Ageing Accelerates at Around Age 50 - Some Organs Faster Than Others (nature.com) 57
A new analysis of protein changes across human tissues has identified an aging acceleration point around age 50, with blood vessels showing the most dramatic deterioration. Researchers examined tissue samples from eight body systems in 76 people of Chinese ancestry aged 14 to 68 who died from accidental brain injury, finding age-related increases in 48 disease-associated proteins.
Between ages 45 and 55, the most significant shift occurred in the aorta, the body's main artery carrying oxygenated blood from the heart. The team identified one aortic protein that triggers accelerated aging signs when administered to mice. Early aging changes appeared around age 30 in the adrenal gland, which produces various hormones. The study, published in Cell, adds to mounting evidence that aging occurs in waves rather than following a steady progression.
Between ages 45 and 55, the most significant shift occurred in the aorta, the body's main artery carrying oxygenated blood from the heart. The team identified one aortic protein that triggers accelerated aging signs when administered to mice. Early aging changes appeared around age 30 in the adrenal gland, which produces various hormones. The study, published in Cell, adds to mounting evidence that aging occurs in waves rather than following a steady progression.
NRA: Idaho (Score:4, Insightful)
"How did you go bankrupt?" Bill asked.
"Two ways," Mike said. "Gradually and then suddenly."
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Lots of friends going well till early 60's and then BAM, everyone getting hit with health problems.
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Nah, turns out the extended warranty is just a scam.
Gradually... (Score:2)
"How did you go bankrupt?" Bill asked.
"Two ways," Mike said. "Gradually and then suddenly."
Don't forget to credit Ernest Hemingway for the quote (from The Sun Also Rises).
Re: Gradually... (Score:2)
What if the Fed, suddenly, bails you out, because you're too big to fail?
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Time to go on a hamburger and chocolate diet, guaranteed bankruptcy protection.
Re: Gradually... (Score:2)
Is it working for Trump?
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Well, that's sad... (Score:5, Funny)
Whatever comes out of this research will be too late to save most of us slashdotters.
But then, Netcraft did confirm our death decades ago.
As soon as they say "mice" (Score:2)
Why do I prefer death to using knowledge gained from torturing fellow mortals?
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The issue is morally complex.
We need the scientific knowledge to save human lives, in potentially very large numbers. If we sit on our hands and just let them die, then we commit a moral sin of inaction.
But the only way to obtain the knowledge involves experimentation that brings suffering and death to a small number of animals. Imposing needless suffering and death on living beings is also a moral sin.
Dammed if you do, dammed if you don't.
The discriminating principle then becomes one of value. Human liv
Re: As soon as they say "mice" (Score:1)
"we commit a moral sin of inaction"
What if everything we do medically is just placebo anyway so we can avoid all the animal torture? Is it possible you will keep coming up with excuses why we need to be violent, because you simply like violence?
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As it turns out, most of what we do medically is not just placebo. In fact, the overwhelming majority of medical practice is not placebo, with elements of the placebo effect engaged only in very specific circumstances. This is for a few reasons, one being that the placebo effect isn't reliable as a form of medical treatment in most cases (even though it needs to be accounted-for in clinical testing). So, the animal testing is still needed to produce non-placebo treatments that are effective and reliable.
Re: As soon as they say "mice" (Score:2)
How come Jains have existed since before recorded history, practicing nonviolence?
Are scientific treatments really more reliable as you claim? Why didn't chemotherapy do anything to stop my Dad's cancer, and why did the depression drugs my brother was prescribed fail to prevent his suicide?
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I am very sad to hear about the deaths in your family. That kind of loss can cause terrible emotional trauma. If you have any support services available, like grief counseling or therapy, I hope that you can reach out. Sometimes we need help to heal from emotional wounds like that. Please don't face that pain alone if you don't have to.
Chemotherapy is an "imperfect solution." It usually works against cancer, but not always. The type of cancer matters a lot, and also how early it is detected matters a
Re: As soon as they say "mice" (Score:2)
So do I still have the freedom to be suspicious of medicine and avoid doctors as much as possible because I don't trust them, and how much freedom of speech do I have to try to make you wary too? If I remain unconvinced by your defense of scientifc medicine because it all just seems like fad, when doctors tell us coffee is bad, then good, and prostate cancer iis an epidemic, then just natural (my Dad underwent prostate surgery then died of cancer just a few years later before any prostate problems would ha
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Well I don't understand you now. I have no influence over your level of freedom. And whether or not you listen to reason is your choice.
Your individual experience does not negate the stats. Medicine gets good results for most people most of the time, in accordance with the details of their condition. And I said before that everyone is different and no principle of human behavior is universal, which is why video games never appealed to you.
You aren't presenting sound arguments against my positions. You
Re: As soon as they say "mice" (Score:2)
Csn you see that every measurement and its interpretation is a social act, such that measurement was used to disprove heliocentricism and continental drift theory? Why do you trust that today's measurements won't be subject to radical revisions, and when that happens will you just happily shift with the consensus and sct as if you'd always been right, because feeling mood affiliated with whatever the consensus is saying these days is the real, emotional, goal you're after?
Life enjoyment (Score:2, Insightful)
It's OK (Score:3, Funny)
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I self-identify as a perpetual 30 year old so I should be fine.
