Medicine

A Nanoscale Look At a Complete Fly Brain (cemag.us) 73

An anonymous reader quotes a report from Controlled Environments Magazine: Two high-speed electron microscopes. 7,062 brain slices. 21 million images. For a team of scientists at the Howard Hughes Medical Institute's Janelia Research Campus in Ashburn, Virginia, these numbers add up to a technical first: a high-resolution digital snapshot of the adult fruit fly brain. Researchers can now trace the path of any one neuron to any other neuron throughout the whole brain, says neuroscientist Davi Bock, a group leader at Janelia who reported the work along with his colleagues on July 19 in the journal Cell.

The fruit fly brain, roughly the size of a poppy seed, contains about 100,000 neurons (humans have 100 billion). Each neuron branches into a starburst of fine wires that touch the wires of other neurons. Neurons talk to one another through these touchpoints, or synapses, forming a dense mesh of communication circuits. Scientists can view these wires and synapses with an imaging technique called serial section transmission electron microscopy. First, they infuse the fly's brain with a cocktail of heavy metals. These metals pack into cell membranes and synapses, ultimately marking the outlines of each neuron and its connections. Then the researchers hit slices of the brain with a beam of electrons, which passes through everything except the metal-loaded parts. "It's the same way that x-rays go through your body except where they hit bone," Bock explains. The resulting images expose the brain's once-hidden nooks and crannies.

Science

Scientists Take Step Toward Creating Artificial Embryos (reuters.com) 118

An international team of scientists has moved closer to creating artificial embryos after using mouse stem cells to make structures capable of taking a crucial step in the development of life. From a report: Experts said the results suggested human embryos could be created in a similar way in future -- a step that would allow scientists to use artificial embryos rather than real ones to research the very earliest stages of human development. The team, led by Magdalena Zernicka-Goetz, a professor at Britain's Cambridge University, had previously created a simpler structure resembling a mouse embryo in a lab dish. That work involved two types of stem cells and a three-dimensional scaffold on which they could grow. But in new work published on Monday in the journal Nature Cell Biology, the scientists developed the structures further -- using three types of stem cells -- enabling a process called gastrulation, an essential step in which embryonic cells begin self-organizing into a correct structure for an embryo to form.
Space

SpaceX Enters a New Stage of Reusability (mashable.com) 151

SpaceX will now be attempting to land and reuse all of the rockets it launches. Over the weekend, SpaceX launched and successfully landed its second Falcon 9 Block 5 rocket in Cape Canaveral, Florida. An anonymous reader writes: The landing of this vehicle, designed with reusability in mind, marks the beginning of a completely recyclable era of rockets for the company. The Block 5 can be used hundreds of times if recovered successfully. Now that the company has transitioned to this more reusable model, recovery will be an even more crucial part of the launch. In a two week period, it's planning five recoveries. Mashable: The landing marks one of the first landings and launches of the company's newest, upgraded Falcon 9 rockets, called Block 5. Before this launch, SpaceX got rid of a backlog of their Block 4 rockets by launching without landing them back on Earth. That type of launch without landing is the traditional way of getting things to orbit, but SpaceX managed to change that. The whole point in the company's rocket landings hinge on the fact that it could reduce the cost of flying to orbit. By reusing rocket stages for multiple launches, it could drive down the exorbitant cost of flying to space for companies and nations around the world. SpaceX has been killing it the past couple years. The company -- founded by Elon Musk -- launched 18 times in 2017.
Science

People Like Getting Thank You Notes, Research Finds (nytimes.com) 68

From a report: O.K., it's not that surprising. But what did surprise two psychologist as they attempted to get to bottom of why so few people actually send thank yous is that many people totally "miscalibrate" the effect of an appreciative email. They underestimate the positive feelings it will bring. "They think it's not going to be that big a deal," said Amit Kumar, a professor at the University of Texas at Austin who studies well-being. They also overestimate how insincere the note may appear and how uncomfortable it will make the recipient feel, their study found.

