Open Source

Graphene As an Open-Source Material (techcrunch.com) 26

An anonymous reader quotes a report from TechCrunch: The 2D wonder-material graphene could greatly benefit from the widespread experimentation of open-source use. In its current state, graphene is primarily researched by scientists in universities and labs, but by making graphene a material that is open to be improved upon by anyone, we might see the fulfillment of the potential that graphene has been hailed for since its discovery. Graphene's capabilities are staggering -- it is essentially 2D, flexible, 200 times stronger than steel, conducts heat 10 times better than copper and conducts electricity 250 times better than silicon. Its abilities are far-reaching and extremely potent, making graphene applications nearly endless. As it stands, graphene research is limited to a select few technology companies -- Samsung, for instance, has the most graphene patents to date. Otherwise, most graphene research is done in university labs. In the same way that open-sourcing has built up software and related technologies, open-sourcing could also viably allow a wider range of individuals and communities to help unlock graphene's unrealized potential.

Graphene is fundamentally different from software in that it is a physical resource. Since the material's discovery, quantity has been a serious issue, preventing the material from seeing widespread use. Natural reserves of graphene are few and far between, and while scientists have discovered ways of producing graphene, the methods have proved unscalable. In addition, graphene would need a way to be experimented with by the average user. For those who don't have the same equipment researchers do, how can they go about tinkering with graphene? In order for graphene to become an open-source material, a solution for these two problems must be found.

Businesses

Digital Marketer Mailchimp Bans Anti-Vaccination Content (nbcnews.com) 193

Digital marketer Mailchimp has removed several anti-vaccination "activists" from its platform and will no longer provide services to newsletters that push anti-vaccination content. From a report: The move to block the anti-vaccination rhetoric follows similar actions by other tech companies and comes on the heels of increased pressure from public health advocates and lawmakers on digital platforms to curtail the spread of health misinformation. "Mailchimp has shut down a number of accounts for anti-vaccination content that violates our Terms of Use, and we're adding this category to our routine searches for prohibited content," a Mailchimp spokesperson said in a statement provided to NBC News. "Spreading misinformation about the safety and efficacy of vaccines poses a serious threat to public health and causes real-world harm. We cannot allow these individuals and groups to use our Marketing Platform to spread harmful messages and expand their audiences." The company began quietly enforcing this decision last week. "We trust the world's leading health authorities, like the CDC, WHO, and the AAP, and follow their guidance when assessing this type of misuse of our platform," the spokesperson said, referring to the Centers for Disease Control and Prevention, the World Health Organization and the American Academy of Pediatrics.
Moon

NASA Estimates It Will Need $20 Billion To $30 Billion For Moon Landing (cnn.com) 241

NASA has touted its bold plan to return American astronauts to the moon by 2024 for months. Now we're starting to get an idea of how much it will cost. From a report: The space agency will need an estimated $20 billion to $30 billion over the next five years for its moon project, NASA Administrator Jim Bridenstine told CNN Business on Thursday. That would mean adding another $4 billion to $6 billion per year, on average, to the agency's budget, which is already expected to be about $20 billion annually. Bridenstine's remarks are the first time that NASA has shared a total cost estimate for its moon program, which is called Artemis (after the Greek goddess of the moon) and could send people to the lunar surface for the first time in half a century. NASA wants that mission to include two astronauts: A man and the first-ever woman to walk on the moon.
Biotech

Lab-Grown Meat Will Overtake Plant-Based Alternatives By 2040, Study Says (inverse.com) 288

An anonymous reader quotes a report from Inverse: Cultured meat could overtake plant-based alternatives like Beyond Meat and Impossible Burger as early as 2040, according to a new report. The research, from consultancy firm AT Kearney, finds that meat grown in a lab from cells will ultimately become more popular than vegetarian food that replicates the taste of animal products. By then, most of the world's burgers will be entirely meat-free. The report claims that, over the next 15 years, the market will shift toward lab-grown meat as alternatives struggle to maintain their momentum from early innovation. Consumer preferences will also drive a shift to the lab-based approach, as the researchers argue that the similarity to meat drives commercial potential and that, ultimately, lab-grown meat will still taste and feel much more like the real thing.

