An anonymous reader shares a report: The moon visits one of the spring constellations this week by traveling through the faint constellation of Virgo, the virgin. On 1 and 2 June, our natural satellite will pass close to Virgo's only bright star, Spica. Memorise its position and then return in the days to come to pick out the constellation's other, fainter stars. Spica is one of the 20 brightest stars in the night sky, located at a distance of about 250 light years. A blue giant star, containing around 10 times the Sun's mass, it is more than 20,000 times more luminous than our star.

NASA and SpaceX are closer than ever to a moment both have been preparing for since the beginning of the Commercial Crew program in 2010. SpaceX's Falcon 9 and Crew Dragon spacecraft are now set to fly with NASA astronauts Doug Hurley and Bob Behnken onboard, making a trip to the International Space Station, and both the agency and SpaceX announced today that they have officially passed the final flight readiness review, meaning everything is now a 'go' for launch. From a report: According to NASA Commercial Crew Program manager Kathy Leuders during a press conference on Monday, everything went well with all pre-launch flight checks thus far, including a full-length static test fire of the Falcon 9's engines, and a dress rehearsal of all launch preparation including strapping Hurley and Behnken into the rocket. The only remaining major hurdle for SpaceX and NASA now is the weather, which is currently only looking around 40% favorable for a launch attempt on schedule for Wednesday, May 27 at 4:33 PM EDT, though during today's press conference officials noted it is actually trending upwards as of today. SpaceX and NASA will be paying close attention to the weather between now and Wednesday, and since this is a highly sensitive mission with actual astronauts on board the spacecraft, you can bet that they'll err on the side of caution for scrubbing the launch if weather isn't looking good. That said, they do have a backup opportunity of May 30 in case they need to make use of that.

Prime minister Shinzo Abe has declared victory for the "Japan model" of fighting coronavirus as he lifted a nationwide state of emergency after seven weeks [Editor's note: the link may be paywalled; alternative source]. From a report: Speaking at a press conference on Monday evening in Tokyo, Mr Abe said that Japan had avoided an explosive increase in cases without the compulsory lockdowns used in Europe or the US. The ending of the state of emergency in the last five prefectures it covered -- Tokyo, Kanagawa, Saitama, Chiba and Hokkaido -- will mean that the world's fourth-largest economy can start to reopen for business. "In a characteristically Japanese way, we have all but brought this epidemic under control in the last month and a half," said Mr Abe. "Surely, it shows the power of the Japan model." Japan's constitution prohibits a compulsory lockdown but, under the state of emergency that began on April 7, the government requested voluntary social distancing and business closures. Under that regime, the number of new Covid-19 cases fell from 600-700 a day in mid-April to about 20-30 a day last week. The country has diagnosed 16,581 cases of coronavirus with 830 deaths -- many fewer than similar-sized populations in Europe or the US.

The World Health Organization is temporarily pausing tests of the anti-malarial drug hydroxychloroquine as a coronavirus treatment in order to review safety concerns, the agency's director-general Tedros Adhanom Ghebreyesu said Monday. From a report: The decision comes after a retrospective review published in The Lancet found that coronavirus patients who took hydroxychloroquine or its related drug chloroquine were more likely to die or develop an irregular heart rhythm that can lead to sudden cardiac death, compared to those who did nothing. The medical journal's review consisted of 96,000 hospitalized patients diagnosed with the coronavirus in six continents, the largest analysis of medical records on the drug, between Dec. 20, 2019, and April 14, 2020. Tedros said that an independent executive panel "agreed to review a comprehensive analysis and critical appraisal of all evidence available globally" regarding hydroxychloroquine in order to determine whether it should continue to be used in WHO's Solidarity Trial, a global effort to test experimental coronavirus treatments.

An anonymous reader quotes Engadget: Texas Instruments' graphing calculators have a reputation as hobbyist devices given their program support, but they just lost some of their appeal. Cemetech has learned (via Linus Tech Tips) that Texas Instruments is pulling support for assembly- and C-based programs on the TI-84 Plus CE and its French counterpart, the TI-83 Premium CE. Install the latest firmware for both (OS 5.6 and OS 5.5 respectively) and you'll not only lose access to those apps, but won't have a way to roll back.

The company explained the move as an effort to "prioritize learning and minimize any security risks." It's to reduce cheating, to put it another way... While this could please teachers worried that students will use apps to cheat during exams, enthusiasts are unsurprisingly mad. This reduces the amount of control programmers have over their calculator apps.

schwit1 quotes UPI: City-dwellers are nearly 30 percent more likely to be diagnosed with multiple sclerosis than those living in more rural areas, a study presented Friday at the European Academy of Neurology Virtual Congress has found.

