An anonymous reader quotes a report from CNN: The U.S. Food and Drug Administration warned Tuesday against using plasma infusions from young blood donors to ward off the effects of normal aging as well as other more serious conditions. Plasma, the liquid portion of the blood, contains proteins that help clot blood. The infusions are promoted to treat a variety of conditions, including normal aging and memory loss as well as serious conditions such as dementia, multiple sclerosis, heart disease and post-traumatic stress disorder.

"There is no proven clinical benefit of infusion of plasma from young donors to cure, mitigate, treat, or prevent these conditions, and there are risks associated with the use of any plasma product," FDA Commissioner Dr. Scott Gottlieb wrote in a statement Tuesday. "The reported uses of these products should not be assumed to be safe or effective," he added, noting that the FDA "strongly" discourages consumers from using this therapy "outside of clinical trials under appropriate institutional review board and regulatory oversight." Gottlieb said that "a growing number of clinics" are offering plasma from young donors and similar therapies, though he did not name any in particular.

An anonymous reader quotes a report from the BBC: Current digital technology gives us flawless music quality without physical deterioration. Music is easy to copy and upload, and can be streamed online without downloading. Since our digital music is less tangible than vinyl or CDs, surely it must be more environmentally friendly? Even though new formats are material-free, that doesn't mean they don't have an environmental impact. The electronic files we download are stored on active, cooled servers. The information is then retrieved and transmitted across the network to a router, which is transferred by wi-fi to our electronic devices. This happens every time we stream a track, which costs energy. Once vinyl or a CD is purchased, it can be played over and over again, the only carbon cost coming from running the record player. However, if we listen to our streamed music using a hi-fi sound system it's estimated to use 107 kilowatt hours of electricity a year, costing about $20 to run. A CD player uses 34.7 kilowatt hours a year and costs about $7 to run.

So, which is the greener option? It depends on many things, including how many times you listen to your music. If you only listen to a track a couple of times, then streaming is the best option. If you listen repeatedly, a physical copy is best -- streaming an album over the internet more than 27 times will likely use more energy than it takes to produce and manufacture a CD. If you want to reduce your impact on the environment, then vintage vinyl could be a great physical option. For online music, local storage on phones, computers or local network drives keeps the data closer to the user and will reduce the need for streaming over distance from remote severs across a power-hungry network.

A new study finds that active middle aged men who can do more than 40 push-ups at a time have a significantly lower risk of heart disease. From a report: Researchers at the Harvard T.H. Chan School of Public Health followed more than 1,100 middle-aged male firefighters over a decade. They looked at two specific measures: how many push-ups they could do and their exercise tolerance on a treadmill. They found that men who could do more than 40 push-ups had a 96-percent lower risk of heart disease than those who could do no more than 10 and their ability to do push-ups was a better predictor of cardiovascular disease than their stamina on a treadmill test.

President Donald Trump signed a directive on Tuesday that ordered the Department of Defense to create a Space Force as a sixth military branch. From a report: With a directive signed Tuesday, Mr. Trump was positioning the Space Force much as the Marine Corps fits into the Navy, officials said, with the result being lower costs and less bureaucracy. The plan would require congressional approval. Mr. Trump is to propose funding in his proposed 2020 budget, and spell out a goal of eventually establishing the Space Force as a separate military department, a senior administration official said. "Space, that's the next step and we have to be prepared," said Mr. Trump, who added that adversaries were training forces and developing technology. "I think we'll have great support from Congress."

The order Mr. Trump signed, Space Policy Directive 4, calls for a legislative proposal by the secretary of defense to establish a chief of staff of the Space Force within the Air Force. That officer would be a member of the Joint Chiefs of Staff, according to an outline. There also be a new under secretary of defense for space to be appointed by the president. The proposal calls for the Space Force to organize, train and equip personnel to defend the U.S. in space, to provide independent military options for "joint and national leadership" and "enable the lethality and effectiveness of the joint force," according to the administration's outline.

Goldman Sachs analysts attempted to address a touchy subject for biotech companies, especially those involved in the pioneering "gene therapy" treatment: cures could be bad for business in the long run. "Is curing patients a sustainable business model?" analysts ask in an April 10 report entitled "The Genome Revolution." From a report: "The potential to deliver 'one shot cures' is one of the most attractive aspects of gene therapy, genetically-engineered cell therapy and gene editing. However, such treatments offer a very different outlook with regard to recurring revenue versus chronic therapies," analyst Salveen Richter wrote in the note to clients Tuesday. "While this proposition carries tremendous value for patients and society, it could represent a challenge for genome medicine developers looking for sustained cash flow."

