An anonymous reader quotes a report from The Verge: Researchers successfully transplanted genetically modified pig hearts into two recently deceased people connected to ventilators, the New York University team announced today. The surgeries are the latest step forward in the field of animal-to-human transplants, or xenotransplantation, which has seen a flurry of successes so far this year -- raising hopes for a new, steady supply of organs to ease shortages. The only thing different about these heart transplants from a normal human-to-human heart transplant was the organ itself, the research team said in a statement.

The team performed the transplants on June 16th and July 9th, and each recipient was monitored for three days. In that time, the hearts functioned normally, and there weren't signs of rejection from the recipients, who were connected to ventilators to keep their body processes functioning semi-regularly, even after death. The two recipients were not able to be organ donors but were able to participate in whole-body donation for this type of research. The two pig hearts came from biotechnology company Revivicor, which produces genetically modified pigs (and also funded the research). The pigs had 10 genetic modifications -- four to block pig genes and prevent rejection and six to add human genes. A living person was successfully given a pig heart in early January, notes the report. While the person responded well to the transplant initially, they died of heart failure in March.

"The specific cause is still unknown, but infection with a pig virus may have contributed to his death," adds The Verge. "The pig hearts are supposed to be free of viruses, but experts say they can be hard to detect." A research paper in late June details everything that went wrong with the transplant.

A volunteer in New Zealand has become the first person to undergo DNA editing in order to lower their blood cholesterol, a step that may foreshadow wide use of the technology to prevent heart attacks. MIT Technology Review reports: The experiment, part of a clinical trial by the US biotechnology company Verve Therapeutics, involved injecting a version of the gene-editing tool CRISPR in order to modify a single letter of DNA in the patient's liver cells. According to the company, that tiny edit should be enough to permanently lower a person's levels of "bad" LDL cholesterol, the fatty molecule that causes arteries to clog and harden with time. The patient in New Zealand had an inherited risk for extra-high cholesterol and was already suffering from heart disease. However, the company believes the same technique could eventually be used on millions of people in order to prevent cardiovascular disease.

In New Zealand, where Verve's clinical trial is taking place, doctors will give the gene treatment to 40 people who have an inherited form of high cholesterol known as familial hypercholesterolemia, or FH. People with FH can have cholesterol readings twice the average, even as children. Many learn they have a problem only when they get hit with a heart attack, often at a young age. The study also marks an early use of base editing, a novel adaptation of CRISPR that was first developed in 2016. Unlike traditional CRISPR, which cuts a gene, base editing substitutes a single letter of DNA for another.

The gene Verve is editing is called PCSK9. It has a big role in maintaining LDL levels and the company says its treatment will turn the gene off by introducing a one-letter misspelling. [...] One reason Verve's base-editing technique is moving fast is that the technology is substantially similar to mRNA vaccines for covid-19. Just like the vaccines, the treatment consists of genetic instructions wrapped in a nanoparticle, which ferries everything into a cell. While the vaccine instructs cells to make a component of the SARS-CoV-2 virus, the particles in Verve's treatment carry RNA directions for a cell to assemble and aim a base-editing protein, which then modifies that cell's copy of PCSK9, introducing the tiny mistake. In experiments on monkeys, Verve found that the treatment lowered bad cholesterol by 60%. The effect has lasted more than a year in the animals and could well be permanent. The report notes that the human experiment does carry some risk. "Nanoparticles are somewhat toxic, and there have been reports of side effects, like muscle pain, in people taking other drugs to lower PCSK9," reports MIT Technology Review. "And whereas treatment with ordinary drugs can be discontinued if problems come up, there's as yet no plan to undo gene editing once it's performed."

