NASA has a launch date for that most Hollywood of missions, the Double Asteroid Redirection Test, which is basically a dry run of the movie "Armageddon." From a report: Unlike the film, this will not involve nukes, oil rigs or Aerosmith, but instead is a practical test of our ability to change the trajectory of an asteroid in a significant and predictable way. The DART mission, managed by the Planetary Defense Coordination Office (!), involves sending a pair of satellites out to a relatively nearby pair of asteroids, known as the Didymos binary. It's one large-ish asteroid, approximately 780 meters across -- that's Didymos proper -- and a 160-meter "moonlet" in its orbit.

The first dog in space. The first man and woman. Now Russia has clinched another spaceflight first before the United States: Beating Hollywood to orbit. From a report: A Russian actress, Yulia Sherepild, a director, Klim Shipenko, and their veteran Russian astronaut guide, Anton Shkaplerov, launched on a Russian rocket toward the International Space Station on Tuesday. Their mission is to shoot scenes for the first feature-length film in space. While cinematic sequences in space have long been portrayed on big screens using sound stages and advanced computer graphics, never before has a full-length movie been shot and directed in space.

Whether the film they shoot in orbit is remembered as a cinematic triumph, the mission highlights the busy efforts of governments as well as private entrepreneurs to expand access to space. Earth's orbit and beyond were once visited only by astronauts handpicked by government space agencies. But a growing number of visitors in the near future will be more like Ms. Sherepild and Mr. Shipenko, and less like the highly trained Mr. Shkaplerov and his fellow space explorers. A Soyuz rocket, the workhorse of Russia's space program, lifted off on time at 4:55 a.m. Eastern time from the Baikonur Cosmodrome in Kazakhstan. Before the launch on Tuesday, the MS-19 crew posed for photos and waved to family and fans in Baikonur. Mr. Shipenko, the director of the film which is named "The Challenge," held up a script as he waved to cameras.

The Swedish Academy of Sciences awarded half of the Nobel Prize in physics jointly to Syukuro Manabe of the United States and Klaus Hasselmann of Germany for modeling Earth's climate and predicting global warming. From a report: Giorgio Parisi of Italy won the other half of the prize for describing fluctuating physical systems on scales from atoms to planets. The three scientists were honored "for groundbreaking contributions to our understanding of complex physical systems," Goran K. Hansson, secretary general Royal Swedish Academy of Sciences, told reporters in Stockholm.

An anonymous reader quotes a report from The Verge: Sarah was the patient in a proof-of-concept trial of a new approach to treating severe, treatment-resistant depression, published today in the journal Nature Medicine. The findings open up another possible strategy for helping people with the disorder. The study only involved Sarah, and it's still not clear how well it might work in other people. The lessons from the trial, though, helped the researchers understand more about the nature of depression and could apply to other efforts to treat the disease. The trial used a technique called deep brain stimulation, where electrodes implanted within the brain deliver electrical impulses in an attempt to change or regulate abnormal brain activity. It's common for conditions like epilepsy and Parkinson's disease. Research over the past decade has shown that it can sometimes help with depression, but the findings have been inconsistent. Most previous efforts delivered stimulation to individual regions of the brain thought to be involved in depression. This study, though, was targeted at regions that were part of specific brain circuits -- interconnected parts of the brain that are responsible for specific functions.

In addition, the circuits involved might be different for each person. So in this trial, the study team personalized the treatment approach to the specific patient's depression. They mapped out the type of brain activity that occurred when Sarah's depression symptoms flared. Then, they surgically implanted a device that could detect that brain activity and send stimulation to the circuit where the activity was happening. For Sarah, the procedure was highly effective. Her scores on depression rating scales dropped the morning after the device was turned on. And perhaps more importantly, she felt dramatic changes in her mood. During her first time getting the stimulation, she laughed out loud in the lab. "And everyone in the room went, 'Oh my god,' because that's the first time I spontaneously laughed and smiled, where it wasn't faked, in five years," she said. Sarah's depression circuit flares up hundreds of times a day, and each time, the implanted device delivers a brief stimulating pulse. In total, she gets around 30 minutes of stimulation each day [...]. Sarah can't feel the pulses, but she said she does have a general idea of when they're happening throughout the day. "There's a sense of alertness and energy or positivity that I'll feel," she said.

