Verily, the Alphabet life sciences division that launched its COVID-19 screening and testing program last month, is still under scrutiny from lawmakers over how it is collecting users' data, as well as its plans to expand its test sites outside of California. From a report: At the end of March, five US senators wrote to Verily asking, among several other things, whether its screening website was compliant with the HIPAA Privacy Rule, and whether Verily intended to remove the requirement that all users who screen for COVID-19 have a Google account. Verily has now addressed those questions in a letter sent to the same senators and obtained by Business Insider. In it, Verily assured the senators that any data collected wouldn't be used for commercial purposes or sold to third parties. But it also confirmed that its screening site was not in compliance with the HIPAA privacy rule.

"Verily has focused on the protection of the security and privacy of personal health information since the inception of its Baseline COVID-19 Program," the company wrote. "With respect to its Baseline COVID-19 Program, Verily is not acting as a covered entity or a business associate as defined by HIPAA. As the Program expands, we will continue to prioritize the protection of individual health data. However, in the future if we engage in a program where we do become a covered entity or we are required to sign a BAA we will take all the appropriate steps to ensure compliance with HIPAA."

Nectar Gan, Caitlin Hu and Ivan Watson, reporting for CNN: China has imposed restrictions on the publication of academic research on the origins of the novel coronavirus, according to a central government directive and online notices published by two Chinese universities, that have since been removed from the web. Under the new policy, all academic papers on Covid-19 will be subject to extra vetting before being submitted for publication. Studies on the origin of the virus will receive extra scrutiny and must be approved by central government officials, according to the now-deleted posts.

A medical expert in Hong Kong who collaborated with mainland researchers to publish a clinical analysis of Covid-19 cases in an international medical journal said his work did not undergo such vetting in February. The increased scrutiny appears to be the latest effort by the Chinese government to control the narrative on the origins of the coronavirus pandemic, which has claimed more than 100,000 lives and sickened 1.7 million people worldwide since it first broke out in the Chinese city of Wuhan in December. Since late January, Chinese researchers have published a series of Covid-19 studies in influential international medical journals.

New submitter wattersa writes: Mathematician/Physicist Stephen Wolfram, founder of Wolfram Research and creator of the technical computation program Mathematica, has announced a discovery in the area of theoretical physics. His long-form blog post discusses the emergence of physical properties of our universe from what he describes as simple, universal, computable rules. He claims the emergent properties are consistent with relativity and quantum mechanics through a 448-page technical paper on the subject, which is posted on a completely new website that just went online.

An anonymous reader quotes a report from Ars Technica: Security researcher Trammell Hudson analyzed the AirSense 10 -- the world's most widely used CPAP -- and made a startling discovery. Although its manufacturer says the AirSense 10 would require "significant rework to function as a ventilator," many ventilator functions were already built into the device firmware. Its manufacturer, ResMed, says the $700 device solely functions as a continuous positive airway pressure machine used to treat sleep apnea. It does this by funneling air into a mask. ResMed says the device can't work as a bilevel positive airway pressure device, which is a more advanced machine that pushes air into a mask and then pulls it back out. With no ability to work in both directions or increase the output when needed, the AirSense 10 can't be used as the type of ventilator that could help patients who are struggling to breathe. After reverse-engineering the firmware, Hudson says the ResMed claim is simply untrue.

To demonstrate his findings, Hudson on Tuesday is releasing a patch that he says unlocks the hidden capabilities buried deep inside the AirSense 10. The patch is dubbed Airbreak in a nod to jailbreaks that hobbyists use to remove technical barriers Apple developers erect inside iPhones and iPads. Whereas jailbreaks unlock functions that allow the installation of unauthorized apps and the accessing of log files and forensic data, Airbreak allows the AirSense 10 to work as a bilevel positive airway pressure machine, a device that many people refer to as a BiPAP. "Our changes bring the AirSense S10 to near feature parity with BiPAP machines from the same manufacturer, boost the maximum pressure output available, and provide a starting point to add more advanced emergency ventilator functionality," Hudson and other researchers wrote on their website disclosing the findings. The researchers say Airbreak isn't ready to be used on any device to treat a patient suffering from COVID-19 -- it's simply to prove that the AirSense 10 does have the ability to provide emergency ventilator functions, and to push ResMed to release its own firmware update that unlocks the ventilator functions.

