The FDA has rejected a first-of-its-kind proposal to use the psychedelic drug MDMA as a treatment for post-traumatic stress disorder (PTSD), according to drugmaker Lykos Therapeutics. NBC News reports: There had been intense political pressure on the FDA to approve the drug. Friday's decision was the first time the agency had considered a Schedule 1 psychedelic for medical use. If approved, it would have been the first new treatment for PTSD in more than two decades. Lykos Therapeutics had asked the FDA to approve the drug as part of a treatment regimen, given alongside talk therapy. The agency's decision came after an independent advisory committee in June declined to recommend approval of the drug, saying there was not enough evidence that the therapy was safe and effective.

The committee cited a myriad of concerns, including poorly designed studies, allegations of sexual misconduct during a midstage clinical trial and the potential for serious health risks after taking the drug, including heart problems and abuse. A review by FDA scientists, published ahead of the June meeting, also raised concerns about how the trials were carried out, including that a number of patients and therapists likely were able to guess who was given the medication and who got the placebo. Despite the rejection, experts say they expect that psychedelic therapies are still on their way to FDA approval. There are around four dozen MDMA trials in various stages of clinical development, according to ClinicalTrials.gov. "I think it will be a temporary setback," said Holly Fernandez Lynch, an associate professor of medical ethics at the University of Pennsylvania. "The advisory committee and FDA gave very clear indications of what they're looking for in terms of study design and adverse event reporting, so Lykos and other companies should know pretty clearly how to proceed going forward if they want to get psychedelics approved."

Toxic PFAS "forever chemicals" that leach from landfills into groundwater are among the major pollution sources in the US, and remain a problem for which officials have yet to find an effective solution. Now new research has identified another route in which PFAS may escape landfills and threaten the environment at even higher levels: the air. From a report: PFAS gas that emits from landfill waste ends up highly concentrated in the facilities' gas treatment systems, but the systems are not designed to manage or destroy the chemicals, and much of them probably end up in the environment.

The findings, which showed up to three times as much PFAS in landfill gas as in leachate, are "definitely an alarming thing for us to see," said Ashley Lin, a University of Florida researcher and the lead author of the study. "These findings suggest that landfill gas, a less scrutinized byproduct, serves as a major pathway for the mobility of PFAS from landfills," the paper's authors wrote.

PFAS are a class of about 16,000 compounds used to make products resistant to water, stains and heat. They are called "forever chemicals" because they do not naturally break down and have been found to accumulate in humans. The chemicals are linked to cancer, birth defects, liver disease, thyroid disease, plummeting sperm counts and a range of other serious health problems. As researchers have begun to understand the chemicals' dangers in recent years, the focus has largely been on water pollution, and regulators have said virtually all leachate from the nation's 200 landfills contain PFAS. But scientists are beginning to understand that PFAS air pollution is also a significant threat.

The first therapy that uses gene-editing is to be offered on the NHS in a "revolutionary breakthrough" for patients. From a report: It will be used as a potential cure for the blood disorder beta thalassaemia. Stem cells which make blood will be extracted, reprogrammed to correct the condition and returned to the patient's body. It could spare them needing a blood transfusion, every three to five weeks, for life. People with beta thalassaemia struggle to produce enough haemoglobin, which is the protein in red blood cells that carries oxygen around the body. It is a genetic disease that is passed down through families and caused by defects in the body's instructions for manufacturing haemoglobin. It can leave people severely tired, weak, and short of breath and also cuts life expectancy.

Another study is raising concern about the safety of the widely used sugar alcohol sweetener erythritol, a low-calorie sugar substitute found in "keto-friendly" foods, baked goods and candies. From a report: Researchers from the Cleveland Clinic compared erythritol to typical sugar and found only erythritol caused worrisome cardiovascular effects. Although the study was small, it's the first head-to-head look at people's blood levels after they consume products with erythritol or sugar (glucose). "We compared the results, and glucose caused none of the problems," said Dr. Stanley Hazen, a cardiologist at the Cleveland Clinic and the lead author of the study, published Thursday morning in the journal Arteriosclerosis, Thrombosis, and Vascular Biology.