Large tree-planting initiatives often fail -- and some have even fueled deforestation. From a report: On November 11, 2019, volunteers planted 11 million trees in Turkey as part of a government-backed initiative called Breath for the Future. In one northern city, the tree-planting campaign set the Guinness World Record for the most saplings planted in one hour in a single location: 303,150. "By planting millions of young trees, the nation is working to foster a new, lush green Turkey," Turkey's president, Recep Tayyip Erdogan, said when he kicked off the project in Ankara. Less than three months later, up to 90 percent of the saplings were dead, the Guardian reported. The trees were planted at the wrong time and there wasn't enough rainfall to support the saplings, the head of the country's agriculture and forestry trade union told the paper.

In the past two decades, mass tree-planting campaigns like this one have gained popularity as a salve for many of our modern woes, from climate change to the extinction crisis. Companies and billionaires love these kinds of initiatives. So do politicians. [...] There's just one problem: These campaigns often don't work, and sometimes they can even fuel deforestation. In one recent study in the journal Nature, for example, researchers examined long-term restoration efforts in northern India, a country that has invested huge amounts of money into planting over the last 50 years. The authors found "no evidence" that planting offered substantial climate benefits or supported the livelihoods of local communities.

The study is among the most comprehensive analyses of restoration projects to date, but it's just one example in a litany of failed campaigns that call into question the value of big tree-planting initiatives. Often, the allure of bold targets obscures the challenges involved in seeing them through, and the underlying forces that destroy ecosystems in the first place. Instead of focusing on planting huge numbers of trees, experts told Vox, we should focus on growing trees for the long haul, protecting and restoring ecosystems beyond just forests, and empowering the local communities that are best positioned to care for them. In the past three decades, the number of tree-planting organizations has skyrocketed, growing nearly threefold in the tropics alone. So have global drives: Today, there are no fewer than three campaigns focused on planting 1 trillion trees, including the World Economic Forum's (WEF) One Trillion Trees Initiative, which launched in 2020.

The Nobel Prize in the field of physiology or medicine has been awarded to U.S.-based scientists David Julius and Ardem Patapoutian. From a report: They were cited for their discovery of receptors for temperature and touch. The winners were announced Monday by Thomas Perlmann, secretary-general of the Nobel Committee.Patrik Ernfors of the Nobel Committee said Julius, 65, used capsaicin, the active component in chili peppers, to identify the nerve sensors that allow the skin to respond to heat. Patapoutian found separate pressure-sensitive sensors in cells that respond to mechanical stimulation, he said. "This really unlocks one of the secrets of nature," said Perlmann. "It's actually something that is crucial for our survival, so it's a very important and profound discovery." The pair also shared the prestigious Kavli Award for Neuroscience last year. Further reading: California Scientists Share Nobel for Work on Sense of Touch.

Opyros writes: Fossil footprints in New Mexico have been dated to 21,000-23,000 years before present. As a result, human habitation of the Americas can be pushed back several thousand years.

The footprints were found in sedimentary rock at White Sands National Park, near the location of a long-vanished lake. Since the rock contains seeds of ditchgrass, it was possible to apply radiocarbon dating, leading to the remarkably early date. Until now, the oldest unequivocally dated signs of human presence in the New World were only 16,000 years old. Hence the great significance of the find.

A New York Times science/global health reporter reminds us that "Newer variants of the coronavirus like Alpha and Delta are highly contagious, infecting far more people than the original virus."

