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Medicine Science

Study Finds Tattoo Ink Moves Through the Body, Killing Immune Cells (latimes.com) 201

Bruce66423 shares a report from the Los Angeles Times: Tattoo ink doesn't just sit inertly in the skin. New research shows it moves rapidly into the lymphatic system, where it can persist for months, kill immune cells, and even disrupt how the body responds to vaccines. Scientists in Switzerland used a mouse model to trace what happens after tattooing. Pigments drained into nearby lymph nodes within minutes and continued to accumulate for two months, triggering immune-cell death and sustained inflammation. The ink also weakened the antibody response to Pfizer Inc. and BioNTech SE's COVID vaccine when the shot was administered in tattooed skin. In contrast, the same inflammation appeared to boost responses to an inactivated flu vaccine. "This work represents the most extensive study to date regarding the effect of tattoo ink on the immune response and raises serious health concerns associated with the tattooing practice," the researchers said. "Our work underscores the need for further research to inform public health policies and regulatory frameworks regarding the safety of tattoo inks."

The findings have been published in the journal Proceedings of the National Academy of Sciences.
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Study Finds Tattoo Ink Moves Through the Body, Killing Immune Cells

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  • by olsmeister ( 1488789 ) on Wednesday December 03, 2025 @04:06AM (#65831753)
    This could be the beginning of the discovery of an amazing time-release drug delivery system!
  • by DrXym ( 126579 ) on Wednesday December 03, 2025 @04:24AM (#65831787)
    So Swiss scientists were giving mice tramp stamps?
  • Wow! (Score:3, Insightful)

    by Viol8 ( 599362 ) on Wednesday December 03, 2025 @04:27AM (#65831793) Homepage

    So injecting an artificial dye into the human body can have deliterious effects! Who'd have thunk it?

    Luckily - other than with criminals - covering yourself in naff tats seems to have been a millennial fad that is slowly fading. I guess they still wanted to look tough (failed) while sipping their skinny latte frappucino with whipped cream.

    Gen-Z seem to be a bit body smarter.

    • Re:Wow! (Score:4, Informative)

      by haruchai ( 17472 ) on Wednesday December 03, 2025 @04:59AM (#65831825)

      "a millennial fad that is slowly fading"
      upvote for the pun but i'm seeing more people getting inked than ever.
      the daughter of a colleague is making nearly 6 figures after only 2 years experience.
      i don't understand the urge to cover oneself in tattoos but different strokes

      • by tlhIngan ( 30335 )

        It's only recently did tattoos go from underground shame to acceptance by most of the public. Probably started around the 90s, and from there the popularity of them took off.

        Before that, usually a person with a tattoo was someone mixed up in bad dealings you wanted to avoid.

        But since general perception has changed, they've gotten a lot more accepted and more people get them in places that are a lot more visible (people who got them usually had them hidden under clothing). In more conservative circles, this

        • by HiThere ( 15173 )

          It varies from time to time. In the 1940's it was common for folk to get tattoos, at least in the US Navy. Ozzy the iceman was covered with tattoos. (Of course, since he was killed it might indicate that he was something analogous to a criminal, but probably not.)

        • by flink ( 18449 )

          The real problem with tattoos is they're permanent, and I can't really tell you anything I liked 10 years ago I still like today, which means "forever" is kind of reserved for something I'm not quite sure what yet.

          So are scars, but people still skateboard or rock climb or whatever. If you care that much about what you might think about it in 10 years then a tattoo is probably not for you. It's an imprint left by a decision that past you made on current you. It's just a little more intentional than that time you decided to dive for a fly ball and landed on a broken bottle or whatever.

          Yeah, current you might not align 100% with past you's choices, but that's life. You integrate them into your identity as best you c

          • by tlhIngan ( 30335 )

            So are scars, but people still skateboard or rock climb or whatever. If you care that much about what you might think about it in 10 years then a tattoo is probably not for you. It's an imprint left by a decision that past you made on current you. It's just a little more intentional than that time you decided to dive for a fly ball and landed on a broken bottle or whatever.

