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News

WHO Says Omicron Has Been Found in 23 Countries Across the World (cnbc.com) 259

The World Health Organization said Wednesday that 23 countries across the world have reported cases of the highly mutated omicron Covid-19 variant. From a report: "At least 23 countries from five of six WHO regions have now reported cases of omicron and we expect that number to grow," WHO Director-General Tedros Adhanom Ghebreyesus told reporters during an update Wednesday in Geneva. "WHO takes this development extremely seriously and so should every country. But it should not surprise us," Tedros continued. "This is what viruses do. And it's what this virus will continue to do, as we long as we allow it to continue spreading."

The new number comes one day after White House chief medical advisor Dr. Anthony Fauci said 226 cases of the variant have been detected across 20 countries. Officials have not confirmed a case in the U.S. yet. The variant, which was reported to WHO by South Africa a week ago, has more than 30 mutations to the spike protein alone. Some of the mutations are associated with a decrease in antibody protection and higher transmission, according to the WHO. Tedros said there is still more to learn about the new variant's effect on transmission, the severity of disease and the effectiveness of tests, therapeutics and vaccines. Several WHO advisory groups have met in the last few days to "evaluate the emerging evidence, and prioritize the studies needed to answer these questions," he said.

United States

Biden Administration Issues New Framework for Space Policy, With a Focus on Climate Change (theverge.com) 31

Today, Vice President Kamala Harris' office released a new framework for US space policy, detailing how the Biden administration plans to approach commercial, civil, and military space activity moving forward. From a report: Called the United States Space Priorities Framework, the document keeps many of the same space priorities from the previous administration but adds a new emphasis on using space to help combat climate change and investing in STEM education. The new framework comes ahead of today's National Space Council meeting, the first one to be held under the Biden administration. Harris, who chairs the National Space Council, will convene the policy advisory group at the United States Institute of Peace in Washington, DC, at 1:30PM ET today.

[...] When it comes to space, the Biden administration is carrying forward many of the priorities set by the Trump administration. Notably, NASA's ambitious Artemis program, which was solidified under Trump, is still a major focus under Biden. And plenty of the topics discussed under Pence's Space Council are included in the new framework released by Harris. A few of the key points include maintaining US leadership in space by sending humans back to the Moon and exploring the Solar System with robotic spacecraft, fostering a competitive, regulatory environment for space companies, and defending against security threats in space while strengthening our space assets. In the biggest break from the previous administration, there looks to be a renewed focus on using space in the fight against climate change. In the new framework, the administration pledges to invest in satellites that can observe Earth from space, helping scientists better understand our changing climate. "Open dissemination of Earth observation data will support both domestic and international efforts to address the climate crisis," the document states. To further drive home this new emphasis on climate research from space, President Biden plans to sign a new Executive Order today that will add five new members to the National Space Council, including the Secretaries of Education, Labor, Agriculture, and the Interior, but also notably the National Climate Advisor.

United States

Wanted: A Town Willing to Host a Dump for U.S. Nuclear Waste (bloomberg.com) 335

The Biden administration is looking for communities willing to serve as temporary homes for tens of thousands of metric tons of nuclear waste currently stranded at power plants around the country. Bloomberg reports: The Energy Department filed (PDF) a public notice Tuesday that it is restarting the process for finding a voluntary host for spent nuclear fuel until a permanent location is identified. "Hearing from and then working with communities interested in hosting one of these facilities is the best way to finally solve the nation's spent nuclear fuel management issues," Energy Secretary Jennifer Granholm said in a statement. The agency, in its notice, requested input on how to proceed with a "consent-based" process for a federal nuclear storage facility, including what benefits could entice local and state governments and how to address potential impediments. Federal funding is also possible, the notice said. Approximately 89,000 metric tons of nuclear waste is being stored at dozens of nuclear power plants and other sites around the country.
[...]
One such interim storage site could be in Andrews, Texas. The Nuclear Regulatory Commission in September approved a license for a proposal by Orano CIS LLC and its joint venture partner, J.F. Lehman & Co.'s Waste Control Specialists LLC, to establish a repository in the heart of Texas' Permian Basin oil fields for as many as 40,000 metric tons of radioactive waste. The joint venture envisioned having nuclear waste shipped by rail from around the country and sealed in concrete casks where it would be stored above ground at a site about 30 miles (48.28 kilometers) from Andrews. But the plan has drawn opposition from Texas authorities and local officials who once embraced it as an economic benefit but have since had a change of heart. A similar nuclear waste storage project, proposed in New Mexico by Holtec International Corp., is awaiting approval by the Nuclear Regulatory Commission. The agency said it expects to make a decision on that proposal in January 2022.