But after receiving thank-you notes and filling out questionnaires about how it felt to get them, many said they were "ecstatic," scoring the happiness rating at 4 of 5. The senders typically guessed they'd evoke a 3. To be clear -- the notes in question were not your typical "thanks for the Amazon gift card." Rather, the 100 or so participants in each of the four experiments were asked to write a short "gratitude letter" to a person who had affected them in some way. Sample letters included missives of appreciation to fellow students and friends who offered guidance through the college admissions process, job searches and tough times. In lab experiments, Dr. Kumar observed that it took most subjects less than five minutes to write the letters.
Further reading: Finding Emails With Certain Variation Of Thank You Vastly Improves Response Rate, Study Finds; and Apparently, People Say 'Thank You' To Self-Driving Pizza Delivery Vehicles.
Science

Rome's Subway Expansion Reveals Artifacts From The Ancient Past (npr.org) 42

All roads may lead to Rome, but once you get there, good luck taking the subway. The sprawling metropolis is expanding its mass transit system -- a sluggish process made even slower as workers keep running into buried ancient ruins. From a report: "I found some gold rings. I found glasswork laminated in gold depicting a Roman god, some amphoras," says Gilberto Pagani, a bulldozer operator at the Amba Aradam metro stop, currently under construction not far from the Colosseum. Pagani is part of an archaeological team at the site, a certified archaeological construction worker trained to excavate, preserve and build in cities like Rome, with thousands of years of civilization buried beneath the surface. The presence of ancient artifacts underground is a daunting challenge for urban developers. For archaeologists, it's the opportunity of a lifetime. "I think it's the luckiest thing that's ever happened to me, professionally speaking," says Simona Morretta, the state archaeologist in charge of the Amba Aradam site. "Because you never get the chance in a regular excavation to dig so deep. That's how we've found architectural complexes as important as this."
Cellphones

Cell Phone Radiation May Affect Memory Performance In Adolescents, Study Finds (sciencedaily.com) 89

dryriver quotes Science Daily: Radiofrequency electromagnetic fields may have adverse effects on the development of memory performance of specific brain regions exposed during mobile phone use. These are the findings of a study involving nearly 700 adolescents in Switzerland. The investigation, led by the Swiss Tropical and Public Health Institute, will be published on Monday, 23 July 2018 in the peer-reviewed journal Environmental Health Perspectives. The study to be published found that cumulative RF-EMF brain exposure from mobile phone use over one year may have a negative effect on the development of figural memory performance in adolescents, confirming prior results published in 2015.

Figural memory is mainly located in the right brain hemisphere, and association with RF-EMF was more pronounced in adolescents using the mobile phone on the right side of the head. 'This may suggest that indeed RF-EMF absorbed by the brain is responsible for the observed associations.' said Martin Röösli, Head of Environmental Exposures and Health at Swiss TPH.

Power

Nanoengineer Finds New Way To Recycle Lithium-Ion Batteries (latimes.com) 72

Zheng Chen, a 31-year-old nanoengineer at UC San Diego, says he has developed a way to recycle used cathodes from spent lithium-ion batteries and restore them to a like-new condition. The cathodes in some lithium-ion batteries are made of metal oxides that contain cobalt, a metal found in finite supplies and concentrated in one of the world's more precarious countries. Los Angeles Times reports how it works: The process takes degraded particles from the cathodes found in a used lithium-ion battery. The particles are then pressurized in a hot alkaline solution that contains lithium salt. Later, the particles go through a short heat-treating process called annealing, in which temperatures reach more than 1,400 degrees Fahrenheit. After cooling, Chen's team takes the regenerated particles and makes new cathodes. They then test the cathodes in batteries made in the lab. The new cathodes have been able to maintain the same charging time, storage capacity and battery lifetime as the originals did. Details of the recycling method were recently published in the research journal Green Chemistry, submitted by Chen and two colleagues.
Sci-Fi

Star Trek: Discovery's Season 2 Trailer Teases Spock, Christopher Pike, and Tig Notaro (theverge.com) 164

