An anonymous reader quotes a report from NPR: It's well known that weightlifting can strengthen our biceps and quads. Now, there's accumulating evidence that strengthening the muscles we use to breathe is beneficial too. New research shows that a daily dose of muscle training for the diaphragm and other breathing muscles helps promote heart health and reduces high blood pressure. "The muscles we use to breathe atrophy, just like the rest of our muscles tend to do as we get older," explains researcher Daniel Craighead, an integrative physiologist at the University of Colorado Boulder. To test what happens when these muscles are given a good workout, he and his colleagues recruited healthy volunteers ages 18 to 82 to try a daily five-minute technique using a resistance-breathing training device called PowerBreathe. The hand-held machine -- one of several on the market -- looks like an inhaler. When people breathe into it, the device provides resistance, making it harder to inhale.

"We found that doing 30 breaths per day for six weeks lowers systolic blood pressure by about 9 millimeters of mercury," Craighead says. And those reductions are about what could be expected with conventional aerobic exercise, he says -- such as walking, running or cycling. A normal blood pressure reading is less than about 120/80 mmHg, according to the Centers for Disease Control and Prevention. These days, some health care professionals diagnose patients with high blood pressure if their average reading is consistently 130/80 mmHg or higher, the CDC notes. The impact of a sustained 9 mmHg reduction in systolic blood pressure (the first number in the ratio) is significant, says Michael Joyner, a physician at the Mayo Clinic who studies how the nervous system regulates blood pressure. "That's the type of reduction you see with a blood pressure drug," Joyner says. Research has shown many common blood pressure medications lead to about a 9 mmHg reduction. The reductions are higher when people combine multiple medications, but a 10 mmHg reduction correlates with a 35% drop in the risk of stroke and a 25% drop in the risk of heart disease.

So, how exactly does breath training lower blood pressure? Craighead points to the role of endothelial cells, which line our blood vessels and promote the production of nitric oxide -- a key compound that protects the heart. Nitric oxide helps widen our blood vessels, promoting good blood flow, which prevents the buildup of plaque in arteries. "What we found was that six weeks of IMST [inspiratory-muscle strength training] will increase endothelial function by about 45%," Craighead explains. [...] There may also be benefits for elite cyclists, runners and other endurance athletes, he says, citing data that six weeks of IMST increased aerobic exercise tolerance by 12% in middle-aged and older adults. "So we suspect that IMST consisting of only 30 breaths per day would be very helpful in endurance exercise events," Craighead says. It's a technique that athletes could add to their training regimens. Craighead, whose personal marathon best is 2 hours, 21 minutes, says he has incorporated IMST as part of his own training.

When they examined decades-old blood samples from 14 NASA astronauts who flew Space Shuttle missions between 1998 and 2001, researchers found that samples from all 14 astronauts showed mutations in their DNA. Futurism reports: While these mutations are likely low enough not to represent a serious threat to the astronauts' long term health, the research underlines the importance of regular health screenings for astronauts, especially as they embark on longer missions to the Moon and beyond in coming years. The specific mutations, as identified in a new study published in the journal Nature Communications Biology, were marked by a high proportion of blood cells that came from a single clone, a phenomenon called clonal hematopoiesis. Mutations like this can be caused by exposure to excess ultraviolet radiation, and other forms of radiation including chemotherapy. In this case, researchers are suspicious that the mutations may have been the result of space radiation.

"Astronauts work in an extreme environment where many factors can result in somatic mutations, most importantly space radiation, which means there is a risk that these mutations could develop into clonal hematopoiesis," said lead author David Goukassian, professor of medicine at the Icahn School of Medicine at Mount Sinai, in a statement. The blood samples for this latest study were collected from 12 male and two female astronauts ten days before their flight and on the day of their landing. The samples were then cryogenically stored at -112 degrees Fahrenheit for around two decades. The mutations observed in the blood samples resemble the kind of somatic mutations we see in older individuals -- which is interesting on its own, considering the median age of the astronauts was only 42.