Based on the results, which will also be published in European Journal of Neurology, air pollution could be a risk factor for the development of the disease, according to the authors, who conducted their research in Italy.

"It is well recognized that immune diseases such as MS are associated with multiple factors, both genetic and environmental," co-author Dr. Roberto Bergamaschi, of the IRCCS Mondino Foundation in Pavia, Italy, said in a statement. "We believe that air pollution interacts through several mechanisms in the development of MS and the results of this study strengthen that hypothesis," he added.

"One of the longer chapters of the International Space Station has come to a close," writes Engadget.

"NASA has sent the last of its 11 ExPRESS (Expedite the Processing of Experiments to the Space Station) science racks to the orbiting facility, 19 years after sending the first two." They don't look like much, but they provide the power, storage, climate control and communications for up to 10 small payloads — they're key to many of the experiments that run aboard the ISS and will help the station live up to its potential research capabilities. This last rack was carried aboard a Japanese cargo ship and should be installed and functioning by fall 2020. While the EXPRESS racks should be useful for a while yet, this effectively marks the end of an era for NASA's ISS work...
Originally developed by engineers at Boeing and the Marshall Space Flight Center in Alabama, "The first two completed racks were delivered to the space station on STS-100 in 2001 and have been in continuous operation ever since," notes a NASA press release, "as have all the subsequent added racks." And since then NASA has logged more than 85 total years of combined rack operational hours. "The sheer volume of science that's been conducted using the racks up til now is just overwhelming," says Shaun Glasgow, project manager for the EXPRESS Racks at Marshall.

"And as we prepare to return human explorers to the Moon and journey on to Mars, it's even more exciting to consider all the scientific investigations still to come."

Russia "is now challenging the United States' long-standing supremacy in space and working to exploit the U.S. military's dependence on space systems for communications, navigation, intelligence, and targeting."

That's the argument made in The Bulletin by a former U.S. Air Force intelligence officer who writes about technology and military strategy, Cold War history, and European security affairs (in an article shared by Lasrick). Moscow is developing counter-space weapons as a part of its overall information warfare strategy. For example, Russia just tested an anti-satellite missile system designed to destroy satellites in low earth orbit. Moreover, military leaders in Russia view U.S. satellites as the key enablers of America's ability to execute rapid, agile, and global military operations; they are intent on echoing this success and modernizing their own military satellites to more effectively support Russian forces.

Since the end of the Cold War, the number of countries with space programs has markedly increased. Many of them are actively developing space weapons. China, for example, has an operational ground-launched anti-satellite system, according to the U.S. intelligence community. India successfully tested its own space weapon in 2019. France announced that it will launch a series of armed satellites. Even Iran is believed to be able to develop a rudimentary anti-satellite weapon in the near term... Space systems are essential for warfighting on Earth and the large growth in the number of countries fielding space weapons means the likelihood that outer space will be transformed into a battlefield has increased... Russia is the only country, however, that is reportedly approaching U.S. satellites in an aggressive manner...

Moscow's destabilizing behavior could prompt the United States to take a more aggressive posture in space in the future... Russia has been taking advantage of the lack of international consensus on what constitutes acceptable behavior in space... It seems clear that Russia is likely testing how the United States and its allies might react to aggressive space behaviors and is gaining important insights into American national security space capabilities...

In 2019, former Secretary of the Air Force Heather Wilson said that at some point, the United States needs the ability to "hit back." Russia's destabilizing actions in space could, therefore, fuel a dangerous arms race in space.

America's Center for Disease Control "is conflating viral and antibody tests..." writes the Atlantic, "distorting several important metrics and providing the country with an inaccurate picture of the state of the pandemic."

Thelasko shared their report: We've learned that the CDC is making, at best, a debilitating mistake: combining test results that diagnose current coronavirus infections with test results that measure whether someone has ever had the virus. The upshot is that the government's disease-fighting agency is overstating the country's ability to test people who are sick with COVID-19... The widespread use of the practice means that it remains difficult to know exactly how much the country's ability to test people who are actively sick with COVID-19 has improved.

"You've got to be kidding me," Ashish Jha, the K. T. Li Professor of Global Health at Harvard and the director of the Harvard Global Health Institute, told us when we described what the CDC was doing. "How could the CDC make that mistake? This is a mess...." By combining the two types of results, the CDC has made them both "uninterpretable," he said...