Medicine

Princeton Team Disables Long-Targeted Gene Behind Spread of Major Cancers (newatlas.com) 55

An anonymous reader writes: The mysterious ways cancer spreads through the body, a process known as metastasis, is what can make it such a difficult enemy to keep at bay. Researchers at Princeton University working in this area have been tugging at a particular thread for more than 15 years, focusing on a single gene central to the ability of most major cancers to metastasize. They've now discovered what they describe as a "silver bullet" in the form of a compound that can disable this gene in mice and human tissue, with clinical trials possibly not too far away.

This discovery has its roots in 2004 research in which Princeton scientists identified a gene implicated in metastatic breast cancer, called metadherin, or MTDH. A 2009 paper by cancer biologist Yibin Kang then showed the gene was amplified and produced abnormally high levels of MTDH proteins in around a third of breast cancer tumors, and was central to not just the process of metastasis, but also the resistance of those tumors to chemotherapy. Subsequent research continued to shed light on the importance of the MTDH gene, demonstrating how it is critical for cancer to flourish and metastasize. Mice engineered to lack the gene grew normally, and those that did get breast cancer featured far fewer tumors -- and those tumors that did form didn't metastasize. This was then found to be true of prostate cancer, lung cancer, colorectal cancer, liver cancer and many other cancers.

The crystal structure of MTDH shows the protein has a pair of protrusions likened to fingers, which interlock with two holes in the surface of another protein called SND1. This is "like two fingers sticking into the holes of a bowling ball," according to Kang, and the scientists suspected if this intimate connection could be broken, it could go a long way to dampening the harmful effects of MTDH. "We knew from the crystal structure what the shape of the keyhole was, so we kept looking until we found the key," Kang says. The team spent two years screening for the right molecules to fill these holes without any great success, until they landed on what they say is a "silver bullet." The resulting compound plugs these voids and prevents the proteins from interlocking, with profound anti-cancer effects that resemble those seen in the MTDH-deficient mice from their earlier work.
"The scientists say that MTDH assists cancer in two primary ways, by helping tumors endure the stresses of chemotherapy and by silencing the alarm that organs normally sound when a tumor invades them," adds New Atlas. "By interlocking with the SND1 protein, it prevents the immune system from recognizing the danger signals normally generated by cancerous cells, and therefore stops it from attacking them. The team is now working to refine the compound, hoping to improve its effectiveness in disrupting the connection between MTDH and SND1 and lower the required dosage. [T]hey hope to be ready for clinical trials on human patients in two to three years."

The research has been published across two papers in the journal Nature Cancer.
NASA

NASA Postpones Spacewalk Citing 'Debris Notification' for ISS (theguardian.com) 13

Nasa has postponed a planned spacewalk outside the International Space Station due to flying "debris," two weeks after Russia blew up one of its own satellites in a missile test that created clouds of zooming shrapnel in orbit. From a report: Washington's space agency did not mention the Russian test in its announcement, but a Nasa official had warned a day earlier of a slightly elevated risk to astronauts due to the 14 November incident. The strike generated thousands of pieces of "space junk" that are now hurling around the Earth at about 17,000 mph (27,400km/h) -- much faster than the speed of a bullet. At that velocity, even tiny flecks of paint can damage spacecraft, with spacesuits even more vulnerable.