Amazon is developing cancer vaccines in collaboration with the Fred Hutchinson Cancer Research Center, and it recently launched an FDA-approved clinical trial. From a report: Amazon and Fred Hutchinson are looking to recruit 20 participants over the age of 18 for the early stage, or phase 1, trial, according to a filing on clinicaltrials.gov, a database of clinical trials run by the National Library of Medicine. The goal is to develop "personalized vaccines" that can treat breast cancer and melanoma, a form of skin cancer, the filing states. Fred Hutchinson is listed as a sponsor of the study, while Amazon is listed as a collaborator, according to the filing. News of the partnership was first reported by Business Insider. The study was first posted last October, and it began June 9. It's expected to be complete by Nov. 1 of 2023. An Amazon spokesperson confirmed the partnership, and said it's being led by Fred Hutch. "Amazon is contributing scientific and machine learning expertise to a partnership with Fred Hutch to explore the development of a personalized treatment for certain forms of cancer," the spokesperson told CNBC in a statement. "It's very early, but Fred Hutch recently received permission from the U.S. Food and Drug Administration to proceed with a Phase I clinical trial, and it's unclear whether it will be successful. This will be a long, multi-year process -- should it progress, we would be open to working with other organizations in health care and life sciences that might also be interested in similar efforts."

An anonymous reader quotes a report from the BBC: In 2020 [EndeavorRx] became the first such game to be approved by the US Food and Drug Administration (FDA) for use in the treatment of ADHD in children. Currently only available on prescription from doctors in the US, EndeavorRx at first glance looks very similar to countless other games. You control a little alien that races on a spaceship through different worlds having to collect things. But the app-based game was developed in conjunction with neuroscientists, and is designed to stimulate and improve areas of the brain that play a key role in attention function. The idea is that it trains a child with ADHD to both better multitask and ignore distractions, with a computer algorithm measuring his or her performance and customizing the difficulty of the game in real time. When doctors prescribe it, the child's parents get sent an activation link that is needed before the game will play.

Eddie Martucci, chief executive of Akili, the Boston-based tech firm behind EndeavorRx, says the game has been designed to boost cognitive progressing. "It is something that's very difficult to get through molecular means, like taking a pill. But it turns out that sensory stimuli can actually directly stimulate parts of the brain controlling cognitive function." His company now plans to launch the game in Europe in the next few years. Akili is one of only a handful of companies with clearance to offer a digital therapeutic as a prescription for medical conditions. Late last year, the FDA approved a virtual reality-based treatment for children with the visual disorder amblyopia, or lazy eye.

"Researchers and engineers from Kyoto University and the Kajima Corporation have released their joint proposal for a three-pronged approach to sustainable human life on the Moon and beyond," reports Gizmodo. The first element involves "The Glass," which aims to bring simulated gravity to the Moon and Mars through centrifugal force. From the report: Gravity on the Moon and Mars is about 16.5% and 37.9% of that on Earth, respectively. Lunar Glass and Mars Glass could bridge that gap; they are massive, spinning cones that will use centrifugal force to simulate the effects of Earth's gravity. These spinning cones will have an approximate radius of 328 feet (100 meters) and height of 1,312 feet (400 meters), and will complete one rotation every 20 seconds, creating a 1g experience for those inside (1g being the gravity on Earth). The researchers are targeting the back half of the 21st century for the construction of Lunar Glass, which seems unreasonably optimistic given the apparent technological expertise required to pull this off.

The second element of the plan is the "core biome complex" for "relocating a reduced ecosystem to space," according to a Google-translated version of the press release. The core biome complex would exist within the Moon Glass/Mars Glass structure and it's where the human explorers would live, according to the proposal. The final element of the proposal is the "Hexagon Space Track," or Hexatrack, a high-speed transportation infrastructure that could connect Earth, Mars, and the Moon. Hexatrack will require at least three different stations, one on Mars's moon Phobos, one in Earth orbit, and one around the Moon.