Slashdot reader and managing director of Adafruit, Phillip Torrone, a.k.a. ptorrone, writes: Tom's Hardware talked to Adafruit about what it's like to switch from selling tech to selling protective gear, and when hobbyists can expect things to return to normal. In March of 2020, Adafruit was deemed an essential service and business for critical manufacturing in NYC by executive order 202.6, making face shields and making/shipping critical components and electronics for COVID-19 related efforts and testing. "We've always needed to make essential electronics for people," Torrone said, stressing that this isn't new for them. "When this hit, there was a very specific short term need. And that was for face shields. And because we have 3D printers, we have laser cutters, we have production capabilities, [when] New York City put out the call, our name came up right away because that's one of the things we do."

On top of that, "we can make components for ventilators," Torrone added: "We can make components for the fast track FDA medical devices that people are trying to get out as fast as possible, from testing equipment to you name it, any type of temperature sensing or pressure sensing...We make electronic components that are used in many, many things. So no matter what, we would still need to be making those components for medical devices...electronics are electronics, so this temperature sensor that we used to use for other things, is going to be used for this now. This barometric pressure sensor, or that barometric pressure sensor [is going to be used for other things]...So for us, it was like 'Oh, this is just going in a different type of box for different types of application.'"

Since Adafruit's shift to essential medical and protective gear, the company's other products are now shipping out on a "when we can do it" basis. Tom's Hardware notes that the company "is still selling to select university and military researchers, but all others will have to wait until an unspecified time in the future to buy their usual Adafruit tech." Thankfully, Torrone says the customer response to the delay of normal business has been largely positive. "We've always been a good cause and a good business with a really good community. So our customers said, 'I'm still going to order and just ship it when you can.' So for regular orders for our customers, they've been fantastic."

The cigar-shaped interstellar visitor to our solar system known as 'Oumuamua could be the remnants of a larger body that was torn apart by its host star, according to researchers. From a report: The dark, reddish object that hurtled into our solar system in 2017 and was named after the Hawaiian word for messenger or scout has long puzzled scientists. Among its peculiarities is the lack of an envelope of gas and dust that comets typically give off as they heat up. Further work by experts suggested the body was accelerated by the loss of water vapour and other gases -- as seen with comets but not asteroids. The upshot was that âOumuamua was labelled a "comet in disguise." Now scientists say they have shed light on the mystery and addressed the myriad pieces of the 'Oumuamua puzzle. They say 'Oumuamua is an "active asteroid" formed from a body that was torn apart by its parent star and then ejected into interstellar space.

"Most planetary bodies ... consist of numerous pieces of rock that have coalesced under the influence of gravity. You could imagine them as sandcastles floating in space," said Dr Yun Zhang, a co-author of the new study from the Observatoire de la Cote d'Azur in France. These bodies experience a number of forces as they pass their star. "A tidal encounter between a planet or small body and a star is a tug-of-war game between the gravitational pull of the star and the self-gravity of the flyby body," said Zhang, noting that when the body passes too close to the star and enters the tidal disruption region, it can stretch and be torn apart giving rise to fragments.

sciencehabit shares a report from Science Magazine: Artificial intelligence (AI) is evolving -- literally. Researchers have created software that borrows concepts from Darwinian evolution, including "survival of the fittest," to build AI programs that improve generation after generation without human input. The program replicated decades of AI research in a matter of days, and its designers think that one day, it could discover new approaches to AI. The program discovers algorithms using a loose approximation of evolution. It starts by creating a population of 100 candidate algorithms by randomly combining mathematical operations. It then tests them on a simple task, such as an image recognition problem where it has to decide whether a picture shows a cat or a truck.

In each cycle, the program compares the algorithms' performance against hand-designed algorithms. Copies of the top performers are "mutated" by randomly replacing, editing, or deleting some of its code to create slight variations of the best algorithms. These "children" get added to the population, while older programs get culled. The cycle repeats. In a preprint paper published last month on arXiv, the researchers show the approach can stumble on a number of classic machine learning techniques, including neural networks.

Researchers have developed a nasal Alzheimer's vaccine that was successful in reducing atrophied brain matter in mice by blocking a protein that causes the disease. It also reduced changes and abnormal behavior in the brain normally associated with the disease. The study was published in the journal Nature. Interesting Engineering reports: "Much more research is necessary for the vaccine to be used in humans, but it is an accomplishment that can contribute to the development of a dementia cure," team member Haruhisa Inoue, a professor at Kyoto University, told The Asahi Shimbun. Alzheimer's disease and other forms of dementia are characterized by an abnormal accumulation of tau proteins in the brain. In the study, the research team incorporated a gene into a harmless virus to make it produce tau.