Erythritol is one ingredient on a growing list of nonsugar sweeteners found in low-calorie and sugar-free foods. Erythritol and xylitol are sugar alcohols that are sweet like sugar but with far fewer calories. Erythritol is often mixed with another sweetener, stevia, and xylitol is often found in gum, mouthwash and toothpaste. Earlier studies from Hazen's lab -- one published last year and the other in June -- found potential links between the sugar alcohols and an increased risk of heart attacks and strokes. The research suggested both sugar alcohols might make blood platelets stickier and therefore more susceptible to clotting and blocking veins or arteries, in turn contributing to heart attacks and strokes. For the new research, Hazen's team analyzed the heart effects of erythritol and regular sugar -- in this case, simple glucose -- by enrolling two groups of healthy middle-aged male and female volunteers: 10 who consumed the erythritol and 10 who consumed sugar.

An anonymous reader quotes a report from the New York Times: For weeks, NASA has downplayed problems experienced by Starliner, a Boeing spacecraft that took two astronauts to the International Space Station in June. But on Wednesday, NASA officials admitted that the problems with the spacecraft were more serious than first thought and that the astronauts may not travel home on the Boeing vehicle, after all. The agency is exploring a backup option for the astronauts, Suni Wiliams and Butch Wilmore, to hitch a ride back to Earth on a vehicle built by Boeing's competitor SpaceX instead. Their stay in orbit, which was to be as short as eight days, may extend into next year. "We could take either path," Ken Bowersox, NASA's associate administrator for the space operations mission directorate, said during a news conference on Wednesday. "And reasonable people could pick either path."

NASA and Boeing officials had maintained that the crew that launched with Starliner on its first crewed test flight was not stranded in space. Ms. Williams and Mr. Wilmore have spent two months aboard the orbital outpost while engineers continue to analyze data about the faulty performance of several of the Starliner's thrusters when it approached for docking. Under the contingency plan, a SpaceX Crew Dragon capsule would travel to the space station with two astronauts instead of its planned crew of four. Ms. Williams and Mr. Wilmore would then join as full-time members of the space station crew for a half-year stay, returning on the Crew Dragon around next February. "In the last few weeks, we have decided to make sure we have that capability there, as our community, I would say, got more and more uncomfortable," said Steve Stich, the manager of the commercial crew program at NASA. NASA officials said no decision had been made yet.

Ocean temperatures in the Great Barrier Reef are now the hottest in at least 400 years and are an "existential threat" to the planet's unique natural wonder , according to new scientific research. From a report: Scientists analysed long-lived corals in and around the reef that keep a record of temperature hidden in their skeleton and matched them to modern observations. The research, published in the journal Nature, used climate models to find the extreme temperatures of recent decades could not have happened without the extra greenhouse gases in the atmosphere caused mostly by burning fossil fuels.

The "existential threat" to the reef from the climate crisis was "now realised," the scientists wrote, and without ambitious and rapid cuts to greenhouse gas emissions "we will likely be witness to the demise of one of the Earth's natural wonders." The research comes two weeks after the World Heritage committee decided not to place the reef, which covers an area larger than Italy, on its list of sites "in danger," saying it would consider the question again in 2026.

For more than 30 years, the world's largest iceberg was stuck in the Antarctic. Five times the size of New York City's land area and more than 1,000 feet deep, the mammoth piece of ice finally became loose in 2020 and began a slow drift toward the Southern Ocean. Now, A23a, as it's known, is spinning in place. From a report: After leaving Antarctic waters, the iceberg got stuck in a vortex over a seamount, or an underwater mountain. Imagine a 1,400-square-mile piece of ice as deep as the Empire State Building spinning slowly but steadily enough to fully rotate it on its head over the course of about 24 days. The iceberg is spinning near the South Orkney Islands, about 375 miles northeast of the Antarctic Peninsula, "maintaining a chill 15 degree rotation per day," the British Antarctic Survey, the United Kingdom's polar research institute, said on social media.