CBS has released a "Season Two Premiere" for Star Trek Discovery, offering the first look at the upcoming season of the show on CBS All Access. The first season launched late last year and finished up in February after a brief hiatus. The Verge reports of what to expect from the upcoming season, which is expected to premiere sometime in early 2019: [It] appears to begin with Captain Christopher Pike (Anson Mount) coming aboard and taking control of the USS Discovery after a series of mysterious "red bursts" are detected, simultaneously spread out across 30,000 light years. Burnham later claims "Spock is linked to these signals." New series guest star Tig Notaro makes a very Tig Notaro joke, Pike encourages the crew to "have a little fun," Tilly yells about "the power of math" -- a good time, in other words. (After all, the whole thing is set the tune of Lenny Kravitz's "Fly Away," so you know it's real.) Bonus: at the end we meet another, very sniffly alien Discovery crew member, proving Saru and the bridge androids aren't the sole non-humans aboard the ship, as we once feared. At the Discovery panel at San Diego Comic Con's Hall H, a new Star Trek series was announced, called Star Trek: Short Treks. It is "a series of monthly short-form stories that will function like bonus content and air on CBS All Access in conjunction with the larger Star Trek: Discovery series," reports The Verge. "CBS says Short Treks, which will air in installments of about 10 to 15 minutes, is 'an opportunity for deeper storytelling and exploration of key characters and themes that fit into... the expanding Star Trek universe.'"
Medicine

ADHD Drugs Aren't Doing What You Think, Scientists Warn (inverse.com) 183

An anonymous reader quotes a report from Inverse: The study authors Lisa Weyandt, Ph.D., a professor of psychology at the University of Rhode Island, and Tara White, Ph.D., an assistant professor of Behavioral and Social Sciences at Brown University, started out investigating the effects of ADHD medications in students that actually have a diagnosable attention deficit disorder. They showed that in these students, there is decreased activity in the areas of the brain controlling "executive functions," which can make it hard for them to stay organized or focused. But because both authors work with college students, they soon became more interested in the misuse of Adderall. In students whose brains aren't affected by ADHD, does Adderall act as a supercharger? Does it make those areas fly into overdrive and unlock otherwise untapped intellectual ability, as all pill-popping students hope?

Weyant and White's double-blind, placebo-controlled study on 13 college students was a small sample, they admit, but their experiment had a rigorous study design. Neither the students nor the researchers knew who was getting Adderall and who was getting placebo sugar pill. The six tests evaluated different aspects of cognition, like working memory, reading ability and reaction time. While students on Adderall did make fewer errors on a reaction time test, it actually worsened working memory, as shown by a decline in performance on a task where they had to repeat sequences of numbers. In short, Adderall improved focus and attention -- but it didn't actually make anyone smarter.
The research has been published in the journal Pharmacy.
Math

Can Nike's $250 Running Shoes Make You Run Faster? NYT Analysis Says Yes (fastcompany.com) 60

Last year, Nike released a new pair of running shoes that claim to make you run 4% faster, thanks to its proprietary sole technology. The new "Vaporfly 4%" shoes would, in theory, "be enough to help a runner break the mythical two-hour marathon barrier for the first time," Fast Company points out. The New York Times decided to put the shoes to the test through an intensive analysis of 500,000 marathon and half marathon running times, culled from the social network Strava. Nike's claims apparently check out. Fast Company reports the findings: We know a lot about the runners in our data set, including their age, gender, race history and, in some cases, how much training they've done in the months before a race. We also know about the races themselves, including the distribution of runners' times and the weather that day. We can put all of this information into a model to try to estimate the change in runners' time from their previous races. After controlling for all of these variables, our model estimates that the shoes account for an expected improvement of about 4 percent over a runner's previous time. Including the uncertainty around the estimates, the Vaporflys are a clear outlier, one of the only popular shoes we can really say makes any difference at all.
Medicine

New Wearable Sensor Detects Stress Hormone In Sweat (ieee.org) 10

An anonymous reader quotes a report from IEEE Spectrum: Today, a team of researchers at Stanford, led by materials science and engineering associate professor Alberto Salleo and postdoctoral research fellow Onur Parlak, announced in Science Advances that they've developed a wearable patch that can determine how much cortisol someone is producing in seconds, using sweat drawn from the skin under the patch. [Cortisol, a steroid hormone, goes up when a person is under physical or emotional strain.] The stretchy patch pulls in the sweat through perforations to a reservoir. A membrane on top of the reservoir allows charged ions, like sodium and potassium, to pass through. Cortisol, which has no charge, can't pass, and instead blocks the charged ions. Signals sent from an electrical sensor in the patch can be used to detect these backups and determine how much cortisol is in the sweat.