"Although the clonal hematopoiesis we observed was of a relatively small size, the fact that we observed these mutations was surprising given the relatively young age and health of these astronauts," Goukassian said. "The presence of these mutations does not necessarily mean that the astronauts will develop cardiovascular disease or cancer," he added, "but there is the risk that, over time, this could happen through ongoing and prolonged exposure to the extreme environment of deep space." Therefore, Goukassian and his team are recommending that NASA should regularly screen astronauts for these kinds of mutations.

A small study on the therapeutic effects of using psychedelics to treat alcohol use disorder found that just two doses of psilocybin magic mushrooms paired with psychotherapy led to an 83 percent decline in heavy drinking among the participants. Those given a placebo reduced their alcohol intake by 51 percent. From a report: By the end of the eight-month trial, nearly half of those who received psilocybin had stopped drinking entirely compared with about a quarter of those given the placebo, according to the researchers. The study, published Wednesday in JAMA Psychiatry, is the latest in a cascade of new research exploring the benefits of mind-altering compounds to treat a range of mental health problems, from depression, anxiety and post-traumatic stress disorder to the existential dread experienced by the terminally ill.

Although most psychedelics remain illegal under federal law, the Food and Drug Administration is weighing potential therapeutic uses for compounds like psilocybin, LSD and MDMA, the drug better known as Ecstasy. Dr. Michael Bogenschutz, director at NYU Langone Center for Psychedelic Medicine and the study's lead investigator, said the findings offered hope for the nearly 15 million Americans who struggle with excessive drinking -- roughly 5 percent of all adults. Excessive alcohol use kills an estimated 140,000 people each year.

A combination of psychedelics and therapy appears to help people with alcoholism cut down on the number of days per month they drink heavily, according to a new study. The Verge reports: Researchers used psilocybin, the psychedelic compound found in magic mushrooms, to treat patients over eight months and saw a dramatic improvement in participants' drinking habits. Using psychedelics as treatments for alcoholism was a popular idea in the 1960s and 1970s, and studies on LSD found that it reduced alcohol misuse. But the approach went quiet in the decades after, according to an editorial published in the journal JAMA Psychiatry alongside the new study.

The new research marks a "rekindling of interest," the authors of the editorial wrote. The study included 93 people with alcohol dependence. In the 12 weeks leading up to the study, the participants drank alcohol an average of around 60 days. Of those 60 drinking days, about half were heavy drinking days -- defined as five or more drinks a day for a man and four or more drinks in a day for a woman. People in the trial were randomly assigned to either take a capsule of psilocybin or an antihistamine twice over the course of the 36-week-long study. They had four sessions with therapists before the first time they took the drug, four sessions between the two drug doses, and four sessions after the second drug dose.

Everyone in the study started drinking less after the first four weeks of therapy -- the percentage of heavy drinking days dropped from around half of all drinking days to around a quarter. But that number kept falling for the people who took psilocybin. After the end of the full study, they drank heavily on around 10 percent of the days when they drank. People who took the antihistamine were still drinking heavily on around a quarter of drinking days. The effects lasted for months after the second dose of the psilocybin, study author Michael Bogenschutz, a psychiatrist and director of the NYU Langone Center for Psychedelic Medicine, stressed during a press briefing. "This suggests that psilocybin is treating the underlying disorder of alcohol addiction rather than merely treating symptoms," he said.

An anonymous reader quotes a report from MIT News: Parkinson's disease is notoriously difficult to diagnose as it relies primarily on the appearance of motor symptoms such as tremors, stiffness, and slowness, but these symptoms often appear several years after the disease onset. Now, Dina Katabi, the Thuan (1990) and Nicole Pham Professor in the Department of Electrical Engineering and Computer Science (EECS) at MIT and principal investigator at MIT Jameel Clinic, and her team have developed an artificial intelligence model that can detect Parkinson's just from reading a person's breathing patterns. The tool in question is a neural network, a series of connected algorithms that mimic the way a human brain works, capable of assessing whether someone has Parkinson's from their nocturnal breathing -- i.e., breathing patterns that occur while sleeping. The neural network, which was trained by MIT PhD student Yuzhe Yang and postdoc Yuan Yuan, is also able to discern the severity of someone's Parkinson's disease and track the progression of their disease over time.