"It's basically just sitting there, spinning around and it will very slowly melt as long as it stays there," said Alex Brearley, a physical oceanographer and head of the Open Oceans research group at the British Antarctic Survey. "What we don't know is how quickly it will actually come out of this." A23a has been embroiled in drama since the start, a trait it picked up from its parent-berg. A23, which was even bigger than A23a, was one of three icebergs that broke off, or calved, from the Filchner Ice Shelf in 1986. At the time of the calving, A23 was home to a Soviet Union research center and researchers eventually had to abandon the base. A23a broke off later that year and hit bottom in the Weddell Sea, where it would remain for 34 more years.

Chinese scientists discovered water molecules in lunar samples brought back by the Chang'e 5 moon probe, marking the first time whole H2O molecules were found in lunar material. The findings have been published in Nature Astronomy. Smithsonian Magazine reports: The team used X-ray diffraction to analyze the grains of moon soil, in which they found a lunar mineral dubbed ULM-1 whose mass is made up of more than 40 percent water and also includes ammonia. "This is a new form of water stored on the moon," Xiaolong Chen, co-author of the study and physics researcher at the Chinese Academy of Sciences, tells New Scientist's Alex Wilkins.

In the words of CNN's Jessie Yeung, water on the moon is nothing new. Though the samples brought back by the U.S. Apollo missions seemed to show that the moon was dry and lifeless, a recent study suggests that water or hydroxyl may be trapped in glass beads on the moon's surface -- and solar winds could turn the hydroxyl (chemical formula OH) into H2O, according to Yeung. And both American and Indian spacecrafts separately registered what is believed to be water on the moon's surface. This recent discovery, however, marks the first time scientists have found whole molecules of H2O in lunar samples. The findings suggest that "water molecules can persist in sunlit areas of the moon in the form of hydrated salts," the authors write in the study.

According to a recent study, SpaceX's new Starlink direct-to-cell (DTC) satellites are nearly five times brighter than traditional Starlinks due to their lower orbit. While these satellites offer the promise of widespread connectivity, their increased brightness poses challenges for astronomical observations, prompting SpaceX to consider applying brightness mitigation techniques. Space.com reports: The higher luminosity of these DTCs compared to regular Starlinks is partly because they circle Earth at just 217 miles (350 kilometers) above the surface, which is lower than traditional Starlink internet satellites, whose altitude is 340 miles (550 kilometers), the study reported. [...] At the time the study was conducted, SpaceX had not yet applied its routine brightness mitigation techniques to the DTCs, such as adjusting their chassis and solar panels to reduce the portion of spacecraft illuminated by the sun, study lead author Anthony Mallama of the IAU Centre for the Protection of Dark and Quiet Skies from Satellite Constellation Interference (IAU-CPS) told Space.com.

SpaceX began applying brightness mitigation techniques to regular Starlinks in 2020, after astronomers voiced serious concerns about the satellites' trails streaking across telescope images, rendering them unusable. Prior to launch, the company now applies a mirror-like dielectric surface to the underside of each Starlink chassis, to help reflect sunlight into space rather than scattering it toward Earth. Post launch, the company adjusts spacecraft chassis and solar panels to further reduce luminosity. Together, these techniques are very effective, reducing Starlink satellites' brightness by a factor of 10, Mallama said. If SpaceX applies these brightness mitigation techniques to the DTCs, which are nearly the same size as the regular Starlinks, the DTCs would still be 2.6 times brighter than their traditional counterparts, Mallama and his colleagues reported in the recent study, which was reviewed internally by IAU-CPS and posted to the preprint server arXiv last month.

However, while DTCs are brighter objects, they move at a faster apparent rate and spend more time in Earth's shadow than regular Starlinks, which would offset some of their negative impact on astronomy observations, the study noted. "I see it as a tradeoff in parameters rather than an absolute better/worse kind of situation," John Barentine, a principal consultant at Arizona-based Dark Sky Consulting who was not involved with the new study, told Space.com.