They then administered the virus nasally to mice with genes that made them prone to developing dementia. The vaccine proceeded to stimulate the mice's immune system, causing them to build antibodies that removed the tau proteins. These antibodies were more than double in mice who had the vaccine administered compared to those that did not. In addition, the vaccinated mice's brain areas were only two-thirds as atrophied as those who were not vaccinated. Finally, no detrimental side effects were recorded during the eight months the scientists observed the mice.

The coronavirus has proven ten times deadlier than the swine flu outbreak that spread across the globe a decade prior, the World Health Organization has confirmed. The Independent reports: The swine flu pandemic, which spanned a stretch of time between January 2009 and August 2010, saw more than 1.6 million confirmed cases, resulting in the confirmed deaths of 18,449 people. Now the World Health Organization's top official Tedros Adhanom Ghebreyesus has warned the coronavirus pandemic currently gripping the planet has outstripped the fatalities caused by the H1N1 strain tenfold.

"We can only say what we know, and we can only act on what we know," he said. "Evidence from several countries is giving us a clearer picture about this virus, how it behaves, how to stop it and how to treat it. We know that Covid-19 spreads fast and we know that it is deadly -- ten times deadlier than the 2009 flu pandemic. We know that the virus can spread more easily in crowded environments like nursing homes. We know that early case finding, testing, isolating, caring for every case, and tracing every contact is essential for stopping transmission. We know that in some countries cases are doubling every three to four days. However while Covid-19 accelerates very fast it decelerates much more slowly. In other words the way down is much slower than the way up. That means control measures must be lifted slowly and with control."

gollum123 shares a report from CNN: States on the country's East and West coasts are forming their own regional pacts to work together on how to reopen from the stay-at-home orders each has issued to limit the spread of the novel coronavirus. The first such group to be announced came Monday on the East Coast. Democratic New York Gov. Andrew Cuomo said his state, New Jersey, Connecticut, Pennsylvania, Delaware and Rhode Island each plan to name a public health and economic official to a regional working group. The chief of staff of the governor of each state also will be a part of the group, which will begin work immediately to design a reopening plan. Later on Monday, the West Coast states of California, Washington and Oregon also announced they are joining forces in a plan to begin incremental release of stay-at-home orders. When announcing the three-state coordination of the western governors during his midday briefing on Monday, Newsom quoted an old proverb: "If you want to go fast, go alone, but if you want to go far, go together." The report notes that other regional pacts could be in the works as well.

"Minnesota Gov. Tim Walz told reporters on Monday that he spoke with Michigan Gov. Gretchen Whitmer and Wisconsin Gov. Tony Evers about working together to open those states from their respective stay-at-home orders," reports CNN. "But the only way that this can happen is if we have widespread testing," Walz said.

kbahey shares a report from Planet Princeton: Renowned mathematician and Princeton University professor John Horton Conway died April 11 as a result of complications from the coronavirus. He was 82. Conway made contributions to many areas of mathematics, including game theory, but was most well known for the invention of the cellular automaton called the Game of Life. The Guardian once called Conway the world's most charismatic mathematician. "John Horton Conway is a cross between Archimedes, Mick Jagger and Salvador Dali. For many years, he worried that his obsession with playing silly games was ruining his career -- until he realized that it could lead to extraordinary discoveries," wrote journalist Siobhan Roberts in a 2015 profile.

There are 70 coronavirus vaccines in development globally, with three candidates already being tested in human trials, according to the World Health Organization, as drugmakers race to find a cure for the deadly pathogen. From a report: The furthest along in the clinical process is an experimental vaccine developed by Hong Kong-listed CanSino Biologics and the Beijing Institute of Biotechnology, which is in phase 2. The other two being tested in humans are treatments developed separately by U.S. drugmakers Moderna and Inovio Pharmaceuticals, according to a WHO document. Progress is occurring at unprecedented speed in developing vaccines as the infectious pathogen looks unlikely to be stamped out through containment measures alone. The drug industry is hoping to compress the time it takes to get a vaccine to market -- usually about 10 to 15 years -- to within the next year.