These products will drive down meat consumption even as the whole industry expands, but scientists are unsure whether this will be good for climate change. University of Oxford research found that, while methane-producing cows are lambasted as a major source of greenhouse gases, the methane they produce only stays in the atmosphere for around 12 years. Carbon dioxide, which a lab would in theory produce in spades to power the production of cultured meat, can last for thousands of years. However, this week's report pushes back on this notion, and finds that meat alternatives are far more resource-efficient than conventional meat. When taken as a grain-to-meat ratio, animals only operate at around 15 percent efficiency. Cultured meat only needs around 1.5 kg of crops like soy, pease and maize to produce 1 kg of beef, resulting in a 70 percent conversion rate. Plant-based products need around 1.3 kg per kilo of "meat," resulting in a 75 percent conversion rate.

Medicine

Sleep Trackers Can Make Your Insomnia Worse 53

Some sleep specialists are warning that the apps and devices that are used to track your sleep may provide inaccurate data and can exacerbate symptoms of insomnia. "Fiddling with your phone in bed, after all, is bad sleep hygiene," reports The New York Times. "And for some, worrying about sleep goals can make bedtime anxiety even worse." From the report: There's a name for an unhealthy obsession with achieving perfect sleep: orthosomnia. It was coined by researchers from Rush University Medical School and Northwestern University's Feinberg School of Medicine in a 2017 case study published in the Journal of Clinical Sleep Medicine. Dr. Kelly Baron, one of the paper's authors and the director of the University of Utah's behavioral sleep medicine program, said that sleep trackers can be helpful in identifying patterns. She herself tracks her bedtime with a Fitbit. But she said she had noticed a trend of patients complaining based on unverified scores, even for things like the amount of deep sleep, which varies by individual.

In the case study on orthosomnia, researchers found that patients had been spending excessive time in bed to try to increase their sleep numbers, which may have made their insomnia worse. And they found it difficult to persuade patients to stop relying on their sleep trackers, even if the numbers had been flawed. Researchers say that trackers can overestimate the amount of sleep that you get, particularly if they focus on tracking movement. If you are lying awake in bed, the tracker might think that you're asleep. While devices that track heart rate or breathing give a more complete picture, they are still only generating estimates.
Earth

Earth Nearing 'Meteor Swarm' That May Have Caused 1908 Tunguska Event (cbsnews.com) 181

A reader quotes a report from CBS News: A swarm of meteors heading towards Earth could have the potential to cause a catastrophic impact, a new study from Western Ontario University says. The so-called Taurid swarm is a recurring event that some scientists believe could have played a role in the biggest Earth impact of modern times, in 1908, when a space rock slammed into Siberia with enough force to destroy an entire forest. What has become known as the Tunguska explosion of 1908 was so powerful that the blast leveled 80 million trees over an 800-square-mile area. It's considered to be a one-in-1,000-year event, according to Western Ontario University. But while the Tunguska explosion occurred just over a century ago, another such phenomenon could occur much sooner than its 1,000-year expectancy, the researchers say. That's why they're focusing new attention on the Taurid swarm.

The Taurid swarm is a dense cluster of meteors within the Taurid meteor stream. Earth periodically passes through the Taurid swarm, and it is one of the three space phenomenons that could result in a catastrophic collision. Near Earth Objects (NEOs) such as asteroids and meteoroids, as well as comets are the other two potential causes. The Taurid swarm is created when Earth passes through the debris left behind by Comet Encke, according to NASA. The comet's dust barrels through Earth's atmosphere at 65,000 mph, burns up and creates a meteor shower. This Taurid meteor shower is usually weak, but there are some years where it is more visible, NASA says. The Taurid swarm heightens the possibility of a large collision, Western Ontario University researchers hypothesized. This summer, Earth will approach within 30,000,000 km of the center of the Taurid swarm, the study says. That would be Earth's closest encounter with the swarm since 1975 and the best viewing opportunity we'll have until the early 2030s.

Medicine

Study Finds Nearly 400 Medical Devices, Procedures and Practices That Are Ineffective (sciencealert.com) 153

An anonymous reader quotes a report from ScienceAlert: A recent study has unearthed nearly 400 established treatments, devices and procedures that are no better than previous or lesser alternatives. [This is referred to as a "medical reversal" in the medical industry.] The findings are based on more than 15 years of randomized controlled trials, a type of research that aims to reduce bias when testing new treatments. Across 3,000 articles in three leading medical journals from the UK and the US, the authors found 396 reversals. While these were found in every medical discipline, cardiovascular disease was by far the most commonly represented category, at 20 percent; it was followed by preventative medicine and critical care.

