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Science

Stressful People in Your Life Could Be Adding Months To Your Biological Age (pnas.org) 34

A study published last week in PNAS found that people who regularly cause problems or make life difficult -- whom the researchers call "hasslers" -- are associated with measurably faster biological aging in those around them, at a rate of roughly 1.5% per additional hassler and about nine months of additional biological age relative to same-age peers.

The research drew on DNA methylation-based epigenetic clocks and ego-centric network data from a state-representative probability sample of 2,345 adults in Indiana, aged 18 to 103. Nearly 29% of respondents reported at least one hassler in their close network. The biological toll varied by relationship type: hasslers who were family members showed the strongest and most consistent associations with accelerated aging, while spouse hasslers showed no significant effect on either epigenetic measure.

The damage also went beyond aging clocks -- each additional hassler was associated with greater depression and anxiety severity, higher BMI, increased inflammation, and higher multimorbidity. When benchmarked against smoking, a major behavioral risk factor for aging, the hassler effect corresponded to roughly 13 to 17% of smoking's estimated impact on the same aging clocks.
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Stressful People in Your Life Could Be Adding Months To Your Biological Age

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  • It's generally relative to expectations and personality types involved.

    • I'd expect it to be entirely relative, but also that it wouldn't matter. I'm sure there are plenty of cases where people are hassling their hasslers, with each accurately blaming the other for making them age faster.
      • by PPH ( 736903 )

        Some people are better equipped to deal with interpersonal relationships than others. What could be a minor, meaningless interaction to one will wind someone else up.

        There was a good post in our local lefty rag about an incident in a coffee shop (one individual's inability to properly resond to "Is ths seat taken.") It devolved into dark muttering on the part of one party. Plus the motivation to write the editorial piece by the other.

        I mean, 'Come on, folks'. If you can't handle a simple 'Yes|No|I don't k

        • I think I get your point, but in this particular case they're talking about long-term relationships, not encounters with strangers who may be having bad days.

          I have a family member that I had to literally kick out of my house. And I'm using the word correctly; my foot hit his ass and propelled him out the door. I believe that is the sort of thing they're talking about.
          And to my point, even though he is directly responsible for all of his problems and has left many ruined lives in his narcissistic wa

          • by PPH ( 736903 )

            but in this particular case they're talking about long-term relationships

            It's a continuum. In my experience, people that can't handle the small stuff and that which has no relationship investment also lack the tool set to fix bigger problems.

    • When everyone is the problem, changes are you are the problem.
    • If you have to ask, it's probably you.

  • by Anonymous Coward

    Summaries that link to actual articles is so 1999.

    Here's TFA for you to not R: https://www.pnas.org/doi/10.10... [pnas.org]

  • For sure (Score:5, Funny)

    by dskoll ( 99328 ) on Monday February 23, 2026 @12:10PM (#66005592) Homepage

    I got divorced 12 years ago. My physical health definitely improved.

    • It's a good joke, but the research doesn't seem to support it (at least not in general):

      > "Moreover, not all hasslers exert the same influence; kin and nonkin hasslers show detrimental associations, whereas spouse hasslers do not."

  • by Somervillain ( 4719341 ) on Monday February 23, 2026 @12:13PM (#66005598)
    Every time you see some article about something in life making you healthier or sicker, ask the question...is there a stress correlation? It's safe to say every modern non-genetic/mutation ailment can be traced very reliably to stress. In the 90s, they thought drinking wine was good for your health. Doctors told my dad, a non-drinker, to have a half glass every night for heart health...he tried it and felt sicker and gave up...even felt bad he couldn't drink wine to be healthy.

    Now we know, wine is bad for you. At best, you don't notice the damage in small doses. It will never make you healthier. I was in college, listening to biochemistry lectures where they studied it...was it the anti-oxidants? Was it reservatrol? No matter how much was given, they couldn't find a dose-dependent response to either. Turns out, it was simply that wine drinkers have less stressful lives, especially in the USA, especially in the 90s. Most were middle class or above. The poor drank hard liquor or beer. People who have time and lack of serious problems in their life to explore wines have time to visit the doctor for routine checkups and get a walk in every night with the dog and go to bed on time, etc.

    Then they thought it was tooth decay. So now scientists are studying to see if bacteria in teeth caused heart attacks...were they producing toxins that are poisoning us? Oh, you're on a statin?...be sure to brush your teeth as well!!!...which is nice advice, but not relevant. More obviously, people who go to routine checkups have less stress, have their act together more, people who take care of their teeth typically take care of their bodies and have their shit together.

    Same for any other ailment...ultra-processed foods? ...yeah, the MAHA/RFK crowd loves to complain about that, but first of all, the healthiest foods we eat are REALLY FUCKING PROCESSED...like yogurt and whey and olive oil...there's no clear definition. However, take things we know are terrible, like hot dogs. Most health concerns found from hot dogs are from overeating. You overeat salad and you're going to be pretty similarly sick. But hot dogs are like wine. People that have their shit together don't eat 7-11 hot dogs. That's for poor people or people that are too stressed out and busy to get a proper meal. Feed rich and relaxed people the same stuff, only in proper proportions and I'll wager you'll barely see a difference in health outcomes.