In 2018, MIT researchers found that if two graphene layers are stacked at a very specific "magic" angle, the twisted bilayer structure could exhibit robust superconductivity, a widely sought material state in which an electrical current can flow through with zero energy loss. Now the team reports that [...] four and five graphene layers can be twisted and stacked at new magic angles to elicit robust superconductivity at low temperatures. Phys.Org reports: This latest discovery, published this week in Nature Materials, establishes the various twisted and stacked configurations of graphene as the first known "family" of multilayer magic-angle superconductors. The team also identified similarities and differences between graphene family members. The findings could serve as a blueprint for designing practical, room-temperature superconductors. If the properties among family members could be replicated in other, naturally conductive materials, they could be harnessed, for instance, to deliver electricity without dissipation or build magnetically levitating trains that run without friction.

In the current study, the team looked to level up the number of graphene layers. They fabricated two new structures, made from four and five graphene layers, respectively. Each structure is stacked alternately, similar to the shifted cheese sandwich of twisted trilayer graphene. The team kept the structures in a refrigerator below 1 kelvin (about -273 degrees Celsius), ran electrical current through each structure, and measured the output under various conditions, similar to tests for their bilayer and trilayer systems. Overall, they found that both four- and five-layer twisted graphene also exhibit robust superconductivity and a flat band. The structures also shared other similarities with their three-layer counterpart, such as their response under a magnetic field of varying strength, angle, and orientation.

These experiments showed that twisted graphene structures could be considered a new family, or class of common superconducting materials. The experiments also suggested there may be a black sheep in the family: The original twisted bilayer structure, while sharing key properties, also showed subtle differences from its siblings. For instance, the group's previous experiments showed the structure's superconductivity broke down under lower magnetic fields and was more uneven as the field rotated, compared to its multilayer siblings. The team carried out simulations of each structure type, seeking an explanation for the differences between family members. They concluded that the fact that twisted bilayer graphene's superconductivity dies out under certain magnetic conditions is simply because all of its physical layers exist in a "nonmirrored" form within the structure. In other words, there are no two layers in the structure that are mirror opposites of each other, whereas graphene's multilayer siblings exhibit some sort of mirror symmetry. These findings suggest that the mechanism driving electrons to flow in a robust superconductive state is the same across the twisted graphene family.

"On Monday, July 11, President Joe Biden released one of the James Webb Space Telescope's first images in a preview event at the White House in Washington," reports NASA in a press release. The full set of Webb's first full-color images and spectroscopic data will be released tomorrow on Tuesday, July 12 at 10:30 a.m. (14:30 UTC). You can watch the live broadcast of the unveiling here. From the report: This first image from NASA's James Webb Space Telescope is the deepest and sharpest infrared image of the distant universe to date. Known as Webb's First Deep Field, this image of galaxy cluster SMACS 0723 is overflowing with detail. Thousands of galaxies -- including the faintest objects ever observed in the infrared -- have appeared in Webb's view for the first time. This slice of the vast universe covers a patch of sky approximately the size of a grain of sand held at arm's length by someone on the ground.

Released one by one, the first images from the world's largest and most powerful space telescope will demonstrate Webb at its full power, ready to begin its mission to unfold the infrared universe. The first images will be added to this page as they are released.

Adding salt to meals at the table is linked to an earlier death, according to a study of 500,000 middle-aged Britons. From a report: Researchers found that always adding salt to food knocks more than two years off life expectancy for men and one-and-a-half years for women. This does not include seasoning during the cooking process. The study did not definitively rule out other factors, such as salt consumption being a proxy for a generally less healthy lifestyle, but the team behind the work said the evidence was compelling enough that people should consider avoiding seasoning their meals.

"To my knowledge, our study is the first to assess the relation between adding salt to foods and premature death," said Prof Lu Qi of Tulane University School of Public Health and Tropical Medicine in New Orleans, who led the work. "Even a modest reduction in sodium intake, by adding less or no salt to food at the table, is likely to result in substantial health benefits, especially when it is achieved in the general population." The findings were based on research involving more than 500,000 participants in the UK Biobank study, who were followed for an average of nine years. When joining the study between 2006 and 2010, they were asked, via a touchscreen questionnaire, whether they added salt to their foods and how often they did so.

