Old Hearts Become Biologically Younger When Transplanted Into Younger People (sciencealert.com) 70
alternative_right shares a report from ScienceAlert: It might be reasonable to think that there's an indelible link between the heart and the body it resides in -- the processes that affect one inevitably affect the other. But a new preprint, uploaded to bioRxiv and yet to be peer-reviewed, suggests that this may only be true up to a point. Take the heart out of the body and put it in a new one, and something incredible happens. The transplanted heart begins to take on the biological age of its new owner. Older hearts transplanted into younger recipients appear to become biologically younger, while younger hearts placed in older bodies show signs of accelerated aging.
Kidneys (Score:5, Interesting)
Re: Kidneys (Score:4, Interesting)
Or take a closer look at blood transfusions.
A biblical verse states the life of an organism is in its blood. It is blood that carries the nutrients, signalling molecules and even free mitochondria that probably signal the transplanted organ to turn younger. The bioelectric environment also matters, but probably not to the same extent as blood does to the transplanted heart.
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A novel idea, but Mr Stoker did have some folk legends to borrow from. Personally, I have no stake in that matter, no fascination with holy water or crucifixes and certainly don't believe in silver bullets. Sunshine, however, is a powerful disinfectant and garlic makes bread tasty! (So, are there no Italian vampires?). It's interesting the actual name of Jesus is never used by the characters in Bram Stoker's Dracula -- his name is the singular artifact of power in the new testament.
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Funny thing is, it apparently works and the current study is just one more bit of proof. One quick trip to Ecuador and bam, 70+ year olds get six months of being as healthy as a 30-something again. Hell, I have to admit some mornings I'm tempted to try it myself, though I'm nowhere near wealthy enough to fly halfway around the world every few months.
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I mean, extending the lives of super-rich people is noble and all [youtu.be], but if you could collect the experimental data to help the unwashed masses, well, then, now you've got a whole new way for youth to support the lives of the elderly other than through Social Security taxes.
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I heard about that. I wonder what the long term effects of that will be on those 70+ year olds. Just look at all the risks listed here:
https://my.clevelandclinic.org... [clevelandclinic.org]
Interestingly, doctors tend to avoid blood transfusions even in the case of heavy bleeding. Instead, they immediately use intravenous fluids to rapidly "fill the pipes" and restore blood pressure and organ perfusion.
Human Growth Hormone (Score:2)
This is the question been pondering for awhile. What is the effect on the body of mothers due to the large amounts human growth hormone produced while she is pregnant versus childless women?
Re: Human Growth Hormone (Score:2)
I plugged that question into ChatGPT. Apparently, HGH is normally produced by the pituitary gland. But during pregnancy, a different version of HGH produced by the placenta takes over its role. It reorganises the mothers body until deli ery. Placental growth hormone disappears from maternal circulation very rapidly after childbirth, generally within about an hour. The mother's usual pituitary growth hormone system then resumes its role.
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But the researchers were told to get to the heart of the matter.
New Business/Health Plan (Score:4, Funny)
2. After I wear theirs out, we swap back and I get my old, now upgraded, heart back.
3. Profit.
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1. Swap hearts with a fit young person. 2. After I wear theirs out, we swap back and I get my old, now upgraded, heart back. 3. Profit.
Actual business/health plan: we find out which signalling factors present in young people's blood cause the old hearts' transformation into young ones, and put those in pills.
You know, contrary to what your leftist paranoia tells you, rich people are not psychopaths, don't project your own faults onto everyone else.
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Re: New Business/Health Plan (Score:1)
jeez you infuse yourself with the blood of your 17 year old son to live forever that one time and everyone loses their shit : /
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the LONG history of funding for war, labor, exploration & colonization says otherwise
Re: New Business/Health Plan (Score:5, Insightful)
If they would stop acting like psychopaths then we would stop assuming they are psychopaths.
Re:New Business/Health Plan (Score:5, Informative)
rich people are not psychopaths
Being a psychopath/sociopath is a key ingredient in getting rich. Generally some opportunity had to come along that required a disregard for the welfare or fairness to others. A lot of folks stepped away from an opportunity because they didn't think it was right, but a wealthy person likely seized upon some such occurances.
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Let me guess, you not only yell at people for jokes, you also yell at people for being upset at jokes.