The UK public will soon be able to find out if they may have been in the vicinity of people unwell with coronavirus via a new contact-tracing app, Matt Hancock, the health secretary, has said. From a report: At No 10's daily press conference on Sunday, Hancock said the NHS app would allow people to report their symptoms, and then the app would anonymously alert other app users that had been in contact with that person in recent days. The Guardian reported last week that the app, developed by NHSX -- the health service's digital transformation arm -- with academic and industry partners, is in the advanced stages of evaluation and is weeks away from being ready to be deployed. About 60% of the adult population would need to sign up and engage with the app by registering their symptoms or positive test results for it to be effective. Their proximity to other users would be logged, and they would follow advice given in alerts to self-isolate -- even in cases where they were not aware of having been in contact with someone infected.

A team in Colombia is to test a ventilator made with a Raspberry Pi computer and easy-to-source parts. From a report: The design and computer code were posted online in March by a man in California, who had no prior experience at creating medical equipment. Marco Mascorro, a robotics engineer, said he built the ventilator because knew the machines were in high demand to treat Covid-19. His post prompted a flood of feedback from healthcare workers. He has used the advice to make improvements. "I am a true believer that technology can solve a lot of the problems we have right now specifically in this pandemic," he told the BBC. The Colombian team said the design was important for their South American country because parts for traditional models could be hard to obtain. By contrast, Mr Mascorro's design uses only easy-to-find parts -- for example, the valves it employs can commonly be found at car and plumbing supply stores. The machine is set to be put through a fast-tracked round of tests at two institutions in Bogota -- the University Hospital of the Pontifical Xavierian University and Los Andes University.

Yahoo News shares an encouraging report from former Newsweek correspondent Andrew Romano: Until very recently, nationwide data about how many COVID-19 patients are currently receiving treatment in hospitals was hard to come by. It's still incomplete and inconsistent. But on April 7, researchers at the University of Minnesota launched the U.S. COVID-19 Hospitalization Tracking Project, which is just what it sounds like: the first effort to capture, track, visualize and compare daily data on the number of COVID-19 hospitalizations from the 37 state departments of health that are reporting this information (so far).

The reason this information is so valuable is simple. Because hospitalization typically occurs a week or so after infection, it's less of a lagging indicator than the death count (which trails by two to two and a half weeks) and more directly tied to the trajectory of the epidemic than the testing-dependent case count. It's also a measure of the most pressing public health concern of all: how close we are to exceeding the capacity of our hospital system, which can make COVID-19 much deadlier than it would otherwise be.

Which brings us to New York and California. Chart each state's hospitalization data over the last seven days or so, and two different narratives emerge. Both are encouraging...

On Wednesday, New York's daily death count hit an all-time high: 799. But that reflects infections from weeks ago, before the state's lockdown started. The number of people testing positive stayed relatively flat. Meanwhile, there were fewer new hospitalizations — just 200 — than on any day since March 18. It wasn't a blip. The amount of new daily hospitalizations has been declining since last Thursday: from 1,427 on April 2 to 1,095 on April 3 to 656 on April 6 to 200 on April 8. (There are some questions about inconsistencies between the data from New York state and New York City, but the trend line is the same.) Previously, the total current number of coronavirus patients in New York hospitals had been increasing by at least 20 percent a day for weeks. Now the overall number of hospitalizations is barely increasing at all...

The good news in New York is that the state might be peaking now. The good news in California is that the state might not peak for a long time — but its path to that peak will be so incremental, its curve so flat, that coronavirus patients will never come close to overwhelming the hospital system.
The numbers do look encouraging. (Click on the "Currently Hospitalized" rectangle and then select each state's two-letter abbreviation from the dropdown menu.) In fact, the San Francisco Bay Area recorded its fourth day of declining ICU patients on Saturday. "Home-sheltering efforts may well be paying off, at least according to the number of hospitalizations and patients in ICU," reports the Bay Area Newsgroup.

And SFGate noted Friday that the statewide hospitalization figures "have also been relatively flat in recent days, with Governor Gavin Newsom expressing guarded optimism after the number of individuals in intensive care units decreased Thursday."

sciencehabit writes: Recycling isn't as guilt-free as it seems. Only about 30% of the plastic that goes into soda bottles gets turned into new plastic, and it often ends up as a lower strength version. Now, researchers report they've engineered an enzyme that can convert 90% of that same plastic back to its pristine starting materials. Work is underway to scale up the technology and open a demonstration plant next year.