The MIT researchers demonstrated that the artificial intelligence assessment of Parkinson's can be done every night at home while the person is asleep and without touching their body. To do so, the team developed a device with the appearance of a home Wi-Fi router, but instead of providing internet access, the device emits radio signals, analyzes their reflections off the surrounding environment, and extracts the subject's breathing patterns without any bodily contact. The breathing signal is then fed to the neural network to assess Parkinson's in a passive manner, and there is zero effort needed from the patient and caregiver. "A relationship between Parkinson's and breathing was noted as early as 1817, in the work of Dr. James Parkinson. This motivated us to consider the potential of detecting the disease from one's breathing without looking at movements," Katabi says. "Some medical studies have shown that respiratory symptoms manifest years before motor symptoms, meaning that breathing attributes could be promising for risk assessment prior to Parkinson's diagnosis." The research has been published in the journal Nature Medicine.

Several readers have shared a report: The ads are everywhere -1 and so are the inflated claims: Special shampoos and treatments, sometimes costing thousands of dollars, will make hair grow. But many dermatologists who specialize in hair loss say that most of these products don't work. [...] But there is a cheap treatment, he and other dermatologists say, costing pennies a day, that restores hair in many patients. It is minoxidil, an old and well-known hair-loss treatment drug used in a very different way. Rather than being applied directly to the scalp, it is being prescribed in very low-dose pills.

Although a growing group of dermatologists is offering low-dose minoxidil pills, the treatment remains relatively unknown to most patients and many doctors. It has not been approved by the Food and Drug Administration for this purpose and so is prescribed off-label -- a common practice in dermatology. "I call us the off-label bandits -- a title I am proud to bear," said Dr. Adam Friedman, professor and chair of dermatology at George Washington University. He explained that dermatologists have been trained to understand how medicines work, which allows them to try drugs off-label.

This week the New England Journal of Medicine published results from a one year, randomized, placebo-controlled study on whether Ivermectin (or the drugs metformin and fluvoxamine) helped patients when administered at the beginning of a COVID-19 infection. Here's how MarketWatch summarized the results:

Ivermectin "failed to prevent the kind of severe COVID-19 that leads to an emergency-room visit or hospitalization." "None of the medications showed any impact on the primary outcome, which included experiencing low oxygen as measured on an home oxygen monitor," said Dr. Carolyn Bramonte, principal investigator of the study and an assistant professor of internal medicine and pediatrics at the University of Minnesota Medical School. Having low blood oxygen levels, or hypoxemia, is a common reason why COVID-19 patients end up seeking care in an ER, being hospitalized, or dying....

Each of the three generic medications has been held up as a possible COVID-19 drug, particularly ivermectin, which gained a cult following over the course of the pandemic despite well-documented issues with the flawed science that in some cases fraudulently touted the drug's benefits. Yet none so far have demonstrated in robust clinical trials that they actually help treat people with COVID-19.

A long-awaited double-blind, randomized, placebo-controlled study conducted by Duke University School of Medicine and funded by the U.S. concluded in June that ivermectin did not improve symptom duration among COVID-19 patients with mild-to-moderate forms of the disease. The same research found that the drug did not reduce hospitalizations or death.

According to a new study published in the journal Nature Biotechnology, researchers implanted corneas made from pig collagen to restore sight in 20 people who were blind or visually impaired. "Fourteen of the patients were blind before they received the implant, but two years after the procedure, they had regained some or all of their vision," notes NBC News. "Three had perfect vision after the surgery." From the report: The patients, in Iran and India, all suffered from keratoconus, a condition in which the protective outer layer of the eye progressively thins and bulges outward. "We were surprised with the degree of vision improvement," said Neil Lagali, a professor of experimental ophthalmology at Linkoping University in Sweden who co-authored the study. Not all patients experienced the same degree of improvement, however. The 12 Iranian patients wound up with an average visual acuity of 20/58 with glasses; functional vision is defined as 20/40 or better with lenses. Nonetheless, Dr. Marian Macsai, a clinical professor of ophthalmology at the University of Chicago who wasn't involved in the study, said the technology could be a game changer for those with keratoconus, which affects roughly 50 to 200 out of every 100,000 people. It might also have applications for other forms of corneal disease.

