the ISS, which it's scheduled to dock with on Thursday, July 29. The problem was attributed to a software issue in a computer aboard Nauka, which prevented the spacecraft's main engines from firing. Nauka's team was able to manage a remote course correction, but a second bout of course corrections were deemed necessary, and scheduled for Friday...

Nauka's also been having issues with one antenna and its docking target, and its uncertain how those issues will affect docking attempts, SpaceNews reported. "Apparently there is still an issue with the Kurs rendezvous system, and that is pretty critical for docking," said Jonathan McDowell, an astrophysicist at the Harvard-Smithsonian Center for Astrophysics, adding that the spacecraft's TORU system — which allows the astronauts aboard the ISS assist with the docking — is working normally. For now, the Pirs docking compartment is currently sitting in Nauka's assigned dock on the ISS. Pirs' scheduled undocking to make way for the new module was postponed from Friday to Sunday, .

Biotech

RNA Breakthrough Creates High-Yield, Drought-Tolerant Rice, Potatoes (upi.com) 120

"Thanks to a breakthrough in RNA manipulation, crop scientists have developed new potato and rice varieties with higher yields and increased drought tolerance," reports UPI: By inserting a gene responsible for production of a protein called FTO, scientists produced bigger rice and potato plants with more expansive root systems. In experiments, the plants' longer roots improved their drought resistance.

Test results — detailed Thursday in the journal Nature Biotechnology — showed the RNA-manipulated plants also improved their rate of photosynthesis, boost yields by as much as 50 percent...

In the lab, the manipulated rice plants grew at three times their normal rate. In the field, the rice plants increased their mass by 50 percent. They also sprouted longer roots, increased their photosynthesis rate and produced larger yields. When they repeated the experiments with potato plants, the researchers got similar results, suggesting the new gene manipulation method could be used to bolster a variety of crops.

The researchers hope this could help crops survive climate change, and even prevent forests from being cleared for food production, according to the article. And one of the study's co-authors adds "This really provides the possibility of engineering plants to potentially improve the ecosystem as global warming proceeds."
Sci-Fi

Virtual Comic-Con Includes Trailers For 'Blade Runner' Series, 'Dune' Movie - and NASA Panels (space.com) 71

Comic-Con went virtual again in 2020. (San Diego businesses will miss the chance to profit from the 100,000 visitors the convention usually attracted.) And NPR reports the convention has gotten smaller in other ways: Both Marvel Studios and DC are staying away; as it did last year, DC is again directing its resources towards its own event, DC FanDome, set for mid-October. But fans of shows like Doctor Who, Dexter and Comic-Con stalwart The Walking Dead will have lots to look forward to.
Rotten Tomatoes and The Verge have gathered up the trailers that did premier. Some of the highlights:

But interestingly, one of the more visibile presenters was: NASA. Current and former NASA officials made appearances on several different panels, according to Space.com, including one on modern space law, U.N. treaty-making, and how it all stacks up against the portrayal we get in our various future-space franchises. And a former NASA astronaut was also part of a panel touting a virtual simulation platform, "where students can have access to the same tools that professionals use and in the case of space are given the opportunity to solve real problems related to missions to our Moon, Mars, and beyond... from piloting to terra-forming to creating habitats and spacecraft."

There was also a panel of four NASA engineers titled "No Tow Trucks Beyond Mars," on "how we go boldly where there's no one around to fix it. Hear stories from the trenches of the heartbreaks, close calls, and adventures of real-life landing (and flying!) on Mars and our round-table discussion of what Netflix got right in their movie Stowaway."

Sunday's panels will include an astronomer, an astrobiologist, and a geologist/paleontologist discussing "The Science of Star Wars" with the concept designer for Star Wars episodes 7-9, Rogue One, and Solo.


Medicine

Three Die After Untreatable 'Superbug' Fungus Infections in Two Different Cities (go.com) 95

"U.S. health officials said Thursday they now have evidence of an untreatable fungus spreading in two hospitals and a nursing home," reports the Associated Press: The "superbug" outbreaks were reported in a Washington, D.C, nursing home and at two Dallas-area hospitals, the Centers for Disease Control and Prevention reported. A handful of the patients had invasive fungal infections that were impervious to all three major classes of medications. "This is really the first time we've started seeing clustering of resistance" in which patients seemed to be getting the infections from each other, said the CDC's Dr. Meghan Lyman...