The prototype cortisol detection patch channels sweat into a reservoir; a membrane selectively lets charged ions through, and the amount of these ions detected can be translated into a reading of cortisol levels in the sweat. Parlak tested the prototype on several runners, and reported that the cortisol levels detected by the wearable sensor patch matched those obtained by running samples of the runners' sweat through an ELISA (enzyme-linked immunosorbent assay) test that takes several hours.

Moon

Who Owns the Moon? A Space Lawyer Answers (theconversation.com) 208

An anonymous reader shares a report: While the legal status of the Moon as a "global commons" accessible to all countries on peaceful missions did not meet any substantial resistance or challenge, the Outer Space Treaty left further details unsettled. Contrary to the very optimistic assumptions made at the time, so far humankind has not returned to the moon since 1972, making lunar land rights largely theoretical.

That is, until a few years ago when several new plans were hatched to go back to the moon. In addition at least two U.S. companies, Planetary Resources and Deep Space Industries, which have serious financial backing, have started targeting asteroids for the purpose of mining their mineral resources. Geek note: Under the aforementioned Outer Space Treaty, the moon and other celestial bodies such as asteroids, legally speaking, belong in the same basket. None of them can become the "territory" of one sovereign state or another.

The very fundamental prohibition under the Outer Space Treaty to acquire new state territory, by planting a flag or by any other means, failed to address the commercial exploitation of natural resources on the moon and other celestial bodies. This is a major debate currently raging in the international community, with no unequivocally accepted solution in sight yet. Roughly, there are two general interpretations possible. Countries such as the United States and Luxembourg (as the gateway to the European Union) agree that the moon and asteroids are "global commons," which means that each country allows its private entrepreneurs, as long as duly licensed and in compliance with other relevant rules of space law, to go out there and extract what they can, to try and make money with it. [...] On the other hand, countries such as Russia and somewhat less explicitly Brazil and Belgium hold that the moon and asteroids belong to humanity as a whole.

China

Some Scientists Work With China, But NASA Won't (wired.com) 52

An anonymous reader shares a report: Inside a sealed clean room near Toulouse, France, Maurice Sylvestre points out something called SuperCam. Sylvestre is outfitted in Tyvex and hairnets, necessary to keep out dust, skin particles, and dirt that could mar the super-smooth surface of his device. SuperCam sits underneath a ventilator hood, glimmering inside a golden-metallic housing. The device is designed to scan the Martian surface with a camera, laser, and spectrometer in hopes of finding organic compounds that could be related to early life on Mars. In two years, this 12-pound, microwave oven-sized unit will blast off as part of the Mars 2020 mission, a spacecraft/lander/rover combo by NASA and its partners that will replace the long-serving Curiosity mission.

Sylvestre is a planetary scientist at France's Institute for Research and Planetary Astronomy, and deputy principal investigator for SuperCam. But he's an international collaborator: Over the years, he's worked on missions to Saturn, the moon, and Mars with NASA colleagues. Sylvestre's lab is currently building an instrument similar to SuperCam that will fly to Mercury on the European-Japanese BepiColombo mission, as well as one called Eclair that is part of a joint French-Chinese satellite. Notably, that makes him one of a small number of planetary scientists who are working with China to boost their science, while doing his best to keep Western technology from getting pilfered. It's a tightrope that not everyone is willing to walk. "We are careful what we are doing," Sylvestre says.

"We understand the security issues. We understand that we should be careful and not be too naive. But at the same time I feel the idea of planetary exploration is for everyone." Working with both NASA and China may seem like a contradiction, or even a conflict. The two superpowers are butting heads on trade, military, and cybersecurity issues. Congress has banned NASA officials and NASA money from going to China. That might be because of a recent history of Chinese espionage targeting US military, aerospace, and technological secrets.

Biotech

AI Plus a Chemistry Robot Finds All the Reactions That Will Work (arstechnica.com) 39

A team of researchers at Glasgow University have built a robot that uses machine learning to run and analyze its own chemical reaction. The system is able to figure out every reaction that's possible from a given set of starting materials. Ars Technica reports: Most of its parts are dispersed through a fume hood, which ensures safe ventilation of any products that somehow escape the system. The upper right is a collection of tanks containing starting materials and pumps that send them into one of six reaction chambers, which can be operated in parallel. The outcomes of these reactions can then be sent on for analysis. Pumps can feed samples into an IR spectrometer, a mass spectrometer, and a compact NMR machine -- the latter being the only bit of equipment that didn't fit in the fume hood. Collectively, these can create a fingerprint of the molecules that occupy a reaction chamber. By comparing this to the fingerprint of the starting materials, it's possible to determine whether a chemical reaction took place and infer some things about its products.