To create the implant, Lagali and his team dissolved pig tissue to form a purified collagen solution. That was used to engineer a hydrogel that mimics the human cornea. Surgeons then made an incision in a patient's cornea for the hydrogel. "We insert our material into this pocket to thicken the cornea and to reshape it so that it can restore the cornea's function," Lagali said. Traditionally, human tissue is required for cornea transplants. But it's in short supply, because people must volunteer to donate it after they die. So, Lagali said, his team was looking for a low-cost, widely available substitute. "Collagen from pigskin is a byproduct from the food industry," he said. "This makes it broadly available and easier to procure." After two years, the patients' bodies hadn't rejected the implants, and they didn't have any inflammation or scarring.

But any experimental medical procedure comes with risk. In this case, Soiberman said, a foreign molecule like collagen could induce an immune reaction. The researchers prescribed patients an eight-week course of immunosuppressive eyedrops to lower the risk, which is less than the amount given to people who receive cornea transplants from human tissue. In those cases, patients take immunosuppressive medicine for more than a year, Lagali said. "There's always a risk for rejection of the human donor tissue because it contains foreign cells," he said. "Our implant does not contain any cells ... so there's a minimal risk of rejection." The procedure itself was also quicker than traditional cornea transplants. The researchers said each operation took about 30 minutes, whereas transplants of human tissue can take a couple of hours. [...] It's not yet clear whether the surgery would work for patients who have other forms of corneal disease aside from keratoconus.

An anonymous reader quotes a report from Phys.Org: In a new University of California, Irvine-led study, researchers define how the circadian clock influences cell growth, metabolism and tumor progression. Their research also reveals how disruption of the circadian clock impacts genome stability and mutations that can further drive critical tumor-promoting pathways in the intestine. In this study, researchers found that both genetic disruption and environmental disruption of the circadian clock contribute to the mutation of the adenomatous polyposis coli (APC) tumor suppressor, which is found in the vast majority of human colorectal cancers (CRC). APC point mutations, deletions, and loss of heterozygosity (LOH) events have been reported in approximately 80 percent of human CRC cases, and it is these mutations that drive the initiation of intestinal adenoma development.

"As a society, we are exposed to several environmental factors that influence our biological clock, including night shift work, extended light exposure, changes in sleep/wake cycles and altered feeding behavior," said Selma Masri, Ph.D., assistant professor of biological chemistry at UCI School of Medicine. "Strikingly, we have seen an alarming increase in several young-onset cancers, including colorectal cancer. The underlying cause of this increased incidence of cancer in adults in their 20s and 30s remains undefined. However, based on our findings, we now believe that disruption of the circadian clock plays an important role." The study has been published in the journal Science Advances.

An anonymous reader quotes a report from The Guardian: China has overtaken the US as the world leader in both scientific research output and "high impact" studies, according to a report published by Japan's science and technology ministry. The report, which was published by Japan's National Institute of Science and Technology Policy (NISTP) on Tuesday, found that China now publishes the highest number of scientific research papers yearly, followed by the US and Germany. The figures were based on yearly averages between 2018 and 2020, and drawn from data compiled by the analytics firm Clarivate.

The Japanese NISTP report also found that Chinese research comprised 27.2% of the world's top 1% most frequently cited papers. The number of citations a research paper receives is a commonly used metric in academia. The more times a study is cited in subsequent papers by other researchers, the greater its "citation impact." The US accounted for 24.9% of the top 1% most highly cited research studies, while UK research was third at 5.5%. China published a yearly average of 407,181 scientific papers, pulling ahead of the US's 293,434 journal articles and accounting for 23.4% of the world's research output, the report found. China accounted for a high proportion of research into materials science, chemistry, engineering and mathematics, while US researchers were more prolific in research into clinical medicine, basic life sciences and physics. "China is one of the top countries in the world in terms of both the quantity and quality of scientific papers," Shinichi Kuroki of the Japan Science and Technology Agency told Nikkei Asia. "In order to become the true global leader, it will need to continue producing internationally recognized research."