Richter cited Gilead Sciences' treatments for hepatitis C, which achieved cure rates of more than 90 percent. The company's U.S. sales for these hepatitis C treatments peaked at $12.5 billion in 2015, but have been falling ever since. Goldman estimates the U.S. sales for these treatments will be less than $4 billion this year, according to a table in the report. "GILD is a case in point, where the success of its hepatitis C franchise has gradually exhausted the available pool of treatable patients," the analyst wrote.

Nine private spaceflight companies are bidding on contracts to deliver robotic NASA payloads to the moon -- and Thursday NASA said they'd like them to start flying "this calendar year."

Discover magazine reports NASA envisions this "as the first step toward returning to the moon, this time for good." The first tasks will be to practice launching and landing on the moon, as well as answering questions about its surface... They will test habitation for future crewed missions. They'll prove that they can collect materials from the lunar surface and return them to space or Earth. And they'll establish communication networks between robots on the moon's surface, way stations in lunar orbit, and mission control on Earth.
But NASA also wants to deploy demo technology that can mine the moon's resources "to pave the way for human settlement," Space.com reports: The main lunar resource to be exploited, at least initially, is water. The lunar surface has lots of this stuff, locked up as ice on the permanently shadowed floors of polar craters. This water will aid lunar settlement and further exploration, and not just by slaking astronauts' thirst, NASA officials say. Water can also be split into its constituent hydrogen and oxygen, the chief components of rocket fuel.

The Commercial Lunar Payload Services program is just part of NASA's broad moon-exploration plan, which prioritizes an open architecture that encourages cooperation with many commercial and international partners. (Indeed, NASA wants to be the commercial landers' first, but not only, customer.) One of the most critical pieces of this plan is a small space station, called the Gateway, which NASA aims to start building in lunar orbit in 2022. Gateway will be a hub for many kinds of lunar exploration, including sorties to the surface by landers both crewed and uncrewed.

If everything goes according to plan, NASA astronauts will take their first such sortie in 2028 -- 56 years after Apollo 17 crewmembers left the last boot prints on the lunar surface

Remember that landmark 2013 study that found that people on a Mediterranean diet had a 30% lower chance of heart attack, stroke, or death from cardiovascular disease than people on low-fat diets? An anonymous reader quotes Vox: Last June, the prestigious New England Journal of Medicine pulled the original paper from the record, issuing a rare retraction. It also republished a new version [of the PREDIMED study] based on a reanalysis of the data that accounted for the missteps... But after spending several days talking with some of the brightest minds in nutrition research and epidemiology, I now feel the PREDIMED retraction is actually cause for hope -- maybe even a new beginning for the field.

Yes, studies with big flaws pass peer review and make it into high-impact journals, but the record can eventually be corrected because of skeptical researchers questioning things. It's science working as it should, and the PREDIMED takedown is a wonderful example of that. This process should bring us a step closer to what really matters: informing people who want to know how to eat for a healthy life.

Long-time Slashdot reader kbahey writes: The increased reliance on machine-learning techniques used by thousands of scientists to analyze data, is producing results that are misleading and often completely wrong, according to the BBC.

Dr. Genevera Allen from Rice University in Houston said that the increased use of such systems was contributing to a "crisis in science".

She warned scientists that if they didn't improve their techniques they would be wasting both time and money. Her research was presented at the American Association for the Advancement of Science in Washington.

This is the oft-discussed 'reproducibility problem' in modern science.
The BBC writes that this irreproducibility happens when experiments "aren't designed well enough to ensure that the scientists don't fool themselves and see what they want to see in the results." But machine learning now has apparently become part of the problem.

Dr. Allen asks "If we had an additional dataset would we see the same scientific discovery or principle...? Unfortunately the answer is often probably not.â

The Laser Interferometer Gravitational-Wave Observatory (LIGO) facilities, residing in Washington and Louisiana, will be upgraded via grants from the U.S. National Science Foundation, UK Research and Innovation and the Australian Research Council -- providing stronger, more frequent detections and decreasing noise. CNET reports: Over $34 million will be provided for the upgrade which makes LIGO sound like the latest iPhone. When it is complete, LIGO will go from its crusty old 2015 "Advanced LIGO" phase to the "Advanced LIGO Plus" phase. LIGO's twin facilities both contain two 4-kilometer long arms that use lasers to detect minute disturbances caused by extremely energetic cosmic events -- like black holes merging. The incredibly high-powered events are responsible for gravitational waves, rippling out through spacetime the same way water does when you drop a rock in a pond. By the time they reach Earth, the ripples are so small that only incredibly tiny disturbances in LIGO's lasers can detect them.