But then they add that "Two new studies offer a possible explanation: The virus is evolving to spread more efficiently through air." Most researchers now agree that the coronavirus is mostly transmitted through large droplets that quickly sink to the floor and through much smaller ones, called aerosols, that can float over longer distances indoors and settle directly into the lungs, where the virus is most harmful. The new studies don't fundamentally change that view. But the findings signal the need for better masks in some situations, and indicate that the virus is changing in ways that make it more formidable.

"This is not an Armageddon scenario," said Vincent Munster, a virologist at the National Institute of Allergy and Infectious Diseases, who led one of the new studies. "It is like a modification of the virus to more efficient transmission, which is something I think we all kind of expected, and we now see it happening in real time." Dr. Munster's team showed that small aerosols traveled much longer distances than larger droplets and the Alpha variant was much more likely to cause new infections via aerosol transmission. The second study found that people infected with Alpha exhaled about 43 times more virus into tiny aerosols than those infected with older variants.

The studies compared the Alpha variant with the original virus or other older variants. But the results may also explain why the Delta variant is so contagious — and why it displaced all other versions of the virus...

At least in some crowded spaces, people may want to consider switching to more protective masks, said Don Milton, an aerosol expert at the University of Maryland who led the research. "Given that it seems to be evolving towards generating aerosols better, then we need better containment and better personal protection," Dr. Milton said of the virus. "We are recommending people move to tighter-fitting masks."

Phys.org reports that a newly published theoretical/computer-modeling study "suggests that the world's most powerful lasers might finally crack the elusive physics behind some of the most extreme phenomena in the universe — gamma ray bursts, pulsar magnetospheres, and more."

The study comes from an international team including researchers from Lawrence Berkeley National Laboratory and France's Alternative Energies and Atomic Energy Commission (publishing in the journal Physical Review Letters.): The team's modeling study shows that petawatt (PW)-class lasers — juiced to even higher intensities via light-matter interactions — might provide a key to unlock the mysteries of the strong-field (SF) regime of quantum electrodynamics (QED). A petawatt is 1 times ten to the fifteenth power (that is, followed by 15 zeroes), or a quadrillion watts. The output of today's most powerful lasers is measured in petawatts... "This is a powerful demonstration of how advanced simulation of complex systems can enable new paths for discovery science by integrating multiple physics processes — in this case, the laser interaction with a target and subsequent production of particles in a second target," said ATAP Division Director Cameron Geddes....

The scheme consists of boosting the intensity of a petawatt laser pulse with a relativistic plasma mirror. Such a mirror can be formed when an ultrahigh intensity laser beam hits an optically polished solid target. Due to the high laser amplitude, the solid target is fully ionized, forming a dense plasma that reflects the incident light. At the same time the reflecting surface is actually moved by the intense laser field. As a result of that motion, part of the reflected laser pulse is temporally compressed and converted to a shorter wavelength by the Doppler effect. Radiation pressure from the laser gives this plasma mirror a natural curvature. This focuses the Doppler-boosted beam to much smaller spots, which can lead to extreme intensity gains — more than three orders of magnitude — where the Doppler-boosted laser beam is focused. The simulations indicate that a secondary target at this focus would give clear SF-QED signatures in actual experiments.

The study drew upon Berkeley Lab's diverse scientific resources, including its WarpX simulation code, which was developed for modeling advanced particle accelerators under the auspices of the U.S. Department of Energy's Exascale Computing Project... The discovery via WarpX of novel high-intensity laser-plasma interaction regimes could have benefits far beyond ideas for exploring strong-field quantum electrodynamics. These include the better understanding and design of plasma-based accelerators such as those being developed at the Berkeley Lab Laser Accelerator. More compact and less expensive than conventional accelerators of similar energy, they could eventually be game-changers in applications that range from extending the reach of high-energy physics and of penetrating photon sources for precision imaging, to implanting ions in semiconductors, treating cancer, developing new pharmaceuticals, and more.

