An anonymous reader writes "Microsoft says there are over 1,000 applications you can run on Windows Vista with few, if any, issues. However, Windows apps number in the tens of thousands. Add to that the facts that x64 Vista versions don't support legacy 16-bit code, and that the Windows Resource Protection in Vista breaks some apps, and you've got a big issue. InformationWeek lists a host of workarounds in How To Manage Windows Vista Application Compatibility. Among the tips discussed are Vista's compatibility mode, its Program Compatibility Assistant wizard, and a little-known form of file and registry virtualization that's built into the OS. What problems have you encountered with incompatible apps, and are any issues you've encountered deal-breakers that could further roil the already muddied adoption picture for Vista?"