The proposed upgrades will greatly increase the number of events that LIGO will detect. With only 11 under its belt so far, [David Reitze, executive director of LIGO] even expects we might see "black hole mergers on a daily basis" and describes neutron star mergers becoming "much more frequent." All that extra power adds up, hopefully revealing some of the cosmos' deepest, darkest secrets. In September 2015, LIGO provided the first evidence for a black hole merger -- and in turn, the existence of gravitational waves -- just four days after a three-year long upgrade. Since then, LIGO has seen 10 black hole mergers and a single, huge collision between two incredibly dense stars, known as neutron stars.

An anonymous reader quotes a report from The Guardian: [R]esearchers have found that the success of a future mission to the red planet may depend on the ship having a class clown. "These are people that have the ability to pull everyone together, bridge gaps when tensions appear and really boost morale," said Jeffrey Johnson, an anthropologist at the University of Florida. "When you're living with others in a confined space for a long period of time, such as on a mission to Mars, tensions are likely to fray. It's vital you have somebody who can help everyone get along, so they can do their jobs and get there and back safely. It's mission critical." Johnson spent four years studying overwintering crews in Antarctica and identified the importance of clowns, leaders, buddies, storytellers, peacemakers and counsellors for bonding teams together and making them work smoothly. He found the same mixes worked in U.S., Russian, Polish, Chinese and Indian bases.

"These roles are informal, they emerge within the group. But the interesting thing is that if you have the right combination the group does very well. And if you don't, the group does very badly," he said. Johnson is now working with Nasa to explore whether clowns and other characters are crucial for the success of long space missions. So far he has monitored four groups of astronauts who spent 30 to 60 days in the agency's mock space habitat, the Human Exploration Research Analog, or Hera, in Houston, Texas. Johnson, who also studied isolated salmon fishers in Alaska, found that clowns were often willing to be the butt of jokes and pranks. In Antarctica, one clown he observed endured a mock funeral and burial in the tundra, but was crucial for building bridges between clusters of overwintering scientists and between contractors and researchers, or "beakers" as the contractors called them.

A team of Canadian scientists has developed a fascinating new experimental drug that is purported to result in rapid improvements to both mood and memory following extensive animal testing. It's hoped the drug will move to human trials within the next two years. New Atlas reports: Gamma-aminobutyric acid (GABA) is a key neurotransmitter, and when altered it can play a role in the development of everything from psychiatric conditions to cognitive degeneration. Benzodiazepines, such as Xanax or Valium, are a class of drugs well known to function by modulating the brain's GABA systems. This new research describes the development of several new molecules that are structurally based on benzodiazepines, but with small tweaks to enhance their ability to specifically target certain brain areas. The goal was to create a new therapeutic agent that can effectively combat age-related mood and memory alterations caused by disruptions in the GABA systems.

In animal tests the drug has been found to be remarkably effective, with old mice displaying rapid improvements in memory tests within an hour of administration, resulting in performance similar to that of young mice. Daily administration of the drug over two months was also seen to result in an actual structural regrowth of brain cells, returning their brains to a state that resembles a young animal. The new study was published in the journal Molecular Neuropsychiatry.

NASA announced this week that it will create the Spectro-Photometer for the History of the Universe, Epoch of Reionization and Ices Explorer: SPHEREx for short. It'll look at how our universe has changed, and how common the ingredients of life are in the Milky Way. From a report: The space agency is aiming for a 2023 launch and has already earmarked $242 million for the project, not including launch costs, which is supposed to last for at least two years. Once SPHEREx is already in orbit, it will observe and collect data on over 300 million galaxies, some as far as 10 billion light-years away from Earth, and 100 million stars in our own Milky Way every six months. It will use technologies adapted from Earth satellites and Mars spacecraft to survey the sky in optical and near-infrared light. Since it will use 96 wavelengths in all, it will give NASA a way to create an extremely detailed sky map with a resolution that's much, much higher than previous ones.