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Actual business/health plan: we find out which signalling factors present in young people's blood cause the old hearts' transformation into young ones, and put those in pills. You know, contrary to what your leftist paranoia tells you, rich people are not psychopaths, don't project your own faults onto everyone else.
Extreme left: paranoia, extreme right, incredibly naive towards white males. Root cause for both? Inability to think beyond black and white. Tip: start with variables of 2 bits. It takes some time to get used to, but it will make your world more nuanced and beautiful. Then try 4 bits!
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2. (swap hearts)
3. Join me on my lawn, my precious!
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GHK-Cu (Score:5, Informative)
A similar thing was found in the 1970s with liver cells, a chemist named Loren Pickart first isolated GHK – a string of three amino acids Glycyl-L-histidyl-L-lysine, after noticing that bathing liver cells in the lab with plasma from younger adults helped revive them.
GHK-Cu has potential for regenerative medicine in many areas, however as it is not patentable it has not seen any proper human trials. It has been used in some expensive skin care products where it has been shown to be effective but that is all. It would be nice to see some proper clinical trials,
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I'm pretty sure that's too simple an answer. There are several lines of evidence that suggest much of aging depends on the blood (at least in mice). Which doesn't imply that there aren't other parts.
(One experiment I read about grafted together the blood steams of a young mouse and an old mouse. The old mouse appeared to get younger.,)
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we have old billionaires and politicians in charge of everything today. They don't care about profits above extending their lives; far too selfish! They will pursue anything that grabs their attention.
Aaand as usual.. (Score:5, Informative)
Upon reading the paper I quickly realized, predictably, that it's all baloney. By new heart they mean methylation patterns imprinted in the DNA. Is methylation anything to give a shit about when it comes to the heart? Most likely no. At best you could fool someone like Peter Thiel I suppose. What makes your heart give out is muscle wasting and narrowed or cholesterol'd up blood vessels .. calcification at the valves, fibrous scar tissue. The methylation pattern in the cells don't do anything much, fucked up methylation can cause cancer I suppose. When was the last time you heard of anyone dying from (primary) "heart cancer"???
Re:Aaand as usual.. (Score:5, Interesting)
Ironically, restoring the old methylation pattern may increase, not decrease, the risk of cancer. Here's why. When you get older, the risk of a cell's DNA accumulating damage increases. Sometimes, this damage can provide the mutations to make the cell cancerous. In order to prevent that, the cell silences gene expression by methylating sections of the DNA. Reference: https://pmc.ncbi.nlm.nih.gov/a... [nih.gov]
Now when you go and do a fool thing like "restore the reduced DNA methylation patterns typically found in young cells" (without repairing the damaged DNA) .. you're actually undoing the bodies protective mechanism and actually increasing the risk of cancer.
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IIUC, there are cells in the body that retain the "true copy". (I.e., they've duplicated VERY few times.) However, they therefore aren't widely distributed. This means no "local process" in most of the body has access to them. It's why women produce only a limited number of ova. S.a. Hayflick limit.
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At best you could fool someone like Peter Thiel I suppose.
Isn't that pretty much the standard tech business plan nowadays? Not to build a sustainably profitable company... but to pull something together that offers the best potential for a quick buyout in the shortest amount of time.
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Can we extract? (Score:2)
Silliness aside, it seems we're getting very close to regeneration and lifespan extension. Anything that will extend old people's lives is generally going to be great for humanity. If I knew in my 20s what I know now sorta thing...
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If we can get the"thing that makes them young" into old people they can be young again?!
https://www.imdb.com/title/tt0... [imdb.com]
Can we fucking fix.. (Score:1)
Asking the seventy-something divorced male victims of modern feminism why they’re quite jaded, is an exercise in futility.
Asking why millions of twenty-something virgin men now feel the same, is an exercise in accountability.
When even young men aren’t bothering to stick their dick into the very thing that makes them young, you know society has a MUCH bigger problem than chasing the fountain of fucking youth.
Re: Can we fucking fix.. (Score:3)
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If we can get the"thing that makes them young" into old people they can be young again?!
https://www.imdb.com/title/tt0... [imdb.com]
Was thinking more like this; https://www.imdb.com/title/tt1... [imdb.com]
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Silliness aside, it seems we're getting very close to regeneration and lifespan extension. Anything that will extend old people's lives is generally going to be great for humanity. If I knew in my 20s what I know now sorta thing...