Taken together, it appears that medication was the most common reversal at 33 percent; procedures came in second at 20 percent, and vitamins and supplements came in third at 13 percent. This line-up is unsurprising given the history of medical reversals that we do know about. In the late 20th century, for instance, sudden cardiac death was deemed a "world wide public health problem." Most cases were thought to arise from an irregular heart rhythm, and so a new generation of antiarrhythmic drugs were developed. "In the late 1980s, the Cardiac Antiarrhythmic Suppression Trial (CAST) was conducted to assess the safety of what was then commonplace. Interestingly, recruitment for the trial was hindered by physicians who refused to let patients undergo randomization with a 50 percent chance of not receiving these medications." In the end, however, the randomized trial found that the medication was even more deadly than a placebo. While not all of these medical reversals are deadly, they are all, by definition, useless expenses.
The research has been published in the journal eLife.
Open Source

'Medicine Needs To Embrace Open Source' (zdnet.com) 77

Steven J. Vaughan-Nichols from ZDNet argues that "the expensive and abusive pharmaceutical industry needs to open up to improve everyone's health." An anonymous reader shares an excerpt from the report: Now, I know little about creating and testing drugs. Here's what I do know: Open source and data produces better results than proprietary methods. In technology, the field I know best, almost every company -- including open source poster-child enemy Microsoft -- has embraced open source. Why? Because it works better than the short-sighted proprietary approaches. It's not just programming that benefits from open source. Cars now run Linux under the hood. Energy and electricity transmission managers are moving to open source. Most of the movies you love are made with open-source programs. Heck, even contract law is going open source.

I'm far from the only one to conclude that open-source methods are needed to break what amounts to broken pharmaceutical research methodology and drug price gouging. Open Source Pharma, an organization devoted to building on existing initiatives to develop an alternative, comprehensive, open-source pharmaceutical system, is leading the way. Dr. Manica Balasegaram, executive director for the Access Campaign of Medecins Sans Frontieres, aka Doctors Without Borders, explained: "There is something rotten in the kingdom of biomedical R&D... That the system is inefficient is probably difficult to dispute. It works in silos, encourages a protectionist, proprietary approach, promotes duplication, multiplies failure, is costly, and importantly, is directed at markets and not at public health needs. The consequences are fatal." Open source can revolutionize our hunt for better, more affordable medicine. It has everywhere else. It can in medicine, too.
"We need to fundamentally let go of thinking that there is only one possible business model," says Balasegaram. "We need alternatives. Open source R&D is the key." Since the biomedical field is dominated by big companies with an iron grip on IP, Balasegaram admitted: "Promoting the concept of sharing will be tough. Sharing, however, is a difficult and somewhat scary idea to promote. It sounds suspiciously 'radical.' However, when one takes into account that this has been done in other areas, we need to rethink our reservations."
Space

India Plans To Have Its Own Space Station (techcrunch.com) 113

India plans to have its own space station in the future and conduct separate missions to study Sun and Venus, it said on Thursday, as the nation moves to bolster its status as a leader in space technologies and inspire the young minds to take an interest in scientific fields. From a report: India's space agency said today that it will begin working on its space station following its first manned mission to space, called Gaganyaan, in 2022 -- just in time to commemorate 75 years of the country's independence from Britain. The government has sanctioned Rs 10,000 crores ($1.5 billion) for Gaganyaan mission, it was unveiled today. "We have to sustain the Gaganyaan program after the launch of the human space mission. In this context, India is planning to have its own space station," said Dr Kailasavadivoo Sivan, chairman of Indian Space Research Organization (ISRO). ISRO is India's equivalent to NASA. "While navigation, communication, and earth observation are going to be the bread and butter for us, it is missions such as Chandrayaan, Mangalyaan, and Gaganyaan that excite the youth, unite the nation, and also pave a technological seed for the future." The ambitious announcements come a day after the space agency said it will launch a lunar mission on July 15 this year in an attempt to become only the fourth nation to land on the moon.
Communications

NASA Overcomes Military's GPS Tweaks To Peer Inside Hurricanes (sciencemag.org) 53

sciencehabit shares a report from Science Magazine: A constellation of eight microsatellites has harvested data that -- if folded into the National Oceanic and Atmospheric Administration's (NOAA's) weather models -- could have sharpened forecasts of several recent hurricanes, including Michael, a category-5 storm in October 2018. But progress was hard-won for scientists on NASA's $157 million Cyclone Global Navigation Satellite System (CYGNSS), who discussed early results at a meeting last week, just as another Atlantic hurricane season kicked off. With its flotilla of satellites crisscrossing the tropical oceans, CYGNSS can see through the thick clouds of cyclones. The satellites collect radio signals beamed from standard GPS beacons after they bounce off the ocean's surface. The reflections are influenced by sea's roughness, which depends on wind speed. But a month after launch in December 2016, the team noticed the GPS signals were wavering.