A broad new scientific analysis of the cancer-causing potential of glyphosate herbicides, the most widely used weedkilling products in the world, has found that people with high exposures to the popular pesticides have a 41% increased risk of developing a type of cancer called non-Hodgkin lymphoma. The Guardian reports: The evidence "supports a compelling link" between exposures to glyphosate-based herbicides and increased risk for non-Hodgkin lymphoma (NHL), the authors concluded, though they said the specific numerical risk estimates should be interpreted with caution. Monsanto maintains there is no legitimate scientific research showing a definitive association between glyphosate and NHL or any type of cancer. Company officials say the EPA's finding that glyphosate is "not likely" to cause cancer is backed by hundreds of studies finding no such connection.

But the new analysis could potentially complicate Monsanto's defense of its top-selling herbicide. Three of the study authors were tapped by the EPA as board members for a 2016 scientific advisory panel on glyphosate. The new paper was published by the journal Mutation Research /Reviews in Mutation Research, whose editor in chief is EPA scientist David DeMarini. [...] The study authors said their new meta-analysis evaluated all published human studies, including a 2018 updated government-funded study known as the Agricultural Health Study (AHS). Monsanto has cited the updated AHS study as proving that there is no tie between glyphosate and NHL. In conducting the new meta-analysis, the researchers said they focused on the highest exposed group in each study because those individuals would be most likely to have an elevated risk if in fact glyphosate herbicides cause NHL.

A new study from the Oxford Internet Institute claims to have found no link between time spent playing violent video games, and increased aggressive behavior teen teenagers. From a report: Published in Royal Society Open Science, the study is "one of the most definitive to date" according to the University of Oxford. While many studies have previously made similar and contrary claims, lead researcher professor Andrew Przybylski said the "idea that violent video games drive real-world aggression is a popular one, but it hasn't tested very well over time". According to the university, this study is set apart from previous work by preregistration, where researchers publish their hypothesis, methods and analysis technique before beginning research.

"Part of the problem in technology research is that there are many ways to analyze the same data, which will produce different results," said Przybylski. "A cherry-picked result can add undue weight to the moral panic surrounding video games. The registered study approach is a safeguard against this." This was supported by co-author Dr Netta Weinstein from Cardiff University who said: "Our findings suggest that researcher biases might have influenced previous studies on this topic, and have distorted our understanding of the effects of video games."

Zorro shares a report from The Register: Older satnavs and such devices won't be able to use America's Global Positioning System properly after April 6 unless they've been suitably updated or designed to handle a looming epoch rollover. GPS signals from satellites include a timestamp, needed in part to calculate one's location, that stores the week number using ten binary bits. That means the week number can have 210 or 1,024 integer values, counting from zero to 1,023 in this case. Every 1,024 weeks, or roughly every 20 years, the counter rolls over from 1,023 to zero. The first Saturday in April will mark the end of the 1,024th week, after which the counter will spill over from 1,023 to zero. The last time the week number overflowed like this was in 1999, nearly two decades on from the first epoch in January 1980. You can see where this is going. If devices in use today are not designed or patched to handle this latest rollover, they will revert to an earlier year after that 1,024th week in April, causing attempts to calculate position to potentially fail. System and navigation data could even be corrupted, we're warned. U.S. Homeland Security explained the issue in a write-up this week. GPS.gov also notes that the new CNAV and MNAV message formats will use a 13-bit week number, so this issue shouldn't happen again anytime soon. The site recommend users consult the manufacturer of their equipment to make sure they have the proper updates in place.

"The BBC reports on the detrimental effects of all of India being in one time zone since British Colonial rule," writes Slashdot reader dryriver. From the report: India stretches 3,000km (1,864 miles) from east to west, spanning roughly 30 degrees longitude. This corresponds with a two-hour difference in mean solar times -- the passage of time based on the position of the sun in the sky. The U.S. equivalent would be New York and Utah sharing one time zone. Except that in this case, it also affects more than a billion people -- hundreds of millions of whom live in poverty. The school day starts at more or less the same time everywhere in India but children go to bed later and have reduced sleep in areas where the sun sets later. An hour's delay in sunset time reduces children's sleep by 30 minutes. Using data from the India Time Survey and the national Demographic and Health Survey, [Cornell University Economist] Maulik Jagnani found that school-going children exposed to later sunsets get fewer years of education, and are less likely to complete primary and middle school. He found evidence that suggested that sunset-induced sleep deprivation is more pronounced among the poor, especially in periods when households face severe financial constraints. "This might be because sleep environments among poor households are associated with noise, heat, mosquitoes, overcrowding, and overall uncomfortable physical conditions. The poor may lack the financial resources to invest in sleep-inducing goods like window shades, separate rooms, indoor beds and adjust their sleep schedules," he told me.