Scientists have discovered that by microwaving fish waste, they can quickly and efficiently create carbon nano-onions (CNOs) -- a unique nanoform of carbon that has applications in energy storage and medicine. This method could be used to make cheaper and more sustainable LEDs in the future. The researchers from Nagoya Institute of Technology in Japan published their findings in Green Chemistry. Smithsonian Magazine reports: CNOs are nanostructures with spherical carbon shells in a concentric layered structure similar to an onion. They have "drawn extensive attention worldwide in terms of energy storage and conversion" because of their "exceptionally high electrical and thermal conductivity, as well as large external surface area," per the paper. They've been used in electronics and for biomedical applications, such as bio-imaging and sensing and drug delivery, write the authors in the study. Though CNOs were first reported in the 1980s, conventional methods of manufacturing them have required high temperatures, a vacuum and a lot of time and energy. Other techniques are expensive and call for complex catalysts or dangerous acidic or basic conditions. This "greatly limits the potential of CNOs," per a statement from Nagoya Institute of Technology.

The newly discovered method requires only one step -- microwave pyrolysis of fish scales extracted from fish waste -- and can be done within ten seconds, per the authors. How exactly the fish scales are converted into CNOs is unclear, though the team thinks it has to do with how collagen in the fish scales can absorb enough microwave radiation to quickly increase in temperature. This leads to pyrolysis, or thermal decomposition, which causes the collagen to break down into gasses. These gasses then support the creation of CNOs. This method is a "straightforward way to convert fish waste into infinitely more useful materials," and the resulting CNOs have a high crystallinity, which gives them "exceptional optical properties," per the statement. They also have high functionalization, which means they're "bonded to other small molecules on their surface," writes Ellen Phiddian for Cosmos. This combination of attributes means the CNOs can glow bright blue.

Several weeks after taking over Ukraine's southern port city of Kherson, Russian soldiers arrived at the offices of local internet service providers and ordered them to give up control of their networks. From a report: "They came to them and put guns to their head and just said, 'Do this,'" said Maxim Smelyanets, who owns an internet provider that operates in the area and is based in Kyiv. "They did that step by step for each company." Russian authorities then rerouted mobile and internet data from Kherson through Russian networks, government and industry officials said. They blocked access to Facebook, Instagram and Twitter, as well as to Ukrainian news websites and other sources of independent information. Then they shut off Ukrainian cellular networks, forcing Kherson's residents to use Russian mobile service providers instead.

What happened in Kherson is playing out in other parts of Russian-occupied Ukraine. After more than five months of war, Russia controls large sections of eastern and southern Ukraine. Bombings have leveled cities and villages; civilians have been detained, tortured and killed; and supplies of food and medicine are running low, according to witnesses interviewed by The New York Times and human rights groups. Ukrainians in those regions have access only to Russian state television and radio. To cap off that control, Russia has also begun occupying the cyberspace of parts of those areas. That has cleaved off Ukrainians in Russia-occupied Kherson, Melitopol and Mariupol from the rest of the country, limiting access to news about the war and communication with loved ones. In some territories, the internet and cellular networks have been shut down altogether.

The Biden administration declared monkeypox a public health emergency on Thursday as cases topped 6,600 nationwide. From a report: The declaration could facilitate access to emergency funds, allow health agencies to collect more data about cases and vaccinations, accelerate vaccine distribution and make it easier for doctors to prescribe treatment. "We're prepared to take our response to the next level in addressing this virus and we urge every American to take monkeypox seriously and to take responsibility to help us tackle this virus," Department of Health and Human Services Secretary Xavier Becerra said in a Thursday briefing about the emergency declaration. A quarter of U.S. cases are in New York state, which declared a state of emergency last week. California and Illinois followed suit with emergency declarations Monday.