            Yeah, current you might not align 100% with past you's choices, but that's life. You integrate them into your identity as best you can a

    • Re:Wow! (Score:5, Insightful)

      by gtall ( 79522 ) on Wednesday December 03, 2025 @05:25AM (#65831853)

      Tats sort of look okay up until age 30. Between 30-40, you look like you are fighting old age and losing. Between 40-50, you look like you are trying to fit into your kids' social group. Between 50-60, you look like your crazy uncle having a mid-life crisis. Between 60-70, you look like you think you are still 18 going on 80. Between 70-80, you look like a badly worn carpet, Between 80-90, you are absolutely hideous and they make you look like a decayed corpse. From 90 on, you will be a decayed corpse before you are a decayed corpse.

      • Re:Wow! (Score:5, Funny)

        by outsider007 ( 115534 ) on Wednesday December 03, 2025 @05:42AM (#65831873)

        That's what it looks to boomers. Who knows what it looks like to zoomers?
        Between 60 and 99 - I only want to see green faded-ass anchors aways and mermaids with titties out.
        Between 50 and 60 - Chinese Symbols are ok, Anchors or titty mermaids are "Oh god, Dad!"
        Between 40 and 50 - Full sleeves or blackouts are cool, Chinese Symbols are trying too hard
        Between 30 and 40 - Full sleeves and blackouts are eww, gross. Full body snakes are TDF
        Between 20 and 30 - I'm guessing the only acceptable tats are skibidi toiilets and minecraft.

        • by AmiMoJo ( 196126 )

          There was that period in the 2000s when faux Celtic symbols were popular. They looked cool for about 5 minutes, then they were too common.

          Most people with Chinese characters don't seem to have bothered to figure out what the actual word they want is, they just pick some that sound kinda like the English version, or what some website claimed it was. Often they end up being kinda funny to people who can read Chinese. I met a guy who thought he had is name in Japanese on his arm, but it actually said "Paula".

          S

          • Same goes for clothes. Super Dry print complete nonsense on their clothes, for some reason. Not even a mistake, it looks like they just randomly selected some text that looks cool from multiple sources, fragments of words here and there, and mashed them all together. At least my Japanese shirt that says "assumption is the mother of screw-up" is attempting to make sense.

            You might enjoy https://engrish.com/ [engrish.com] Some of it makes sense after a little thought. Some of the things on T-shirts will probably get you asked to change if you wear them in an English speaking country.

            • by AmiMoJo ( 196126 )

              Sometimes they aren't even mistakes. A classic one is "Diet Water". In Japanese, the word "water", as in the English loan word that they have adopted, refers to flavoured health/energy drinks. They have a word for actual water, "mizu", as you might expect.

        • Between 18 and 20: 67
        • by shanen ( 462549 )

          Is it funny because of "TDF"? Even with the AIs I couldn't figure that one out.

      • There's are other factors to consider. The decline in degree to which people care about what others think of them as they get older, and the value of a permanent souvenir of a past life, however faded.
      • The real question is why you are so concerned as to how other peoples bodies look.

      • Tattoos look fine on old Maori. And face and neck tattoos are common. It's all about expectations. We expect 70 year olds to have faded military tattoos because that's what guys of their generation got tattooed on then.

    • by Tom ( 822 )

      Luckily - other than with criminals - covering yourself in naff tats seems to have been a millennial fad that is slowly fading.

      My observation is the opposite. In my 20s tattoos were just common enough to be accepted as normal, but the majority of people didn't have them and most people who did had one or two fairly small ones.

      Today, it seems everyone and their dog has them.

    • Re:Wow! (Score:5, Insightful)

      by thegarbz ( 1787294 ) on Wednesday December 03, 2025 @05:40AM (#65831871)

      So injecting an artificial dye into the human body can have deliterious effects! Who'd have thunk it?