[T]he portion of tests coming back positive has plummeted, from a seven-day average of 10 percent at the month's start to 6 percent on Wednesday. "The numbers have outstripped what I was expecting," Jha said. "My sense is people are really surprised that we've moved as much as we have in such a short time period. I think we all expected a move and we all expected improvement, but the pace and size of that improvement has been a big surprise."

The intermingling of viral and antibody tests suggests that some of those gains might be illusory.
"The CDC is not alone in its errors," notes a Reason article shared by schwit1. "Several states have been blending their test results as well, rendering it difficult to determine the local impact of the virus." But the CDC's role as the officially designated first line of defense makes the agency's failure far more significant. Without clear, reliable, and accurate reporting from the CDC, it becomes nearly impossible to take stock of the pandemic's damage.

The virus has upended American life in ways that make it unusually difficult to predict the future. But thanks to the CDC, we have a problem that is even worse: No only do we not know what is going to happen, but we don't know what is happening.

Sweden's death rate per million (376) "is far in advance of Norway's (44), Denmark's (96) and Finland's (55) — countries with similar welfare systems and demographics, but which imposed strict lockdowns..." reports the Guardian, "raising concerns that the country's light-touch approach to the coronavirus may not be helping it build up broad immunity."

"According to the scientific online publication Ourworldindata.com, Covid-19 deaths in Sweden were the highest in Europe per capita in a rolling seven-day average between 12 and 19 May. The country's 6.25 deaths per million inhabitants a day was just above the UK's 5.75."

Slashdot reader AleRunner writes: Immunity levels in Sweden, which were expected to reach 33% by the start of May have been measured at only 7.3%, suggesting that Sweden's lighter lockdown may continue indefinitely whilst other countries begin to revive their economies. Writing about new Swedish antibody results in the Guardian Jon Henley goes on to report that other European countries like Finland are already considering blocking travel from Sweden which may increase Sweden's long term isolation.

We have discussed before whether Sweden, which locked down earlier than most but with fewer restrictions could be a model for other countries.

As it is, now, the country is looking more like a warning to the rest of the world.
The Guardian concludes that the Swedish government's decision to avoid a strict lockdown "is thought unlikely to spare the Swedish economy. Although retail and entertainment spending has not collapsed quite as dramatically as elsewhere, analysts say the country will probably not reap any long-term economic benefit."

New research from Imperial College London suggests the coronavirus "may still be spreading at epidemic rates" in 24 different states in America, reports the Washington Post: Some states have had little viral spread or "crushed the curve" to a great degree and have some wiggle room to reopen their economies without generating a new epidemic-level surge in cases. Others are nowhere near containing the virus. The model, which has not been peer reviewed, shows that in the majority of states, a second wave looms if people abandon efforts to mitigate the viral spread. "There's evidence that the U.S. is not under control, as an entire country," said Samir Bhatt, a senior lecturer in geostatistics at Imperial College....

The Imperial College researchers found in 24 states, the model shows a reproduction number over 1 [suggesting the virus is not waning]. Texas tops the list, followed by Arizona, Illinois, Colorado, Ohio, Minnesota, Indiana, Iowa, Alabama, Wisconsin, Mississippi, Tennessee, Florida, Virginia, New Mexico, Missouri, Delaware, South Carolina, Massachusetts, North Carolina, California, Pennsylvania, Louisiana and Maryland....

This has become a geographically complex pandemic, one that will evolve, especially as people increase their movements in coming weeks. Laws and health regulations vary from state to state, county to county and city to city. There are communities where wearing facial coverings is culturally the norm, while in other places it is rejected on grounds of personal liberty or as refutation of the consensus view of the hazards posed by the virus... Experts in Tennessee are also concerned about people from other states beginning to flock to Nashville and Memphis on summer vacations.

If a surge happens, said David Aronoff, director of the Vanderbilt University infectious disease division, "the tricky part will be putting the toothpaste back in the tube" by shutting down again.
In addition to "behavioural precautions," the researchers recommend rapid testing and contact tracing. But If there's no change in the relationship between mobility and transmission, their report states bluntly that "We predict that deaths over the next two-month period will exceed current cumulative deaths by greater than two-fold...

"We predict that increased mobility following relaxation of social distancing will lead to resurgence of transmission, keeping all else constant."

"The drug US President Donald Trump said he was taking to ward off Covid-19 actually increases the risk of patients with the disease dying from it," reports the BBC, citing a new study published Friday in the Lancet.