Researchers from two Germany universities 'have demonstrated quantum entanglement of two atoms separated by 33 km (20.5 miles) of fiber optics," reports New Atlas.

Besides being a new distance record, "The team says this is an important step on the way to realizing a practical quantum internet." In their experiments, the team entangled two rubidium atoms kept in optical traps in two different buildings on the Ludwig-Maximilians-University Munich campus. They were separated by 700 m (2,297 ft) of fiber optics, which was extended out to 33 km with extra spools of cable. Each atom was excited with a laser pulse, which causes it to emit a photon that's quantum entangled with the atom. The photons are then sent down the fiber optic cables to meet at a receiving station in the middle. There, the photons undergo a joint measurement, which entangles them — and because they're each already entangled with their own atom, the two atoms become entangled with each other as well.

While photons have been entangled over great distances before, this study marks a new distance record for entangling two atoms, which could function as "quantum memory" nodes, over fiber optics.

It's the world's largest particle accelerator — and after a three-year pause for upgrades, CERN's Large Hadron Collider now detects more data, runs at higher speeds, and performs at its highest energy level ever — a whopping 13.6 trillion electron volts.

Will that prove the existence of dark matter? The Washington Post reports: Though scientists largely believe dark matter is real, none have been able to see or create it. Data collection and power upgrades made to the particle smasher could provide researchers one of their best chances to visualize and understand the substance.... Inside the collider, superconducting magnets are chilled to roughly minues-456 degrees Fahrenheit — colder than space — while two particle beams traveling close to the speed of light are made to collide. Using advanced sensors and monitors, scientists analyze the substances created by those collisions, which replicate conditions similar to the Big Bang. It allows them to learn about the earliest moments of the universe...

During the Large Hadron Collider's four-year experiment, scientists are hoping to find evidence of dark matter. As they fire up the machine, protons will spin at nearly the speed of light. The hope, researchers said, is that when they collide, it creates new particles resembling the properties of dark matter.... "High-energy colliders remain the most powerful microscope at our disposal to explore nature at the smallest scales and to discover the fundamental laws that govern the universe," said Gian Giudice, head of CERN's theory department....

If CERN scientists do not discover dark matter in the next four years, they have more upgrades in the works. The upgrades are likely to take three years after the current run stops, leaving the fourth round of data collection and experiments to start in 2029.

As planned, the trial could capture 10 times more data than previous experiments, according to CERN's website.

In October 2020, the agency's OSIRIS-REx spacecraft nearly sank into the surface of the rubbly asteroid while picking up rocks for shipment to Earth in 2023, team members revealed Thursday (July 7). The spacecraft only escaped getting stuck or sinking into oblivion within Bennu by firing its thrusters at the right moment. Space.com reports: "We expected the surface to be pretty rigid," principal investigator Dante Lauretta, a planetary scientist at the University of Arizona, told Space.com. "We saw a giant wall of debris flying away from the sample site. For spacecraft operators, it was really frightening." Now that the spacecraft (more formally known as Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer) is safely on its way back to our planet to deliver its precious cargo, scientists are digging into the science implications of the dramatic moment.

"It turns out that the particles making up Bennu's exterior are so loosely packed and lightly bound to each other that they act more like a fluid than a solid," Lauretta said in a University of Arizona statement. That structure is why the OSIRIS-REx sampling probe had such a close call, he and his colleagues determined. The loose surface, made up of particles jostling against each other like plastic balls in a children's play area, has implications for how asteroids were formed and also for planetary defense techniques to protect against potential rogue space rocks coming near our planet, NASA added in a second statement.

On Wednesday evening NASA released a "test" image from the telescope that suggests the forthcoming scientific images and data will be spectacular. Ars Technica reports: The release of the test photo, which NASA casually says is "among the deepest images of the Universe ever taken," almost feels like a flex because it is so good for a throw-away engineering image. The space agency collected the image in late May during a week-long stability test intended to demonstrate the capabilities of the telescope's Fine Guidance Sensor. This instrument helps Webb find and lock onto astronomical targets, and it was built by the Canadian Space Agency.