Me too! I'm trans-age and age-fluid.
Gee thanks (Score:2)
Aging occurs in stages (Score:4, Insightful)
And yeah, for me, 48 years old was the big downslide. So many small things start going wrong at the same time. And the maddening thing is, you still feel young inside. It's just that you slowly give up on stuff because the body doesn't follow. It's like seeing opportunities disappear and doors closing. Not fun...
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I'm 48 and holy crap I must agree. My back is hurting on and off, never used to. Foods I used to eat just fine now make me feel bleah and sick to my stomach. I've needed new eyeglass prescriptions four times in the last five years; before I went with the same prescription for a decade.
It's perfectly normal but still scary. It's like suddenly your body goes "Okay I've had enough" and yells at you to take it easier.
I hate it.
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Thankfully, lifestyle can have a big impact on the age when this slide starts to occur. At 59, by eating (mostly) healthy and daily bike rides, I've been able to stay healthier than most 50-year-olds. Sure, I feel an occasional twinge of early arthritis, and I've had cataract surgery. But I'm *far* more healthy than my own younger brother. Some of that is genetics, but a lot comes down to how well you take care of yourself.
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Same here.
However, fixing food, sleep and exercise has been tremendous! At the moment, at 52, the physiological clock is back in so many ways. Even eyesight improved a little bit.
Energy levels, fat content, brain power, muscle strength, explosiveness and elasticity, heart, lungs, skin....I have that better now than when I was 40. Sure, there is no ultimate win against time, but the divergence between people as they age is so enormous as to be baffling to me for the longest time. I always thought genetics is
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All of you in your 50's and believe that your still doing great, may have a big surprise soon. I was fine until my mid 50's then shit hit the fan. It does not take much to start the slide, for me it was a knee replacement, that led to forced retirement, not being able to train and work out as usual, which led to everything else going to hell, etc. Around and around we go. I'm now in my mid 60's and am not half the man I was just ten years ago. Now this is all just my experience and YMMV, but just don't
Well thats encouraging... (Score:3)
...for someone wearing C/pap with 80 breath stops an hour. Fun times ahead for me.
Well - accelerated fun living it is then, live it up folks!
Transalation (Score:1)
Next story: How to build your digital gravestone with Free software.
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Makes sense that organs age varying-ly (Score:2)
The jokes are real! (Score:2)
I think we've all experienced this. At 30-ish, suddenly you can't drink as much, your neck and back start to get tweaked more often, you're not as powerful an athlete as you used to be (though sometimes you get better in other ways).
At 40 my eyesight started to go. I started wearing computer glasses. My aches and pains were worse, and I took so much longer to heal. I went on statins because even while I stayed athletic and ate pretty well, I just couldn't get my triglicerides any lower.
I'm 48 now, and I'll
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Yeah, the worse your mind is doing, the easier it is to be satisfied with life.
Exercise (Score:2)
When you are in your teens and twenties you are in your physical prime and everything comes easy to you with little exercise. Later in life its more like the Red Queen, "it takes all the running you can do, to keep in the same place. If you want to get somewhere else, you must run at least twice as fast as that!".
You are going to need to do some serious exercise as you get older in order to keep the health you used to get for free. And I don't mean taking leisurely walks either, it has to seriously work you
What's the distribution? (Score:2)
News articles like to talk about a single inflection point because it's easier for everyone to understand. However, the likely reality is that there is a distribution. The shape and width of that distribution is just as important, if not more important. Do some people see this effect at age 40 or age 70? Are there genetic or environmental effects? Or is this a threshold that is independent of genetics and environment?
Unfortunately the article is paywalled.
I was OK at 53, but at 56 it's catching up (Score:1)
At 53, I lost some weight, and felt and looked healthier than I had been in many years. Doctors were happy with my condition. As had been the case for all my life, in my photos, I looked far younger than I was.
Just three years later, I now look my age, for the first time ever. My appearance aged many years in a short time. I now have to do "intermittent fasting", about 40 hours of no food, two or three times per week. Not because it's a fad, not because I'm trying to get thin, but just to fix my digesti
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Thanks!
I've tried some probiotics, with little effect, but knew there had to be one that would help. I'll get some Florastor soon, to see if it works for me.
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Agreed!
Along that line, I suspect that in a few years we will find out that many mental conditions are caused or exacerbated by a lack of or excess of a vitamin or mineral. Our overprocessed diet has been making it far worse. Medicine needs to happen differently for each person, and diet needs to get back to fundamental, natural foods.
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Can confirm (Score:2)
I lost an organ the year I turned 50. Had to get a transplant.
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I was one of those who always looked much younger than my actual age. Then, when I was 53, my left internal carotid artery unraveled. Right out of the blue. Besides the obvious plumbing issue, there was collateral damage to the wiring, and there are neurological issues as well. I have no stamina (chronic fatigue), my eyes are all fracked up, and I have serious vertigo problems - like just falling down at random times. I call it 'tumbling the gyros'. Lord knows how many micro-strokes I had before it smoothly
Inherently physical or social? (Score:2)
Many questions... (Score:3)
So many factors potentially involved - we need, IMO, answers based on complete questions that factor in as many variables as possible. Remember how so many people believed that your metabolism tanks after 30, and yet years later on it was found that in fact it stays relatively level until ~60?