      Said literally about every discovery of the hundreds of chemicals we put into our body that cause problems, all while giving a free pass to the thousands of others we presume inert because we're ignorant as to otherwise.

      Luckily - other than with criminals - covering yourself in naff tats seems to have been a millennial fad that is slowly fading.

      Tell us you haven't left your parents basement in 20 years without telling us. You really should get out more, that stale air is turning you into a judgmental arsehole. Millennials have the most, but Gen-Z are only slightly behind in the stats, and they have another 10 years to make these decisions as well.

      Gen-Z seem to be a bit body smarter.

      The generation we've nicknamed the Tide-Pod generation because they were eating tidepods as a TikTok challenge? Is that the Gen-Z you're talking about? If you're not going to leave the basement at least read the news occasionally.

      • The generation we've nicknamed the Tide-Pod generation because they were eating tidepods as a TikTok challenge? Is that the Gen-Z you're talking about? If you're not going to leave the basement at least read the news occasionally.

        In the young groups I am around, Tattoos are considered passe', and not cool.

        As one young lady said, "In 40 years, we'll hear "Tattoos? Ewwww, my Grandma has them, they look gross" "

        A lot of Pop culture is still stuck in the idea that the more tats, the cooler. But that's how fads and social trends go. When the Tattoo craze ends - there might be a surge in laser removal, at least until the person having them removed ends up with a tattoo ghosting - the removal process removes skin pigments with the ta

        • In the young groups I am around, Tattoos are considered passe', and not cool. As one young lady said, "In 40 years, we'll hear "Tattoos? Ewwww, my Grandma has them, they look gross" "

          We don't need to guess and go out and talk to kids. The statistics can be looked up. Depending on studies GenZers are only about 10-20% behind Millenials. If you then look at the general distribution of *when* people get tattoos you can expect GenZ's percentage to increase further over time while Millennial's are unlikely to change from this point forward.

          Anecdotes and soundbites are irrelevant.

          The rest of us are allowed to have our opinions (and sometimes facts) about that.

          Indeed, but when your opinions don't fit facts (such as the fact that 25% of millennials don't actually have a cri

      • The generation we've nicknamed the Tide-Pod generation because they were eating tidepods as a TikTok challenge? Is that the Gen-Z you're talking about?

        Yeah well my generation voted for Brexit in the UK and Trump in the US. Doesn't matter what generation you are, you're in a fuck off massive glass house.

    • In another article, I saw a suggestion that scientists were trying the opposite: injecting vaccines with a tattoo gun. The whole point of that is that the immune system is very active just below the skin, while deep in the muscle tissue you are too far behind the defenses.
      • by dgatwood ( 11270 )

        In another article, I saw a suggestion that scientists were trying the opposite: injecting vaccines with a tattoo gun. The whole point of that is that the immune system is very active just below the skin, while deep in the muscle tissue you are too far behind the defenses.

        Not with a tattoo gun, but yes, microneedle delivery [nih.gov] is a new experimental way to deliver vaccines. It's less like a tattoo gun and more like a nicotine patch or a bandaid, though.

    • So injecting an artificial dye into the human body can have deliterious effects! Who'd have thunk it?

      Luckily - other than with criminals - covering yourself in naff tats seems to have been a millennial fad that is slowly fading. I guess they still wanted to look tough (failed) while sipping their skinny latte frappucino with whipped cream.

      Gen-Z seem to be a bit body smarter.

      Thats quite a weak justification to assume they’re smarter. Tattoos have gotten a HELL of a lot more expensive in the last decade, and I’d say that has a bit more influence on it. I’m not even in that age demographic and make decent money. I can’t justify the cost, and I’m not going to shame the artist by asking for discounts.

    • Millenials is a very brought term but the youngest millenials are now 25 and the oldest 45. I'm at the far end of that range, and here tattoos weren't very common. Of course some people would have it but it wasn't that many and it was often in somewhat discrete locations e.g. upper arms etc. so it was hidden with clothes on. It seems to me it is the younger generation, those who are actually young now who have really picked up on it, often with extensive tattoos on the entire forearm and this being an entir
      • I looked it up - most researchers would probably pick 29 years as the current age of the youngest millenials!
    • Luckily - other than with criminals - covering yourself in naff tats seems to have been a millennial fad that is slowly fading.

