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Lung Cancer Diagnoses On the Rise Among Never-Smokers Worldwide (theguardian.com) 46

The proportion of people being diagnosed with lung cancer who have never smoked is increasing, with air pollution an "important factor," the World Health Organization's cancer agency has said. From a report: Lung cancer in people who have never smoked cigarettes or tobacco is now estimated to be the fifth highest cause of cancer deaths worldwide, according to the International Agency for Research on Cancer (IARC). Lung cancer in never-smokers is also occurring almost exclusively as adenocarcinoma, which has become the most dominant of the four main subtypes of the disease in both men and women globally, the IARC said.

About 200,000 cases of adenocarcinoma were associated with exposure to air pollution in 2022, according to the IARC study published in the Lancet Respiratory Medicine journal. The largest burden of adenocarcinoma attributable to air pollution was found in east Asia, particularly China, the study found.

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Lung Cancer Diagnoses On the Rise Among Never-Smokers Worldwide

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  • Well Duh (Score:4, Insightful)

    by rossdee ( 243626 ) on Tuesday February 04, 2025 @11:06AM (#65140965)

    "The largest burden of adenocarcinoma attributable to air pollution was found in east Asia, particularly China, the study found."

    Remember in the years before covid they were all wearing cloth masks because of the pollution...

    • Add disgusting CA to the list next year. Yuck.
      • Except no....
        Southern California has the highest average lifespan in the country.

        • Well what do you know its the midwest and southern states with the highest lung cancer rates. https://www.cdc.gov/mmwr/volum... [cdc.gov]

          • But is it high among non-smokers?

            I can see those states still having a high proportion of smokers given demographics, culture war stuff, etc.

          • Wildfires aren't as hazardous to your health as oil refineries and manufacturing. Companies try to locate those things away from major cities with lawyers and stuff like that.

        • by Hadlock ( 143607 )

          Wildfire smoke only lasts for 6-36 hours every 2-5 years and is largely negated by staying inside. I'm not sure historic drought conditions and a handful of recent wildfires is going to have much impact on lung cancer rates in the short or medium term

      • Add Utah (2 million of the 3.8 million residents live in along biseasonly heavily polluted Wasatch Front. Summer and Winter.) For about 20-60 days every year it has the worse air pollution in the western hemisphere. And often the world.
    • Many, yes, but wearing masks is common enough in China just for general health infections reasons - ie if you have a cold/caugh/etc and are on public transport...in my experience anyway.

  • Not surprising. (Score:5, Insightful)

    by Geraden ( 15689 ) on Tuesday February 04, 2025 @11:07AM (#65140971) Homepage

    Given the global news stories about the air pollution in China, and the persistent smog(s) associated with that, is anyone really surprised?

    • I think your news is out of date. Pollution levels have been improved drastically.

  • Air pollution causes cancer -- WHO.
    CO_2 is air pollution -- EPA
    Therefore CO_2 causes cancer.

    • Because all air pollution = CO2?

      Brilliant.

      • by Bert64 ( 520050 )

        Off on a slight tangent here, but a lot of countries focused very heavily specifically on reducing CO2 emissions.
        CO2 was the target they were measured against, so you had vehicle manufacturers design vehicles to emit less CO2, but this often resulted in greater emissions of other things instead.

        A lot of regulation ends up this way, focus too much on a specific thing and it ends up being replaced with something worse.

        • Pretty sure that CO2 is a good thing for regular old passenger vehicles. Incomplete combustion is the biggest source of the hazards of car exhaust. The only useful way to lower CO2 on vehicles is better fuel efficiency. I would be interested in seeing citations on the specific vehicle emissions standards that focus on CO2 that you're referring to.

        • CO2 was the target they were measured against, so you had vehicle manufacturers design vehicles to emit less CO2, but this often resulted in greater emissions of other things instead.

          I very much doubt that.

          These are separate problems. Increasing fuel efficiency does not lead to an increase in other emissions. LEVs and ULEVs (stringent NOx and NMOG emissions permile limits) also universally have excellent mileage (low CO2 emissions per mile)

          I think you're full of shit.

          • by Bert64 ( 520050 )

            Several countries set vehicle tax rates solely based on CO2 and ignoring other factors.

            A focus on CO2 in european countries led to increased sales of diesel cars, precisely because they emit less CO2.
            Instead you get more PM10, PM2.5, NO2 or NOx, which later became a problem. Now the focus has shifted.

            • Several countries set vehicle tax rates solely based on CO2 and ignoring other factors.

              No. Part of that sentence is true, the other half of it you made up.

              A focus on CO2 in european countries led to increased sales of diesel cars, precisely because they emit less CO2.

              Europe has been diesel-heavy since I was a kid. First, the oil shock in the 70s, then advent of really good TDI engines. The European diesel-heavy vehicle population predates concern about CO2 by 2 decades.

              Instead you get more PM10, PM2.5, NO2 or NOx, which later became a problem. Now the focus has shifted.

              Diesel vehicles are being replaced by electric vehicles.
              The focus hasn't shifted, because those that care about efficiency have upgraded to the next best thing.
              Diesels are still vastly cheaper than gasoline cars in Europe.

              Your narrati

              • by Bert64 ( 520050 )

                Various factors, including a focus on CO2 resulted in an increase in diesel sales in many european countries.