For more than 14 years, the Opportunity rover crawled up and down craters, snapped pictures of a strange landscape and revealed surprising glimpses into the distant past of Mars. On Wednesday, NASA announced that Opportunity, the longest-lived robot ever sent from Earth to the surface of another planet, is dead. The New York Times: "It is therefore that I am standing here with a deep sense of appreciation and gratitude that I declare the Opportunity mission is complete," said Thomas Zurbuchen, NASA's associate administrator for science. That ends a mission of unexpected endurance: it was designed to last only three months. Opportunity provided scientists a close-up view of Mars that they had never seen: finely layered rocks that preserved ripples of flowing water several billion years ago, a prerequisite for life.

The steady stream of photographs and data from Opportunity -- as well as its twin, Spirit, which survived until 2010 -- also brought Mars closer to people on Earth. Because the rovers continued so much longer than expected, NASA has now had a continuous robotic presence on Mars for more than 15 years. That streak seems likely to continue for many more years. A larger, more capable rover, Curiosity, arrived in 2012, and NASA is planning to launch another in 2020. Live telecast here.

According to a new study published in the journal Geophysical Research Letters, NASA glaciologists found a crater thought to be more than 22 miles wide. "It is only 114 miles from the Hiawatha impact crater that was discovered in 2018," MIT Technology Review reports. "The identification of that first crater led NASA to dedicate additional resources for investigating the land under Greenland's ice." From the report: NASA glaciologists used topographical maps, satellite images, and radar scans to analyze the area. What they found was a flat, bowl-shaped depression in the bedrock. This was surrounded by an elevated edge and characteristic central peaks, which form on the crater floor after an impact. The crater has eroded significantly over time, causing the team to estimate it was created somewhere between a hundred thousand years and a hundred million years ago. That suggests it probably wasn't formed at the same time as the Hiawatha crater, which is younger. This would be the third pair of craters that sit close to one another that we've found on Earth. "We've surveyed the Earth in many different ways, from land, air, and space. It's exciting that discoveries like these are still possible," says Joe MacGregor, a glaciologist with NASA's Goddard Space Flight Center.

A reader shares a report from Space.com: A test fire of SpaceX's newest engine reached the power level necessary for the company's next round of rocket designs, CEO Elon Musk said on Twitter. "Raptor just achieved power level needed for Starship & Super Heavy," he tweeted on Feb. 7, four days after he shared a photograph of the first test of a flight-ready engine. [Musk added: "Raptor reached 268.9 bar today, exceeding prior record by the awesome Russian RD-180. Great work by @SpaceX engine/test team!"

The Raptor engine is designed to power the spaceship currently known as Starship as part of the rocket assembly currently known as Super Heavy (previously dubbed the BFR). The first Raptor test fire took place in September 2016, when the company was targeting an uncrewed Mars launch in 2018. Three Raptor engines like this one are built in to the Starship Hopper, which has been under construction in Texas and which SpaceX will use to begin testing the rocket technology in real life. Eventually, SpaceX plans to assemble 31 Raptor engines into the Super Heavy rockets, with another seven Raptors on the Starship itself.

An anonymous reader quotes a report from The New York Times: The study, in JAMA Internal Medicine, tracked diet and health over eight years in more than 44,000 French men and women. Their average age was 58 at the start. About 29 percent of their energy intake was ultraprocessed foods. Such foods include instant noodles and soups, breakfast cereals, energy bars and drinks, chicken nuggets and many other ready-made meals and packaged snacks containing numerous ingredients and manufactured using industrial processes. There were 602 deaths over the course of the study, mostly from cancer and cardiovascular disease. Even after adjusting for many health, socioeconomic and behavioral characteristics, including scores on a scale of compliance with a healthy diet, the study found that for every 10 percent increase in ultraprocessed food consumption, there was a 14 percent increase in the risk of death (Warning: source may be paywalled; alternative source). The authors suggest that high-temperature processing may form contaminants, that additives may be carcinogenic, and that the packaging of prepared foods can lead to contamination.