"It is gratifying to be able to contribute to the validation of new, potentially very impactful ideas via the use of our novel algorithms and codes," Vay said of the Berkeley Lab team's contributions to the study. "This is part of the beauty of collaborative team science."
Long-time Slashdot reader fahrbot-bot has suggested that the article deserves an alternate title: "Article I Read Three Times and Still Don't Completely Understand."

In 1999 Los Angeles Times reporter Michael Hiltzik won a Pulitzer Prize. Now a business columnist for the Times, he writes that "new evidence undermines the COVID lab-leak theory — but the press keeps pushing it." A paper posted online [in September] chiefly by researchers at France's Institut Pasteur and under consideration for publication in a Nature journal...reports that three viruses were found in bats living in caves in northern Laos with features very similar to SARS-CoV-2, the virus responsible for COVID-19. As Nature reported, those viruses are "more similar to SARS-CoV-2 than any known viruses."

Another paper, posted in late August by researchers from the Wuhan lab, reports on viruses found in rats also with features similar to those that make SARS-CoV-2 infectious in humans.

Two other papers published on the discussion forum virological.org present evidence that the virus jumped from animals to humans at more than one animal market in Wuhan, not just the Huanan seafood market. Given that these so-called wet markets have long been suspected as transmission points of viruses from animals to humans because they sell potentially infected animals, that makes the laboratory origin vastly less likely, according to a co-author of one of the papers. "That a laboratory leak would find its way to the very place where you would expect to find a zoonotic transmission is quite unlikely," Joel Wertheim, an associate professor at UC San Diego's medical school, told me. "To have it find its way to multiple markets, the exact place where you would expect to see the introduction, is unbelievably unlikely."

As virologist Robert F. Garry of Tulane, one of Wertheim's co-authors, told Nature, the finding is "a dagger into the heart" of the lab-leak hypothesis.

Last month U.S. President Biden issued "a mandate that all companies with more than 100 workers require vaccination or weekly testing," remembers the New York Times, and "also moved to mandate shots for health care workers, federal contractors and a vast majority of federal workers, who could face disciplinary measures if they refuse."

So what happened next? Until now, the biggest unknown about mandating COVID-19 vaccines in workplaces has been whether such requirements would lead to compliance or to significant departures by workers unwilling to get shots — at a time when many places were already facing staffing shortages. So far, a number of early mandates show few indications of large-scale resistance. "Mandates are working," said John Swartzberg, a physician and professor at the School of Public Health at the University of California, Berkeley. "If you define 'working' by the percentage of people getting vaccinated and not leaving their jobs in droves."

Unlike other incentives — "prizes, perks, doughnuts, beer, we've seen just about everything offered to get people vaccinated" — mandates are among the few levers that historically have been effective in increasing compliance, said Swartzberg, who has tracked national efforts to increase rates of inoculation...

[T]he pushback has been less dramatic than initially feared. At Houston Methodist Hospital, which mandated vaccines this summer for 25,000 employees, for example, only about 0.6% of employees quit or were fired. Dorit Reiss, a professor at the University of California Hastings College of the Law in San Francisco who is tracking employer mandates, said that, despite their propensity for backlash and litigation, mandates generally increase vaccine compliance because the knowledge that an order is coming has often been enough to prompt workers to seek inoculation before courts even can weigh in. Mandates are becoming more commonplace as several other states have imposed requirements for workers. In New York, Rhode Island, Maine, Oregon and the District of Columbia, health care workers must get vaccinated to remain employed.
The Times's article (original URL here) provides statistics from specific examples:

• "When Tyson Foods announced Aug. 3 that it would require coronavirus vaccines for all 120,000 of its U.S. employees, less than half of its workforce was inoculated. Nearly two months later, 91% of the company's U.S. workforce is fully vaccinated, said Dr. Claudia Coplein, Tyson's chief medical officer."