                For example, UK vehicle tax rates were previously tied directly to CO2 emissions:

                https://www.gov.uk/vehicle-tax... [www.gov.uk]

                Now (since 2017) they have explicitly higher tax rates for diesel vehicles because they realised the side effects of solely focusing on co2:

                https://www.gov.uk/vehicle-tax... [www.gov.uk]

                The CO2 tied tax rate resulted in a significant increase in sales of diesel vehicles, and prompted manufacturers who

    • by allo ( 1728082 )

      And witches are made of wood.

    • Some air pollution causes cancer
      Some CO2 is air pollution
      CO2...may have nothing to do with cancer. There is zero data available.

      Not sure if your first grade understanding of pollution is intentional or fake, but PM2.5 particulates are the most likely worst culprit.

  • Huh (Score:2, Informative)

    by Anonymous Coward
    As it happens I was diagnosed with lung cancer last week. 50 yo, zero risk factors. Started seeing doctors a couple years ago because of a marked and continual decline in aerobic capacity and increasing fatigue, to where I was falling asleep at my desk a few times per day.

    Doctors (well, not M.D.s, you can't see a full M.D. these days) thought it was aging, depression, bronchial infection, low T, because all those things were happening too. Blood tests did not reveal anything. Not until one of my lymph

  • One thing found so far that doesn't cause cancer ... https://www.marketwatch.com/st... [marketwatch.com]
  • by spitzak ( 4019 ) on Tuesday February 04, 2025 @12:13PM (#65141141) Homepage

    The proportion of the population that has never smoked is going up. If how much lung cancer is caused by smoking does not change, and all other cancer is spread evenly among the population, then the proportion of people with lung cancer who never smoked is going to increase. It does not matter if there is more or less or the same amount of cancer caused by air pollution.

    • In most developed countries, the air quality has been steadily improving for over a century, and is still improving. Switching from coal to petrol or electricity for transport,switching from wood to gas for heating and cooking, all made a huge difference. And we've got cleaner industry and cleaner cars now, so even the air in city centers is way better than it was 10, 20, 50 or 100 years ago.

      So is the total number of people getting cancer going up? Maybe there's another cause, microplastics, or some o
    • The proportion of the population that has never smoked is going up. If how much lung cancer is caused by smoking does not change, and all other cancer is spread evenly among the population, then the proportion of people with lung cancer who never smoked is going to increase. It does not matter if there is more or less or the same amount of cancer caused by air pollution.

      Beat me to it.

      Cancer itself, you'll recall, loomed larger as cause of death after infections were knocked out of first place (by antibiotics). Because more people weren't killed off by infections and now lived long enough to get cancers. Not because cancers magically became more prolific in and of themselves.

      Things are gonna shift around, but that doesn't mean that simple soundbites about new positions for the remaining maladies will be all that meaningful.

    • by jonadab ( 583620 )
      > The proportion of the population that has never smoked is going up.

      That's very true in the first world, particularly North America.

      But in certain other parts of the world, it's almost certainly mostly the increase in pollution. The international poster child for this is, of course, China; but a number of other countries have a serious air-pollution problem as well, not least India.
  • Let's see this data alongside:
      * prevalence of smoking in movies (as a factor: scenes with one or more smokers divided by total scenes) against time
      * Sales of cigarettes against time

  • But, but, we recycle everything to avoid pollution! (jump to 2:25) [cbsnews.com]

    I wouldn't be surprised if microplastics were part of this cancer rise, too. Pick your poison...
  • by SchroedingersCat ( 583063 ) on Tuesday February 04, 2025 @12:48PM (#65141253)
    If pollution is going to kill you might as well enjoy a good cigar in the meantime.
    • >"If pollution is going to kill you might as well enjoy a good cigar in the meantime."

      Pipe/cigar smoking very rarely (if ever) involves inhaling smoke into the lungs (my understanding it is generally mouth-only or sometimes mouth-to-nose only). This is why the stats I have seen about men who regularly smoke pipes/cigars (and never cigarettes) are at barely any additional risk for lung cancer vs. non-smokers. I suppose the risk would increase if regularly done inside instead of outside, though (SHS).

      • by jbengt ( 874751 )
        Serious cigar smokers, like my dad used to be, definitely inhale plenty of tobacco smoke.
  • ... smoking on public transit. Our state health department says it's nothing to worry about. Even if the bus drivers complain about dizziness and the stink.

    Just don't try to light up a cigarette within 25 feet of a bus stop.

  • no matter whether it's deployed by left-wingers, right-wingers, Republicans, Democrats, non Americans, etc. It's the tactic, and it's deliberately deceptive.

    Note the headline: "Lung cancer diagnoses on the rise among never-smokers worldwide". The problematic bit is the "worldwide". When one says "worldwide", the reader is encouraged to think there's an essentially even distribution globally. Had it said "nationwide", the reader would have been encouraged to assume an even distribution throughout the nation.

  • Recommend reading Weinberg and Hanahan's Hallmarks of Cancer series of papers.

    The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list—reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.

    https://www.cell.com/fulltext/... [cell.com]

    Then "Pan-cancer analysis of whole genomes." Paying specific attention to figure 2. https://www.nature.com/article... [nature.com]

    Doesn't take much for lung cancer

    we show that only three sequential mutations are required to develop lung and colon adenocarcinomas, a number that is lower than what is typically thought to be required for the formation of cancers of these and other organs. https://pmc.ncbi.nlm.nih.gov/a... [nih.gov]

    Hanan Polansky's Microcompetition with Foreign DNA and the Origin of Chronic Disease. https://archive.org/details/mi... [archive.org]

    An under recognized risk factor may be viruses. Some lay dormant in most of us. Co-infection with multiple viruses looks to

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