Moderna Shares Plunge After Leak of Cancer Vaccine Data (cnbc.com) 42
Moderna shares plunged as much as 25% after partial clinical trial data leaked for its personalized cancer vaccine developed with Merck, despite the full results showing promising outcomes for melanoma patients. Analysts attribute the selloff largely to inflated investor expectations rather than disappointing clinical results. CNBC reports: The personalized vaccine, known as intismeran autogene, paired with Merck's immunotherapy Keytruda reduced the risk of recurrence or death in certain melanoma patients by 42% compared with Keytruda alone. The data also showed the shot along with Keytruda reduced the risk of cancer spreading to distant parts of the body or death by 38%, compared with just the immunotherapy. The companies say about 82% of patients who received the personalized cancer vaccine alongside Keytruda were alive without their melanoma returning at two years, compared with 70% of those who received Keytruda alone.
[...] Investors see the targeted vaccine as a possible breakthrough treatment, with the potential to be used in other forms of cancer in the future. It could also offer Moderna a critical additional commercial product in its pipeline, following vaccines for Covid-19, the flu and respiratory syncytial virus. "We assert this relative reduction in recurrence/death is clinically meaningful," said BMO Capital Markets analyst Evan Seigerman. "Such a reaction likely reflects inflated expectations into the full data release, rather than a true indictment on the efficacy of the combo therapy."
UBS analysts said "this is overall a strong data set" and gives more confidence in upcoming studies of the vaccine in kidney and bladder cancers. They added the stock reaction may be due more to massive expectations than disappointing data.
[...] Investors see the targeted vaccine as a possible breakthrough treatment, with the potential to be used in other forms of cancer in the future. It could also offer Moderna a critical additional commercial product in its pipeline, following vaccines for Covid-19, the flu and respiratory syncytial virus. "We assert this relative reduction in recurrence/death is clinically meaningful," said BMO Capital Markets analyst Evan Seigerman. "Such a reaction likely reflects inflated expectations into the full data release, rather than a true indictment on the efficacy of the combo therapy."
UBS analysts said "this is overall a strong data set" and gives more confidence in upcoming studies of the vaccine in kidney and bladder cancers. They added the stock reaction may be due more to massive expectations than disappointing data.
Re: (Score:2, Informative)
Re:Not surprising (Score:5, Informative)
pushed mRNA Covid vaccine on billions of people around the world without having to pass safety trials.
Why are we still doing this? Why of god in 2026 are we still fucking doing this shit? Holy living mother of Jesus can we please stop this.
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [nejm.org] Published Dec 30 2020
The trial enrolled 30,420 volunteers who were randomly assigned in a 1:1 ratio to receive either vaccine or placebo (15,210 participants in each group).
Sick fucks (Score:4, Insightful)
I see we have some slavery game in the audience tonight. We already knew that though, because they're the same people as the child rape fans.
Re: (Score:2)
Racists sure get angry when you call them out.
Re: (Score:2)
Slashdot moderation gives them a safe place to snipe from.
Re: (Score:2)
So it's obvious which way the mods here go.
I get modded down by obviously racist mods every day. So yes, it's obvious that AC comments are 99.999% shit, and you're 100% troll.
Re: (Score:2)
Got it - if us leftists are the majority here, you're post is virtue signaling for stupid racist pedophiles.
Re: (Score:2)
Re: (Score:3, Informative)
Oh and for the nitpickers it's not one and done, they keep track of these and even do more trials for all the variants and long term effects, hell, Moderna is doing a phase 4 trial on the covid vaccine right now! [clinicaltrials.gov]
Because Republican politicians have nothing (Score:4, Insightful)
And it's the same thing in every single country with a right-wing party. The right wing party wants power without actually making the world a better place for anyone except a handful of Epstein Island frequenters.
So they have to invent fake issues to give people a reason to vote for them and give them money and power. Vaccine denial was one of them. Freaking out about trans girls is another one. I'm old enough to remember when heavy metal music and violent video games were on the list. For a little while there the Democrats joined in on those two but Democrats eventually join us in the real world and listen to experts that just does not happen with Republicans.
Re:Not surprising (Score:4, Insightful)
the deplorables are incorrigible.
Not even Trump himself could even get them to consider the vaccine.