On Tuesday, about five hours before the astronauts Thomas Marshburn and Kayla Barron were due to venture outside the space station, Nasa said on Twitter that the spacewalk to fix a failed antenna had been cancelled. "Nasa received a debris notification for the space station. Due to the lack of opportunity to properly assess the risk it could pose to the astronauts, teams have decided to delay the 30 November spacewalk until more information is available," it tweeted. Moscow has said its test to destroy its own spacecraft, Tselina-D, which had been in orbit since 1982, was successful and the debris posed no "threat to space activity."

Medicine

Moderna CEO Says Vaccines Likely Less Effective Against Omicron (reuters.com) 311

The head of drugmaker Moderna said COVID-19 vaccines are unlikely to be as effective against the Omicron variant of the coronavirus as they have been previously, sparking fresh worry in financial markets about the trajectory of the pandemic. From a report: "There is no world, I think, where (the effectiveness) is the same level... we had with Delta," Moderna Chief Executive Stephane Bancel told the Financial Times in an interview. "I think it's going to be a material drop. I just don't know how much because we need to wait for the data. But all the scientists I've talked to are like 'this is not going to be good.'"

Vaccine resistance could lead to more sickness and hospitalisations and prolong the pandemic, and his comments triggered selling in growth-exposed assets like oil, stocks and the Australian dollar. Bancel added that the high number of mutations on the protein spike the virus uses to infect human cells meant it was likely the current crop of vaccines would need to be modified. He had earlier said on CNBC that it could take months to begin shipping a vaccine that does work against Omicron.

Cellphones

Israel Authorizes Use of Phone Tracking Tech To Contain Spread of Omicron Covid Variant (reuters.com) 70

An anonymous reader quotes a report from Reuters: Rights groups petitioned Israel's top court on Monday to repeal new COVID-19 measures that authorize the country's domestic intelligence service to use counter-terrorism phone tracking technology to contain the spread of the Omicron virus variant. Announcing the emergency measures on Saturday, Prime Minister Naftali Bennett said the phone tracking would be used to locate carriers of the new and potentially more contagious variant in order to curb its transmission to others. Israeli rights groups say the emergency measures violate previous Supreme Court rulings over such surveillance, used on-and-off by the country's Shin Bet domestic intelligence agency since March, 2020.

A senior health ministry official said on Sunday that use of phone tracking would be "surgical" in nature, only to be utilized on confirmed or suspected carriers of the variant. The surveillance technology matches virus carriers' locations against other mobile phones nearby to determine with whom they have come into contact. Israel's Supreme Court this year limited the scope of its use after civil rights groups mounted challenges over privacy concerns.
Further reading: Omicron Covid Variant Poses Very High Global Risk, Says WHO
Robotics

World's First Living Robots Can Now Reproduce, Scientists Say (cnn.com) 77

The US scientists who created the first living robots say the life forms, known as xenobots, can now reproduce -- and in a way not seen in plants and animals. CNN reports: Formed from the stem cells of the African clawed frog (Xenopus laevis) from which it takes its name, xenobots are less than a millimeter (0.04 inches) wide. The tiny blobs were first unveiled in 2020 after experiments showed that they could move, work together in groups and self-heal. Now the scientists that developed them at the University of Vermont, Tufts University and Harvard University's Wyss Institute for Biologically Inspired Engineering said they have discovered an entirely new form of biological reproduction different from any animal or plant known to science.

[T]hey found that the xenobots, which were initially sphere-shaped and made from around 3,000 cells, could replicate. But it happened rarely and only in specific circumstances. The xenobots used "kinetic replication" -- a process that is known to occur at the molecular level but has never been observed before at the scale of whole cells or organisms [...]. With the help of artificial intelligence, the researchers then tested billions of body shapes to make the xenobots more effective at this type of replication. The supercomputer came up with a C-shape that resembled Pac-Man, the 1980s video game. They found it was able to find tiny stem cells in a petri dish, gather hundreds of them inside its mouth, and a few days later the bundle of cells became new xenobots.