Scientists studying lunar samples brought back by the Apollo missions have determined that the moon's thin atmosphere is produced largely by meteorite impacts. "Our findings provide a clearer picture of how the moon's surface and atmosphere interact over long timescales, [and] enhance our understanding of space weathering processes," said Dr Nicole Nie, the co-author of the new study based at MIT's department of Earth, atmospheric, and planetary sciences. The Guardian reports: Writing in the journal Science Advances, Nie and her colleagues describe how the lunar atmosphere must be constantly replenished because its atoms are continuously being lost to space, primarily because of the moon's weak gravity, or trapped on the lunar surface. Ultraviolet photons from the sun can rerelease the latter, but the researchers say replenishment of the atmosphere is thought to rely on atoms being released from within lunar minerals -- either via vaporisation by meteorite impacts, or by solar wind sputtering, a process in which charged particles from the sun hit the moon and eject atoms. But which of the two factors dominates had been unclear, with data from Nasa's lunar atmosphere and dust environment explorer, launched in 2013, suggesting both were at play.

Nie and colleagues unpicked the conundrum by studying the different forms, or isotopes, of potassium and rubidium in 10 samples of lunar soil from the Apollo missions. The team say meteorite impacts and solar wind sputtering both favor the release of lighter forms of the elements, but that the actual proportion of heavy to light isotopes that end up in the lunar atmosphere and soil would differ depending on the process. "After measuring the isotopic compositions of lunar soils, we built a mathematical model taking into account various space weathering processes, and solve for the contribution of each of them by matching the measured isotopic compositions," said Nie. The results suggest about 70% of the moon's atmosphere is down to impact vaporization and 30% to solar wind sputtering.

Late Friday Elon Musk appeared on Lex Fridman's podcast for a special eight-hour episode about Neuralink.

It's already been viewed 1,702,036 times on YouTube — and resulted in this report from Reuters: Neuralink has successfully implanted in a second patient its device designed to give paralyzed patients the ability to use digital devices by thinking alone, according to the startup's owner Elon Musk... [Musk] gave few details about the second participant beyond saying the person had a spinal cord injury similar to the first patient, who was paralyzed in a diving accident.

Musk said 400 of the implant's electrodes on the second patient's brain are working. Neuralink on its website states that its implant uses 1,024 electrodes... Musk said he expects Neuralink to provide the implants to eight more patients this year as part of its clinical trials.
Neuralink's device "has allowed the first patient to play video games, browse the internet, post on social media and move a cursor on his laptop," according to the article: The first patient, Noland Arbaugh, was also interviewed on the podcast, along with three Neuralink executives, who gave details about how the implant and the robot-led surgery work. Before Arbaugh received his implant in January, he used a computer by employing a stick in his mouth to tap the screen of a tablet device. Arbaugh said with the implant he now can merely think about what he wants to happen on the computer screen, and the device makes it happen... Arbaugh has improved on his previous world record for the speed at which he can control a cursor with thoughts alone "with only roughly 10, 15% of the electrodes working," Musk said on the podcast.
Fridman said his interview with Musk was "the longest podcast I've ever done," calling their conversation "fascinating, super technical, and wide-ranging... I loved every minute of it."

A new type of antibiotic "targets bacteria in two ways," writes SciTechDaily, which "could make it 100 million times harder for bacteria to develop resistance, according to recent research from the University of Illinois Chicago." Their experiments demonstrate that [a class of synthetic drugs called] macrolones can work two different ways — either by interfering with protein production or corrupting DNA structure. Because bacteria would need to implement defenses to both attacks simultaneously, the researchers calculated that drug resistance is nearly impossible. "The beauty of this antibiotic is that it kills through two different targets in bacteria," said Alexander Mankin, distinguished professor of pharmaceutical sciences at UIC. "If the antibiotic hits both targets at the same concentration, then the bacteria lose their ability to become resistant via the acquisition of random mutations in any of the two targets."

Macrolones are synthetic antibiotics that combine the structures of two widely used antibiotics with different mechanisms. Macrolides, such as erythromycin, block the ribosome, the protein manufacturing factories of the cell. Fluoroquinolones, such as ciprofloxacin, target a bacteria-specific enzyme called DNA gyrase.... "The main outcome from all of this work is the understanding of how we need to go forward," Mankin said. "And the understanding that we're giving to chemists is that you need to optimize these macrolones to hit both targets."
Thanks to long-time Slashdot reader schwit1 for sharing the news.

The planet Mercury could have "a layer of diamonds," reports CNN, citing new research suggesting that about 310 miles (500 kilometers) below the surface...could be a layer of diamonds 11 miles (18 kilometers) thick.