"The resulting engineering test image has some rough-around-the-edges qualities to it," NASA said in a news release. "It was not optimized to be a science observation; rather, the data was taken to test how well the telescope could stay locked onto a target, but it does hint at the power of the telescope. It carries a few hallmarks of the views Webb has produced during its postlaunch preparations. Bright stars stand out with their six, long, sharply defined diffraction spikes-- an effect due to Webb's six-sided mirror segments. Beyond the stars, galaxies fill nearly the entire background." Ars notes that we will see the public release of the first science images from the James Webb Space Telescope in just five days, beginning at 10:30 am ET (14:30 UTC).

Sunny Balwani, the former president and chief operating officer of bankrupt blood-testing company Theranos, on Thursday was found guilty of 12 counts of conspiracy and fraud against certain investors and patients. Axios reports: It's a similar verdict to one handed down in January to Theranos founder and ex-CEO Elizabeth Holmes, who once dated Balwani. Balwani isn't a household name like Holmes, but he was instrumental in building a billion-dollar house of cards that duped both investors and patients. Balwani's attorneys tried to pin the blame for Theranos' failures on Holmes, much as her attorneys had tried to blame Balwani.

As we wrote when the trial began: Holmes tried to thread an incredibly narrow rhetorical needle, denying the existence of fraud while also redirecting blame. Balwani seems to be attempting something similar; claiming he was a savvy executive with lots of past success, but also a naif who was bamboozled by Holmes. But prosecutors, who originally wanted to try the pair together, often used Balwani's own words against him. For example, they presented a text message from Balwani to Holmes that read: "I am responsible for everything at Theranos." One big difference between the trials, however, was that Balwani didn't testify in his own defense.

Among the ocean's menagerie of bizarre creatures, sea dragons stand out. From a report: Relatives of sea horses and pipefish, sea dragons have long narrow snouts that they use like a straw to suck up meals of microscopic crustaceans. Instead of scales, the fish are covered in bony armor, and their backbones are kinked. Like their sea horse cousins, male sea dragons gestate a female's fertilized eggs in a pouch. They come in two groups of species, leafy and weedy. "Leafies" have elaborate branching appendages that make them virtually indistinguishable from the floating seaweed in their Southern Australian habitats. Weedy sea dragons are more streamlined but are also more colorful, with purple stripes and yellow polka dots.

Bill Cresko at the University of Oregon studies sea dragon genetics to answer one fundamental question: He and his colleagues want to know "how the hell" these fish came to look the way they do. "We're just really fascinated by, 'How can you have an organism that looks like that? What has changed in the genome?'" he said. A study published in June in the Proceedings of the National Academy of Sciences tried to answer these questions. Researchers sequenced the genomes of leafy and weedy sea dragons and compared them with other fish. The strange appearance of sea dragons made the team think that there might have been something unusual happening with their fibroblast growth factor genes, "which are really important for development of things like teeth, which they don't have, or the shape of faces or appendage outgrowth, to name just a few," said Susie Bassham, a researcher in Dr. Cresko's lab and an author of the paper. But when they zeroed in on the animals' genomes, the researchers were surprised to see that sea dragons were missing several of these key developmental genes altogether.

While the sea dragons were missing these growth genes, their genomes were packed with repetitive sections of code called transposons. This sort of repetitive code throughout the genome was once called "junk DNA," as scientists were not sure what it did. But transposons, or "jumping genes," are actually capable of cutting and pasting themselves from one spot within the genetic code to another, preventing other genes from shaping an organism's traits. The researchers cannot say for sure if the jumping genes are responsible for the absence of the growth factor genes. There is evidence of repeating genetic code near the spots where genes are missing, which might point to transposon activity, Dr. Small said. But scientists will need more genomes from across the fish family tree to confirm a cause-and-effect relationship.