An anonymous reader quotes a report from Phys.Org: Scientists at the University of Virginia School of Medicine and their collaborators have used DNA to overcome a nearly insurmountable obstacle to engineer materials that would revolutionize electronics. One possible outcome of such engineered materials could be superconductors, which have zero electrical resistance, allowing electrons to flow unimpeded. That means that they don't lose energy and don't create heat, unlike current means of electrical transmission. Development of a superconductor that could be used widely at room temperature -- instead of at extremely high or low temperatures, as is now possible -- could lead to hyper-fast computers, shrink the size of electronic devices, allow high-speed trains to float on magnets and slash energy use, among other benefits.

One such superconductor was first proposed more than 50 years ago by Stanford physicist William A. Little. [...] One possible way to realize Little's idea for a superconductor is to modify lattices of carbon nanotubes, hollow cylinders of carbon so tiny they must be measured in nanometers -- billionths of a meter. But there was a huge challenge: controlling chemical reactions along the nanotubes so that the lattice could be assembled as precisely as needed and function as intended.

[Edward H. Egelman, Ph.D., of UVA's Department of Biochemistry and Molecular Genetics] and his collaborators found an answer in the very building blocks of life. They took DNA, the genetic material that tells living cells how to operate, and used it to guide a chemical reaction that would overcome the great barrier to Little's superconductor. In short, they used chemistry to perform astonishingly precise structural engineering -- construction at the level of individual molecules. The result was a lattice of carbon nanotubes assembled as needed for Little's room-temperature superconductor. [...] The lattice they built has not been tested for superconductivity, for now, but it offers proof of principle and has great potential for the future, the researchers say. The findings have been published in the journal Science.

Live and high-resolution images of a patient's internal organs are already possible with ultrasound imaging technology. But currently the technology "requires bulky and specialized equipment available only in hospitals and doctor's offices," explains an annoncement from MIT.

Now a new design by MIT engineers "might make the technology as wearable and accessible as buying Band-Aids at the pharmacy." In a paper appearing today in Science, the engineers present the design for a new ultrasound sticker — a stamp-sized device that sticks to skin and can provide continuous ultrasound imaging of internal organs for 48 hours.

The researchers applied the stickers to volunteers and showed the devices produced live, high-resolution images of major blood vessels and deeper organs such as the heart, lungs, and stomach. The stickers maintained a strong adhesion and captured changes in underlying organs as volunteers performed various activities, including sitting, standing, jogging, and biking....

From the stickers' images, the team was able to observe the changing diameter of major blood vessels when seated versus standing. The stickers also captured details of deeper organs, such as how the heart changes shape as it exerts during exercise. The researchers were also able to watch the stomach distend, then shrink back as volunteers drank then later passed juice out of their system. And as some volunteers lifted weights, the team could detect bright patterns in underlying muscles, signaling temporary microdamage.

"With imaging, we might be able to capture the moment in a workout before overuse, and stop before muscles become sore," says Chen. "We do not know when that moment might be yet, but now we can provide imaging data that experts can interpret."
They're already envisioning other possibilities: If the devices can be made to operate wirelessly — a goal the team is currently working toward — the ultrasound stickers could be made into wearable imaging products that patients could take home from a doctor's office or even buy at a pharmacy. "We envision a few patches adhered to different locations on the body, and the patches would communicate with your cellphone, where AI algorithms would analyze the images on demand," says the study's senior author, Xuanhe Zhao, professor of mechanical engineering and civil and environmental engineering at MIT.

"We believe we've opened a new era of wearable imaging: With a few patches on your body, you could see your internal organs."

"Two new studies provide more evidence that the coronavirus pandemic originated in a Wuhan, China market where live animals were sold," reports the Associated Press, "further bolstering the theory that the virus emerged in the wild rather than escaping from a Chinese lab."

CNN reports: "All eight COVID-19 cases detected prior to 20 December were from the western side of the market, where mammal species were also sold," the [first] study says. The proximity to five stalls that sold live or recently butchered animals was predictive of human cases... The "extraordinary" pattern that emerged from mapping these cases was very clear, said another co-author, Michael Worobey, department head of Ecology and Evolutionary Biology at the University of Arizona.