And the study's co-author believes lava might carry some of those diamonds up to the surface: The diamonds might have formed soon after Mercury itself coalesced into a planet about 4.5 billion years ago from a swirling cloud of dust and gas, in the crucible of a high-pressure, high-temperature environment. At this time, the fledgling planet is believed to have had a crust of graphite, floating over a deep magma ocean.

A team of researchers recreated that searing environment in an experiment, with a machine called an anvil press that's normally used to study how materials behave under extreme pressure but also for the production of synthetic diamonds. "It's a huge press, which enables us to subject tiny samples at the same high pressure and high temperature that we would expect deep inside the mantle of Mercury, at the boundary between the mantle and the core," said Bernard Charlier, head of the department of geology at the University of Liège in Belgium and a coauthor of a study reporting the findings.

The team inserted a synthetic mixture of elements — including silicon, titanium, magnesium and aluminum — inside a graphite capsule, mimicking the theorized composition of Mercury's interior in its early days. The researchers then subjected the capsule to pressures almost 70,000 times greater than those found on Earth's surface and temperatures up to 2,000 degrees Celsius (3,630 degrees Fahrenheit), replicating the conditions likely found near Mercury's core billions of years ago.

After the sample melted, the scientists looked at changes in the chemistry and minerals under an electron microscope and noted that the graphite had turned into diamond crystals.
The researchers believe this mechanism "can not only give us more insight into the secrets hidden below Mercury's surface, but on planetary evolution and the internal structure of exoplanets with similar characteristics."

"Generation X and millennials are at an increased risk of developing certain cancers compared with older generations," reports the Washington Post, "a shift that is probably due to generational changes in diet, lifestyle and environmental exposures, a large new study suggests."

Researchers from the American Cancer analyzed data from more than 23.5 million patients who had been diagnosed with 34 types of cancer from 2000 to 2019 — and also studied mortality data that included 7 million deaths in the U.S. from 25 types of cancer among people ages 25 to 84. [The researchers reported] that cancer rates for 17 of the 34 most common cancers are increasing in progressively younger generations. The findings included:

- Cancers with the most significant increased risk are kidney, pancreatic and small intestine, which are two to three times as high for millennial men and women as baby boomers.
- Millennial women also are at higher risk of liver and bile duct cancers compared with baby boomers.
- Although the risk of getting cancer is rising, for most cancers, the risk of dying of the disease stabilized or declined among younger people. But mortality rates increased for gallbladder, colorectal, testicular and uterine cancers, as well as for liver cancer among younger women.

"It is a concern," said Ahmedin Jemal, senior vice president of the American Cancer Society's surveillance and health equity science department, who was the senior author of the study. If the current trend continues, the increased cancer and mortality rates among younger people may "halt or even reverse the progress that we have made in reducing cancer mortality over the past several decades," he added.

While there is no clear explanation for the increased cancer rates among younger people, the researchers suggest that there may be several contributing factors, including rising obesity rates; altered microbiomes from unhealthy diets high in saturated fats, red meat and ultra-processed foods or antibiotic use; poor sleep; sedentary lifestyles; and environmental factors, including exposure to pollutants and carcinogenic chemicals.

New preliminary evidence for phosphine and ammonia in Venus's atmosphere deepens the mystery of their origins, suggesting the possibility of a biological source. The detections, made using the James Clerk Maxwell Telescope and the Green Bank Telescope, point to potential microbial life in Venus's clouds despite the planet's extreme surface conditions. Space.com reports: The new detections of phosphine and ammonia were obtained by a team led by Jane Greaves of the University of Cardiff using submillimeter radio wavelength data collected by the James Clerk Maxwell Telescope (JCMT) in Hawaii and the Green Bank Telescope in West Virginia. "We don't know how you make phosphine or ammonia in an oxygenating atmosphere like that of Venus," said team member and astrophysicist Dave Clements of Imperial College, London, in an interview with Space.com. Then again, it's not clear why biology on Earth produces phosphine, either." Whether it's in penguin poop or badger guts, we don't know why bacteria make phosphine, but they do."