Health officials have sounded alarms for years about the superbug after seeing infections in which commonly used drugs had little effect. In 2019, doctors diagnosed three cases in New York that were also resistant to a class of drugs, called echinocandins, that were considered a last line of defense. In those cases, there was no evidence the infections had spread from patient to patient — scientists concluded the resistance to the drugs formed during treatment. The new cases did spread, the CDC concluded....

Those cases were seen from January to April. Of the five people who were fully resistant to treatment, three died — both Texas patients and one in Washington.

Lyman said both are ongoing outbreaks and that additional infections have been identified since April. But those added numbers were not reported.

The fungus, Candida auris, "is a harmful form of yeast that is considered dangerous to hospital and nursing home patients with serious medical problems," they add — and it's spread through contaminated surfaces or contact with patients.

Newsweek points out that while it's only recently appeared in America, "infections have occurred in over 30 countries worldwide."
Earth

Society Is Right On Track For a Global Collapse, New Study of Infamous 1970s Report Finds 323

fahrbot-bot shares a report from Live Science: Human society is on track for a collapse in the next two decades if there isn't a serious shift in global priorities, according to a new reassessment of a 1970s report, Vice reported. In that report -- published in the bestselling book "The Limits to Growth" (1972) -- a team of MIT scientists argued that industrial civilization was bound to collapse if corporations and governments continued to pursue continuous economic growth, no matter the costs. The researchers forecasted 12 possible scenarios for the future, most of which predicted a point where natural resources would become so scarce that further economic growth would become impossible, and personal welfare would plummet.

The report's most infamous scenario -- the Business as Usual (BAU) scenario -- predicted that the world's economic growth would peak around the 2040s, then take a sharp downturn, along with the global population, food availability and natural resources. This imminent "collapse" wouldn't be the end of the human race, but rather a societal turning point that would see standards of living drop around the world for decades, the team wrote.

So, what's the outlook for society now, nearly half a century after the MIT researchers shared their prognostications? Gaya Herrington, a sustainability and dynamic system analysis researcher at the consulting firm KPMG, decided to find out. [...] Herrington found that the current state of the world -- measured through 10 different variables, including population, fertility rates, pollution levels, food production and industrial output -- aligned extremely closely with two of the scenarios proposed in 1972, namely the BAU scenario and one called Comprehensive Technology (CT), in which technological advancements help reduce pollution and increase food supplies, even as natural resources run out. While the CT scenario results in less of a shock to the global population and personal welfare, the lack of natural resources still leads to a point where economic growth sharply declines -- in other words, a sudden collapse of industrial society.
"The good news is that it's not too late to avoid both of these scenarios and put society on track for an alternative -- the Stabilized World (SW) scenario," the report notes. "This path begins as the BAU and CT routes do, with population, pollution and economic growth rising in tandem while natural resources decline. The difference comes when humans decide to deliberately limit economic growth on their own, before a lack of resources forces them to."

"The SW scenario assumes that in addition to the technological solutions, global societal priorities change," Herrington wrote. "A change in values and policies translates into, amongst other things, low desired family size, perfect birth control availability, and a deliberate choice to limit industrial output and prioritize health and education services." After this shift of values occurs, industrial growth and global population begin to level out. "Food availability continues to rise to meet the needs of the global population; pollution declines and all but disappears; and the depletion of natural resources begins to level out, too," adds Live Science. "Societal collapse is avoided entirely."
Space

Oregon Congressman Proposes New Space Tourism Tax (space.com) 155

U.S. Rep. Earl Blumenauer (D-Oregon) plans to introduce legislation called the Securing Protections Against Carbon Emissions (SPACE) Tax Act, which would impose new excise taxes on space tourism trips. Space.com reports: "Space exploration isn't a tax-free holiday for the wealthy. Just as normal Americans pay taxes when they buy airline tickets, billionaires who fly into space to produce nothing of scientific value should do the same, and then some," Blumenauer said in a statement issued by his office. "I'm not opposed to this type of space innovation," added Blumenauer, a senior member of the House of Representatives' Ways and Means Committee. "However, things that are done purely for tourism or entertainment, and that don't have a scientific purpose, should in turn support the public good."