The xenobots are very early technology -- think of a 1940s computer -- and don't yet have any practical applications. However, this combination of molecular biology and artificial intelligence could potentially be used in a host of tasks in the body and the environment, according to the researchers. This may include things like collecting microplastics in the oceans, inspecting root systems and regenerative medicine. While the prospect of self-replicating biotechnology could spark concern, the researchers said that the living machines were entirely contained in a lab and easily extinguished, as they are biodegradable and regulated by ethics experts.
"Most people think of robots as made of metals and ceramics but it's not so much what a robot is made from but what it does, which is act on its own on behalf of people," said Josh Bongard, a computer science professor and robotics expert at the University of Vermont and lead author of the study, writing in the Proceedings of the National Academy of Sciences. "In that way it's a robot but it's also clearly an organism made from genetically unmodified frog cell."

"The AI didn't program these machines in the way we usually think about writing code. It shaped and sculpted and came up with this Pac-Man shape," Bongard said. "The shape is, in essence, the program. The shape influences how the xenobots behave to amplify this incredibly surprising process."
Science

Stamping Bar Codes on Cells To Solve Medical Mysteries (nytimes.com) 14

No one really knew why some patients with a white blood cell cancer called chronic lymphocytic leukemia, or C.L.L., relapsed after treatment and got a second cancer. Were some cancer cells just resistant? An unexpected answer to this mystery has been found using a new technique that researchers call bar coding: The treatment does not always target the right cells. From a report: Scientists discovered that the cancer does not always originate in the mature bone marrow cells where it is found and where textbooks say it originates. Instead, for some patients, the mother lode of the cancer can be primitive bone marrow cells, the stem cells, that give rise to all of the body's white and red blood cells. Those cells, not affected by the chemotherapy treatment, can spawn new cancer cells, causing a relapse. The discovery is one early fruit of the bar coding method, which is aiding the study of the origins of cancer and other diseases. The results are too new to have led to patient therapies. But they are leading to provocative discoveries that are expected to inspire novel methods for treating diseases.

The method works by marking individual cells with a stamp that is passed on to all of a cell's progeny. Researchers can look at a cell, note its bar code and trace its lineage back to its parents, grandparents, great-grandparents -- all the way back to its origins -- because each cell that arose from the original bar coded cell has the same stamp. The idea for bar coding during embryonic development originated with Dr. Jay Shendure and his colleagues at the University of Washington, and this class of methods was anointed the breakthrough of the year by Science magazine in 2018. Now there is a variety of methods for bar coding ranging from embryo cells to cancer cells to mature cells.

For example, Dr. Shendure and another group of colleagues at the University of Pennsylvania are using bar codes in mice with pancreatic cancer to study the spread of cancer cells in their bodies. In the case of C.L.L. above, Dr. Vijay Sankaran at Boston Children's Hospital and his colleagues bar coded human cancer cells by taking advantage of innocuous, naturally occurring mutations that mark individual cells and are inherited by their progeny. Bar coding, Dr. Sankaran said, "starts to give us a view of cancer that we never had before."

Science

How to Read a Jellyfish's Mind (phys.org) 24

Researchers at the California Institute of Technology have developed "a kind of genetic toolbox" for tiny one-centimeter jellfyfish, reports Phys.org. Specifically, the jellyfish "have been genetically modified so that their neurons individually glow with fluorescent light when activated." Because a jellyfish is transparent, researchers can then watch the glow of the animal's neural activity as it behaves naturally. In other words, the team can read a jellyfish's mind as it feeds, swims, evades predators, and more, in order to understand how the animal's relatively simple brain coordinates its behaviors. A paper describing the new study appears in the journal Cell on November 24....