      Fifty plus years ago, tattoos were a symbol of rebellion.

      Around twenty-five years ago, it became a matter of conformity.

    • So injecting an artificial dye into the human body can have deliterious effects! Who'd have thunk it?

      Luckily - other than with criminals - covering yourself in naff tats seems to have been a millennial fad that is slowly fading. I guess they still wanted to look tough (failed) while sipping their skinny latte frappucino with whipped cream.

      Gen-Z seem to be a bit body smarter.

      You're at 4 funny, but I hope it is true. I don't like tats on anyone, but it is especially sad on women. I will note that I've noticed that women around 21 are sporting less tattoos than many I see in public that are a bit older. At the restaurants My wife and I go to, there seems to be a correlation between tattoos and lack of a wedding ring.

      This does not mean that they lack in male attention, but they are considered entertainment only, and the men who use them for entertainment are generally not good

    • by 0xG ( 712423 )

      Gen-Z seem to be a bit body smarter.

      Visiting Spain & Portugal a lot lately.
      Pretty much everyone of all ages - including cops - is wearing ink.
      I, with my virgin skin, was definitely in a very small minority.

    • Prison tattoos use different techniques and inks than commercial tattoos. This study may not apply to those.

  • by Tom ( 822 ) on Wednesday December 03, 2025 @05:29AM (#65831855) Homepage Journal

    It's good that there is scientific proof, but seriously, "stuff you put into your body doesn't just sit there" is the expected outcome, isn't it?

    • by geekmux ( 1040042 ) on Wednesday December 03, 2025 @06:59AM (#65831991)

      It's good that there is scientific proof, but seriously, "stuff you put into your body doesn't just sit there" is the expected outcome, isn't it?

      Given the rather life-long permanent effects of those tattoos and the proven fact that it is a royal BITCH to try and remove them, I’d say it’s a pretty damn strong assumption among the inked and non-inked that some things DO appear to just sit there.

      Sell to to me another way.

      • it is a royal BITCH to try and remove them

        It's worth noting that the way you remove them is by making them stop just sitting there, to the degree they do. The various approaches ultimately just try to break the ink up into smaller pieces that can be absorbed into the bloodstream and carried throughout the body... hopefully to get filtered out by the kidneys and liver and then excreted, but who knows? It seems likely to me that tattoo removal may create exactly the same effects as tattoo application, but moreso.

      • Do tattoos fade over time?

        Sure, 'most' of the ink 'just sits there' 'most of the time'.

        But certainly not all, and all the time.

        If those molecules end up getting transported around our bodies and into different organs, it's not a stretch they may have an unexpected impact on different biological systems.

      • by flink ( 18449 )

        Tattoo ink get encysted by immune cells. Over time these cells die, and as the dead cell breaks down, new cells come along and gobble up the ink to trap it in place. This is why fine details tend to blur out over time. The ink doesn't exactly stay put, and particles that are small enough do get carried away in the lymph system, contributing to fading.

    • Yeah it isn't really shocking that something your body doesn't destroy easily both persists and has an effect on the systems your body uses to clean up similar things. It is also not a surprise that metal and salt injections modulate immune response, these are called adjuvants when used on purpose. Still cool to have hard data on it.
    • by jd ( 1658 )

      That's actually a good question. Inks have changed somewhat over the past 5,000 years, and there's no particular reason to think that tattoo inks have been equally mobile across this timeframe.

      But now we come to a deeper point. Basically, tattoos (as I've always understand it) are surgically-engineered scars, with the scar tissue supposedly locking the ink in place. It's quite probable that my understanding is wrong - this isn't exactly an area I've really looked into in any depth, so the probability of me

  • by Zarhan ( 415465 ) on Wednesday December 03, 2025 @06:13AM (#65831901)

    Did they test with multiple kinds of dyes? Do Maori (and other polynesians) that might have every part of their body painted use different kinds of inks than in the west?