• "In New York, where some 650,000 employees at hospitals and nursing homes were to have received at least one vaccine dose by the start of this week, 92% were in compliance, state officials said. That was up significantly from a week ago, when 82% of the state's nursing home workers and at least 84% of its hospital workers had received at least one dose."

• "As California's requirement that all health care workers be vaccinated against the coronavirus took effect Thursday, major health systems reported that the mandate had helped boost their vaccination rates to 90% or higher."

People benefit from deep and meaningful conversations that help us forge connections with one another, but we often stick to small talk with strangers because we underestimate how much others are interested in our lives and wrongly believe that deeper conversations will be more awkward and less enjoyable than they actually are, according to research published by the American Psychological Association. Phys.Org reports: If connecting with others in deep and meaningful ways increases well-being, then why aren't people doing it more often in daily life? To answer that question, [researchers] designed a series of twelve experiments with more than 1,800 total participants. The researchers asked pairs of people -- mainly strangers -- to discuss either relatively deep or shallow topics. In some experiments, people received shallow or deep questions to discuss. Shallow questions included typical small-talk topics, such as, "What is the best TV show you've seen in the last month? Tell your partner about it" or "What do you think about the weather today?" while deep questions elicited more personal and intimate information, such as, "Can you describe a time you cried in front of another person?" or "If a crystal ball could tell you the truth about yourself, your life, your future, or anything else, what would you want to know?" In other experiments, people generated their own deep and shallow conversation topics.

Before the conversations, participants predicted how awkward they thought the conversations would be, how connected they thought they would feel to their conversation partner and how much they would enjoy the conversation. Afterward, they rated how awkward the conversations actually were, how connected they actually felt and how much enjoyment they actually experienced. Overall, the researchers found that both deep and shallow conversations felt less awkward and led to greater feelings of connectedness and enjoyment than the participants had expected. That effect tended to be stronger for deep conversations. Participants who discussed the deep questions overestimated how awkward the conversation would be significantly more than those who discussed shallow questions. Deep conversations were also more enjoyable and led to a stronger sense of connection.

A spacecraft bound for the planet Mercury will take a first look at the target tonight, when it makes its first-ever flyby of the small rocky world during an incredibly close encounter tonight. Space.com reports: The mission, called BepiColombo, is a joint project of the European Space Agency (ESA) and the Japanese Aerospace Exploration Agency (JAXA). It is only the second mission in history sent to orbit Mercury, the smallest and innermost planet of the solar system. BepiColombo's flyby tonight (Oct. 1) will bring the spacecraft within just 124 miles (200 kilometers) of the surface of Mercury, the closest the probe will ever get to the planet during its mission. The first images from the encounter are expected to reach Earth early Saturday (Oct. 2) and will be the first close images of Mercury's scorched surface since the end of NASA's Messenger orbiter mission in 2015.

BepiColombo will make its closest approach to Mercury at 7:34 p.m. EDT (2334 GMT) today (Oct.1), ESA said in a statement. The spacecraft will then continue on its winding trajectory around the sun. This close pass is one of nine gravity-assist flybys, maneuvers that use the gravity of celestial bodies to adjust a spacecraft's trajectory, that BepiColombo needs to perform before it can enter its target orbit around the planet. This flyby, however, will take the spacecraft even closer to the scorched planet's surface, than its ultimate scientific orbit of 300 to 930 miles (480 to 1,500 kilometers). The $750 million BepiColombo mission will be able to make measurements of the environment around the planet and take images with its black and white 'selfie' cameras, which provide a 1024 by 1024 pixel resolution (comparable to an early-2000s flip phone.) [...] After tonight's close pass, it will take four more flybys of Mercury by BepiColombo before the spacecraft is in the correct position to finally enter the planet's orbit, which is set to happen in 2025.