"The study said there were no benefits to treating patients with the anti-malarial drug hydroxychloroquine..." Hydroxychloroquine is safe for malaria, and conditions like lupus or arthritis, but no clinical trials have recommended the use of hydroxychloroquine for coronavirus. The Lancet study involved 96,000 coronavirus patients, nearly 15,000 of whom were given hydroxychloroquine — or a related form chloroquine — either alone or with an antibiotic.

The study found that the patients were more likely to die in hospital and develop heart rhythm complications than other Covid patients in a comparison group. The death rates of the treated groups were: hydroxychloroquine 18%; chloroquine 16.4%; control group 9%. Those treated with hydroxychloroquine or chloroquine in combination with antibiotics had an even higher death rate.

The researchers warned that hydroxychloroquine should not be used outside of clinical trials.
The BBC also reports that a separate trial involving over 40,000 healthcare workers around the world is now testing whether hydroxychloroquine could prevent infection.

UPDATE (6/4/2020): The study's three authors retracted their study on June 4th, "because independent peer reviewers could not access the data used for the analysis," reports The Hill. "The source of the data was Surgisphere Corporation, which told peer reviewers it would not transfer the full dataset used for the study because it would violate client agreements and confidentiality requirements."

However, the same day the New England Journal of Medicine published results from a new double-blind randomized, placebo-controlled trial which found hydroxychloroquine didn't help prevent people exposed to others with Covid-19 from developing the disease. One of the study's co-authors said that as a preventative agent, "It doesn't seem to work."

An anonymous reader quotes a report from The Wall Street Journal, written by James Nestor: Breathing is a missing pillar of health, and our attention to it is long overdue. Most of us misunderstand breathing. We see it as passive, something that we just do. Breathe, live; stop breathing, die. But breathing is not that simple and binary. How we breathe matters, too. Inside the breath you just took, there are more molecules of air than there are grains of sand on all the world's beaches. We each inhale and exhale some 30 pounds of these molecules every day -- far more than we eat or drink. The way that we take in that air and expel it is as important as what we eat, how much we exercise and the genes we've inherited. This idea may sound nuts, I realize. It certainly sounded that way to me when I first heard it several years ago while interviewing neurologists, rhinologists and pulmonologists at Stanford, Harvard and other institutions. What they'd found is that breathing habits were directly related to physical and mental health.

Today, doctors who study breathing say that the vast majority of Americans do it inadequately. [...] But it's not all bad news. Unlike problems with other parts of the body, such as the liver or kidneys, we can improve the airways in our too-small mouths and reverse the entropy in our lungs at any age. We can do this by breathing properly. [...] [T]he first step in healthy breathing: extending breaths to make them a little deeper, a little longer. Try it. For the next several minutes, inhale gently through your nose to a count of about five and then exhale, again through your nose, at the same rate or a little more slowly if you can. This works out to about six breaths a minute. When we breathe like this we can better protect the lungs from irritation and infection while boosting circulation to the brain and body. Stress on the heart relaxes; the respiratory and nervous systems enter a state of coherence where everything functions at peak efficiency. Just a few minutes of inhaling and exhaling at this pace can drop blood pressure by 10, even 15 points. [...] [T]he second step in healthy breathing: Breathe through your nose. Nasal breathing not only helps with snoring and some mild cases of sleep apnea, it also can allow us to absorb around 18% more oxygen than breathing through our mouths. It reduces the risk of dental cavities and respiratory problems and likely boosts sexual performance. The list goes on.

Scientists found that when deprived of pollen, bumblebees will nibble on the leaves of flowerless plants to trick them into flowering, sometimes up to 30 days earlier than normal. The BBC reports: Writing in the journal Science, the scientists say they have struggled to replicate the bees' trick in the laboratory. Scientists in Switzerland found that when the bees were deprived of pollen, they started to nibble on the leaves of plants that hadn't yet flowered. The bees used their proboscises and mandibles (mouthparts) to cut distinctively-shaped holes in the leaves. But the creatures didn't eat the material or use it in their nests. The damaged plants responded by blooming earlier than normal - in some cases up to 30 days ahead of schedule.

When the researchers tried to emulate the damage done to the plants by the bumblebees they weren't able to achieve the same results. The bee-damaged plants flowered 30 days earlier than undamaged plants and 25 days earlier than ones damaged by the scientists. The research team believes there may be something else going on here apart from nibbles. [...] The researchers say that when pollen is available the bees don't damage plants. They've also found this behavior is in wild bees. However the team are keeping an open mind on whether the plants might be the ones in the driving seat. It could be that some plants have evolved a strategy to push out their flowers when they recognize the bee doing damage to their leaves.