    • in assuming they tested with standard approved inks. But what other parts of the world use may have a different outcome. It's not unusual to have 3rd worlds inks contain heavy metals. Those are a bad idea to begin with, never mind the impact on your flue shot.

    • Did they test with multiple kinds of dyes? Do Maori (and other polynesians) that might have every part of their body painted use different kinds of inks than in the west?

      Maoris's are susceptible to diabetes. I only mention that because I had a friend who developed an allergic reaction to a tattoo (the gold color in it specifically) and soon after came down with insulin dependent diabetes.

      That's pure speculation at this point, the standard reason is that they eat the same food we do now.

  • Tattoos have been around for a very long time. A lot longer than clickbait has.

    Can we confirm that tattoos have had a measurable negative impact on human immunity that shows itself in longevity statistics, while also proving it was in fact the tattoo that was the cause?

    Yes, I’m well aware that lifestyle choices of those sporting ink is a factor here. As well as ink technology. Now let’s account for those factors and prove the study. On the surface this should be rather easy to validate. Heal

    • what problems do you experience with the covid vaccine?

    • As far as trying to drag this argument into the COVID vaccines, that sounds like a horrific weak-ass excuse to dismiss the problems that have risen from those particular emergency-authorized solutions.

      What problems? You mean the ones that are way less risky than unvaccinated exposure? Whatever, antivaxxer.

      • As far as trying to drag this argument into the COVID vaccines, that sounds like a horrific weak-ass excuse to dismiss the problems that have risen from those particular emergency-authorized solutions.

        What problems? You mean the ones that are way less risky than unvaccinated exposure? Whatever, antivaxxer.

        Risk, is not the topic that will earn you a smile from a grieving mother of a perfectly healthy child who's now dead. Let's stop pretending we can easily explain every completely unexpected death in recent times when almost all of them have one thing in common.

        Anyone who understands vaccines and the human body will understand there will be those who suffer from side effects. That's not the problem here, and certainly doesn't make me "anti" vax. I'm more questioning why vaccine companies were not forced t

  • by nospam007 ( 722110 ) * on Wednesday December 03, 2025 @07:54AM (#65832057)

    As usual with self-inflicted problems.

    • As usual with self-inflicted problems.

      AFAICT, people with ink generally have more kids than those who don't.

  • Comment removed based on user account deletion
    • there are many types of tattoo inks with various bases and a multitude of pigment chemicals. To make blanket statements about " a tattoo" causing a particular list of problems is as silly as saying "food coloring causes stomach cancer" without specifying which one.

      You appear to be making a statement that sounds like "Until every combination of tattoo inks is proven to cause problems, none do." I'm sure you aren't saying that, right?

      What this study has said is that the ink migrates within the body to lymph nodes causes inflammation, and oddly enough, causes different reactions to different vaccines. Also an induction of apoptosis in cells, including macrophages. The macrophages see the ink as an infection, and do what macrophages do.

      https://www.pnas.org/doi/10.10 [pnas.org]

  • "The ink also weakened the antibody response to Pfizer Inc. and BioNTech SE's COVID vaccine when the shot was administered in tattooed skin"

    Well, simple solution to that. Most people with tattoos aren't 100% covered.

  • While tattooing probably was never safe, it would seem that someone has an axe to grind.
  • How will you get your justice against a billion Dollar company--when your child or loved one is killed?
  • I swear there must be a conspiracy to cover up the success of the Johnson & Johnson vaccine.

    Why would you test two COVID MRNA vaccines and a flu vaccine, but not an adenovirus COVID vaccine? Now we don't know if the difference is COVID vs flu or MRNA vs adenovirus, because you decided to conflate variables.

    My guess is J&J COVID vaccine probably performs more like a flu vaccine re: tattoos. The immune pathways for developing immunity are very similar between the two, but completely different in MRNA

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