All of that is a substitute for a chemist's hands, but it doesn't replace the brains that evaluate potential reactions. That's where a machine-learning algorithm comes in. The system was given a set of 72 reactions with known products and used those to generate predictions of the outcomes of further reactions. From there, it started choosing reactions at random from the remaining list of options and determining whether they, too, produced products. By the time the algorithm had sampled 10 percent of the total possible reactions, it was able to predict the outcome of untested reactions with more than 80-percent accuracy. And, since the earlier reactions it tested were chosen at random, the system wasn't biased by human expectations of what reactions would or wouldn't work.
The research has been published in the journal Nature.
United States

Weird New Fruits Could Hit Aisles Soon Thanks To Gene Editing (theguardian.com) 307

An anonymous reader quotes a report from The Guardian: Smooth or hairy, pungent or tasteless, deep-hued or bright: new versions of old fruits could be hitting the produce aisles as plant experts embrace cutting-edge technology, scientists say. While researchers have previously produced plants with specific traits through traditional breeding techniques, experts say new technologies such as the gene-editing tool Crispr-Cas9 could be used to bring about changes far more rapidly and efficiently. Among the genes flagged in the new study in the journal Trends in Plant Science are those behind the production of a family of substances known as MYBs, which are among the proteins that control whether other genes are switched on or off.

"MYBs are great targets because they are central to several consumer traits or features like color, flavor [and] texture," said Andrew Allan, a co-author of the review from the University of Auckland whose own projects include working on red-fleshed apples and changing the color of kiwi fruits. "Russet skin in apple and pear [is linked to MYBs]. Hairs on peaches but not nectarines -- another type of MYB." Dr Richard Harrison, head of genetics, genomics and breeding at the horticultural organization NIAB EMR, who was not involved in the article, said tweaking MYB genes or the way such genes are themselves controlled was a fruitful approach. Gene-editing of MYB genes and other genes could bring a host of benefits, Harrison said, adding: "There is a large opportunity to improve the nutritional profile of fruits and vegetables in the future using gene-editing technology, as well as other techniques." Such techniques, he said, introduce the same sort of DNA changes as plant breeders have introduced by artificially selecting traits that cropped up through spontaneous DNA mutation -- but much faster.
Next week, the European Court of Justice will decide if or how plants that have been gene-edited will be regulated, and whether they will be treated like genetically modified plants. In April, the U.S. Department of Agriculture announced it will no longer regulate genetically altered plants, so long as the changes could have been produced through traditional plant-breeding techniques.
Space

ESO's Very Large Telescope Now Delivers Images Sharper Than Hubble (eso.org) 139

ffkom shares an excerpt from a press release via the European Southern Observatory: ESO's Very Large Telescope (VLT) has achieved first light with a new adaptive optics mode called laser tomography -- and has captured remarkably sharp test images of the planet Neptune, star clusters and other objects. The pioneering MUSE instrument in Narrow-Field Mode, working with the GALACSI adaptive optics module, can now use this new technique to correct for turbulence at different altitudes in the atmosphere. It is now possible to capture images from the ground at visible wavelengths that are sharper than those from the NASA/ESA Hubble Space Telescope. The combination of exquisite image sharpness and the spectroscopic capabilities of MUSE will enable astronomers to study the properties of astronomical objects in much greater detail than was possible before.
NASA

Chinese Space Official Seems Unimpressed With NASA's Lunar Gateway (arstechnica.com) 97

schwit1 shares a report from Behind The Black: At a science workshop in Europe this week, Chinese space officials made it clear that they found the concept of NASA Lunar Orbiting Platform-Gateway (LOP-G) to be unimpressive and uninteresting. Moreover, they said that while it appears we will be delaying our landings on the Moon for at least a decade because of LOP-G, they will be focused on getting and building a research station on the surface, right off the bat.