He got booed by MAGA at least twice when he tried in 2021
Re: (Score:3, Funny)
Re: (Score:2)
That might be the thing with such irony so thick you could cut it, Operation Warp Speed was something even I will give the Trump admin credit for, it was a successful program, they actually did quite a few innovative things to move the development along and to their credit they waited until all the testing was done. It should be a thing he can point back to.
Now Trump can't take any credit for it because they relied on poisoning their supporters brains on nonstop conspiracies to where they think it's a very
Well it IS October. (Score:2)
It's "scary month," so we need to throw around the scary words.
VACCINE! mRNA! VACCINE! Medical Establishment! VACCINE! Scientific consensus!
Ooooooooo......
Re: (Score:2)
"I've been jabbed so many times I glow in the dark, and get five bars of 5G in a coal mine" - Cory Doctorow
Re:Not surprising (Score:5, Informative)
You must be one of those who claims there's never been a double-blind study for vaccines even though they've been done. This article [historyofvaccines.org], published before covid hit, lays out the lies people like you put out and why they're lies.
And here's the results of a double-blind study on the effectiveness of the MMRV vaccine [nih.gov] from 2016. How timely considering Kennedy lies about the measles vaccine.
Re: (Score:2)
"Is there a vaccine that cures Maga Gullibility Syndrome?"
they voted for Trump 3 times. that should answer your question.
Re: (Score:2)
Re: (Score:1)
Don flips faster than his hair in the wind.
Re: (Score:1)
I'm honestly stumped why the market reacted as badly as it did to this news - That's still a 100% viable product, and it targets people desperate for any reduction in recurrence! Exactly 0 people will turn down 42% who would have been thrilled with 49%.
Re: (Score:3)
"The benefit appeared even larger after the six-month vaccine regimen, with a separate analysis showing a 58% reduction in risk of recurrence or death. The companies say it is still too early to determine whether the treatment helps patients live longer overall."
It's far more promising than people expected. What happened was the analysts, who while they know pharma companies still barely understand the science, thought it would be higher and were estimating that so the stock pumped u
Re: (Score:3)
I'm honestly stumped why the market reacted as badly as it did to this news
Stock trading for profit is an insider's game. It has little to do with news, new information, changes to the market, etc., and everything to do with financial games and market manipulation tricks by well-moneyed, powerful groups and individuals.
For the rest of us who are not insiders, the best way to make money on the stock market is buy and hold for the long term, and be sure to diversify. If you try to play the game and pick individual stock winners and losers...remember, the house always wins.
Re: (Score:2)
It also seems some investors were hoping to see data on a broader set of tumors and cancers, but the success report was for a more limited range of tumors, with more studies already underway.
Vaccine
Re: (Score:2)
Re: (Score:2)
I took a look at the share price history... if you bought at the beginning of August, you have nearly a 4x gain (56 => 200). If you go back a year, it is nearly 8x (26 => 200). The peak was 254 which is where the comparison is coming from. The fact of the matter is that their new product increased their share price enormously. I wouldn't cry over shareholders losing a bit of those massive gains.
Re:Not surprising (Score:5, Informative)
mRNA vaccine research was funded for 9 years before COVID broke out, by DARPA. It turned out it was highly effective at stopping aggressive immune responses, which is what actually kills people with infectious diseases and pandemics; our body's response to the disease.
Moderna had already done some generic testing with both animals and hundreds of human studies for years before COVID; we had nearly a decade of non-stop research that included human trials [darpa.mil] before Covid even happened. Framing it as untested and not passing safety trials is simply FUD.
WTF? Wallstreet ignores Swiss cheese? (Score:2)
And not due to the fact Moderna has leaky cybers?
Massive expectations = disappointing data (Score:2)
Point of stock market is educated gambling (Score:3)
Re: (Score:2)
If everyone only invested on the bases of future dividends and we didn't have day traders to create liquidity then the companies won't be able to raise as much money for new capital
Shucks.
Re: (Score:2)
"Buy on the rumor, sell on the news" old but pretty accurate description of herd mentality of stock trading. Now codified in algorithmic trading.
Recall that Moderna stock (MRNA) is up over 600% YTD and that is based on the "We cured cancer** " rumor narrative. A little pull back when this is narrowed to "only" better outcomes on certain cancer in combination with an existing drug and at exorbitant expense...I think a little pullback on the stock price is warranted. Its also a little weird to me as a l