As sea levels rise, coastal areas face a growing risk of flooding. But humans and environments near urban centers and the ocean may face issues beyond rising water. These areas have also been home to a large number of manufacturing facilities. From a report: Over the years, many of them may have left toxic chemicals in the soil. And now, those areas are also being threatened by floods. When it rains too hard or the sea rises too much, people nearby can expect to be exposed to a wide variety of leftover material and chemicals, some of which aren't meant to be ingested or touched by humans. How big is the risk? Many of our largest cities lie near the sea. By some counts, in 2020, around 400 million people lived within 20 meters of sea level and within 20 kilometers of a coastline.

New research has used historical data coupled with sea level rise projections to dive into how this issue may affect the United States. It finds that as the climate warms and floods become more common, more people will likely be exposed to industrial pollution from the manufacturing sites. Urban areas and marginalized groups within them may be particularly at risk. "We have all these sites; we know where they're at," Thomas Marlow, the research's lead author and a postdoctoral researcher at New York University's Abu Dhabi campus, located in the United Arab Emirates, told Ars. "What are some of the climate risks they are facing, including from extreme weather events, rainfall -- that type of thing -- or sea level rise?"

British scientists and academic researchers have been dealt a blow after 115 grants from a flagship EU research programme were terminated because of the continuing Brexit row over Northern Ireland. From a report: One academic said he was "relieved" to be exiting the country and feared the UK was going down a "dark path" like Germany in the 1930s. One hundred and fifty grants were approved for British applicants after the then Brexit minister, David Frost, successfully negotiated associate membership of the $95.3bn Horizon Europe programme but most will now be cancelled. Beneficiaries in the UK were told by the European Research Council (ERC) that unless associate membership had been approved by 29 June, the grants would not be available unless the researchers moved their work to a European institution.

Ratification of the membership has been in abeyance because the UK has not implemented the Brexit trading arrangements agreed under the Northern Ireland protocol. With the deadline passed, it has emerged that just 18 of the 150 academics will take up the grants but must move to an EU institution to get the funds. Thiemo Fetzer, a professor of economics at the University of Warwick who was approved for $1.53m of funding for research into media and geopolitics, confirmed he was one of the 18 who had reluctantly decided to move to the EU. He said: "I am relieved as this whole Brexit process has eroded my trust in the UK's institutions and this Horizon Europe association was just another incarnation of this."

Methane is four times more sensitive to global warming than previously thought, a new study shows. The result helps to explain the rapid growth in methane in recent years and suggests that, if left unchecked, methane related warming will escalate in the decades to come. From a report: The growth of this greenhouse gas -- which over a 20 year timespan is more than 80 times as potent than carbon dioxide -- had been slowing since the turn of the millennium but since 2007 has undergone a rapid rise, with measurements from the US National Oceanic and Atmospheric Administration recording it passing 1,900 parts a billion last year, nearly triple pre-industrial levels. "What has been particularly puzzling has been the fact that methane emissions have been increasing at even greater rates in the last two years, despite the global pandemic, when anthropogenic sources were assumed to be less significant," said Simon Redfern, an earth scientist at Nanyang Technological University in Singapore.

About 40% of methane emissions come from natural sources such as wetlands, while 60% come from anthropogenic sources such as cattle farming, fossil fuel extraction and landfill sites. Possible explanations for the rise in methane emissions range from expanding exploration of oil and natural gas, rising emissions from agriculture and landfill, and rising natural emissions as tropical wetlands warm and Arctic tundra melts. But another explanation could be a slowdown of the chemical reaction that removes methane from the atmosphere. The predominant way in which methane is "mopped up" is via reaction with hydroxyl radicals (OH) in the atmosphere.