Rather than being centralized in one part of the body like our own brains, the jellyfish brain is diffused across the animal's entire body like a net. The various body parts of a jellyfish can operate seemingly autonomously, without centralized control; for example, a jellyfish mouth removed surgically can carry on "eating" even without the rest of the animal's body.

This decentralized body plan seems to be a highly successful evolutionary strategy, as jellyfish have persisted throughout the animal kingdom for hundreds of millions of years. But how does the decentralized jellyfish nervous system coordinate and orchestrate behaviors...? [T]hough the network of jellyfish neurons originally seemed diffuse and unstructured, the researchers found a surprising degree of organization that only became visible with their fluorescent system.

Ultimately the researchers say they've identified "patches" of neurons that work together, and they now want to study how various "modules" of neuron groups are coordinating.
Math

Researchers Claim Locally-Testable-Code Breakthrough With Exotic Multi-Dimensional Graph (quantamagazine.org) 62

"A team of researchers has finally created a long-sought locally testable code that can immediately betray whether it's been corrupted..." reports Quanta magazine.

"Many thought local testability would never be achieved in its ideal form." Now, in a preprint released on November 8, the computer scientist Irit Dinur of the Weizmann Institute of Science and four mathematicians, Shai Evra, Ron Livne, Alex Lubotzky and Shahar Mozes, all at the Hebrew University of Jerusalem, have found it. "It's one of the most remarkable phenomena that I know of in mathematics or computer science," said Tom Gur of the University of Warwick. "It's been the holy grail of an entire field."

Their new technique transforms a message into a super-canary, an object that testifies to its health better than any other message yet known. Any corruption of significance that is buried anywhere in its superstructure becomes apparent from simple tests at a few spots. "This is not something that seems plausible," said Madhu Sudan of Harvard University. "This result suddenly says you can do it."

Most prior methods for encoding data relied on randomness in some form. But for local testability, randomness could not help. Instead, the researchers had to devise a highly nonrandom graph structure entirely new to mathematics, which they based their new method on. It is both a theoretical curiosity and a practical advance in making information as resilient as possible....

To get a sense of what their graph looks like, imagine observing it from the inside, standing on a single edge. They construct their graph such that every edge has a fixed number of squares attached. Therefore, from your vantage point you'd feel as if you were looking out from the spine of a booklet. However, from the other three sides of the booklet's pages, you'd see the spines of new booklets branching from them as well. Booklets would keep branching out from each edge ad infinitum. "It's impossible to visualize. That's the whole point," said Lubotzky. "That's why it is so sophisticated...."

[A] test at one node can reveal information about errors from far away nodes. By making use of higher dimensions, the graph is ultimately connected in ways that go beyond what we typically even think of as connections... It establishes a new state of the art for error-correcting codes, and it also marks the first substantial payoff from bringing the mathematics of high-dimensional expanders to bear on codes...

Practical and theoretical applications should soon follow. Different forms of locally testable codes are now being used in decentralized finance, and an optimal version will allow even better decentralized tools.

Medicine

A Stem-Cell Cure For Type 1 Diabetes? For One Man, It Seems To Have Worked (yahoo.com) 48

Long-time Slashdot reader fahrbot-bot shares the New York Times' report on a 64-year-old man who participated in a clinical trial by Vertex Pharmaceuticals involving an infusion of insulin-producing pancreas cells grown from stem cells.

"Now his body automatically controls its insulin and blood sugar levels." Mr. Shelton, now 64, may be the first person cured of the disease with a new treatment that has experts daring to hope that help may be coming for many of the 1.5 million Americans suffering from Type 1 diabetes. "It's a whole new life," Mr. Shelton said. "It's like a miracle." Diabetes experts were astonished but urged caution.

The study is continuing and will take five years, involving 17 people with severe cases of Type 1 diabetes. It is not intended as a treatment for the more common Type 2 diabetes.