The proposed new tax would likely be levied on a per-passenger basis, as is done with commercial aviation, the statement said. "Exemptions would be made available for NASA spaceflights for scientific research purposes," the statement reads. "In the case of flights where some passengers are working on behalf of NASA for scientific research purposes and others are not, the launch excise tax shall be the pro rata share of the non-NASA researchers." There would be two taxation tiers, one for suborbital flights and another for missions that reach orbit. The statement did not reveal how much the tax would be in either case or if the collected revenue would be earmarked for any specific purpose. Such a purpose could be the fight against climate change, if the proposed act's full name is any guide. Blumenauer is concerned about the potential carbon footprint of the space tourism industry once it gets fully up and running, the statement said.

Medicine

Maker of Dubious $56K Alzheimer's Drug Offers Cognitive Test No One Can Pass (arstechnica.com) 56

An anonymous reader quotes a report from Ars Technica: Do you ever forget things, like a doctor's appointment or a lunch date? Do you sometimes struggle to think of the right word for something common? Do you ever feel more anxious or irritable than you typically do? Do you ever feel overwhelmed when trying to make a decision? If you answered "no, never" to all of those questions, there's a possibility that you may not actually be human. Nevertheless, you should still talk to a doctor about additional cognitive screenings to check if you have Alzheimer's disease. At least, that's the takeaway from a six-question quiz provided in part by Biogen, the maker of an unproven, $56,000 Alzheimer's drug.

The six questions include the four above, plus questions about whether you ever lose your train of thought or ever get lost on your way to or around a familiar place. The questions not only bring up common issues that perfectly healthy people might face from time to time, but the answers any quiz-taker provides are also completely irrelevant. No matter how you answer -- even if you say you never experience any of those issues -- the quiz will always prompt you to talk with your doctor about cognitive screening. The results page even uses your zip code to provide a link to find an Alzheimer's specialist near you. Biogen says the quiz website is part of a "disease awareness educational program." But it appears to be part of an aggressive strategy to sell the company's new Alzheimer's drug, Aduhelm, which has an intensely controversial history, to say the least.
What's the controversial history you may ask? According to Ars, the drug "flunked out of two identical Phase III clinical trials in 2019." A panel of expert advisors for the FDA overwhelmingly voted against approval, yet it still was approved by the FDA on June 7. It also has a list price of $56,000 for a year's supply.

The report goes on to say that the company is basically making up the statistic that "about 1 in 12 Americans 50 years and older" has mild cognitive impairment due to Alzheimer's. Experts say they know of no evidence to back up that statistic and it appears to be a significant overestimate.

Furthermore, two medical experts from Georgetown University said the company's quiz website "appears designed to ratchet up anxiety in anyone juggling multiple responsibilities or who gets distracted during small talk." They added: "Convincing perfectly normal people they should see a specialist, be tested for amyloid plaque, and, if present, assume they have early Alzheimer's is a great strategy for increasing Aduhelm prescriptions... [It] could lead to millions of prescriptions -- and billions of dollars in profit -- for an ineffective and expensive drug."
NASA

Jeff Bezos and Sir Richard Branson Not Yet Astronauts, US Says (bbc.com) 80

New Federal Aviation Administration (FAA) rules say astronaut hopefuls must be part of the flight crew and make contributions to space flight safety. That means Jeff Bezos and Sir Richard Branson may not yet be astronauts in the eyes of the US government. The BBC reports: These are the first changes since the FAA wings program began in 2004. The Commercial Astronaut Wings program updates were announced on Tuesday -- the same day that Amazon's Mr Bezos flew aboard a Blue Origin rocket to the edge of space. To qualify as commercial astronauts, space-goers must travel 50 miles (80km) above the Earth's surface, which both Mr Bezos and Mr Branson accomplished. But altitude aside, the agency says would-be astronauts must have also "demonstrated activities during flight that were essential to public safety, or contributed to human space flight safety." What exactly counts as such is determined by FAA officials.