The researchers mapped the earliest cases that had no connection to the market, Worobey noted, and those people lived or worked in close proximity to the market. "This is an indication that the virus started spreading in people who worked at the market but then started that spread ... into the surrounding local community as vendors went into local shops, infected people who worked in those shops," Worobey said.

The other study takes a molecular approach and seems to determine when the first coronavirus infections crossed from animals to humans.... The researchers suggest that the first animal-to-human transmission probably happened around November 18, 2019, and it came from lineage B. They found the lineage B type only in people who had a direct connection to the Huanan market.
"All this evidence tells us the same thing: It points right to this particular market in the middle of Wuhan," said Kristian Andersen a professor in the Department of Immunology and Microbiology at Scripps Research and coauthor of one of the studies. The AP quotes Andersen as saying "I was quite convinced of the lab leak myself until we dove into this very carefully and looked at it much closer." Andersen said they found case clusters inside the market, too, "and that clustering is very, very specifically in the parts of the market" where they now know people were selling wildlife, such as raccoon dogs, that are susceptible to infection with the coronavirus.... Matthew Aliota, a researcher in the college of veterinary medicine at the University of Minnesota, said in his mind the pair of studies "kind of puts to rest, hopefully, the lab leak hypothesis."

"Both of these two studies really provide compelling evidence for the natural origin hypothesis," said Aliota, who wasn't involved in either study. Since sampling an animal that was at the market is impossible, "this is maybe as close to a smoking gun as you could get."
CNN notes that Worobey also had initially thought the lab leak had been a possibility, but now says the epidemiological preponderance of cases linked to the market is "not a mirage. It's a real thing.

"It's just not plausible that this virus was introduced any other way than through the wildlife trade." To reduce the chances of future pandemics, the researchers hope they can determine exactly what animal may have first become infected and how.

"The raw ingredients for a zoonotic virus with pandemic potential are still lurking in the wild," said Joel Wertheim, an associate adjunct professor of medicine at the University of California, San Diego. He believes the world needs to do a much better job doing surveillance and monitoring animals and other potential threats to human health.

An anonymous reader quotes a report from Reuters: The oldest patient yet has been cured of HIV after receiving a stem cell transplant for leukaemia, researchers reported on Wednesday. While the transplant was planned to treat the now-66-year-old's leukaemia, the doctors also sought a donor who was naturally resistant to the virus that causes AIDS, a mechanism that first worked to cure the "Berlin patient," Timothy Ray Brown, in 2007.

The latest patient, the fourth to be cured in this way, is known as the "City of Hope" patient after the U.S. facility in Duarte, California, where he was treated, because he does not want to be identified. As well as being the oldest, the patient has also had HIV the longest, having been diagnosed in 1988 with what he described as a "death sentence" that killed many of his friends. He has been on antiretroviral therapy (ART) to control his condition for more than 30 years. [...] Scientists think the process works because the donor individual's stem cells have a specific, rare genetic mutation which means they lack the receptors used by HIV to infect cells. "Scientists think the process works because the donor individual's stem cells have a specific, rare genetic mutation which means they lack the receptors used by HIV to infect cells," adds Reuters.

"After the transplant three and a half years ago, which followed chemotherapy, the City of Hope patient stopped taking ART in March 2021. He has now been in remission from both HIV and leukaemia for more than a year, the team said."

Researchers in Spain also presented a case of a 59-year-old woman who is considered to be in a state of viral remission. "She has now maintained a fully suppressed viral load for over 15 years," reports NBC News. "Unlike the handful of people either cured or possibly cured by stem cell transplants, however, she still harbors virus that is capable of producing viable new copies of itself. Her body has actually controlled the virus more efficiently with the passing years, according to Dr. Juan Ambrosioni, an HIV physician in the Barcelona clinic."

Reuters reports: The rapidly spreading monkeypox outbreak represents a global health emergency, the World Health Organization's highest level of alert, WHO Director-General Tedros Adhanom Ghebreyesus said on Saturday.