A reader shares a report from Phys.Org: In our 13.8 billion-year-old universe, most galaxies like our Milky Way form gradually, reaching their large mass relatively late. But a new discovery made with the Atacama Large Millimeter/submillimeter Array (ALMA) of a massive rotating disk galaxy, seen when the universe was only ten percent of its current age, challenges the traditional models of galaxy formation. Galaxy DLA0817g, nicknamed the Wolfe Disk after the late astronomer Arthur M. Wolfe, is the most distant rotating disk galaxy ever observed. The unparalleled power of ALMA made it possible to see this galaxy spinning at 170 miles (272 kilometers) per second, similar to our Milky Way.

The discovery of the Wolfe Disk provides a challenge for many galaxy formation simulations, which predict that massive galaxies at this point in the evolution of the cosmos grew through many mergers of smaller galaxies and hot clumps of gas. In most galaxy formation scenarios, galaxies only start to show a well-formed disk around 6 billion years after the Big Bang. The fact that the astronomers found such a disk galaxy when the universe was only ten percent of its current age, indicates that other growth processes must have dominated. "We think the Wolfe Disk has grown primarily through the steady accretion of cold gas," said J. Xavier Prochaska, of the University of California, Santa Cruz and coauthor of the paper. "Still, one of the questions that remains is how to assemble such a large gas mass while maintaining a relatively stable, rotating disk." "The star formation rate in the Wolfe Disk is at least ten times higher than in our own galaxy," adds Prochaska. "It must be one of the most productive disk galaxies in the early universe."

The findings have been published in the journal Nature.

An anonymous reader quotes a report from Space.com: No showstoppers were found during a crucial flight readiness review (FRR) for SpaceX's Demo-2 mission, keeping the company's first-ever crewed flight on track for a May 27 liftoff, NASA officials announced today (May 22). "The Flight Readiness Review has concluded, and NASA's SpaceX Demo-2 mission is cleared to proceed toward liftoff on the first crewed flight of the agency's Commercial Crew Program," NASA officials wrote in an update today. Demo-2 will send NASA astronauts Bob Behnken and Doug Hurley to the International Space Station (ISS) aboard SpaceX's Crew Dragon capsule, which will launch atop a Falcon 9 rocket from Kennedy Space Center (KSC) in Florida. The mission will be the first orbital human spaceflight to depart from American soil since NASA retired its space shuttle fleet in July 2011. Ever since then, the space agency has relied completely on Russian Soyuz rockets and spacecraft to get its astronauts to and from the orbiting lab.

The FRR began yesterday (May 21) at KSC and stretched into this afternoon. During the meeting, NASA, ISS and SpaceX managers discussed in detail "the readiness of the Crew Dragon and systems for the Demo-2 mission; the readiness of the International Space Station Program and its international partners to support the flight; and the certification of flight readiness," NASA officials wrote in an update yesterday. And everything went very well, NASA officials said. "It was an excellent review," NASA associate administrator Steve Jurczyk said during a teleconference with reporters today. "There are no significant open issues, I am happy to report." There are still some boxes to tick before Demo-2 can get off the ground. "For example, this afternoon, SpaceX will conduct a 'static fire' of the Falcon 9 that will launch the mission, testing out its first-stage engines while the rocket remains tethered to the ground," reports Space.com. "And tomorrow (May 23), the teams will hold a 'dry dress' exercise, during which Behnken and Hurley will suit up and the teams will run through many of the procedures that will occur on launch day."

"Data from these two tests, as well as other information, will then be analyzed in detail on Monday (May 25) during a final launch readiness review."

A research team from Duke University has found a small area of the brain in mice that can profoundly shut down pain. "It's located in an area where few people would have thought to look for an anti-pain center, the amygdala, which is often considered the home of negative emotions and responses, like the fight or flight response and general anxiety," reports ScienceDaily. From the report: The researchers found that general anesthesia also activates a specific subset of inhibitory neurons in the central amygdala, which they have called the CeAga neurons (CeA stands for central amygdala; ga indicates activation by general anesthesia). Mice have a relatively larger central amygdala than humans, but [senior author Fan Wang, the Morris N. Broad Distinguished Professor of neurobiology in the School of Medicine] said she had no reason to think we have a different system for controlling pain. Using technologies that Wang's lab has pioneered to track the paths of activated neurons in mice, the team found the CeAga was connected to many different areas of the brain, "which was a surprise," Wang said.