An anonymous reader quotes a report from Ars Technica: An oral antiviral drug appears to cut the risk of hospitalization and death from COVID-19 by roughly 50 percent in people newly diagnosed with the infection and at risk for severe disease, pharmaceutical company Merck announced Friday morning. The drug-maker and its partner, Ridgeback Biotherapeutics, released top-line results of a Phase III trial, which the companies ended early given the positive results. The companies say they will apply for an Emergency Use Authorization from the US Food and Drug Administration as soon as possible.

The trial enrolled people who had newly tested positive for a SARS-CoV-2 infection and had onset of mild-to-moderate COVID-19 symptoms within just the past five days of starting the trial. The enrollees also had to have at least one risk factor for a poor outcome, such as having obesity, diabetes, heart disease, or being age 60 or above. While some participants received a placebo and standard care, others took an oral dose of the drug every 12 hours for five days. After 29 days of follow-up, 53 out of 377 participants who received the placebo were hospitalized with COVID-19, and eight of those participants died. Among those who received the drug, only 28 of 385 were hospitalized and none of those patients died. Put another way, 7.3 percent of patients on the drug were either hospitalized or died compared with 14.1 percent in the placebo group. Merck also highlighted that the trial was global and that the drug appeared to work equally well against varying SARS-CoV-2 variants, including delta, gamma, and mu. The drug-maker noted that it had viral genetic data to identify variants from 40 percent of participants. The safety data was equally promising, with participants reporting similar numbers of drug-related adverse events between the placebo group than the drug group (11 percent and 12 percent, respectively). About 3.4 percent of people in the placebo group quit the study due to adverse events, while only 1.3 percent quit in the drug group.

The drug at the center of these seemingly smashing results is dubbed molnupiravir -- a name inspired by that of Thor's hammer, Mjolnir. The idea is that the drug will strike down SARS-CoV-2, like a mighty blow from the god of thunder. In an interview with Stat news, Merck's head of research and development, Dean Li, said that the new data proves the drug's mythological force. "Our prediction from our in vitro studies and now with this data is that molnupiravir is named after the right [thing]... this is a hammer against SARS-CoV-2 regardless of the variant." Molnupiravir is a small molecule that wallops the work of a viral RNA-dependent RNA polymerase, an enzyme critical for making copies of RNA viruses, such as SARS-CoV-2. [...] Molnupiravir delivers a precise blow to viral RNA polymerase by posing as a building block for RNA. In the body, molnupiravir is forged into a deceptive ribonucleoside that the polymerase unwittingly incorporates into new strands of viral RNA instead of cytidine. This is essentially lethal. Researchers call the effect a "viral error catastrophe," in which the rate of genetic mutations or errors exceeds a threshold compatible with the virus surviving.

sciencehabit shares a report from Science.org: In late 1791 and early 1792, on the eve of the French Revolutionary Wars, Queen Marie Antoinette engaged in a secret correspondence with her confidant and rumored lover, Swedish Count Axel von Fersen. Nearly 50 letters from that exchange survive at the French National Archives. But certain passages in 15 of the letters were unreadable, obscured by redactions made with swirls of dark ink. Now, researchers have revealed the words beneath 45 of these alterations using x-ray technology. They have also discovered the censor's identity: von Fersen, himself. The idea that von Fersen made the redactions is "a revelation," says Catriona Seth, a professor of French literature at the University of Oxford who was not involved with the work. Historians had thought the letters were censored in the second half of the 19th century -- most likely by von Fersen's great-nephew -- to protect the writers' reputations. Now, she says, scholars will need to rethink the cover-up -- and the reasons behind it.