The JCMT's initial detection of phosphine on Venus in 2020 by Greaves and her team was met by fierce disagreement from some quarters. This disagreement focused on how the data was processed and whether that was creating spurious signals since observations by other telescopes struggled to detect the phosphine. Clements said those technical disagreements have now been resolved and that the latest measurements, using a new detector on the JCMT called Namakanui (meaning 'Big Eyes' in Hawaiian), have come from three observing campaigns, each providing 140 times as much data as the initial detection. [...]

Clements is open to the possibility that both phosphine and ammonia are being produced by some rare photochemistry in Venus' upper atmosphere involving solar ultraviolet breaking up molecules and allowing phosphine and ammonia to form from the molecular debris. If that is the case, nobody has observed this process yet, not even in the laboratory. Another possibility that has been mooted is that the phosphine could be produced by Venusian volcanoes. Clements also pointed out that the European Space Agency's Jupiter Icy Moons Explorer (JUICE) is making a fly-by of Venus in August 2025 to help slingshot it towards the Jovian system. JUICE carries instruments capable of detecting phosphine and ammonia, but there's no guarantee that its instruments will be switched on and deployed at Venus.

An anonymous reader quotes a report from Ars Technica: The US government will pay Moderna $176 million to develop an mRNA vaccine against a pandemic influenza -- an award given as the highly pathogenic bird flu virus H5N1 continues to spread widely among US dairy cattle. The funding flows through BARDA, the Biomedical Advanced Research and Development Authority, as part of a new Rapid Response Partnership Vehicle (RRPV) Consortium. The program is intended to set up partnerships with industry to help the country better prepare for pandemic threats and develop medical countermeasures, the Department of Health and Human Services said in a press announcement Tuesday.

In its own announcement on Tuesday, Moderna noted that it began a Phase 1/2 trial of a pandemic influenza virus vaccine last year, which included versions targeting H5 and H7 varieties of bird flu viruses. The company said it expects to release the results of that trial this year and that those results will direct the design of a Phase 3 trial, anticipated to begin in 2025. The funding deal will support late-stage development of a "pre-pandemic vaccine against H5 influenza virus," Moderna said. But, the deal also includes options for additional vaccine development in case other public health threats arise.

US health officials have said previously that they were in talks with Moderna and Pfizer about the development of a pandemic bird flu vaccine. The future vaccine will be in addition to standard protein-based bird flu vaccines that are already developed. In recent weeks, the health department has said it is working to manufacture 4.8 million vials of H5 influenza vaccine in the coming months. The plans come three months into the H5N1 dairy outbreak, which is very far from the initial hopes of containment. [...] The more the virus expands its footprint across US dairy farms, adapts to its newfound mammalian host, and comes in contact with humans, the more and more chances it has to leap to humans and gain the ability to spread among us. "The award made today is part of our longstanding commitment to strengthen our preparedness for pandemic influenza," said Dawn O'Connell, assistant secretary for Preparedness and Response. "Adding this technology to our pandemic flu toolkit enhances our ability to be nimble and quick against the circulating strains and their potential variants."

In a separate article, Ars Technica reports on a small study in Texas that suggests human cases are going undetected on dairy farms where the H5N1 virus has spread in cows.

An anonymous reader quotes a report from the New York Times: People who regularly eat processed red meat, like hot dogs, bacon, sausage, salami and bologna, have a greater risk of developing dementia later in life. That was the conclusion of preliminary research presented this week at the Alzheimer's Association International Conference. The study tracked more than 130,000 adults in the United States for up to 43 years. During that period, 11,173 people developed dementia. Those who consumed about two servings of processed red meat per week had a 14 percent greater risk of developing dementia compared to those who ate fewer than three servings per month. Eating unprocessed red meat, like steak or pork chops, did not significantly increase the risk for dementia, though people who ate it every day were more likely to report that they felt their cognition had declined than those who ate red meat less often. (The results of the study have not yet been published in a journal.) There have been several studies published in the past few years that have found an association between ultraprocessed foods and cognitive decline. The report notes a study of more than 10,000 middle-aged adults in Brazil, which found that "people who consumed 20 percent or more of their daily calories from ultraprocessed foods experienced more rapid cognitive decline, particularly on tests of executive functioning, over the course of eight years."