An anonymous reader quotes a report from The Guardian: Researchers have created cloned mice from freeze dried skin cells in a world first that aims to help conservationists revive populations of endangered species. The breakthrough paves the way for countries to store skin cells from animals as an insurance policy, as the cells can be used to create clones that boost the species' genetic diversity if they become threatened with extinction in the future. While scientists have used frozen cells to produce clones for conservation projects, the cells are kept in liquid nitrogen which is expensive and risky: if there are power outages or the liquid nitrogen is not regularly topped up, the cells melt and become unusable. Freeze dried sperm can also be used to create clones, but cannot be obtained from all animals.

In the latest work, researchers froze dried skin cells from mouse tails and stored them for up to nine months before trying to create clones from them. The freeze-drying processes killed the cells, but the scientists found they could still create early stage cloned embryos by inserting the dead cells into mouse eggs that had their own nuclei removed. These early stage mouse embryos, known as blastocysts, were used to create stocks of stem cells that were put through another round of cloning. The stem cells were inserted into mouse eggs emptied of their own nuclei, leading to embryos that surrogate mice carried to term. The first cloned mouse, named Dorami after a melon bread-loving robot in the Doraemon Manga series, was followed by 74 more. To check whether the clones had healthy fertility, nine females and three males were bred with normal mice. All the females went on to have litters.

Despite the achievement, the process is inefficient -- freeze drying damaged DNA in the skin cells -- and the success rate for creating healthy female and male mouse pups was only 0.2 to 5.4%. In some of the cells, the Y chromosome was lost, leading to female mice being born from cells obtained from male animals. "If the same treatment could be performed in endangered species where only males survived, it would be possible to produce females and naturally preserve the species, the authors write in Nature Communications.

AmiMoJo writes: Finnish researchers have installed the world's first fully working 'sand battery' which can store green power for months at a time. The developers say this could solve the problem of year-round supply, a major issue for green energy. Using low-grade sand, the device is charged up with heat made from cheap electricity from solar or wind. The device has been installed in the Vatajankoski power plant which runs the district heating system for the area. Low-cost electricity warms the sand up to 500C by resistive heating (the same process that makes electric fires work). This generates hot air which is circulated in the sand by means of a heat exchanger. Sand is a very effective medium for storing heat and loses little over time. The developers say that their device could keep sand at 500C for several months. So when energy prices are higher, the battery discharges the hot air which warms water for the district heating system which is then pumped around homes, offices and even the local swimming pool.

Four mathematicians whose research covers areas like prime numbers and the packing of eight-dimensional spheres are the latest recipients of the Fields Medals, which are given out once every four years to some of the most accomplished mathematicians under the age of 40. From a report: At a ceremony in Helsinki on Tuesday, the International Mathematical Union, which administers the awards, bestowed the medals, made of 14-karat gold, to Hugo Duminil-Copin, 36, of the Institut des Hautes Etudes Scientifiques just south of Paris and the University of Geneva in Switzerland; June Huh, 39, of Princeton University; James Maynard, 35, of the University of Oxford in England; and Maryna Viazovska, 37, of the Swiss Federal Institute of Technology in Lausanne.

Mark Braverman, 38, of Princeton University received the Abacus Medal, a newer award that was modeled after the Fields for young computer scientists. Dr. Viazovska is just the second woman to receive a Fields Medal, while Dr. Huh defies the stereotype of a math prodigy, having not been drawn into the field until he was already 23 and in his last year of college. The Fields Medals, first awarded in 1936, were conceived by John Charles Fields, a Canadian mathematician. They and the Abacus Medal are unusual among top academic honors in that they go to people who are still early in their careers -- younger than 40 years on Jan. 1 -- and honor not just past achievements but also the promise of future breakthroughs. That the Fields are given only once every four years adds prestige through rarity -- something more like gold medals at the Olympics. Another award, the Abel Prize, is modeled more on the Nobel Prize and recognizes mathematicians annually for work over their careers. The recipients learned months ago that they had been chosen but were told not to share the news with friends and colleagues.