The newly legible passages are largely sentimental, phrases like "made my heart happy," and "you that I love." Comments on politics and world events, meanwhile, remain uncensored. But even these seemingly intimate phrases don't definitively tell historians anything new about Marie Antoinette and von Fersen's relationship, Seth says. Scholars, she notes, already knew Marie Antoinette had "a very deep affection for him." Still, she adds, the letters offer "direct insight into the thoughts and feelings of Marie Antoinette." In the future, the techniques in this study could be used in combination with machine algorithms to automatically transcribe old texts, the researchers say, making it easier to understand these important documents -- and others like them. The researchers published their findings in the journal Science Advances.

skam240 writes: California has just become the first state to add Covid-19 vaccination to its list of required vaccines for in-school attendance. "The requirement will go into effect at the start of the term that follows the FDA's full approval for that grade group -- either January 1 or July 1," reports CNN, citing a release from Gov. Gavin Newsom's office. For grades 7-12 the requirement is expected to begin on July 1, 2022. Newsom's office said independent study is an option for unvaccinated students. "This will accelerate our effort to get this pandemic behind us," Newsom told CNN's Ana Cabrera minutes after making the announcement. "We already mandate 10 vaccines. In so many ways... it's probably the most predictable announcement."

"I have four young kids. I can't take this anymore. I'm like most parents, I want to get this behind us, get this economy moving again, make sure our kids never have to worry about getting a call saying they can't go to school the next day because one of the kids or a staff member tested positive," the governor added.

Artificial intelligence can tell whether it is going to rain in the next two hours, research suggests. The BBC reports: Scientists at Google-owned London AI lab DeepMind and the University of Exeter partnered with the Met Office to build the so-called nowcasting system. Traditional methods use complex equations and often forecast for only between six hours and two weeks' time. The AI system can make more accurate short-term predictions, including for critical storms and floods. The system learned how to identify common patterns of rainfall, using UK radar maps from 2016 to 2018, was tested on maps from 2019 and found, by 50 Met Office meteorologists, to be accurate in 89% of cases. The research, published in the journal Nature, found: "Meteorologists significantly preferred the [AI] approach to competing methods."

An anonymous reader quotes a report from Ars Technica: A former communications executive at Blue Origin and 20 other current and former employees have written a blistering essay about the company's culture, citing safety concerns, sexist attitudes, and a lack of commitment to the planet's future. "In our experience, Blue Origin's culture sits on a foundation that ignores the plight of our planet, turns a blind eye to sexism, is not sufficiently attuned to safety concerns, and silences those who seek to correct wrongs," the essay authors write. "That's not the world we should be creating here on Earth, and certainly not as our springboard to a better one." Published Thursday on the Lioness website, the essay is signed publicly by only Alexandra Abrams, who led employee communications for the company until she was terminated in 2019. The other signatories, a majority of whom were engineers, declined to publicly disclose their names because they did not want to jeopardize employment at Blue Origin or harm their prospects in the aerospace industry for other jobs.

At times, the essay is shocking in its candor. Many of the essay's authors said they would not feel safe flying on a Blue Origin vehicle. And the anecdotes of sexism and an unhealthy work culture are vivid. "Former and current employees have had experiences they could only describe as dehumanizing, and are terrified of the potential consequences for speaking out against the wealthiest man on the planet," the authors write. "Others have experienced periods of suicidal thoughts after having their passion for space manipulated in such a toxic environment. One senior program leader with decades in the aerospace and defense industry said working at Blue Origin was the worst experience of her life."

After publication of the essay, Ars spoke with several current and former employees who have provided reliable information in the past about the company. Although it is clear the essay was a product of disgruntled workers, these sources agreed that there were elements of truth in the essay. For these sources, the withering criticism of Blue Origin founder Jeff Bezos, and his hand-picked chief executive, Bob Smith, rang especially true. The essay authors write, "Professional dissent at Blue Origin is actively stifled. Smith personally told one of us to not make it easy for employees to ask questions at company town halls -- one of the only available forums for live, open discussion." These town halls are typically moderated so that employees cannot directly ask questions of Smith. In one infamous exchange, there were apparently so few substantive questions Smith was willing to answer that the moderator resorted to asking Smith what his favorite ice cream was. "Sorbet," Smith answered. Another example of unwelcome management tactics cited in the essay was Bezos' decision, after the Supreme Court ruling in the Epic Systems arbitration case, to force employees to sign away their right to resolve employment disputes in court. Sources confirmed to Ars that they were indeed faced with the choice of signing such an onerous contract or realizing they would eventually have to leave Blue Origin. It seemed grossly unfair. In response, Blue Origin said in a statement: "Ms. Abrams was dismissed for cause two years ago after repeated warnings for issues involving federal export control regulations. Blue Origin has no tolerance for discrimination or harassment of any kind. We provide numerous avenues for employees, including a 24/7 anonymous hotline, and will promptly investigate any new claims of misconduct."