"We've been looking for something like this to happen literally for decades," said Dr. Irl Hirsch, a diabetes expert at the University of Washington who was not involved in the research. He wants to see the result, not yet published in a peer-reviewed journal, replicated in many more people. He also wants to know if there will be unanticipated adverse effects and if the cells will last for a lifetime or if the treatment would have to be repeated. But, he said, "bottom line, it is an amazing result...."

For Mr. Shelton the moment of truth came a few days after the procedure, when he left the hospital. He measured his blood sugar. It was perfect. He and Ms. Shelton had a meal. His blood sugar remained in the normal range.

Mr. Shelton wept when he saw the measurement.

"The only thing I can say is 'thank you.'"

15 people in a lab spent over 20 years working on converting the stem cells, the article reports. The total cost: about $50 million.
Science

'Squeezed' Light Might Produce Breakthroughs in Nano-Sized Electronics (engadget.com) 15

"It's one thing to produce nanoscale devices, but it's another to study and improve on them — they're so small they can't reflect enough light to get a good look," reports Engadget. "A breakthrough might make that possible, however." Univeristy of California Riverside researchers have built technology that squeezes tungsten lamp light into a 6-nanometer spot at the end of a silver nanowire. That lets scientists produce color imaging at an "unprecedented" level, rather than having to settle for molecular vibrations. The developers modified an existing "superfocusing" tool (already used to measure vibrations) to detect signals across the entire visible spectrum. Light travels in a flashlight-like conical path. When the nanowire's tip passes over an object, the system records that item's influence on the beam shape and color (including through a spectrometer). With two pieces of specrtra for every 6nm pixel, the team can create color photos of carbon nanotubes that would otherwise appear gray.
"The researchers expect that the new technology can be an important tool to help the semiconductor industry make uniform nanomaterials with consistent properties for use in electronic devices," according to an announcement from University of California Riverside, adding that the new full-color nano-imaging technique "could also be used to improve understanding of catalysis, quantum optics, and nanoelectronics."
Canada

Breakthrough By McMaster PhD Student Creates Laser In Silicon (mcmaster.ca) 60

Long-time Slashdot reader thisisnotreal writes: Long sought-after, and previously thought impossible — a McMaster University PhD student in Hamilton Canada demonstrates a cost-effective and simple laser in silicon.

This could have dramatic consequences for the SiP (Silicon Photonics) — a hot topic for those working in the field of integrated optics. Integrated optics is a critical technology involved in advanced telecommunications networks, and showing increasing importance in quantum research and devices, such as QKD (Quantum Key Distribution) and in various entanglement type experiments (involved in Quantum Compute).

"This is the holy grail of photonics," says Jonathan Bradley, an assistant professor in the Department of Engineering Physics (and the student's co-supervisor) in an announcement from McMaster University. "Fabricating a laser on silicon has been a longstanding challenge." Bradley notes that Miarabbas Kiani's achievement is remarkable not only for demonstrating a working laser on a silicon chip, but also for doing so in a simple, cost-effective way that's compatible with existing global manufacturing facilities. This compatibility is essential, as it allows for volume manufacturing at low cost. "If it costs too much, you can't mass produce it," says Bradley.
Medicine

Booster Shots Create a 23X Increase in Protective Antibody Levels, Study Suggests (yahoo.com) 375

The Los Angeles Times summarizes the results of a new medical study conducted by Northwestern University researchers on antibody levels protecting against Covid-19 in 974 people. "Those who were immunized against COVID-19 with two doses of an mRNA vaccine and received a booster shot about eight months later saw their levels of neutralizing antibodies skyrocket.

"Among this group of 33 fully vaccinated and boosted people, the median level of these antibodies was 23 times higher one week after the booster shot than it had been just before the tune-up dose." What's more, their median post-booster antibody level was three times higher than was typical for another group of people whose antibodies were measured a few weeks after getting their second dose of vaccine, when they're close to their peak.