The U.S. military runs the GPS system, and in January 2017, it began to boost the radio power on 10 of its GPS satellites as they passed over a broad region centered on northern Syria. The power boosts, which can thwart jamming, have recurred without warning, each lasting several hours. The swings don't interfere with other scientific uses of GPS. But they threw off the constellation's measurements of high winds by 5 meters a second or more -- the difference between a category-2 and category-3 hurricane. After 2 years of work, the CYGNSS team has compensated by reprogramming its satellites on the fly. The satellites carry large antennas to catch reflected GPS signals, but they also have small antennas that receive direct GPS signals, for tracking time and location. The team repurposed the small antennas to measure the signal strength of the GPS satellites, making it possible to correct the wind speed measures

Medicine

Researchers Use Lasers To Detect and Destroy Tumor Cells In Melanoma Patients (ieee.org) 66

An anonymous reader quotes a report from IEEE Spectrum: Tumor cells that spread cancer via the bloodstream face a new foe: a laser beam, shined from outside the skin, that finds and kills these metastatic little demons on the spot. In a study published today in Science Translational Medicine, researchers revealed that their system accurately detected these cells in 27 out of 28 people with cancer, with a sensitivity that is about 1,000 times better than current technology. That's an achievement in itself, but the research team was also able to kill a high percentage of the cancer-spreading cells, in real time, as they raced through the veins of the participants. If developed further, the tool could give doctors a harmless, noninvasive, and thorough way to hunt and destroy such cells before those cells can form new tumors in the body.

Researchers led by Vladimir Zharov, director of the nanomedicine center at the University of Arkansas for Medical Sciences, tested their system in people with melanoma, or skin cancer. The laser, beamed at a vein, sends energy to the bloodstream, creating heat. Melanoma CTCs absorb more of this energy than normal cells, causing them to heat up quickly and expand. This thermal expansion produces sound waves, known as the photoacoustic effect, and can be recorded by a small ultrasound transducer placed over the skin near the laser. The recordings indicate when a CTC is passing in the bloodstream. The same laser can also be used to destroy the CTCs in real time. Heat from the laser causes vapor bubbles to form on the tumor cells. The bubbles expand and collapse, interacting with the cell and mechanically destroying it.

Communications

SpaceX Successfully Launches and Lands Its Falcon 9 Rocket On the California Coast (theverge.com) 59

SpaceX successfully launched and deployed three RADARSAT Canadian satellites into orbit this morning. Despite heavy fog, the company also landed the Falcon 9 rocket on the California coast. The Verge reports: The trio of satellites going up on today's flight are part of the RADARSAT Constellation developed by the Canadian Space Agency. The spacecraft are meant to operate nearly 400 miles up, where they will observe Canada's land and waters, as well as the Arctic. The goal is to gather data on sea ice in nearby oceans and the Great Lakes, as well as the changing ecosystems within Canada. Such information will be useful for many groups, including mariners who navigate in Arctic waters and scientists who want to understand the impact of climate change in the region. Satellite imagery from RADARSAT could also help with disaster relief.

SpaceX is using one of its used Falcon 9 rockets for the mission, a vehicle that previously flew the company's Crew Dragon capsule on its very first flight to the International Space Station back in March. After that launch, the Falcon 9 landed on one of SpaceX's drone ships off the coast of Florida in the Atlantic, but now it's ready to make a ground landing on the opposite coast. The first and only time that SpaceX has landed a Falcon 9 rocket on California land was in October of 2018. Nearly all of the company's attempts to land on solid ground have been successful, save for one that missed its pad in Florida and landed in the ocean instead.

United States

The Long-Awaited Upgrade To the US Weather Forecast Model Is Here (arstechnica.com) 59

An anonymous reader quotes a report from Ars Technica: For the first time in about 40 years, the guts of the U.S. model got swapped out for something new today. The upgrade brings us a new "Finite-Volume Cubed-Sphere" (or FV3) dynamical core, which simulates the basic atmospheric physics at the heart of this endeavor, a change that has been in the works for a while. The new core had its origins in simulating atmospheric chemistry but ended up being adapted into other models. A few years ago, it was selected to replace the old core in the U.S. Global Forecast System model. And for more than a year now, the new version of the model has been running in parallel so its results could be compared to the operational model.