The WHO label — a "public health emergency of international concern" — is designed to trigger a coordinated international response and could unlock funding to collaborate on sharing vaccines and treatments. Members of an expert committee that met on Thursday to discuss the potential recommendation were split on the decision, with nine members against and six in favour of the declaration, prompting Tedros himself to break the deadlock, he told reporters. "Although I am declaring a public health emergency of international concern, for the moment this is an outbreak that is concentrated among men who have sex with men, especially those with multiple sexual partners," Tedros told a media briefing in Geneva.

A 37-year-old junior professor in Tennessee "identified apparently altered or duplicated images in dozens of journal articles," reports Science magazine.

But that was just the beginning for Matthew Schrag, whose sleuthing then "drew him into a different episode of possible misconduct, leading to findings that threaten one of the most cited Alzheimer's studies of this century and numerous related experiments." The first author of that influential study, published in Nature in 2006, was an ascending neuroscientist: Sylvain Lesné of the University of Minnesota, Twin Cities. His work underpins a key element of the dominant yet controversial amyloid hypothesis of Alzheimer's, which holds that A clumps, known as plaques, in brain tissue are a primary cause of the devastating illness, which afflicts tens of millions globally. In what looked like a smoking gun for the theory and a lead to possible therapies, Lesné and his colleagues discovered an A subtype and seemed to prove it caused dementia in rats.

If Schrag's doubts are correct, Lesné's findings were an elaborate mirage....

A 6-month investigation by Science provided strong support for Schrag's suspicions and raised questions about Lesné's research. A leading independent image analyst and several top Alzheimer's researchers — including George Perry of the University of Texas, San Antonio, and John Forsayeth of the University of California, San Francisco (UCSF) — reviewed most of Schrag's findings at Science's request. They concurred with his overall conclusions, which cast doubt on hundreds of images, including more than 70 in Lesné's papers. Some look like "shockingly blatant" examples of image tampering, says Donna Wilcock, an Alzheimer's expert at the University of Kentucky. The authors "appeared to have composed figures by piecing together parts of photos from different experiments," says Elisabeth Bik, a molecular biologist and well-known forensic image consultant. "The obtained experimental results might not have been the desired results, and that data might have been changed to ... better fit a hypothesis...."

Schrag's work, done independently of Vanderbilt and its medical center, implies millions of federal dollars may have been misspent on the research — and much more on related efforts. Some Alzheimer's experts now suspect Lesné's studies have misdirected Alzheimer's research for 16 years. "The immediate, obvious damage is wasted NIH funding and wasted thinking in the field because people are using these results as a starting point for their own experiments," says Stanford University neuroscientist Thomas Südhof, a Nobel laureate and expert on Alzheimer's and related conditions.

Lesné did not respond to requests for comment....

Some Alzheimer's experts see a failure of skepticism, including by journals that published the work.
Schrag has warned America's National Institutes of Health that the suspect work "not only represents a substantial investment in [NIH] research support, but has been cited ... thousands of times and thus has the potential to mislead an entire field of research."

And Harvard neurologic disease professor Dennis Selkoe told Science "There are certainly at least 12 or 15 images where I would agree that there is no other explanation" than manipulation. Selkoe's bigger worry, he says, is that the Lesné episode might further undercut public trust in science during a time of increasing skepticism and attacks. But scientists must show they can find and correct rare cases of apparent misconduct, he says. "We need to declare these examples and warn the world."
Thanks to Slashdot reader Crypto Fireside for sharing the story!

An unvaccinated young adult from New York recently contracted polio, the first U.S. case in nearly a decade, health officials said Thursday. The Associated Press reports: Officials said the patient, who lives in Rockland County, had developed paralysis. The person developed symptoms a month ago and did not recently travel outside the country, county health officials said. It appears the patient had a vaccine-derived strain of the virus, perhaps from someone who got live vaccine -- available in other countries, but not the U.S. -- and spread it, officials said. The person is no longer deemed contagious, but investigators are trying to figure out how the infection occurred and whether other people may have been exposed to the virus. The report notes that polio was declared eliminated in the U.S. in 1979, "meaning there was no longer routine spread."