And it was 53 times higher than that of a group of 76 unvaccinated people who had recovered from COVID-19 just two to six weeks earlier. Even compared to a group of 73 people who had weathered a bout with COVID-19 and went on to get two doses of an mRNA vaccine, the boosted group's median antibody level was 68% higher.

Study leader Alexis Demonbreun, a cell biologist at Northwestern University's Feinberg School of Medicine, said the data demonstrate that no matter how well protected a vaccinated person may think she is, getting a booster shot is likely to increase her neutralizing antibodies — and with it, her immunity — considerably. And because scientists expect large antibody responses to create more durable immunity, the protection afforded by the booster should last longer than the initial two-shot regimen did...

Among their other findings: After receiving two doses of vaccine, people who'd already had an asymptomatic infection were typically no better protected than vaccinated people who had never been infected.

Science

Physicists Start Detecting Signs of Neutrinos At Large Hadron Collider (phys.org) 34

"The international Forward Search Experiment team, led by physicists at the University of California, Irvine, has achieved the first-ever detection of neutrino candidates produced by the Large Hadron Collider at the CERN facility near Geneva, Switzerland," reports Phys.org.

Long-time Slashdot reader fahrbot-bot shared their report: In a paper published Friday in the journal Physical Review D, the researchers describe how they observed six neutrino interactions during a pilot run of a compact emulsion detector installed at the LHC in 2018. "Prior to this project, no sign of neutrinos has ever been seen at a particle collider," said co-author Jonathan Feng, UCI Distinguished Professor of physics & astronomy and co-leader of the FASER Collaboration. "This significant breakthrough is a step toward developing a deeper understanding of these elusive particles and the role they play in the universe."

He said the discovery made during the pilot gave his team two crucial pieces of information. "First, it verified that the position [480 meters] forward of the ATLAS interaction point at the LHC is the right location for detecting collider neutrinos," Feng said. "Second, our efforts demonstrated the effectiveness of using an emulsion detector to observe these kinds of neutrino interactions...."

"Given the power of our new detector and its prime location at CERN, we expect to be able to record more than 10,000 neutrino interactions in the next run of the LHC, beginning in 2022," said co-author David Casper, FASER project co-leader and associate professor of physics & astronomy at UCI. "We will detect the highest-energy neutrinos that have ever been produced from a human-made source."

The article also points out that in future experiments the researchers hope to explore dark matter — and how it interacts with normal atoms.
Medicine

Top Vaccine Makers Already Preparing to Fight Omicron Coronavirus Variant (usatoday.com) 165

While the Omicron mutation might "impact" the effectiveness of our current vaccines, they're "super unlikely" to render them useless, according to Dr. Ashish Jha, dean of Brown University's School of Public Health.

And USA Today reports that vaccine makers are already getting ready to fight the variant: Health experts have said it will likely be weeks before the world has good data about how omicron may reduce the effectiveness of current vaccines, but Moderna has already announced a three-point strategy to combat the new variant...

Moderna's strategy involves three options for boosting COVID-19 vaccination, should omicron prove problematic for current vaccines. The three options, according to a Friday release from the company: A higher dose booster, shots currently being studied that are designed to "anticipate mutations such as those that have emerged in the Omicron variant" and an omicron-specific booster — which is already in the works.

Andy Slavitt, who previously served as President Joe Biden's White House senior adviser for COVID response, said in a tweet that both Moderna and Pfizer-BioNTech have estimated a vaccine to combat a new variant could be developed in about 3 months, with some regulatory and logistical hurtles to follow. "If we start in early December, new vaccines could be available by summer in much of the world," Slavitt tweeted.

Multiple media organizations on Friday reported Pfizer-BioNTech is studying the new variant and expects data within weeks. If warranted, a targeted vaccine could be developed within 6 weeks and ship within 100 days, the reports say.

