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Science

Scientists Propose 'Bodyoids' To Address Medical Research and Organ Shortage Challenges (technologyreview.com) 32

Stanford University researchers have proposed creating "bodyoids" -- ethically sourced human bodies grown from stem cells without neural components for consciousness or pain sensation -- to revolutionize medical research and address organ shortages. In a new opinion piece published in MIT Technology Review, scientists Carsten T. Charlesworth, Henry T. Greely, and Hiromitsu Nakauchi argue that recent advances in biotechnology make this concept increasingly plausible. The approach would combine pluripotent stem cells, artificial uterus technology, and genetic techniques to inhibit brain development.

The researchers point to persistent shortages of human biological materials as a major bottleneck in medical progress. More than 100,000 patients currently await solid organ transplants in the US alone, while less than 15% of drugs entering clinical trials receive regulatory approval. These lab-grown bodies could potentially generate patient-specific organs that are perfect immunological matches, eliminate the need for lifelong immunosuppression, and provide personalized drug screening models.

Scientists Propose 'Bodyoids' To Address Medical Research and Organ Shortage Challenges

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  • Just grow a new body every so often, and move your brain over.
  • by zawarski ( 1381571 ) on Friday March 28, 2025 @04:05PM (#65266117)
    Nah. That is apparently impossible.
  • by gurps_npc ( 621217 ) on Friday March 28, 2025 @04:11PM (#65266137) Homepage

    First, let me state that more viable organs for transplants will definitely save lives. I speak from experience, as I underwent a kidney transplant about 5 years ago. Their are long waiting lists, and if could give out organs to all that need them, we could probably expand the lists and save cancer patients by cutting deeper.

    Second, there are multiple ways to solve this problem. Certain less reputable countries solve it via prisoners. Others solve it via cash payments. But these less reputable solutions are not the only ones.

    Some countries solve the problem not with money or unethical laws, but instead with social engineering. Spain is the world leader in organ transplants. They do so not with criminals and not with money. Instead they have an 82% consent record. That means that 82% of families asked to donate organs do so.

    Others countries do it by switching from an opt-in (you agree to donate), to an opt-out (where if you do not want to donate after death you must sign an opt-out preventing donation). Though truthfully this does not result in a huge difference unless the culture also changes.

    But even without attempting to change the culture / laws, there are good reasons to create these organs for the purpose of transplantation. New tech does not just solve the existing problems, it also creates new demand for problems we did not know existed.

    For example, there are things called domino transplants, where an organ donor gives a healthy organ to someone in desperate need while simultaneously getting a less healthy organ themselves from a deceased donor. This lets someone that is borderline donor candidate give to someone that is a borderline recipient candidate, where normally the doctor would say it is too risky for either of them.

    If we have an excess of cheap organs, then we could significantly lower the requirements before we transplant. It would be nice for people with failing organs that also have hepatitis to get an organ transplant and hope to cure the hepatitis, rather than waiting to cure the disease before they transplant.

    If hospitals had organs ready to go, stored in the hospital, then when someone is in an accident, they could both fix the accident damage and give them a new organ in one surgery, rather than patching them up and waiting for them to make it to the top of the organ list.

  • Ithought we were going to grow hearts on demand using pigs? I've sunk all my wealth in to pigs for this!
  • Well... (Score:4, Informative)

    by sconeu ( 64226 ) on Friday March 28, 2025 @04:14PM (#65266147) Homepage Journal

    Slashdot has perfected "Storyoids" where there are multiple identical stories, so that researchers can use story parts from any of them in any other of them.

  • Let's go with brainless monkeys/apes before trying brainless humans.

    Why? Mostly to cut down on the screaming by those who will say "brainless people are people" and "you are murdering people."

  • that Real Dolls was already working on this problem for... call it an adjacent market.
    • There's very little chance for this to become a sex doll. They propose a brainless body. It is still a body, born as a braindead baby. You need 24/7 healthcare monitoring with specialized nurses to have it survive. The daily hospital fee during years makes that nothing other than organ harvesting for use in the same hospital where the bodyoid is grown/bred makes sense as a business model. Of course someone can abuse the body, but that can't be an official business at scale because the service would have to

  • by Pseudonymous Powers ( 4097097 ) on Friday March 28, 2025 @04:30PM (#65266185)
    Mark my words, one day somebody's gonna find the place where they dump all the heads that supposedly never existed.
  • Hopefully this works out better than the chicken meat grown from stem cells in that episode of Eureka...
    • by ebunga ( 95613 )

      Rumors of kidnappings. Missing persons cases closed almost as soon as they're opened. Houses going vacant, and being bulldozed overnight. Everything changed as soon as that new medical research lab opened up.

      Goddammit, now I need to write a screenplay this weekend.

    • That sounds interesting, anyone have a link to where people can view the episode?

  • Just go straight to the Axlotl Tanks? https://dune.fandom.com/wiki/A... [fandom.com] ;-D
  • I've seen this movie. It's called The Island [imdb.com] .
  • Wow! now we know what the union run public schools are doing!
  • But it will happen covertly somewhere like designer babies that have been offered since the late 1990s to 'parents' willing to pay. Saw an ad in the Palo Alto Weekly in the 1990s that allowed 'parents' to select the characteristics of their 'child'. Ad was by a biomed company trailing the technique. The ethical factors here are off the scale.
  • At least on a small, dip their toes in the water kind of way.

    They grow organoids -- and we have the ability to trigger differentiating gene's to cause the stem sells to organize in to heart tissue, brain tissue, retinal tissue -- you name it. And they are getting better and growing these faster and scaling up for better research.

    For those who don't know, easy to look up. The nutshell is they are mini versions of organs and tissue types which are all kinds of useful in studying the effects of disease, medi

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