The researchers generated hundreds of mutant enzymes changing amino acids as they went. They then mass produced the mutants in bacteria and screened them to find efficient breakers of plastic bonds. After repeating this process for several rounds, they isolated a mutant enzyme that's 10,000 times more efficient at breaking down an important bond that allows plastic to be recycled.

The team is currently building a demonstration plant that is expected to recycle hundreds of tons of plastic per year. The enzyme can't recycle other major types of plastics, such as polyethylene and polystyrene, which have bonds between building blocks that are harder to break. But if successful, it could make it help society deal with one of the most challenging plastic problems we face.
John McGeehan, who directs the center for enzyme innovation at the University of Portsmouth, also tells Science that now recycling companies typically melt plastics together to make carpets or other low-grade plastic fibers that will eventually end up in a landfill or get incinerated.

"It's not really recycling at all."

This week the Washington Post asked their "business of health care" reporter to explain the true status in the scientific community of hydroxychloroquine, an already-approved malaria drug also used to control inflammation in lupus and rheumatoid arthritis patients.

"There is no clear evidence that the drugs work against the coronavirus," he writes, "despite their use by hospitals and doctors in the United States and other countries since the outbreak began." Their antiviral properties have been proved in test tubes, but rigorous clinical trials to test their effectiveness in humans have not been completed. Limited studies on coronavirus patients have been published by researchers in France and China, but their extremely small size and other problems prevented them from being statistically significant. The French study included a combination of hydroxychloroquine with the antibiotic azithromycin that showed benefit in six patients... Another study in 11 patients in France showed no evidence the regimen works. A Chinese study also showed no benefit over the standard course of treatment.

Mainstream scientists caution against using the drugs without more evidence they are effective... The dangerous side effects of the drugs are much better known. Most seriously, the drugs can trigger arrhythmia, which can lead to a fatal heart attack in patients with cardiovascular disease or who are taking certain drugs, including anti-depression medications. Doctors recommend screening with an electrocardiogram to prevent the drug from being given to the 1 percent of patients at the greatest risk of a cardiac event. The drugs also can cause vision loss called retinopathy with long-term use, and chloroquine has been associated with psychosis...

As the coronavirus has spread from China across the world and to the United States, the dire reality is that there is no vaccine and no approved drug available to treat the serious respiratory symptoms that are claiming thousand of lives.
Long-time Slashdot reader UnknowingFool shares doubts raised about that small French study, as even its publisher now acknowledges it "does not meet" their own expected standards.

The Post does note that multiple trials are "ongoing" (though six different research centers testing the drug told CNN it would be "months" before results were known). But the Post adds that already "public and political interest has caused runs, hoarding and severe shortages in recent weeks."

An anonymous reader quotes Reuters: U.S. deaths due to the coronavirus surpassed 20,000 on Saturday, the highest reported number in the world, according to a Reuters tally, although there are signs the pandemic might be nearing a peak. Italy has the second most reported deaths at 19,468 and Spain is in third place with 16,353.

The United States has five times the population of Italy and nearly seven times the population of Spain.

The United States has seen its highest death tolls to date in the epidemic with roughly 2,000 deaths a day reported for the last four days in a row.
While America has 4.3% of the world's population, it appears to have nearly 20% of the world's 100,000 confirmed fatalities from COVID-19. [Update: This comparison might be skewed by countries underreporting their fatalities.] Long-time blogger Jason Kottke notes the virus is now causing more deaths per day in the U.S. than any other cause, including heart disease and cancer.

But earlier this week Kottke also shared graphs from six different countries visualizing positive new statistics from the Imperial College team suggesting social distancing has worked in 11 European countries they analyzed.

"We estimate that interventions across all 11 countries will have averted 59,000 deaths up to 31 March," the researchers write, adding "Many more deaths will be averted through ensuring that interventions remain in place until transmission drops to low levels."

Long-time Slashdot reader lkcl quotes NASA: Over the past several weeks, NASA satellite measurements have revealed significant reductions in air pollution over the major metropolitan areas of the Northeast United States. Similar reductions have been observed in other regions of the world....

March 2020 shows the lowest monthly atmospheric nitrogen dioxide levels of any March during the OMI data record, which spans 2005 to the present. In fact, the data indicate that the nitrogen dioxide levels in March 2020 are about 30% lower on average across the region of the I-95 corridor from Washington, DC to Boston than when compared to the March mean of 2015-19.