    Health and diet are the new religion for the secular crowd. We believe that if we can be more pure...cut out the nitrates and red dye 50, we can be more holy. There's just no evidence. I've eaten like shit as a poor college student. I ate healthy once I graduated and could afford fresh fruit and vegetables and to cook real meals....there was no difference. But I've had stressful jobs that made me feel like ABSOLUTE SHIT while eating PERFECTLY and working out daily. I've had jobs I loved where I worked out very inconsistently and ate junk food....felt much better (chubbier, but healthier).

    I'm guilty of this too. I want to believe that if I live off lean protein, "good carbs," and a fuckton of fruits and vegetables...I'll be holy too!...I'll be rewarded for my virtuous eating with good health.

    During the pandemic I achieved this because I work from home and can afford whatever food I like....didn't make a difference. I take my vitamins like clockwork and workout nightly...even walk the dog to clear the head, like clockwork. Part of me still thinks, with each meal planned, that if I eat a salad, instead of a slice of pizza (same amount of calories of each), I'll be healthier...but I've NEVER seen ANY evidence...on the scale...in the mirror...in my mood...in my energy levels....in my bloodwork. Calories are calories....I eat too much salad, I feel like shit. I eat an appropriate amount of pizza, I feel fine. I still take my vitamins and eat healthy...but I can't prove it works. I am not sure it does.

    I wouldn'
    • Diet isn't a one way street. People with food allergies will obviously put their body under a lot of stress from eating something that disagrees with them. I suspect refined carbs cause stress to a degree as well as they spike insulin and lacking necessary vitamins, mineral, or proteins in the diet will also place the body under undo stress if the insufficiency causes health problems. I also think there may be a psychological effect where people who are taking some kind of action to improve their health fee
    • ... no visible health problems.

      Research is now revealing that food is more than fuel, it's changes how our body works: Much like drugs. It adds to the idea of good foods and bad foods. Genetics, the usual answer for different tolerances to the same human stresses, may be more about neutralizing bad foods/emotions, less about magical immunity to those stressors and to disease.

      The bad cholesterol and other toxins are accumulating in their body: When they turn 50 and the body can't repair itself overnight, those toxins will start degr

      • ... no visible health problems.

        Research is now revealing that food is more than fuel, it's changes how our body works: Much like drugs. It adds to the idea of good foods and bad foods. Genetics, the usual answer for different tolerances to the same human stresses, may be more about neutralizing bad foods/emotions, less about magical immunity to those stressors and to disease.

        The bad cholesterol and other toxins are accumulating in their body: When they turn 50 and the body can't repair itself overnight, those toxins will start degrading their metabolic function: They will get sick. Maybe, nothing serious but it's a message that they need to stop doing that shit. Or maybe, do it much more and make room for young people.

        I want to believe you. It's what I've been told since I'm a small child, but I am not confident it's true. I am confident macro nutrients matter and that calories matter. We can observe what happens if you don't eat enough fiber or eat too much. However, my own doctors tell me they don't know if vitamins work. I still take one....just in case. But no one knows if multivitamins work. Eating 300 calories of salad vs a PBJ...not sure. There's definitely a placebo effect. There's definitely a mindfuln

  • by marcle ( 1575627 ) on Monday February 23, 2026 @12:19PM (#66005616)

    You certainly can't choose all your relatives. But at least, if you're choosing a spouse, learn how they react to adversity and disagreement. And the same goes for their family. It can mean the difference between a happy life and a world of hurt and melodrama.

  • And particularly nasty clickbait at that.

    Yes we know stress kills. The fact that you can be stressed out by certain people is hardly news.

    But tying it to individuals makes for great clickbait because it gets you thinking about every little niggling problem in your life caused by the people around you.

    This is not to say that there aren't some people you shouldn't get away from. You absolutely should. But a study or story like this is it going to help.
    • Yeah, let's just give up on trying to understand how humans work, and measuring things scientifically: just knowing "people stress people out" is enough. /s

  • ... or it seems that way, with the Idiot in charge in the WH

  • by Fons_de_spons ( 1311177 ) on Monday February 23, 2026 @02:40PM (#66005940)
    I find these Handlers extend my life span. Whenever one of these types tries to get on my nerves, I play with them. Give off false clues. They always crave for your weaknesses. Just lead them around the garden, as they say in Dutch. I pretend to be insecure. They like that. Then when they go all in, I just shrug it all off. They hate that. They start avoiding me after a while as they can't figure me out. I really learned to enjoy this process. It is very rewarding if it works out. In some cases they actually become reasonable after they figured it out. Humans...
  • ...then you should definitively build "the hassler" [cusersvitt...flayoutpdf]!
  • If you're not married or otherwise in a dependent type of relationship, then your boss is the stressful person in your life. Even when I "fix" my boss's attitude for a few months by giving them a good talking to, they come back with more of the same stress eventually. Quality of life would be a lot better if corporations didn't insist on managing us to death. "If you work for a living, why work yourself to death?" - Eli Wallach

  • I never got carded after 16, because my family added at least 2 years to my life.

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