Johnson & Johnson is also testing its current vaccine against omicron, according to CNBC.

Moon

3D Printer Using Living Ink Made of Microbes Could Print Healing Structures in Space (nytimes.com) 13

"The thought of combining a printer (the bane of office workers) with the bacterium E. coli (the scourge of romaine lettuce) may seem an odd, if not unpleasant, collaboration," writes the New York Times.

"But scientists have recently melded the virtues of the infuriating tool and of the toxic microbe to produce an ink that is alive, made entirely from microbes." The microbial ink flows like toothpaste under pressure and can be 3D-printed into various tiny shapes — a circle, a square and a cone — all of which hold their form and glisten like Jell-O. The researchers describe their recipe for their programmable, microbial ink in a study published on Tuesday in the journal Nature Communications.

The material is still being developed, but the authors suggest that the ink could be a crucial renewable building material, able to grow and heal itself and ideal for constructing sustainable homes on Earth and in space... [T]he new substance contains no additional polymers; it is produced entirely from genetically engineered E. coli bacteria. The researchers induce bacterial cultures to grow the ink, which is also made of living bacteria cells. When the ink is harvested from the liquid culture, it becomes firm like gelatin and can be plugged into 3D-printers and printed into living structures, which do not grow further and remain in their printed forms...

Bacteria may seem an unconventional building block. But microbes are a crucial component of products such as perfumes and vitamins, and scientists have already engineered microbes to produce biodegradable plastics. A material like a microbial ink has more grandiose ambitions, according to Neel Joshi, a synthetic biologist at Northeastern University and an author on the new paper. Such inks are an expanding focus of the field of engineered living materials. Unlike structures cast from concrete or plastic, living systems would be autonomous, adaptive to environmental cues and able to regenerate — at least, that is the aspirational goal, Dr. Joshi said. "Imagine creating buildings that heal themselves," said Sujit Datta, a chemical and biological engineer at Princeton University who was not involved with the research....

Dr. Manjula-Basavanna is shooting for the moon, Earth's satellite, where there are no forests to harvest for wood and no easy way to send bulk building materials. There, he said, the ink might be used as a self-regenerating substance to help build habitats on other planets, as well as places on Earth. "There is a lot of work to be done to make it scalable and economic," Dr. Datta conceded. But, he noted, just five years ago creating robust structures out of microbes was unimaginable; conceivably, self-healing buildings could be a reality in our lifetime.

United States

Biden Admin Announces Travel Ban for South Africa and 7 Other Countries, Citing New Variant (politico.com) 258

The Biden administration announced plans on Friday to ban travel to the United States from South Africa and seven other countries, just hours after a new coronavirus variant was deemed a highly transmissible virus of concern. From a report: The travel restrictions will begin Monday, affecting South Africa, Botswana, Zimbabwe, Namibia, Lesotho, Eswatini, Mozambique and Malawi, according to a senior administration official. The administration's decision was in response to advice from Anthony Fauci, the president's chief medical adviser, and the Centers for Disease Control and Prevention, the official said. Roughly a dozen countries took similar action on Friday.

President Joe Biden, who is in Nantucket for the holiday, was briefed on the new variant Friday. He urged fully vaccinated Americans to get booster shots and the unvaccinated to get the "life-saving protection." Biden also addressed the global community in his statement, saying the new variant shows the pandemic won't end until vaccines are readily available around the world. He said the U.S. has donated more vaccines than every country combined, calling on others to match "America's speed and generosity."

Science

Einstein Foundation To Present the Inaugural Award for Promoting Quality in Research (idw-online.de) 11

The Einstein Foundation Berlin is honoring the American physicist Paul Ginsparg and the Center for Open Science with the inaugural Einstein Foundation Award for Promoting Quality in Research. Paul Ginsparg is the founder of the preprint server arXiv.org, the first platform to exchange scientific discoveries among scientists immediately, openly and globally without review- and paywall restrictions.

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