Abrams disputes those claims, saying that she never received any warnings, verbal or written, from management issues involving federal export control regulations.

Virgin Galactic is cleared to resume flights of its SpaceShipTwo space plane, the Federal Aviation Administration (FAA) said Wednesday, after capping a safety investigation into issues that came up during the company's July flight carrying its founder Richard Branson. During that mission, SpaceShipTwo strayed from its designated airspace on its descent from space, and Virgin Galactic didn't tell the FAA about it when it was supposed to. The Verge reports: With the investigation now closed, the FAA required Virgin Galactic to make changes "on how it communicates to the FAA during flight operations to keep the public safe," it said in a statement. Virgin Galactic said that includes "updated calculations to expand the protected airspace for future flights" and "additional steps into the Company's flight procedures to ensure real-time mission notifications to FAA Air Traffic Control." Another change: "Updated calculations to expand the protected airspace for future flights," the company said. "We appreciate the FAA's thorough review of this inquiry. Our test flight program is specifically designed to continually improve our processes and procedures," Virgin Galactic CEO Michael Colglazier said in a statement. "The updates to our airspace and real-time mission notification protocols will strengthen our preparations as we move closer to the commercial launch of our spaceflight experience."

An anonymous reader quotes a report from NPR: Carlene Knight's vision was so bad that she couldn't even maneuver around the call center where she works using her cane. But that's changed as a result of volunteering for a landmark medical experiment. Her vision has improved enough for her to make out doorways, navigate hallways, spot objects and even see colors. Knight is one of seven patients with a rare eye disease who volunteered to let doctors modify their DNA by injecting the revolutionary gene-editing tool CRISPR directly into cells that are still in their bodies. Knight and [another volunteer in the experiment, Michael Kalberer] gave NPR exclusive interviews about their experience. This is the first time researchers worked with CRISPR this way. Earlier experiments had removed cells from patients' bodies, edited them in the lab and then infused the modified cells back into the patients. [...]

CRISPR is already showing promise for treating devastating blood disorders such as sickle cell disease and beta thalassemia. And doctors are trying to use it to treat cancer. But those experiments involve taking cells out of the body, editing them in the lab, and then infusing them back into patients. That's impossible for diseases like [Leber congenital amaurosis, or LCA], because cells from the retina can't be removed and then put back into the eye. So doctors genetically modified a harmless virus to ferry the CRISPR gene editor and infused billions of the modified viruses into the retinas of Knight's left eye and Kalberer's right eye, as well as one eye of five other patients. The procedure was done on only one eye just in case something went wrong. The doctors hope to treat the patients' other eye after the research is complete. Once the CRISPR was inside the cells of the retinas, the hope was that it would cut out the genetic mutation causing the disease, restoring vision by reactivating the dormant cells.

The procedure didn't work for all of the patients, who have been followed for between three and nine months. The reasons it didn't work might have been because their dose was too low or perhaps because their vision was too damaged. But Kalberer, who got the lowest dose, and one volunteer who got a higher dose, began reporting improvement starting at about four to six weeks after the procedure. Knight and one other patient who received a higher dose improved enough to show improvement on a battery of tests that included navigating a maze. For two others, it's too soon to tell. None of the patients have regained normal vision -- far from it. But the improvements are already making a difference to patients, the researchers say. And no significant side effects have occurred. Many more patients will have to be treated and followed for much longer to make sure the treatment is safe and know just how much this might be helping.