Physicists have been exploring the theoretical possibility of warp drives, which could propel spaceships faster than light by compressing spacetime. A new study published in the Open Journal of Astrophysics simulates the gravitational waves such a drive might emit if it failed, showing potential detectable signals by future high-frequency instruments and advancing our understanding of exotic spacetimes. Phys.Org reports: The results are fascinating. The collapsing warp drive generates a distinct burst of gravitational waves, a ripple in spacetime that could be detectable by gravitational wave detectors that normally target black hole and neutron star mergers. Unlike the chirps from merging astrophysical objects, this signal would be a short, high-frequency burst, and so current detectors wouldn't pick it up. However, future higher-frequency instruments might, and although no such instruments have yet been funded, the technology to build them exists. This raises the possibility of using these signals to search for evidence of warp drive technology, even if we can't build it ourselves.

The study also delves into the energy dynamics of the collapsing warp drive. The process emits a wave of negative energy matter, followed by alternating positive and negative waves. This complex dance results in a net increase in the overall energy of the system, and in principle could provide another signature of the collapse if the outgoing waves interacted with normal matter.

An anonymous reader quotes a report from The Guardian: With thousands of species at risk of extinction, scientists have devised a radical plan: a vault filled with preserved samples of our planet's most important and at-risk creatures located on the moon. An international team of experts says threats from climate change and habitat loss have outpaced our ability to protect species in their natural habitats, necessitating urgent action. A biorepository of preserved cells, and the crucial DNA within them, could be used to enhance genetic diversity in small populations of critically endangered species, or to clone and create new individuals in the worst-case scenario of extinction.

The proposed lunar biorepository, as described in the journal BioScience, would be beyond the reach of climate breakdown, geopolitical events or other Earth-based disasters. The moon's naturally frigid environment means samples would remain frozen year-round without the need for human involvement or an energy source. By taking advantage of deep craters near the polar regions that are never exposed to sunlight, the moon is one of few places that can provide the ultra-low temperature of -196C necessary to preserve the samples in a way suitable for future cloning. [...] Besides those facing the imminent risk of extinction, the proposed repository would prioritize species with important functions in their environment and food webs. Through careful selection, those housed could be used to re-establish an extinct population on Earth or even to terraform another planet. Dr Mary Hagedorn of the Smithsonian's national zoo and conservation biology institute and the proposal's lead author believes the biorepository proposal will come to fruition, although perhaps not in our lifetime: "We know how to do this and can do this and will do this, but it may take decades to finally achieve," she said.

The report says the next steps "will be to develop packaging for the cryopreserved samples that can withstand the conditions of space, and to work out the logistics of transporting samples to the moon."

An anonymous reader shares a report: A recent meeting of the American Society for Nutrition in Chicago was presented with an observational study of more than 500,000 people in the US. It found that those who ate the most UPFs (ultra-processed foods ) had a roughly 10% greater chance of dying early, even accounting for their body-mass index and overall quality of diet. In recent years, lots of other observational studies have shown a similar link - but that's not the same as proving that how food is processed causes health problems, or pinning down which aspect of those processes might be to blame.

So how could we get to the truth about ultra-processed food?

The kind of study needed to prove definitively that UPFs cause health problems would be extremely complex, suggests Dr Nerys Astbury, a senior researcher in diet and obesity at Oxford University. It would need to compare a large number of people on two diets -- one high in UPFs and one low in UPFs, but matched exactly for calorie and macronutrient content. This would be fiendishly difficult to actually do. Participants would need to be kept under lock and key so their food intake could be tightly managed. The study would also need to enrol people with similar diets as a starting point.

It would be extremely challenging logistically. And to counter the possibility that people who eat fewer UPFs might just have healthier lifestyles such as through taking more exercise or getting more sleep, the participants of the groups would need to have very similar habits. "It would be expensive research, but you could see changes from the diets relatively quickly," Dr Astbury says. Funding for this type of research could also be hard to come by. There might be accusations of conflicts of interest, since researchers motivated to run these kind of trials may have an idea of what they want the conclusions to be before they started.