The results have been a little mixed. The new core improves computational efficiency and allows some processes to be simulated at a higher resolution -- unequivocal improvements. It also simulates the physics of water vapor more realistically. In a press conference today, NOAA scientists cited a number of areas where forecast improvements have been seen. Forecast tracks of hurricanes and the mid-latitude storms that frequently sweep across the U.S. have both improved, they said, along with forecasts of hurricane strength. Forecast precipitation amounts were also cited as a key area of progress. But there have also been grumblings in the weather community over the past year about results that didn't seem so hot. For example, surface temperatures have been biased low in some situations, throwing off forecasts.

Space

India Set To Launch Second Lunar Mission; Land Rover on the Moon (reuters.com) 93

India said on Wednesday it will launch its second lunar mission in mid-July, as it moves to consolidate its status as a leader in space technology by achieving a controlled landing on the moon. From a report: The mission, if successful, would make India only the fourth country behind the United States, Russia and China to perform a "soft" landing on the moon and put a rover on it. China successfully landed a lunar rover in January. The unmanned mission, called Chandrayaan-2, which means "moon vehicle" in Sanskrit, will involve an orbiter, a lander and a rover, which have been built by the Indian Space Research Organization (ISRO). The mission is scheduled to launch on July 15 aboard ISRO's Geosynchronous Satellite Launch Vehicle Mark III. It will cost about 10 billion rupees ($144 million), ISRO said. After a journey of more than 50 days, ISRO's lander will attempt a "soft," controlled landing on the lunar surface on around Sept. 6.
Moon

Scientists Discover Previously Unidentified Mass Beneath Surface of the Moon (cbsnews.com) 139

pgmrdlm shares a report from CBS News: A previously unknown deposit of an unidentified physical substance larger than the size of Hawaii has been discovered beneath the surface of the moon. Scientists at Baylor University published a study detailing their findings of this "anomaly" beneath the moon's largest crater, at its South Pole. They believe the mass may contain metal carried over from an earlier asteroid crash. According to the study -- "Deep Structure of the Lunar South Pole-Aitken Basin" -- which was published in the journal Geophysical Research Letters in April, the large mass of material was discovered beneath the South Pole-Aitken crater, an oval-shaped crater that is 2,000 kilometers (about 1,243 miles) wide and roughly 4 billion years old. According to Baylor University, the unidentified mass was discovered "hundreds of miles" beneath the basin and is "weighing the basin floor downward by more than half a mile." The scientists discovered the mass by analyzing data taken from a spacecraft used during NASA's Gravity Recovery and Interior Laboratory (GRAIL) mission, which was a lunar gravity mapping exploration to study the moon's interior and thermal history.

According to the published study, "Plausible sources for this anomaly include metal from the core of a differentiated impactor or oxides from the last stage of magma ocean crystallization," which hypothesizes the moon's surface was once a molten liquid ocean of magma. They also believe the mass could be suspended iron-nickel core from an asteroid that previously impacted the moon's surface.
Software

Scientists Train AI To Learn People's Voices, Then Generate Their Faces (livescience.com) 63

JustAnotherOldGuy shares a report from Live Science: An neural network named "Speech2Face" was trained by scientists on millions of educational videos from the internet that showed over 100,000 different people talking. From this dataset, Speech2Face learned associations between vocal cues and certain physical features in a human face, researchers wrote in a new study. The AI then used an audio clip to model a photorealistic face matching the voice, and the results are surprisingly close to the actual faces of the people whose voices it listened to. The faces generated by Speech2Face didn't precisely match the people behind the voices. But the images did usually capture the correct age ranges, ethnicities and genders of the individuals, according to the study. The findings have been published in the preprint journal arXiv but have not been peer-reviewed.
Canada

Canada Plans To Ban 'Harmful' Single-Use Plastics By 2021 307

Prime Minister Justin Trudeau announced on Monday that Canada will ban many single-use plastic items by 2021, including bags, straws, cutlery and stirring sticks, to cut harmful waste damaging the country's ecosystems. CNN reports: Trudeau announced the measures Monday, describing "a problem we simply can't ignore." "Plastic waste ends up in our landfills and incinerators, litters our parks and beaches, and pollutes our rivers, lakes, and oceans, entangling and killing turtles, fish, and marine mammals," the Canadian leader said in a statement. "Less than 10 per cent of plastic used in Canada gets recycled. Without a change in course, Canadians will throw away an estimated $11 billion worth of plastic materials each year by 2030." Trudeau said his government will work with companies that use or create plastic products to set targets on waste.
NASA