In a statement, the FAA said that these changes brought the wings scheme more in line with its role to protect public safety during commercial space flights. On July 11, Sir Richard flew on-board Virgin Galactic's SpaceShipTwo to the edge of space as a test before allowing customers aboard next year. Mr Bezos and the three other crew members who flew on Blue Origin's spacecraft may have less claim to the coveted title. Ahead of the launch, Blue Origin CEO Bob Smith said that "there's really nothing for a crew member to do" on the autonomous vehicle. Those wishing for commercial wings need to be nominated for them as well. An FAA spokesperson told CNN they are not currently reviewing any submissions.

There are two other ways to earn astronaut wings in the US - through the military or Nasa. However, a glimmer of hope remains for Sir Richard, Mr Bezos and any future stargazers hoping to be recognized as astronauts. The new order notes that honorary awards can be given based on merit -- at the discretion of the FAA's associate administrator. Astronaut wings were first awarded to astronauts Alan Shepard Jr and Virgil Grissom in the early 1960s for their participation in the Mercury Seven program.

Earth

A 3-degree Celsius World Has No Safe Place (economist.com) 229

The extremes of floods and fires are not going away, but adaptation can lessen their impact. Economist (paywalled): If temperatures rise by 3C above pre-industrial levels in the coming decades -- as they might even if everyone manages to honour today's firm pledges -- large parts of the tropics risk becoming too hot for outdoor work. Coral reefs and the livelihoods that depend on them will vanish and the Amazon rainforest will become a ghost of itself. Severe harvest failures will be commonplace. Ice sheets in Antarctica and Greenland will shrink past the point of no return, promising sea rises measured not in millimetres, as today's are, but in metres.

Six years ago, in Paris, the countries of the world committed themselves to avoiding the worst of that nightmare by eliminating net greenhouse-gas emissions quickly enough to hold the temperature rise below 2C. Their progress towards that end remains woefully inadequate. Yet even if their efforts increased dramatically enough to meet the 2C goal, it would not stop forests from burning today; prairies would still dry out tomorrow, rivers break their banks and mountain glaciers disappear. Cutting emissions is thus not enough. The world also urgently needs to invest in adapting to the changing climate. The good news is that adaptation makes political sense. People can clearly see the need for it. When a country invests in flood defences it benefits its own citizens above all others -- there is no free-rider problem, as there could be for emissions reduction. Nor does all the money come from the public purse; companies and private individuals can see the need for adaptation and act on it. When they do not do so, insurance companies can open their eyes to the risks they are running.

Some adaptation is fairly easily set in place. Systems for warning Germans of coming floods will surely now improve. But other problems require much larger public investment, like that which has been put into water-management in the Netherlands. Rich countries can afford such things. Poor countries and poor people need help, which is why the Paris climate agreement calls for annual transfers of $100bn from rich to poor. The rich countries have not yet lived up to their side of this. On July 20th John Kerry, President Joe Biden's special envoy on climate change, reiterated America's pledge to triple its support to $1.5bn for adaptation in poorer countries by 2024, part of a broader move to increase investment in adaptation and mitigation in developing countries. More such efforts are vital.

Medicine

Most Unvaccinated Americans Don't Want Shots: AP-NORC Poll (apnews.com) 657

Most Americans who haven't been vaccinated against COVID-19 say they are unlikely to get the shots and doubt they would work against the aggressive delta variant despite evidence they do, according to a new poll that underscores the challenges facing public health officials amid soaring infections in some states. AP: Among American adults who have not yet received a vaccine, 35% say they probably will not, and 45% say they definitely will not, according to a poll from The Associated Press-NORC Center for Public Affairs Research. Just 3% say they definitely will get the shots, though another 16% say they probably will. What's more, 64% of unvaccinated Americans have little to no confidence the shots are effective against variants -- including the delta variant that officials say is responsible for 83% of new cases in the U.S. -- despite evidence that they offer strong protection. In contrast, 86% of those who have already been vaccinated have at least some confidence that the vaccines will work.

That means "that there will be more preventable cases, more preventable hospitalizations and more preventable deaths," said Dr. Amesh Adalja, an infectious disease specialist at Johns Hopkins University. "We always knew some proportion of the population would be difficult to persuade no matter what the data showed, (and) a lot of people are beyond persuasion," said Adalja. He echoed Centers for Disease Control and Prevention Director Rochelle Walensky in calling the current surge "a pandemic of the unvaccinated" because nearly all hospital admissions and deaths have been among those who weren't immunized.

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