50 million human lives are prematurely ended every year on this planet. That’s a World War II death toll, every two years. Across decades. Thats more than any animal, disease, plague, virus, or asteroid has ever inflicted on this planet or likely ever will. That, is abortion.
Japan has sold more adult diapers than infant diapers for over a decade now. The birth rate across many countries, has been below sustainment levels for years now.
For the first time in decades, both cognitive ability and long
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Or consider why you don’t hang out with 19-year olds to have intellectual conversations ripe with common life experiences and perspectives
I literally do.
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Or consider why you don’t hang out with 19-year olds to have intellectual conversations ripe with common life experiences and perspectives
I literally do.
If your UID does, and you in fact enrich yourself from it without the use of DMT, then understand even the 19-year old in the room grasps the fact their intellectual maturity represents maybe 10% of their generation. Proven factually and statistically.
Not sure what your point is against a reality like that.
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Not sure what your point is against a reality like that.
My point is that you're deluded.
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Not sure what your point is against a reality like that.
My point is that you're deluded.
Society deluding itself by painting personal experiences as the statistical norm, is how we managed to create a situation where even the liberal goalposts can't keep up.
https://www.youtube.com/watch?... [youtube.com]
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It's called birth control.
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There is a big effort to discourage, limit, or ban birth control. Usually religion based because that is how they boost their numbers; not conversion. They are not so confident they can honestly grow their numbers so they resort to conditioning and indoctrination. I like to point out to people: if they are really able to think for themselves, then why are they in their parents religion?
"Great" for frightened, not for the species. (Score:2)
Old people lingering longer instead of passing away has no benefits for the species, only emotional benefits (which will vary according to circumstance!) for the old (most of) who instinctively fear death.
The species thrives because individual lives expire. Most lives contribute nothing so prolonging them does nothing useful for our species. Death really IS natures change agent.
Fear of death does not in any way make death somehow wrong.
Turnover replaces intellectually ossified old minds with new minds in n
Re: "Great" for frightened, not for the species. (Score:2)
Once most humans didn't make it past 50 - yet we now regularly see 80 and yet humanity has prospered.
It seems convenient now th
ship of Theseus (Score:2)
Well, will my brain become younger (Score:2)
if the brain of a younger body is removed and mine is plugged in?
That's the question every billionaire is asking today.
Get in line!
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Well, it would lose all sensory and motor connections. Sometimes some of them reconnect over a period of several months...but many never do.
I think you die of various neural problems before the reconnection has a chance to get started. (And, of course, you've got a horrendous case of "bubble boy" syndrome for the rest of your life.)
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They fully expect the "AGI" to make the required number of tests and fix those problems in time for them to use.
Small wonder (Score:2)
Rich people get young blood transfusions for the very same reason.
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That one actually has some science behind it. Not enough to trust, but some.
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Luckily, our fascist government will work hard for "the corporations" (mega rich who own/run them, who still fear death) to discover why there is something to young blood and make some kind of drug... they've probably not found it already because they are fixated on the blood of youths (maybe some Epstein like appeal?) when it's actually something else creating the benefits which only slightly shows up from young blood transfusionsâ¦
"why" is the real question (Score:2)
The articles do a good job of establishing "what" but a poor job of establishing or even speculating on "why", which I think is the deeper question. If as they measured, older hearts become younger in younger bodies, knowing why that happens may give us clues on longevity treatments.
But it seems like the only consideration is that this gives them more organs to choose from for transplants.
Conclusion ... (Score:2)
If you are an old guy with a failing heart, don't go for a heart transplant - go for a full body transplant.
Maybe just keep your brain and take the new head too, to avoid that wizened head on gen Z body look.
On a more serious note, maybe there is something to the blood boy thing? Is there an anti-aging treatment to be had?
:P (Score:1)
no wonder the rich are all vampires. It confers immortality - who knew!?!?
Why, oh why? (Score:2)
Why are we showing an article about yet-to-be-reviewed finding when given the nature of the finding it's highly likely it may turn out to be a total bs or an AI hallucination?
Not peer reviewed (Score:2)
Somebody uploaded a study to a website, but it's not peer reviewed. I'll be more interested when the peer reviews are done, by reputable scientists.