[From a report via Ars Technica:] "Overall, [Pei Zhaoyu, who is deputy director of the Lunar Exploration and Space Program Center of the China National Space Administration], does not appear to be a fan of NASA's plan to build a deep space gateway, formally known as the Lunar Orbital Platform-Gateway, at a near-rectilinear halo orbit. Whereas NASA will focus its activities on this gateway away from the Moon, Pei said China will focus on a 'lunar scientific research station.' Another slide from Pei offered some thoughts on the gateway concept, which NASA intends to build out during the 2020s, delaying a human landing on the Moon until the end of the decade at the earliest. Pei does not appear to be certain about the scientific objectives of such a station, and the deputy director concludes that, from a cost-benefit standpoint, the gateway would have 'lost cost-effectiveness.'"

Science

Frequent Smart Phone, Internet Use Linked To Symptoms Of ADHD in Teens (npr.org) 119

Most teens today own a smartphone and go online every day, and about a quarter of them use the internet "almost constantly," according to a 2015 report by the Pew Research Center. Now a study published this week in JAMA suggests that such frequent use of digital media by adolescents might increase their odds of developing symptoms of attention deficit hyperactivity disorder. From a report: "It's one of the first studies to look at modern digital media and ADHD risk," says psychologist Adam Leventhal, an associate professor of preventive medicine at the University of Southern California and an author of the study. When considered with previous research showing that greater social media use is associated with depression in teens, the new study suggests that "excessive digital media use doesn't seem to be great for [their] mental health," he adds. Previous research has shown that watching television or playing video games on a console put teenagers at a slightly higher risk of developing ADHD behaviors. But less is known about the impact of computers, tablets and smartphones.
Earth

Is the Earth's Mantle Full of Diamonds? (gizmodo.com) 109

An anonymous reader quotes a report from Gizmodo: Scientists' models show that sound waves seem to travel too quickly through the old, stable cores of continents, called "cratons," which extend deep into the mantle at depths around 120 to 150 kilometers (75 to 93 miles). Through observations, experiments, and modeling, one team figured that a potential way to explain the sound speed anomaly would be the presence of a lot of diamonds, a medium that allows for a faster speed of sound than other crystals. Perhaps the Earth is as much as 2 percent diamonds by volume, they found. Scientists have modeled the rock beneath continents through tomography, which you can think of as like an x-ray image, but using sound waves. But sound-wave velocities of around 4.7 kilometers per second (about 10,513 mph) are faster than sound-wave velocities in other kinds of minerals beneath the crust, according to the paper in the journal Geochemistry, Geophysics, Geosystems.

The researchers realized that if the regions had either 3 percent diamonds by volume or 50 percent of a rock formed at high pressure and temperature called eclogite, it would enable the sound speeds they observed. But both of those numbers seemed too high, based on observations of the minerals that end up on the Earth's surface: diamond-containing rocks called kimberlites. The researchers compromised and figured that 20 percent eclogite and 2 percent diamonds could explain the high velocities. The diamonds could be sprinkled as crystals found uniformly throughout the cratons.

Medicine

Health Insurers Are Vacuuming Up Details About You -- And It Could Raise Your Rates (propublica.org) 299

schwit1 shares an excerpt from an in-depth report via ProPublica and NPR, which have been investigating for the past year the various tactics the health insurance industry uses to maximize its profits: A future in which everything you do -- the things you buy, the food you eat, the time you spend watching TV -- may help determine how much you pay for health insurance. With little public scrutiny, the health insurance industry has joined forces with data brokers to vacuum up personal details about hundreds of millions of Americans, including, odds are, many readers of this story. The companies are tracking your race, education level, TV habits, marital status, net worth. They're collecting what you post on social media, whether you're behind on your bills, what you order online. Then they feed this information into complicated computer algorithms that spit out predictions about how much your health care could cost them. Patient advocates warn that using unverified, error-prone "lifestyle" data to make medical assumptions could lead insurers to improperly price plans -- for instance raising rates based on false information -- or discriminate against anyone tagged as high cost. And, they say, the use of the data raises thorny questions that should be debated publicly, such as: Should a person's rates be raised because algorithms say they are more likely to run up medical bills? Such questions would be moot in Europe, where a strict law took effect in May that bans trading in personal data.

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