NASA 'Snoopy' Lunar Module Likely Found 50 Years After Being Jettisoned Into Space (techcrunch.com) 117

An anonymous reader quotes a report from TechCrunch: NASA's trip to the Moon's surface in July 1969 was preceded by a lot of preparatory missions -- including Apollo 10, which involved a mock mission with everything but the actual landing. Astronauts Thomas Stafford and Eugene Cernan flew a lunar module, nicknamed "Snoopy" by the agency, nearly all the way to the Moon during Apollo 10, and then shot the module off into space once they'd completed their task. There was never any intent to return Snoopy to Earth -- it was sent into an orbit around the sun beyond the Moon after the astronauts completed their maneuvers and returned to the command module, and NASA did not track its trajectory. The effort to discover its location began in 2011, undertaken by a group of amateur U.K. astronomers led by Nick Howes -- the same who now claim they're "98 percent convinced" they've discovered where it ended up, according to Sky News. Howes' further speculated that if they confirm its location, someone like Elon Musk could recover it and preserve it as a key cultural artifact.
Businesses

Raytheon, United Technologies Merger Will Create a New Aerospace Giant (npr.org) 45

The Raytheon Co. and United Technologies Corp. are merging in an all-stock deal that the two companies say is a merger of equals. The new company's name will be Raytheon Technologies Corp. -- and it's expected to have nearly $74 billion in annual sales. NPR reports: The new defense and aerospace company would be second only to Boeing in the U.S., according to the latest Forbes 500 rankings by annual revenue. On that list, Boeing had more than $101 billion in revenue while another rival, Lockheed Martin, racked up $53.7 billion, according to Forbes. "The combination of United Technologies and Raytheon will define the future of aerospace and defense," United Technologies Chairman and CEO Greg Hayes said in a statement about the deal. Hayes is set to become the leader of the new company: He'll take the titles of chairman and CEO two years after the merger is finalized.

Under the deal, United Technologies' shareholders will own about 57% and Raytheon shareholders will own about 43% of the merged company. Both Raytheon's and United Technologies' board of directors have unanimously approved the merger, which is expected to close during the first half of 2020. The headquarters of Raytheon Technologies will be in the Boston metro area, the companies say. Raytheon is currently based in Waltham, Mass., while United Technologies is based in Farmington, Conn. Under the deal, the new Raytheon Technologies will consolidate its operations into four businesses. One will be based on intelligence and aerospace and another based on defense and missile systems. Those entities will join Collins Aerospace (the recently acquired Rockwell Collins Inc.) and jet engine-maker Pratt & Whitney -- two of United Technologies' high-revenue divisions.

Science

Type A Blood Converted To Universal Donor Blood With Help From Bacterial Enzyme (sciencemag.org) 44

An anonymous reader quotes a report from Science Magazine: For a transfusion to be successful, the patient and donor blood types must be compatible. Now, researchers analyzing bacteria in the human gut have discovered that microbes there produce two enzymes that can convert the common type A into a more universally accepted type. If the process pans out, blood specialists suggest it could revolutionize blood donation and transfusion. To up the supply of universal blood, scientists have tried transforming the second most common blood, type A, by removing its "A-defining" antigens. But they've met with limited success, as the known enzymes that can strip the red blood cell of the offending sugars aren't efficient enough to do the job economically.

After 4 years of trying to improve on those enzymes, a team led by Stephen Withers, a chemical biologist at the University of British Columbia (UBC) in Vancouver, Canada, decided to look for a better one among human gut bacteria. Some of these microbes latch onto the gut wall, where they "eat" the sugar-protein combos called mucins that line it. Mucins' sugars are similar to the type-defining ones on red blood cells. So UBC postdoc Peter Rahfeld collected a human stool sample and isolated its DNA, which in theory would include genes that encode the bacterial enzymes that digest mucins. Chopping this DNA up and loading different pieces into copies of the commonly used lab bacterium Escherichia coli, the researchers monitored whether any of the microbes subsequently produced proteins with the ability to remove A-defining sugars. At first, they didn't see anything promising. But when they tested two of the resulting enzymes at once -- adding them to substances that would glow if the sugars were removed -- the sugars came right off. The enzymes also worked their magic in human blood. Tiny amounts added to a unit of type A blood could get rid of the offending sugars, they found.
The findings have been reported today in the journal Nature Microbiology.

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