By giving mice a mild pain stimulus, the researchers could map all of the pain-activated brain regions. They discovered that at least 16 brain centers known to process the sensory or emotional aspects of pain were receiving inhibitory input from the CeAga. Using a technology called optogenetics, which uses light to activate a small population of cells in the brain, the researchers found they could turn off the self-caring behaviors a mouse exhibits when it feels uncomfortable by activating the CeAga neurons. Paw-licking or face-wiping behaviors were "completely abolished" the moment the light was switched on to activate the anti-pain center.

When the scientists dampened the activity of these CeAga neurons, the mice responded as if a temporary insult had become intense or painful again. They also found that low-dose ketamine, an anesthetic drug that allows sensation but blocks pain, activated the CeAga center and wouldn't work without it. Now the researchers are going to look for drugs that can activate only these cells to suppress pain as potential future pain killers, Wang said. The study has been published in the journal Nature Neuroscience.

An anonymous reader quotes a report from CNBC: Stay-at-home orders intended to curb the spread of the coronavirus could end up causing "irreparable damage" if imposed for too long, White House health advisor Dr. Anthony Fauci told CNBC on Friday. "I don't want people to think that any of us feel that staying locked down for a prolonged period of time is the way to go," Fauci said during an interview with CNBC's Meg Tirrell on "Halftime Report."

He said the U.S. had to institute severe measures because Covid-19 cases were exploding then. "But now is the time, depending upon where you are and what your situation is, to begin to seriously look at reopening the economy, reopening the country to try to get back to some degree of normal." However, Fauci also cautioned states against reducing social distancing measures too quickly, adding they must take "very significant precautions." "In general, I think most of the country is doing it in a prudent way," he said. "There are obviously some situations where people might be jumping over that. I just say please proceed with caution if you're going to do that." In regard to a coronavirus vaccine, Dr. Fauci told NPR that it remains "conceivable" that a vaccine for the deadly pathogen could be available by the end of the year.

We will need a comprehensive strategy to reduce the sort of interactions that can lead to more infections. The Atlantic: COVID-19 has mounted a sustained attack on public life, especially indoor life. Many of the largest super-spreader events took place inside -- at a church in South Korea, an auditorium in France, a conference in Massachusetts. The danger of the indoors is more than anecdotal. A Hong Kong paper awaiting peer review [PDF] found that of 7,324 documented cases in China, only one outbreak occurred outside -- during a conversation among several men in a small village. The risk of infection indoors is almost 19 times higher than in open-air environments, according to another study [PDF] from researchers in Japan. Appropriately, just about every public indoor space in America has been shut down or, in the case of essential businesses such as grocers, adapted for social-distancing restrictions. These closures have been economically ruinous, transforming large swaths of urban and suburban life into a morbid line of darkened windows.

Today, states are emerging from the lockdown phase of the crisis and entering a queasy period of reopening. But offices, schools, stores, theaters, restaurants, bars, gyms, fitness centers, and museums will have no semblance of normalcy until we learn how to be safe -- and feel safe -- inside. To open these spaces, we must be guided by science and expertise. Fortunately for us, researchers are discovering the secrets of how COVID-19 spreads with a combination of clever modeling and detective work. Before we review the relevant studies and draw out lessons for the future of the great indoors, a brief word of humility. Our understanding of this disease is dynamic. Today's conventional wisdom could be tomorrow's busted myth. Think of these studies not as gospels, but as clues in a gradually unraveling mystery.

schwit1 shares a report from Financial Post: The United States has secured almost a third of the first one billion doses planned for AstraZeneca's experimental COVID-19 vaccine by pledging up to $1.2 billion, as world powers scramble for medicines to get their economies back to work. While not proven to be effective against the coronavirus, vaccines are seen by world leaders as the only real way to restart their stalled economies, and even to get an edge over global competitors. The U.S. Department of Health agreed to provide up to $1.2 billion to accelerate AstraZeneca's vaccine development and secure 300 million doses for the United States.

"This contract with AstraZeneca is a major milestone in Operation Warp Speed's work toward a safe, effective, widely available vaccine by 2021," U.S. Health Secretary Alex Azar said. The vaccine, previously known as ChAdOx1 nCoV-19 and now as AZD1222, was developed by the University of Oxford and licensed to British drugmaker AstraZeneca. Immunity to the new coronavirus is uncertain and so the use of vaccines unclear. The U.S. deal allows a late-stage -- Phase III -- clinical trial of the vaccine with 30,000 people in the United States.